Angus Kt Wann
Affiliation: Queen Mary
- Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cellsR J McMurray
Institute of Bioengineering and School of Engineering and Materials Science, Queen Mary University of London, Bancroft Road, Mile End, London E1 4NS, UK
Sci Rep 3:3545. 2013..This negative regulation, on grooved topography, was reversed by siRNA to IFT88. This indicates that subtle regulation of IFT and associated cilia structure, tunes the wnt response controlling stem cell differentiation. ..
- Interleukin-1β sequesters hypoxia inducible factor 2α to the primary ciliumAngus Kt Wann
Institute of Bioengineering and School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK
Cilia 2:17. 2013..The present study tests the hypothesis that an association exists between the primary cilium and HIFs in inflammatory signalling...
- Primary cilia elongation in response to interleukin-1 mediates the inflammatory responseA K T Wann
Biomedical Engineering, 2nd Floor Cell and Tissue Laboratories, School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
Cell Mol Life Sci 69:2967-77. 2012..These results suggest that cilia assembly regulates the response to inflammatory cytokines. Therefore, the cilia proteome may provide a novel therapeutic target for the treatment of inflammatory pathologies, including OA...
- Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradationAngus K T Wann
School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK
Arthritis Res Ther 12:R207. 2010..The aim of this study was to examine the therapeutic potential of n-3 polyunsaturated fatty acids (PUFAs) in an in vitro model of cartilage inflammation...