N J Wald

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Assay precision of serum alpha fetoprotein in antenatal screening for neural tube defects and Down's syndrome
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    J Med Screen 7:74-7. 2000
  2. ncbi request reprint Quantifying the effect of folic acid
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts, Charterhouse Square, London, UK
    Lancet 358:2069-73. 2001
  3. ncbi request reprint Multiple marker second trimester serum screening for pre-eclampsia
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    J Med Screen 8:65-8. 2001
  4. pmc Chlamydia pneumoniae infection and mortality from ischaemic heart disease: large prospective study
    N J Wald
    BUPA Epidemiological Research Group, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, London EC1M 6BQ
    BMJ 321:204-7. 2000
  5. ncbi request reprint Routine ultrasound scanning for congenital abnormalities
    N Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s, London, United Kingdom
    Ann N Y Acad Sci 847:173-80. 1998
  6. ncbi request reprint SP1 in pregnancies with Down syndrome in the first trimester of pregnancy. International Prenatal Screening Research Group
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, UK
    Prenat Diagn 19:517-20. 1999
  7. ncbi request reprint Maternal serum prostate-specific antigen and Down syndrome in the first and second trimesters of pregnancy. International Prenatal Screening Research Group
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomews and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, U K
    Prenat Diagn 19:674-6. 1999
  8. ncbi request reprint SURUSS in perspective
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, UK
    Semin Perinatol 29:225-35. 2005
  9. ncbi request reprint Inaccurate estimation of risk in second trimester serum screening for Down syndrome among women who have already had first trimester screening
    A K Hackshaw
    Department of Environmental and Preventive Medicine, The Wolfson Institute of Preventive Medicine, Queen Mary and Westfield College, University of London, UK
    Prenat Diagn 21:741-6. 2001
  10. ncbi request reprint SURUSS in perspective
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, UK
    BJOG 111:521-31. 2004

Detail Information

Publications43

  1. ncbi request reprint Assay precision of serum alpha fetoprotein in antenatal screening for neural tube defects and Down's syndrome
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    J Med Screen 7:74-7. 2000
    ..To assess the impact of current serum alpha fetoprotein (AFP) assays on the performance of screening for open neural tube defects and Down's syndrome...
  2. ncbi request reprint Quantifying the effect of folic acid
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts, Charterhouse Square, London, UK
    Lancet 358:2069-73. 2001
    ..Folic acid is known to prevent neural-tube defects (NTDs) but the size of the effect for a given dose is unclear. We aimed to quantify such an effect...
  3. ncbi request reprint Multiple marker second trimester serum screening for pre-eclampsia
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    J Med Screen 8:65-8. 2001
    ....
  4. pmc Chlamydia pneumoniae infection and mortality from ischaemic heart disease: large prospective study
    N J Wald
    BUPA Epidemiological Research Group, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, London EC1M 6BQ
    BMJ 321:204-7. 2000
    ..To determine whether there is an independent association between infection with Chlamydia pneumoniae and ischaemic heart disease...
  5. ncbi request reprint Routine ultrasound scanning for congenital abnormalities
    N Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s, London, United Kingdom
    Ann N Y Acad Sci 847:173-80. 1998
    ....
  6. ncbi request reprint SP1 in pregnancies with Down syndrome in the first trimester of pregnancy. International Prenatal Screening Research Group
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, UK
    Prenat Diagn 19:517-20. 1999
    ..76 to 0.97). This difference, though statistically significant, was not large enough for SP1 to be a useful marker in screening, at least from 10 weeks onwards where most of our data lie...
  7. ncbi request reprint Maternal serum prostate-specific antigen and Down syndrome in the first and second trimesters of pregnancy. International Prenatal Screening Research Group
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomews and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, U K
    Prenat Diagn 19:674-6. 1999
    ..1 and 0.9 multiple of the normal median, respectively, in affected pregnancies. There was no indication that PSA would be a useful screening marker...
  8. ncbi request reprint SURUSS in perspective
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, UK
    Semin Perinatol 29:225-35. 2005
    ..We here present the main results from SURUSS, updated to take account of recent information on nuchal translucency in Down's Syndrome pregnancies, and discuss their implications...
  9. ncbi request reprint Inaccurate estimation of risk in second trimester serum screening for Down syndrome among women who have already had first trimester screening
    A K Hackshaw
    Department of Environmental and Preventive Medicine, The Wolfson Institute of Preventive Medicine, Queen Mary and Westfield College, University of London, UK
    Prenat Diagn 21:741-6. 2001
    ..The practice of offering second trimester serum screening to women who have already been screened is best avoided...
  10. ncbi request reprint SURUSS in perspective
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, UK
    BJOG 111:521-31. 2004
    ..We here present the main results from SURUSS, updated to take account of recent information on nuchal translucency in Down's Syndrome pregnancies, and discuss their implications...
  11. ncbi request reprint Validation plots in antenatal screening for Down's syndrome
    N J Wald
    Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 13:166-71. 2006
    ....
  12. ncbi request reprint Assessment of the value of reporting partial screening results in prenatal screening for Down syndrome
    A K Hackshaw
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary and Westfield College, University of London, London, UK
    Prenat Diagn 21:737-40. 2001
    ..It is therefore not worthwhile reporting partial risk estimates in screening programmes using the Combined Test or Integrated Test...
  13. doi request reprint Multiple-marker screening for Down's syndrome: a method of assessing the statistical robustness of proposed tests
    J K Morris
    Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 15:55-61. 2008
    ..We used the maximum variance inflation factor (VIF(max)) to determine whether a screening test using multiple markers was robust to imprecision in the estimation of the marker distribution parameters...
  14. ncbi request reprint First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Bart s and The London School of Medicine and Dentistry, London EC1M 6BQ, UK
    J Med Screen 10:56-104. 2003
  15. ncbi request reprint Repeat testing in antenatal screening for Down syndrome using dimeric inhibin-A in combination with other maternal serum markers
    A K Hackshaw
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Prenat Diagn 21:58-61. 2001
    ..For a 5% false-positive rate the increase in detection rate was only about 3-5 percentage points; a modest increase which is probably not worthwhile in the light of the extra cost and delay...
  16. pmc Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials
    M R Law
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ
    BMJ 326:1427. 2003
    ....
  17. ncbi request reprint Using Down syndrome serum screening results to predict low birthweight
    T Huang
    Wolfson Institute of Preventive Medicine, Bart s and The London School of Medicine and Dentistry, Charterhouse Square, London, UK
    Prenat Diagn 23:420-6. 2003
    ..To investigate the use of prenatal maternal serum screening results for Down syndrome, for the prediction of low (<2500 g) and very low (<1500 g) birthweight...
  18. ncbi request reprint First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Bart s and The London School of Medicine and Dentistry, UK
    Health Technol Assess 7:1-77. 2003
  19. ncbi request reprint The effect of correlations between screening markers on screening performance
    J K Morris
    Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 14:151-7. 2007
    ....
  20. ncbi request reprint The performance of blood pressure and other cardiovascular risk factors as screening tests for ischaemic heart disease and stroke
    M R Law
    Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ
    J Med Screen 11:3-7. 2004
    ..Among persons with no history of cardiovascular disease, age is a better screening test than the reversible risk factors, and the best policy is to offer treatment to all persons above a specified age such as 55 years...
  21. pmc The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer
    M R Law
    BUPA Epidemiology Research Group, Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and The Royal London School of Medicine, UK
    Br J Cancer 75:1690-3. 1997
    ..The anomaly is explained by the observation that heavier smokers inhale less smoke from each cigarette...
  22. pmc Insulin-like growth factors and cancer: no role in screening. Evidence from the BUPA study and meta-analysis of prospective epidemiological studies
    J K Morris
    Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 95:112-7. 2006
    ..Our results suggest that IGF-1, IGF-2, and IGFBP-3 measurements have no value in cancer screening, although IGF-1 and IGF-2 may be of aetiological significance in relation to colorectal and prostate cancer...
  23. pmc Helicobacter pylori infection and mortality from ischaemic heart disease: negative result from a large, prospective study
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s, London
    BMJ 315:1199-201. 1997
    ..To determine whether there is an independent association between Helicobacter pylori infection of the stomach and ischaemic heart disease...
  24. ncbi request reprint Graphical presentation of distributions of risk in screening
    J K Morris
    Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, London EC1M 6BQ, UK
    J Med Screen 12:155-60. 2005
    ..However, this approximation sometimes fails. Here we examine the circumstances when this occurs...
  25. pmc Distribution of nuchal translucency in antenatal screening for Down's syndrome
    J P Bestwick
    Wolfson Institute of Preventive Medicine, Barts and the London Queen Marys School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 17:8-12. 2010
    ....
  26. ncbi request reprint Estimating the risk of Down's syndrome in antenatal screening and the gestation at which this risk applies
    J K Morris
    Wolfson Institute of Preventive Medicine, Barts and the Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 14:5-7. 2007
    ..Therefore the early second trimester of pregnancy is the gestational age at which all screening performances should be given for the different antenatal screening programmes for Down's syndrome...
  27. pmc Evaluation of a proposed mixture model to specify the distributions of nuchal translucency measurements in antenatal screening for Down's syndrome
    J P Bestwick
    Wolfson Institute of Preventive Medicine, Barts and the London Queen Marys School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 17:13-8. 2010
    ..Settings A routine antenatal screening programme for Down's syndrome comprising 104 affected and 22,284 unaffected pregnancies...
  28. pmc Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    M R Law
    Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 338:b1665. 2009
    ..To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment...
  29. ncbi request reprint Is cascade testing a sensible method of screening a population for autosomal recessive disorders?
    J K Morris
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Am J Med Genet A 128:271-5. 2004
    ..The performance of cascade testing is too poor to justify its introduction into practice as a screening test for any autosomal recessive disorder...
  30. pmc Environmental tobacco smoke exposure and ischaemic heart disease: an evaluation of the evidence
    M R Law
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s, London
    BMJ 315:973-80. 1997
    ....
  31. pmc Adding free to total prostate-specific antigen levels in trials of prostate cancer screening
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Br J Cancer 82:731-6. 2000
    ..Over a 6-year period (based on 41 cancers) a similar difference occurred (52% and 56% detection rates respectively). We conclude that there is no material advantage in adding free to total PSA in prostate cancer screening trials...
  32. pmc Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis
    M R Law
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ
    BMJ 326:1423. 2003
    ..To determine by how much statins reduce serum concentrations of low density lipoprotein (LDL) cholesterol and incidence of ischaemic heart disease (IHD) events and stroke, according to drug, dose, and duration of treatment...
  33. doi request reprint Antenatal screening for Down's syndrome using the Integrated test at two London hospitals
    N J Wald
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, London
    J Med Screen 16:7-10. 2009
    ..The audit demonstrated that it is feasible to conduct integrated screening within the NHS with a high acceptance rate and a screening performance consistent with that determined from previous research studies...
  34. pmc Serum cholesterol and subsequent risk of cancer: results from the BUPA study
    N J Wald
    Department of Environmental and Preventive Medicine, St Bartholomew s Hospital Medical College, London, UK
    Br J Cancer 59:936-8. 1989
    ..Our results, which are consistent with the majority of other published studies, indicate that a low serum cholesterol is not a cause of cancer...
  35. ncbi request reprint A new approach to antenatal screening for Fragile X syndrome
    N J Wald
    Department of Environmental Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, UK
    Prenat Diagn 23:345-51. 2003
    ..To describe a new approach to antenatal screening for Fragile X syndrome and to evaluate its effectiveness...
  36. ncbi request reprint Prevalence of neural tube defect pregnancies in England and Wales from 1964 to 2004
    J K Morris
    Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 14:55-9. 2007
    ....
  37. doi request reprint Improvements in antenatal screening for Down's syndrome
    N J Wald
    FRS, Professor and Institute Director, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 20:7-14. 2013
    ....
  38. ncbi request reprint Cystic fibrosis: selecting the prenatal screening strategy of choice
    N J Wald
    Wolfson Institute of Preventive Medicine, Barts and the London Queen Mary School of Medicine and Dentistry, London, UK
    Prenat Diagn 23:474-83. 2003
    ..Setting up a national prenatal screening programme for cystic fibrosis is timely and should be implemented using the couple screening method...
  39. pmc A strategy to reduce cardiovascular disease by more than 80%
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ
    BMJ 326:1419. 2003
    ..The strategy was to simultaneously reduce four cardiovascular risk factors (low density lipoprotein cholesterol, blood pressure, serum homocysteine, and platelet function) regardless of pretreatment levels...
  40. ncbi request reprint Guidance on terminology
    N J Wald
    Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 13:53. 2006
  41. doi request reprint A randomized double-blind crossover trial to investigate the efficacy of screening for adult hypothyroidism
    M Abu-Helalah
    Centre for Environmental and Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 17:164-9. 2010
    ..To assess the value of population screening for adult hypothyroidism...
  42. ncbi request reprint Comparison of models of maternal age-specific risk for Down syndrome live births
    J K Morris
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Prenat Diagn 23:252-8. 2003
    ..To display and compare the different published formulae that specify the association between maternal age and the risk of a Down syndrome live birth...
  43. pmc Serum beta-carotene and subsequent risk of cancer: results from the BUPA Study
    N J Wald
    Department of Environmental and Preventive Medicine, St Bartholomew s Hospital Medical College, London, UK
    Br J Cancer 57:428-33. 1988
    ....