Research Topics
Genomes and Genes | Muy Teck TehSummaryAffiliation: Queen Mary Country: UK Publications
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Publications
Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosisMuy Teck Teh
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, England, United Kingdom
Int J Cancer 132:2095-106. 2013..With further validation, qMIDS could enable early HNSCC detection and guide appropriate treatment. Early treatment intervention can lead to long-term reduction in healthcare costs and improve patient outcome...
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinomaMuy Teck Teh
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, England, United Kingdom
PLoS ONE 7:e34329. 2012....- Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytesMuy Teck Teh
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK
Mol Cancer 9:45. 2010..This indicates that upregulation of FOXM1 may be an early molecular signal required for aberrant cell cycle and cancer initiation... 
Role for WNT16B in human epidermal keratinocyte proliferation and differentiationMuy Teck Teh
Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and London School of Medicine and Dentistry, Queen Mary, University of London, Blizard Building, 4 Newark Street, London, E1 2AT, UK
J Cell Sci 120:330-9. 2007..This work presents the first evidence that WNT16B activates human keratinocyte proliferation possibly via a beta-catenin-independent non-canonical WNT transduction pathway...- FOXM1 is a downstream target of Gli1 in basal cell carcinomasMuy Teck Teh
Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, United Kingdom
Cancer Res 62:4773-80. 2002.... - Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic eventMuy Teck Teh
Centre for Cutaneous Research, Institute of Cell and Molecular Science, England, United Kingdom
Cancer Res 65:8597-603. 2005..Furthermore, we provide the first evidence that uniparental disomy due to somatic recombination constitutes one of the mechanisms of LOH in basal cell carcinoma tumorigenesis... - Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signallingAmrita Bose
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
PLoS ONE 7:e38599. 2012..This study provides insights into the mechanisms of K15 expression in the basal and differentiating keratinocytes... - A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinomaMuy Teck Teh
Queen Mary University of London, Barts and The London, School of Medicine and Dentistry, Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, London, UK
J Oral Pathol Med 40:67-76. 2011..These findings suggest dysfunction and loss of desmosomal components are common events in the immortal class of oral SCC and that these events may precede overt malignancy... - Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysisKarin J Purdie
Cancer Research UK Skin Tumour Laboratory, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, England, UK
Genes Chromosomes Cancer 46:661-9. 2007..Two of the 3 primary SCC with PTPRD deletion had demonstrated metastatic potential. Our data identify PTPRD as a candidate tumor suppressor gene in cutaneous SCC with a possible association with metastasis... - Induction of human epithelial stem/progenitor expansion by FOXM1Emilios Gemenetzidis
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Institute of Dentistry, Centre for Clinical and Diagnostic Oral Sciences, London, England
Cancer Res 70:9515-26. 2010.... - FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformationEmilios Gemenetzidis
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
PLoS ONE 4:e4849. 2009..The survival of patients is very poor due to the lack of effective early biomarkers. FOXM1 overexpression is linked to the majority of human cancers but its mechanism remains unclear in head and neck squamous cell carcinoma (HNSCC)... - Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinomaAhmad Waseem
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, England, United Kingdom
Oral Oncol 46:536-42. 2010..This study provides strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression... - An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severityAnand Lalli
Programme in Muco Cutaneous Oncology, Centre for Clinical and Diagnostic Oral Sciences, Institute of Cell and Molecular Sciences, London, UK
J Oral Pathol Med 37:211-20. 2008..We propose that the altered keratin profiles could be useful as histological diagnostic markers and provide important insights into the pathogenesis of the disease and its predisposition to malignancy... - Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageingGayani N Pitiyage
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
J Oral Pathol Med 41:454-62. 2012..Therefore, increased fibroblast TIMP-1/2 levels could be early disease-specific markers of OSMF onset, DDBs and ageing and may have clinical significance, as OSMF can be reversed in its early stages... - Desmoglein 3, via an interaction with E-cadherin, is associated with activation of SrcSiu Man Tsang
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, United Kingdom
PLoS ONE 5:e14211. 2010..However, increasing evidence suggests that the role of Dsg3 may involve more than just cell-cell adhesion... - Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosisDavid P Kelsell
Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Am J Hum Genet 76:794-803. 2005..This finding paves the way for early prenatal diagnosis. In addition, functional studies of ABCA12 will lead to a better understanding of epidermal differentiation and barrier formation... - The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychiaDiana C Blaydon
Centre for Cutaneous Research, Institute of Cell and Molecular Science, Queen Mary s School of Medicine and Dentistry, Queen Mary, University of London, Whitechapel, London E1 4AT, UK
Nat Genet 38:1245-7. 2006..Rspo4 expression was specifically localized to developing mouse nail mesenchyme at embryonic day 15.5, suggesting a crucial role in nail morphogenesis... - Desensitization of pigment granule aggregation in Xenopus leavis melanophores: melatonin degradation rather than receptor down-regulation is responsibleMuy-Teck Teh
Endocrinology and Reproduction Research Group, School of Biomedical Sciences, New Hunts House, Kings College London, Guy's Campus, London Bridge, London SE1 1UL, UK
J Neurochem 81:719-27. 2002....