Muy Teck Teh

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. doi request reprint Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, England, United Kingdom
    Int J Cancer 132:2095-106. 2013
  2. pmc FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, England, United Kingdom
    PLoS ONE 7:e34329. 2012
  3. pmc Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK
    Mol Cancer 9:45. 2010
  4. ncbi request reprint Role for WNT16B in human epidermal keratinocyte proliferation and differentiation
    Muy Teck Teh
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and London School of Medicine and Dentistry, Queen Mary, University of London, Blizard Building, 4 Newark Street, London, E1 2AT, UK
    J Cell Sci 120:330-9. 2007
  5. ncbi request reprint FOXM1 is a downstream target of Gli1 in basal cell carcinomas
    Muy Teck Teh
    Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, United Kingdom
    Cancer Res 62:4773-80. 2002
  6. ncbi request reprint Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event
    Muy Teck Teh
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, England, United Kingdom
    Cancer Res 65:8597-603. 2005
  7. pmc Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling
    Amrita Bose
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 7:e38599. 2012
  8. doi request reprint A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma
    Muy Teck Teh
    Queen Mary University of London, Barts and The London, School of Medicine and Dentistry, Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, London, UK
    J Oral Pathol Med 40:67-76. 2011
  9. pmc Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis
    Karin J Purdie
    Cancer Research UK Skin Tumour Laboratory, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, England, UK
    Genes Chromosomes Cancer 46:661-9. 2007
  10. pmc Induction of human epithelial stem/progenitor expansion by FOXM1
    Emilios Gemenetzidis
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Institute of Dentistry, Centre for Clinical and Diagnostic Oral Sciences, London, England
    Cancer Res 70:9515-26. 2010

Collaborators

Detail Information

Publications18

  1. doi request reprint Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, England, United Kingdom
    Int J Cancer 132:2095-106. 2013
    ..With further validation, qMIDS could enable early HNSCC detection and guide appropriate treatment. Early treatment intervention can lead to long-term reduction in healthcare costs and improve patient outcome...
  2. pmc FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, England, United Kingdom
    PLoS ONE 7:e34329. 2012
    ....
  3. pmc Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK
    Mol Cancer 9:45. 2010
    ..This indicates that upregulation of FOXM1 may be an early molecular signal required for aberrant cell cycle and cancer initiation...
  4. ncbi request reprint Role for WNT16B in human epidermal keratinocyte proliferation and differentiation
    Muy Teck Teh
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and London School of Medicine and Dentistry, Queen Mary, University of London, Blizard Building, 4 Newark Street, London, E1 2AT, UK
    J Cell Sci 120:330-9. 2007
    ..This work presents the first evidence that WNT16B activates human keratinocyte proliferation possibly via a beta-catenin-independent non-canonical WNT transduction pathway...
  5. ncbi request reprint FOXM1 is a downstream target of Gli1 in basal cell carcinomas
    Muy Teck Teh
    Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, United Kingdom
    Cancer Res 62:4773-80. 2002
    ....
  6. ncbi request reprint Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event
    Muy Teck Teh
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, England, United Kingdom
    Cancer Res 65:8597-603. 2005
    ..Furthermore, we provide the first evidence that uniparental disomy due to somatic recombination constitutes one of the mechanisms of LOH in basal cell carcinoma tumorigenesis...
  7. pmc Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling
    Amrita Bose
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 7:e38599. 2012
    ..This study provides insights into the mechanisms of K15 expression in the basal and differentiating keratinocytes...
  8. doi request reprint A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma
    Muy Teck Teh
    Queen Mary University of London, Barts and The London, School of Medicine and Dentistry, Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, London, UK
    J Oral Pathol Med 40:67-76. 2011
    ..These findings suggest dysfunction and loss of desmosomal components are common events in the immortal class of oral SCC and that these events may precede overt malignancy...
  9. pmc Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis
    Karin J Purdie
    Cancer Research UK Skin Tumour Laboratory, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, England, UK
    Genes Chromosomes Cancer 46:661-9. 2007
    ..Two of the 3 primary SCC with PTPRD deletion had demonstrated metastatic potential. Our data identify PTPRD as a candidate tumor suppressor gene in cutaneous SCC with a possible association with metastasis...
  10. pmc Induction of human epithelial stem/progenitor expansion by FOXM1
    Emilios Gemenetzidis
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Institute of Dentistry, Centre for Clinical and Diagnostic Oral Sciences, London, England
    Cancer Res 70:9515-26. 2010
    ....
  11. pmc FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation
    Emilios Gemenetzidis
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    PLoS ONE 4:e4849. 2009
    ..The survival of patients is very poor due to the lack of effective early biomarkers. FOXM1 overexpression is linked to the majority of human cancers but its mechanism remains unclear in head and neck squamous cell carcinoma (HNSCC)...
  12. doi request reprint Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma
    Ahmad Waseem
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, England, United Kingdom
    Oral Oncol 46:536-42. 2010
    ..This study provides strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression...
  13. doi request reprint Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageing
    Gayani N Pitiyage
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Oral Pathol Med 41:454-62. 2012
    ..Therefore, increased fibroblast TIMP-1/2 levels could be early disease-specific markers of OSMF onset, DDBs and ageing and may have clinical significance, as OSMF can be reversed in its early stages...
  14. doi request reprint An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity
    Anand Lalli
    Programme in Muco Cutaneous Oncology, Centre for Clinical and Diagnostic Oral Sciences, Institute of Cell and Molecular Sciences, London, UK
    J Oral Pathol Med 37:211-20. 2008
    ..We propose that the altered keratin profiles could be useful as histological diagnostic markers and provide important insights into the pathogenesis of the disease and its predisposition to malignancy...
  15. pmc Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src
    Siu Man Tsang
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    PLoS ONE 5:e14211. 2010
    ..However, increasing evidence suggests that the role of Dsg3 may involve more than just cell-cell adhesion...
  16. pmc Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis
    David P Kelsell
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Am J Hum Genet 76:794-803. 2005
    ..This finding paves the way for early prenatal diagnosis. In addition, functional studies of ABCA12 will lead to a better understanding of epidermal differentiation and barrier formation...
  17. ncbi request reprint The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
    Diana C Blaydon
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Queen Mary s School of Medicine and Dentistry, Queen Mary, University of London, Whitechapel, London E1 4AT, UK
    Nat Genet 38:1245-7. 2006
    ..Rspo4 expression was specifically localized to developing mouse nail mesenchyme at embryonic day 15.5, suggesting a crucial role in nail morphogenesis...
  18. ncbi request reprint Desensitization of pigment granule aggregation in Xenopus leavis melanophores: melatonin degradation rather than receptor down-regulation is responsible
    Muy Teck Teh
    Endocrinology and Reproduction Research Group, School of Biomedical Sciences, New Hunts House, Kings College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    J Neurochem 81:719-27. 2002
    ....