David Sinclair

Summary

Affiliation: Queen Alexandra Hospital
Country: UK

Publications

  1. ncbi request reprint Intravascular haemolysis: a potential missed diagnosis
    David Sinclair
    Department of Chemical Pathology, Queen Alexandra Hospital, Cosham, Portsmouth, United Kingdom
    Clin Lab 48:483-5. 2002
  2. pmc The predictive value of total serum IgE for a positive allergen specific IgE result
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    J Clin Pathol 57:956-9. 2004
  3. ncbi request reprint In vitro allergy investigation: Does a multiple allergen testing system give useful information?
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 51:395-401. 2005
  4. ncbi request reprint Clinical and laboratory aspects of thyroid autoantibodies
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 43:173-83. 2006
  5. ncbi request reprint Can an ELISA replace immunofluorescence for the detection of anti-nuclear antibodies?--The routine use of anti-nuclear antibody screening ELISAs
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 53:183-91. 2007
  6. doi request reprint Analytical aspects of thyroid antibodies estimation
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Autoimmunity 41:46-54. 2008
  7. pmc What happens to patients with positive tissue transglutaminase and endomysium antibody results in general practice?
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    J Clin Pathol 57:943-5. 2004
  8. ncbi request reprint Role of antineutrophil cytoplasmic antibodies and glomerular basement membrane antibodies in the diagnosis and monitoring of systemic vasculitides
    David Sinclair
    Department of Clinical Biochemistry, Wessex Renal and Transplant Service, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 44:432-42. 2007
  9. ncbi request reprint How lab staff and the estimation of free light chains can combine to aid the diagnosis of light chain disease
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, United Kingdom
    Clin Lab 53:267-71. 2007
  10. ncbi request reprint Complementing the patient: a complement component deficiency in a patient with recurrent infections and glomerulonephritis
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 51:505-7. 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Intravascular haemolysis: a potential missed diagnosis
    David Sinclair
    Department of Chemical Pathology, Queen Alexandra Hospital, Cosham, Portsmouth, United Kingdom
    Clin Lab 48:483-5. 2002
    ..The case is a reminder to biochemistry and haematology laboratories and clinical staff to investigate the possibility of haemolysis as well as hepatitis and Gilbert's disease as a cause of an isolated raised bilirubin...
  2. pmc The predictive value of total serum IgE for a positive allergen specific IgE result
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    J Clin Pathol 57:956-9. 2004
    ..This increases the likelihood of detecting borderline increases in allergen specific IgE of uncertain relevance, and has important cost implications for the service...
  3. ncbi request reprint In vitro allergy investigation: Does a multiple allergen testing system give useful information?
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 51:395-401. 2005
    ....
  4. ncbi request reprint Clinical and laboratory aspects of thyroid autoantibodies
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 43:173-83. 2006
    ..Finally, taking the current literature into account, an algorithm is recommended for the most effective use of these antibodies in the investigation of autoimmune thyroid disease...
  5. ncbi request reprint Can an ELISA replace immunofluorescence for the detection of anti-nuclear antibodies?--The routine use of anti-nuclear antibody screening ELISAs
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 53:183-91. 2007
    ..Results show that the ANA ELISA can successfully replace IIF for the detection of clinically significant antibodies...
  6. doi request reprint Analytical aspects of thyroid antibodies estimation
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Autoimmunity 41:46-54. 2008
    ..TSHR antibody heterogeneity can coexist within an individual patient and change over time is one reason why it has been difficult to develop diagnostically accurate TSHR antibody tests...
  7. pmc What happens to patients with positive tissue transglutaminase and endomysium antibody results in general practice?
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    J Clin Pathol 57:943-5. 2004
    ....
  8. ncbi request reprint Role of antineutrophil cytoplasmic antibodies and glomerular basement membrane antibodies in the diagnosis and monitoring of systemic vasculitides
    David Sinclair
    Department of Clinical Biochemistry, Wessex Renal and Transplant Service, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 44:432-42. 2007
    ....
  9. ncbi request reprint How lab staff and the estimation of free light chains can combine to aid the diagnosis of light chain disease
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, United Kingdom
    Clin Lab 53:267-71. 2007
    ....
  10. ncbi request reprint Complementing the patient: a complement component deficiency in a patient with recurrent infections and glomerulonephritis
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 51:505-7. 2005
    ..Investigations of "? immune deficiency" should always include tests to assess the patency of the patient's complement system...
  11. pmc Can the laboratory affect the investigation and diagnosis of primary biliary cirrhosis?
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    J Clin Pathol 59:360-2. 2006
    ..Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterised by the presence of various laboratory abnormalities but the precise role of laboratory staff in initiating clinical referral and subsequent biopsy is not clear...
  12. pmc Acquired C1 esterase inhibitor deficiency or serendipity? The chance finding of a paraprotein after an apparently low C1 esterase inhibitor concentration
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK
    J Clin Pathol 57:445-7. 2004
    ..It also confirms the need to obtain repeat confirmatory samples before arriving at a diagnosis, however convincing the clinical signs may be...
  13. ncbi request reprint Spurious hyperphosphataemia caused by an IgA paraprotein: a topic revisited
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 41:119-24. 2004
    ..There are reports in the literature describing artefactually raised phosphate concentrations in serum samples of patients with myeloma. However, IgA paraproteins have been reported only rarely as a potential cause...
  14. ncbi request reprint IgD myeloma: clinical, biological and laboratory features
    David Sinclair
    Department of Chemical Pathology, Queen Alexandra Hospital, Portsmouth, United Kingdom
    Clin Lab 48:617-22. 2002
    ..However, the management of any associated renal failure will always remain a challenge, I suspect. The progress being made in the treatment of myeloma as a whole, is bound to have a positive impact on the treatment of IgD myeloma...
  15. ncbi request reprint Why do general practitioners request rheumatoid factor? A study of symptoms, requesting patterns and patient outcome
    David Sinclair
    Department of Chemical Pathology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 40:131-7. 2003
    ..To investigate the reasons why general practitioners (GPs) request rheumatoid factor (RF) assays, we studied 200 consecutive requests for RF from general practice in 1995...
  16. ncbi request reprint Paraprotein and beta2-microglobulin analyses in multiple myeloma--do we need to monitor both?
    David Sinclair
    Department of Chemical Pathology, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 49:129-34. 2003
    ..7% of myeloma patients indicating that no extra information was gained from measuring both analytes routinely. As a result, the workload for B2m fell without any diminution in clinical service...
  17. pmc Seasonal pseudohyperkalaemia
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, Hampshire PO6 3LY, UK
    J Clin Pathol 56:385-8. 2003
    ..To investigate the relation between ambient temperature and serum potassium concentrations in samples from primary care...
  18. ncbi request reprint A comparative study of tissue transglutaminase antibodies and endomysium antibody immunofluorescence in routine clinical laboratory practice
    David Sinclair
    Department of Chemical Pathology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    Ann Clin Biochem 40:411-6. 2003
    ..This study compares tissue transglutaminase (TTG) and endomysium antibodies (EMA) in a routine clinical laboratory situation...
  19. ncbi request reprint Stridor: unusual presentation of multiple myeloma
    David Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    J Laryngol Otol 117:829-31. 2003
    ..Chemotherapy and localized radiotherapy were commenced. This is a most unusual presentation of multiple myeloma and shows that immunoglobulin profiles should be properly investigated in such cases...
  20. pmc The effect of a symptom related "gating policy" on ANCA requests in routine clinical practice
    D Sinclair
    Department of Chemical Pathology, Queen Alexandra Hospital, Portsmouth PO6 3 LY, UK
    J Clin Pathol 57:131-4. 2004
    ..The outcome of applying similar guidelines in a routine laboratory is reported...
  21. ncbi request reprint Use of the anti-endomysial antibody test to diagnose coeliac disease in clinical practice
    Allum B Pearce
    Department of Gastroenterology, Queen Alexandra Hospital, Cosham, Portsmouth, UK
    Clin Lab 48:319-25. 2002
    ..Guidelines suggest that duodenal biopsies should be taken in patients with iron deficiency anaemia...
  22. pmc Do we need to measure total serum IgA to exclude IgA deficiency in coeliac disease?
    D Sinclair
    Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
    J Clin Pathol 59:736-9. 2006
    ..Screening for IgA deficiency in patients with coeliac disease is essential because of the increased incidence of IgA deficiency associated with the disease, which usually relies on the estimation of IgA levels in each case...
  23. ncbi request reprint Antibodies to thyroid peroxidase (TPOAb) in serum from patients with slightly raised thyrotropin (TSH) levels
    Phillip Briston
    Department of Chemical Pathology, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab 50:383-6. 2004
    ..Our data suggest that it would be more effective if laboratory staff were to request thyroid antibodies on specimens from patients with persistently raised TSH concentrations and to comment further on the significance of the result...
  24. ncbi request reprint Occurrence of autoantibodies in chronic graft vs. host disease after allogeneic stem cell transplantation
    A Wechalekar
    Department of Haematology, Queen Alexandra Hospital, Portsmouth, UK
    Clin Lab Haematol 27:247-9. 2005
    ..In conclusion, this small series raises interesting questions about the presence and role of autoantibodies after SCT and their association with cGVHD...
  25. ncbi request reprint West Nile virus in horses
    Karen Coumbe
    Vet Rec 159:823. 2006
  26. ncbi request reprint Pneumocystis carinii pneumonia infection in a patient with known chronic mucocutaneous candidiasis
    Damian J McKeon
    Department of Respiratory Medicine, Torbay Hospital, Torquay, United Kingdom
    Respirology 10:399-401. 2005
    ..There have been two previous cases of Pneumocystis carinii pneumonia reported with this condition. We report a fatal case in a 34-year-old male...
  27. ncbi request reprint Listening to the socially excluded: the European national action plan
    David Sinclair
    Help the Aged
    Br J Community Nurs 12:571-3. 2007
    ....