Louise E Reynolds

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome
    Louise E Reynolds
    Adhesion and Angiogenesis Laboratory, Barts Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    Nature 465:813-7. 2010
  2. pmc β3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear
    Ivan Brunetta
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, UK
    BMC Cell Biol 13:5. 2012
  3. pmc Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF
    Rita Graça da Silva
    Adhesion and Angiogenesis Laboratory, Barts Institute of Cancer, Queen Mary University of London, London, UK
    Am J Pathol 177:1534-48. 2010
  4. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
  5. pmc Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice
    Dylan T Jones
    Centre for Tumour Biology, Barts Cancer Institute A CR UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
    Dis Model Mech 6:115-24. 2013
  6. doi request reprint Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis
    Mitchel Germain
    The Adhesion and Angiogenesis Laboratory, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK
    J Pathol 220:370-81. 2010
  7. pmc Endothelial FAK is required for tumour angiogenesis
    Bernardo Tavora
    Adhesion and Angiogenesis Laboratory, Centre of Tumour Biology, Institute of Cancer and Cancer Research UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, UK
    EMBO Mol Med 2:516-28. 2010
  8. pmc Regulation of lymphatic-blood vessel separation by endothelial Rac1
    Gabriela D'Amico
    Adhesion and Angiogenesis Laboratory, Institute of Cancer and Cancer Research UK, Bart s and the London Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
    Development 136:4043-53. 2009

Collaborators

Detail Information

Publications8

  1. pmc Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome
    Louise E Reynolds
    Adhesion and Angiogenesis Laboratory, Barts Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    Nature 465:813-7. 2010
    ....
  2. pmc β3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear
    Ivan Brunetta
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, UK
    BMC Cell Biol 13:5. 2012
    ..The OC-2 cells are thus a useful model system for testing mechanism of hair cells differentiation...
  3. pmc Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF
    Rita Graça da Silva
    Adhesion and Angiogenesis Laboratory, Barts Institute of Cancer, Queen Mary University of London, London, UK
    Am J Pathol 177:1534-48. 2010
    ..These data, therefore, identify directly that endothelial alpha3beta1 negatively regulates pathological angiogenesis and implicate an unexpected role for low levels of endothelial-VEGF as an activator of neovascularization...
  4. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
    ..Our data suggest that beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2...
  5. pmc Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice
    Dylan T Jones
    Centre for Tumour Biology, Barts Cancer Institute A CR UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
    Dis Model Mech 6:115-24. 2013
    ..Overall, our results identify that loss or depletion of RPL29 can reduce angiogenesis in vivo and ex vivo...
  6. doi request reprint Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis
    Mitchel Germain
    The Adhesion and Angiogenesis Laboratory, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK
    J Pathol 220:370-81. 2010
    ..By developing the first endothelial-specific alpha6-knockout mice, we show that the expression of the alpha6-integrin subunit in endothelial cells acts as a negative regulator of angiogenesis both in vivo and ex vivo...
  7. pmc Endothelial FAK is required for tumour angiogenesis
    Bernardo Tavora
    Adhesion and Angiogenesis Laboratory, Centre of Tumour Biology, Institute of Cancer and Cancer Research UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, UK
    EMBO Mol Med 2:516-28. 2010
    ..Our data suggest that FAK is required for adult pathological angiogenesis and validates FAK as a possible target for anti-angiogenic therapies...
  8. pmc Regulation of lymphatic-blood vessel separation by endothelial Rac1
    Gabriela D'Amico
    Adhesion and Angiogenesis Laboratory, Institute of Cancer and Cancer Research UK, Bart s and the London Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
    Development 136:4043-53. 2009
    ..Our studies identify Rac1 as a crucial part of the migratory machinery required for endothelial cells to separate and form lymphatic vasculature...