J R Puddefoot

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Non-competitive steroid inhibition of oestrogen receptor functions
    John R Puddefoot
    School of Biological Sciences, Queen Mary, University of London, United Kingdom
    Int J Cancer 101:17-22. 2002
  2. ncbi request reprint Trilostane in advanced breast cancer
    John R Puddefoot
    School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Expert Opin Pharmacother 7:2413-9. 2006
  3. ncbi request reprint The role of angiotensin II in the regulation of breast cancer cell adhesion and invasion
    J R Puddefoot
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Endocr Relat Cancer 13:895-903. 2006
  4. ncbi request reprint Modulation of very late activation-2 laminin receptor function in breast cancer metastasis
    G P Gui
    Department of Surgery, St Bartholomew s Hospital, London, UK
    Surgery 118:245-50. 1995
  5. pmc Oestrogen receptor isoforms, their distribution and relation to progesterone receptor levels in breast cancer samples
    V A Baker
    Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary Westfield College, University of London, UK
    Br J Cancer 66:1083-7. 1992
  6. pmc Localisation of renin-angiotensin system (RAS) components in breast
    M Tahmasebi
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Br J Cancer 95:67-74. 2006
  7. doi request reprint Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor
    M A Redondo-Müller
    School of Biological and Chemical Sciences, Queen Mary, University of London, London, UK
    Endocr Relat Cancer 15:277-88. 2008
  8. pmc Altered cell-matrix contact: a prerequisite for breast cancer metastasis?
    G P Gui
    Department of Surgery, St Bartholomew s Hospital, West Smithfield, London, UK
    Br J Cancer 75:623-33. 1997
  9. pmc Epidermal growth factor receptor and oestrogen receptors in the non-malignant part of the cancerous breast
    S Barker
    Department of Biochemistry, Medical College of St Bartholomew s Hospital, London, UK
    Br J Cancer 60:673-7. 1989
  10. ncbi request reprint A two cell type theory for aldosterone biosynthesis: the roles of 11 beta-hydroxylase and aldosterone synthase, and a high capacity tightly binding steroid carrier for 18-hydroxydeoxycorticosterone in rat adrenals
    G P Vinson
    Department of Biochemistry, Queen Mary and Westfield College, London, UK
    J Endocrinol 144:359-68. 1995

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Non-competitive steroid inhibition of oestrogen receptor functions
    John R Puddefoot
    School of Biological Sciences, Queen Mary, University of London, United Kingdom
    Int J Cancer 101:17-22. 2002
    ..The beneficial actions of trilostane in breast cancer may be attributed to the combination of this antioestrogen effect with its well documented suppression of steroidogenesis...
  2. ncbi request reprint Trilostane in advanced breast cancer
    John R Puddefoot
    School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Expert Opin Pharmacother 7:2413-9. 2006
    ..Ongoing and future clinical trials are examining the potential for the use of trilostane in premenopausal breast cancer, as well as in other malignancies such as prostate cancer...
  3. ncbi request reprint The role of angiotensin II in the regulation of breast cancer cell adhesion and invasion
    J R Puddefoot
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Endocr Relat Cancer 13:895-903. 2006
    ..These data suggest that AII reduces cell adhesion and invasion through the type 1 receptor and that this effect may be due to reduced expression of integrins, and in particular alpha3 and beta1...
  4. ncbi request reprint Modulation of very late activation-2 laminin receptor function in breast cancer metastasis
    G P Gui
    Department of Surgery, St Bartholomew s Hospital, London, UK
    Surgery 118:245-50. 1995
    ..001). CONCLUSIONS. VLA-2-mediated adhesion of primary breast cancer cells to laminin differs with nodal status. Measurement of VLA-2 expression may thus be of clinical value as a prognostic indicator in the assessment of breast cancer...
  5. pmc Oestrogen receptor isoforms, their distribution and relation to progesterone receptor levels in breast cancer samples
    V A Baker
    Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary Westfield College, University of London, UK
    Br J Cancer 66:1083-7. 1992
    ..001). This variability in the ER isoform profile of breast tumours and their correlation with PgR levels may have a bearing on prognosis and tumour response to endocrine therapy...
  6. pmc Localisation of renin-angiotensin system (RAS) components in breast
    M Tahmasebi
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Br J Cancer 95:67-74. 2006
    ..3) Angiotensin converting enzyme was shown in epithelial cells in both normal and malignant tissue. The results are consistent with the hypothesis that a tRAS is present in the breast, and is disrupted in invasive cancer...
  7. doi request reprint Anti-cancer actions of a recombinant antibody (R6313/G2) against the angiotensin II AT1 receptor
    M A Redondo-Müller
    School of Biological and Chemical Sciences, Queen Mary, University of London, London, UK
    Endocr Relat Cancer 15:277-88. 2008
    ..The data suggest that the anti-cancer action of R6313/G2 is considerably more effective than AT1 antagonists...
  8. pmc Altered cell-matrix contact: a prerequisite for breast cancer metastasis?
    G P Gui
    Department of Surgery, St Bartholomew s Hospital, West Smithfield, London, UK
    Br J Cancer 75:623-33. 1997
    ..This study demonstrates a link between altered integrin expression and function in primary breast cancers predisposed to metastasize...
  9. pmc Epidermal growth factor receptor and oestrogen receptors in the non-malignant part of the cancerous breast
    S Barker
    Department of Biochemistry, Medical College of St Bartholomew s Hospital, London, UK
    Br J Cancer 60:673-7. 1989
    ..This suggests different regulation of receptor expression in malignant and non-malignant tissue...
  10. ncbi request reprint A two cell type theory for aldosterone biosynthesis: the roles of 11 beta-hydroxylase and aldosterone synthase, and a high capacity tightly binding steroid carrier for 18-hydroxydeoxycorticosterone in rat adrenals
    G P Vinson
    Department of Biochemistry, Queen Mary and Westfield College, London, UK
    J Endocrinol 144:359-68. 1995
    ..The results also indicate the existence of an entirely novel tightly binding steroid carrier from which steroid cannot be extracted by organic solvent unless first subjected to proteolytic degradation...
  11. ncbi request reprint Regulation of hepatic steroid receptors and enzymes by the 3beta-hydroxysteroid dehydrogenase inhibitor trilostane
    S D M Malouitre
    School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    J Steroid Biochem Mol Biol 101:97-105. 2006
    ..The combination of increased 11beta-HSD2 and reduced GR expression in target organs could be expected to ameliorate the effects of excess glucocorticoid, suggesting new therapeutic approaches...
  12. ncbi request reprint Angiotensin II in human seminal fluid
    O A O'Mahony
    Academic Department of Obstetrics and Gynaecology and Reproductive Physiology, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Hum Reprod 15:1345-9. 2000
    ..The results are consistent with the concept that angiotensin II has an important role in male fertility...
  13. ncbi request reprint The distribution of angiotensin II type 1 receptors, and the tissue renin-angiotensin systems
    G P Vinson
    Department of Biochemistry, St Bartholomew s, London, UK
    Mol Med Today 1:35-9. 1995
    ..This paracrine function is brought about by the existence of complete, localized tissue RASs, which respond to physiological demand independently from the systemic system...
  14. ncbi request reprint Synthesis and secretion of angiotensin II by the prostate gland in vitro
    Orla A O'Mahony
    School of Biological Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Endocrinology 146:392-8. 2005
    ..These findings all suggest the independence of prostate and systemic renin angiotensin system regulation. The data presented here suggest that the prostate may be a source of the secreted angiotensin II found in seminal plasma...
  15. ncbi request reprint Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta
    Stewart Barker
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK
    J Steroid Biochem Mol Biol 100:141-51. 2006
    ..Trilostane-specific up-regulation of ERbeta could explain its positive benefit rates in acquired tamoxifen resistance...
  16. ncbi request reprint Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation
    Fang Xiao
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Hypertension 44:340-5. 2004
    ..One way it may act is by modulating the expression and functions of the AT1 receptor...
  17. ncbi request reprint Integrin beta1-mediated invasion of human breast cancer cells: an ex vivo assay for invasiveness
    M G Berry
    Department of Surgery, St Bartholomew s and the Royal London School of Medicine and Dentistry, St Bartholomew s Hospital, UK
    Breast Cancer 10:214-9. 2003
    ..Our aims were to optimise culture conditions in order to establish a reliable invasion assay and to assess the effect on invasion of perturbations of the beta1 integrin receptors...