Research Topics
Genomes and Genes | Nimesh S A PatelSummaryAffiliation: Queen Mary Country: UK Publications
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Publications
Urocortin does not reduce the renal injury and dysfunction caused by experimental ischaemia/reperfusionNimesh S A Patel
Centre for Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, UK
Eur J Pharmacol 496:175-80. 2004..Thus, we propose that the pharmacological application of urocortin does not reduce the renal injury caused by bilateral renal ischaemia/reperfusion...
Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injuryNimesh S A Patel
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, The William Harvey Research Institute, London, UK
Mol Med 18:719-27. 2012..Interestingly, the phosphorylation of endothelial nitric oxide synthase was enhanced by EPO and, to a much lesser extent, by pHBSP, suggesting that the signaling pathways activated by EPO and pHBSP may not be identical...- The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivoNimesh S A Patel
Centre for Experimental Medicine and Nephrology and Critical Care, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Eur J Pharmacol 562:148-54. 2007.... 
Peroxisome proliferator-activated receptor-alpha contributes to the resolution of inflammation after renal ischemia/reperfusion injuryNimesh S A Patel
Centre for Translational Medicine and Nephrology, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, United Kingdom
J Pharmacol Exp Ther 328:635-43. 2009....- A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shockNimesh S A Patel
Centre for Translational Medicine and Therapeutics, Queen Mary University of London, William Harvey Research Institute, Barts and The London, London, UK
Mol Med 17:883-92. 2011.... - Erythropoietin in the intensive care unit: beyond treatment of anemiaNimesh Sa Patel
Centre for Translational Medicine and Therapeutics, Queen Mary University of London, William Harvey Research Institute, Barts and The London, London, UK
Ann Intensive Care 1:40. 2011..This review article summarizes what is known in preclinical models of critical illness and discusses why this does not correlate with randomized, controlled clinical trials... - Inhibiting glycogen synthase kinase 3beta in sepsisLaura Dugo
Centre for Experimental Medicine, Nephrology and Critical Care Medicine, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London ECIM 6BQ, UK
Novartis Found Symp 280:128-42; discussion 142-6, 160-4. 2007..We propose that GSK-3beta inhibition may be useful in the therapy of sepsis, shock and other diseases associated with local or systemic inflammation... - GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the ratLaura Dugo
Centre for Experimental Medicine, Nephrology and Critical Care Medicine, The William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, UK
Crit Care Med 33:1903-12. 2005..We propose that GSK-3beta inhibition may be useful in the therapy of the organ injury/dysfunction associated with sepsis, shock, and other diseases associated with local or systemic inflammation... - Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shockMaha Abdelrahman
Centre of Experimental Medicine, Nephrology, and Critical Care, The William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London EC1M 6BQ, UK
Shock 23:107-14. 2005.... - GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injuryPrabal K Chatterjee
Department of Experimental Medicine and Nephrology, The William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, London, United Kingdom
Kidney Int 63:853-65. 2003..The aim of this study was to investigate the effects of GW274150, a novel, highly selective, potent and long-acting inhibitor of iNOS activity in rat and mouse models of renal I/R... - The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failurePrabal Kumar Chatterjee
Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary-University of London, Charterhouse Square, London EC1M 6BQ, UK
Cardiovasc Res 61:630-43. 2004.... - Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileutonMarika Collin
Centre for Experimental Medicine, Nephrology and Critical Care, The William Harvey Research Institute, Queen Mary, University of London, UK
J Leukoc Biol 76:961-70. 2004.... - Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injuryNimesh S A Patel
Centre for Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK
J Am Soc Nephrol 16:712-9. 2005..Thus, it is proposed that endogenous PARG(110) plays a pivotal role in the pathophysiology of I/R injury of the kidney... - The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the ratPrabal K Chatterjee
Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary - University of London, London, United Kingdom
Kidney Int 64:1605-19. 2003..We propose that inhibition of tyrosine kinase activity may be useful against renal I/R injury... - Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusionNimesh S A Patel
Centre for Experimental Medicine, Nephrology, and Critical Care, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
J Pharmacol Exp Ther 312:1170-8. 2005..We propose that endogenous IL-6 enhances the degree of renal injury, dysfunction, and inflammation caused by I/R of the kidney by promoting the expression of adhesion molecules and subsequent oxidative and nitrosative stress... - Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileutonNimesh S A Patel
Centre for Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary - University of London, United Kingdom
Mol Pharmacol 66:220-7. 2004.... - High density lipoprotein (HDL) reduces renal ischemia/reperfusion injuryChristoph Thiemermann
Department of Experimental Medicine and Nephrology, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
J Am Soc Nephrol 14:1833-43. 2003..It is proposed that the mechanism of protection involves reduction of the expression of adhesion molecules, resulting in reduction of PMN infiltration and oxidative stress... - GW274150 inhibits nitric oxide production by primary cultures of rat proximal tubular cellsPrabal K Chatterjee
Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary-University of London, UK
Med Sci Monit 9:BR357-62. 2003..CONCLUSIONS: GW274150 inhibits NO production by primary cultures of PTCs and may therefore be useful in conditions associated with nitrosative stress of the kidney... - Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivoNimesh S A Patel
Centre for Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary - University of London, London, United Kingdom
Kidney Int 66:983-9. 2004..We propose that different mechanisms underlie the protective effects seen with EPO when given as either a daily pretreatment or as a single bolus, which need to be further investigated... - Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injuryAhila Sivarajah
Department of Experimental Medicine and Nephrology, William Harvey Research Institute, Queen Mary-University of London, UK
Am J Nephrol 23:267-76. 2003..We propose that one mechanism underlying the protective effects involves inhibition of the expression of ICAM-1, a reduction of PMN infiltration into renal tissues and subsequent reduction of oxidative stress... - EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidneyPrabal K Chatterjee
Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary University of London, London, UK
Am J Nephrol 24:165-77. 2004..CONCLUSION: We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R... - TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidneyNimesh S A Patel
Department of Experimental Medicine and Nephrology, The William Harvey Research Institute, London, England
Free Radic Biol Med 33:1575-89. 2002.... - Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductasePinpat Tripatara
Centre for Experimental Medicine and Nephrology and Critical Care, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
J Am Soc Nephrol 18:570-80. 2007..These observations suggest that nitrite therapy might prove beneficial in protecting kidney function and integrity during periods of I/R such as those encountered in renal transplantation... - Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the ratKiran K Nandra
The William Harvey Research Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
Shock 37:592-8. 2012.... - Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunctionPinpat Tripatara
Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Lab Invest 88:1038-48. 2008.... - Dexamethasone ameliorates renal ischemia-reperfusion injurySanjeev Kumar
Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, St Bartholomew s, University of London, London EC1M 6BQ, United Kingdom
J Am Soc Nephrol 20:2412-25. 2009..In summary, in the setting of renal ischemia-reperfusion injury, dexamethasone directly protects against kidney injury by a receptor-dependent, nongenomic mechanism... - Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxinMarika Collin
William Harvey Research Institute, Department of Experimental Medicine, Nephrology and Critical Care, St. Bartholomew's, and the Royal London School of Medicine and Dentistry, London, UK
Crit Care Med 32:826-31. 2004..We propose that 15 d-PGJ2 or other ligands for PPAR-gamma may be useful in treating organ injury associated with endotoxic shock... - The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusionMassimo Collino
Centre for Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary-University of London, London, UK
Kidney Int 68:529-36. 2005..CONCLUSION: We document here for the first time that endogenous ligands of PPARgamma may contribute to the protection against renal I/R injury afforded by LPS pretreatment in the rat... - Protective role of peroxisome proliferator-activated receptor-β/δ in septic shockAmar Kapoor
Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, London, United Kingdom
Am J Respir Crit Care Med 182:1506-15. 2010..Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown... - Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo studyPinpat Tripatara
Centre for Translational Medicine and Therapeutics, Queen Mary University of London, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
Eur J Pharmacol 606:205-9. 2009.... - Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemiaMaha Abdelrahman
Centre of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
Shock 22:63-9. 2004..We propose that the acute administration of EPO on reperfusion and/or resuscitation will reduce the tissue injury caused by ischemia-reperfusion of the heart (and other organs) and hemorrhagic shock... - Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injuryPrabal K Chatterjee
Department of Experimental Medicine and Nephrology, The William Harvey Research Institute, St Bartholomew s, Charterhouse Square, London, EC1M 6BQ England, United Kingdom
Kidney Int 61:862-71. 2002.... - Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shockKiran K Nandra
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
Dis Model Mech 6:701-9. 2013.... - Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injuryChristoph Scheiermann
Barts and the London School of Medicine and Dentistry, Queen Mary University of London, William Harvey Research Institute, London, UK
Arterioscler Thromb Vasc Biol 29:1509-15. 2009..Here we investigated the role of JAM-C in leukocyte migration in response to ischemia reperfusion (I/R) injury... - Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gammaSalvatore Cuzzocrea
University of Messina, Messina, Italy
Arthritis Rheum 48:3544-56. 2003..The aim of this study was to investigate the effects of rosiglitazone on the inflammatory response in mice with collagen-induced arthritis (CIA)... - Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in miceSalvatore Cuzzocrea
Institute of Pharmacology, School of Medicine, Torre Biologicala, Policlinico Universitario, University of Messina, Via C Valeria Gazzi, 98100, Messina, Italy
Intensive Care Med 29:2016-25. 2003..Dithiocarbamates are anti-oxidants which are potent inhibitors of NF-kappaB. We postulated that pyrrolidine dithiocarbamate (PDTC) would attenuate multiple-organ failure (MOF)... - Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gutSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
Br J Pharmacol 140:366-76. 2003..8. These results demonstrate that the two PPAR-gamma agonists, rosiglitazone and 15d-PGJ2, significantly reduce I/R injury of the intestine... - Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammationSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
Eur J Pharmacol 483:79-93. 2004..We propose that rosiglitazone and other potent PPAR-gamma agonists may be useful in the therapy of inflammation... - High-density lipoproteins reduce the intestinal damage associated with ischemia/reperfusion and colitisSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, 98100 Messina, Italy
Shock 21:342-51. 2004..Thus, recHDL reduces the inflammation caused by intestinal I/R and colitis. HDLs may represent a novel therapeutic approach for the therapy of inflammation of the gut... - Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietinMichael Brines
Warren Pharmaceuticals, Ossining, NY 10562, USA
Proc Natl Acad Sci U S A 105:10925-30. 2008..Thus, the tissue-protective activities of EPO are mimicked by small, nonerythropoietic peptides that simulate a portion of EPO's three-dimensional structure... - Erythropoietin reduces the development of experimental inflammatory bowel diseaseSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policino Universitario, Italy
J Pharmacol Exp Ther 311:1272-80. 2004..Thus, treatment of rat with EPO reduces the degree of colitis caused by DNBS. We propose that EPO may be useful in the treatment of inflammatory bowel disease... - Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord traumaTiziana Genovese
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C. Valeria, Gazzi, 98100 Messina, Italy
J Pharmacol Exp Ther 312:449-57. 2005..Taken together, our results clearly demonstrate that treatment with PARP inhibitors reduces the development of inflammation and tissue injury events associated with spinal cord trauma... - Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in miceVirginie Petrilli
International Agency for Research on Cancer, 69008 Lyons, France
J Clin Invest 114:1072-81. 2004..This study provides a novel insight into the function of PARP-1 in inflammation and ischemia-related pathophysiologies... - Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces the development of nonseptic shock induced by zymosan in miceSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, Policlinico Universitario, Messina, Italy
Crit Care Med 32:457-66. 2004..CONCLUSIONS: This study provides evidence, for the first time, that rosiglitazone attenuates the degree of zymosan-induced nonseptic shock in mice... - Tempol reduces the activation of nuclear factor-kappaB in acute inflammationSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
Free Radic Res 38:813-9. 2004..These data confirm that Tempol exerts potent anti-inflammatory properties and clearly demonstrates for the first time that Tempol reduces the activation of NF-kappaB in vivo... - Beneficial effects of GW274150 treatment on the development of experimental colitis induced by dinitrobenzene sulfonic acidRosanna Di Paola
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
Eur J Pharmacol 507:281-9. 2005..Thus, GW274150 treatment reduced the degree of colitis caused by dinitrobenzene sulfonic acid. We propose that selective inhibition of iNOS activity with GW274150 may be useful in the treatment of inflammatory bowel disease... - Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouseSalvatore Cuzzocrea
University of Messina, Messina, Italy
Arthritis Rheum 52:940-50. 2005..Erythropoietin (EPO) is a potent stimulator of erythroid progenitor cells, and its expression is enhanced by hypoxia. The aim of this study was to investigate the effect of EPO on collagen-induced arthritis (CIA) in the mouse...