J S Oxford

Summary

Affiliation: Queen Mary's School of Medicine and Dentistry
Country: UK

Publications

  1. ncbi request reprint The survival of influenza A(H1N1)pdm09 virus on 4 household surfaces
    John Oxford
    Blizard Institute of Cell and Molecular Science, St Barts and The London School of Medicine and Dentistry, London, United Kingdom Electronic address
    Am J Infect Control 42:423-5. 2014
  2. pmc Towards a universal influenza vaccine: volunteer virus challenge studies in quarantine to speed the development and subsequent licensing
    John S Oxford
    Blizard Institute of Cell and Molecular Science, Bart s and the London and Retroscreen Virology Ltd, Queen Mary s BioEnterprises, Innovation Centre, London, E1 2AX, UK
    Br J Clin Pharmacol 76:210-6. 2013
  3. pmc Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection
    Paul Rennie
    Procter and Gamble Health Sciences Institute, Egham, Surrey, UK
    Respir Res 8:38. 2007
  4. doi request reprint The end of the beginning: vaccines for the next 25 years
    J S Oxford
    Centre for Infectious Diseases and Retroscreen Virology Ltd, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, United Kingdom
    Vaccine 26:6179-82. 2008
  5. ncbi request reprint The threat of avian influenza H5N1: 'do we have the tools for the job'?
    John Oxford
    Centre for Infectious Diseases, Retroscreen Virology Ltd, London, UK
    Antivir Chem Chemother 18:71-4. 2007
  6. ncbi request reprint Oseltamivir in the management of influenza
    John Oxford
    Retroscreen Virology Limited, The Medical Building, Queen Mary, University of London, London, E1 4NS, UK
    Expert Opin Pharmacother 6:2493-500. 2005
  7. ncbi request reprint A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV
    John S Oxford
    Retroscreen Virology Ltd, UK
    Antivir Chem Chemother 16:129-34. 2005
  8. ncbi request reprint New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus
    John S Oxford
    Retroscreen Virology Ltd, Centre for Infectious Diseases, Barts, UK
    Antivir Chem Chemother 16:13-21. 2005
  9. ncbi request reprint A hypothesis: the conjunction of soldiers, gas, pigs, ducks, geese and horses in northern France during the Great War provided the conditions for the emergence of the "Spanish" influenza pandemic of 1918-1919
    J S Oxford
    St Bartholomew s and The Royal London, and Retroscreen Virology Ltd, Queen Mary s School of Medicine and Dentistry, London E1 4NS, UK
    Vaccine 23:940-5. 2005
  10. ncbi request reprint Scientific lessons from the first influenza pandemic of the 20th century
    J S Oxford
    Retroscreen Virology Ltd, Centre for Infectious Diseases, Bart s and The London, Queen Mary s School of Medicine and Dentistry, 327 Mile End Road, London E1 4NS, United Kingdom
    Vaccine 24:6742-6. 2006

Collaborators

Detail Information

Publications35

  1. ncbi request reprint The survival of influenza A(H1N1)pdm09 virus on 4 household surfaces
    John Oxford
    Blizard Institute of Cell and Molecular Science, St Barts and The London School of Medicine and Dentistry, London, United Kingdom Electronic address
    Am J Infect Control 42:423-5. 2014
    ....
  2. pmc Towards a universal influenza vaccine: volunteer virus challenge studies in quarantine to speed the development and subsequent licensing
    John S Oxford
    Blizard Institute of Cell and Molecular Science, Bart s and the London and Retroscreen Virology Ltd, Queen Mary s BioEnterprises, Innovation Centre, London, E1 2AX, UK
    Br J Clin Pharmacol 76:210-6. 2013
    ....
  3. pmc Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection
    Paul Rennie
    Procter and Gamble Health Sciences Institute, Egham, Surrey, UK
    Respir Res 8:38. 2007
    ..The work described here investigated the sensitivity of influenza viruses to low pH, and the activity of low pH nasal sprays on the course of an influenza infection in the ferret model...
  4. doi request reprint The end of the beginning: vaccines for the next 25 years
    J S Oxford
    Centre for Infectious Diseases and Retroscreen Virology Ltd, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, United Kingdom
    Vaccine 26:6179-82. 2008
    ..War has been declared on pandemic influenza but with this zoonotic virus containment is key, with vaccines used alongside antivirals and social distancing. Undoubtedly "we have the guns, and now we can finish the job"...
  5. ncbi request reprint The threat of avian influenza H5N1: 'do we have the tools for the job'?
    John Oxford
    Centre for Infectious Diseases, Retroscreen Virology Ltd, London, UK
    Antivir Chem Chemother 18:71-4. 2007
    ..However there are optimistic analyses: judicious and swift application of NIs, vaccine and hygiene to an outbreak epicentre, most likely in South-East Asia, could break the chain of transmission...
  6. ncbi request reprint Oseltamivir in the management of influenza
    John Oxford
    Retroscreen Virology Limited, The Medical Building, Queen Mary, University of London, London, E1 4NS, UK
    Expert Opin Pharmacother 6:2493-500. 2005
    ..As a result, the World Health Organization has recommended the stockpiling of oseltamivir in the event of an influenza pandemic...
  7. ncbi request reprint A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV
    John S Oxford
    Retroscreen Virology Ltd, UK
    Antivir Chem Chemother 16:129-34. 2005
    ....
  8. ncbi request reprint New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus
    John S Oxford
    Retroscreen Virology Ltd, Centre for Infectious Diseases, Barts, UK
    Antivir Chem Chemother 16:13-21. 2005
    ....
  9. ncbi request reprint A hypothesis: the conjunction of soldiers, gas, pigs, ducks, geese and horses in northern France during the Great War provided the conditions for the emergence of the "Spanish" influenza pandemic of 1918-1919
    J S Oxford
    St Bartholomew s and The Royal London, and Retroscreen Virology Ltd, Queen Mary s School of Medicine and Dentistry, London E1 4NS, UK
    Vaccine 23:940-5. 2005
    ..The final trigger for the ensuing pandemic was the return of millions of soldiers to their homelands around the entire world in the autumn of 1918...
  10. ncbi request reprint Scientific lessons from the first influenza pandemic of the 20th century
    J S Oxford
    Retroscreen Virology Ltd, Centre for Infectious Diseases, Bart s and The London, Queen Mary s School of Medicine and Dentistry, 327 Mile End Road, London E1 4NS, United Kingdom
    Vaccine 24:6742-6. 2006
    ....
  11. ncbi request reprint A designer drug against influenza: the NA inhibitor oseltamivir (Tamiflu)
    J S Oxford
    Retroscreen Virology Ltd, Bart s and The London, Queen Mary s School of Medicine and Dentistry, 327 Mile End Road, London E1 4NS, UK
    Expert Rev Anti Infect Ther 1:337-42. 2003
    ..SARS has shown that the public and media response to a serious epidemic is not always rational and this could easily become panic if it became apparent that treatment was possible, but not available...
  12. ncbi request reprint A new European perspective of influenza pandemic planning with a particular focus on the role of mammalian cell culture vaccines
    J S Oxford
    Centre for Infectious Diseases, Retroscreen Virology Ltd, Bart s and The London, Queen Mary s School of Medicine and Dentistry, 327 Mile End Road, London E1 4NS, UK
    Vaccine 23:5440-9. 2005
    ..The wider scientific community is more energised than previously for very serious preparations to be in place way before the outbreak begins as this is a major public health problem, completely dwarfing concerns about bioterrorism...
  13. pmc A new infectious disease challenge: Urbani severe acute respiratory syndrome (SARS) associated coronavirus
    J S Oxford
    Retroscreen Virology Ltd, Queen Mary s School of Medicine and Dentistry, London, UK
    Immunology 109:326-8. 2003
  14. ncbi request reprint Treatment of epidemic and pandemic influenza with neuraminidase and M2 proton channel inhibitors
    J S Oxford
    Academic and Retroscreen Virology, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Clin Microbiol Infect 9:1-14. 2003
    ....
  15. ncbi request reprint Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trial
    R Welliver
    The Medical Building, 327 Mile End Rd, London, England E1 4NS
    JAMA 285:748-54. 2001
    ..Influenza virus is easily spread among the household contacts of an infected person, and prevention of influenza in household contacts can control spread of influenza in the community...
  16. ncbi request reprint Interfering vaccine (defective interfering influenza A virus) protects ferrets from influenza, and allows them to develop solid immunity to reinfection
    A Mann
    Retroscreen Virology Ltd, Barts and London Hospital Medical School, 327 Mile End Road, London E1 4NS, UK
    Vaccine 24:4290-6. 2006
    ..Animals recovered fully and were solidly immune to reinfection, in line with the view that treatment converts the otherwise virulent disease into a subclinical and immunizing infection...
  17. ncbi request reprint Influenza is now a preventable disease
    J S Oxford
    Retroscreen Virology Ltd, Centre for Infectious Diseases, Bart s and The London, Queen Mary s School of Medicine and Dentistry, 327 Mile End Road, London E1 4NS, UK
    Int J Antimicrob Agents 27:271-3. 2006
    ....
  18. ncbi request reprint A new millennium conundrum: how to use a powerful class of influenza anti-neuraminidase drugs (NAIs) in the community
    John Oxford
    Barts and The London, Retroscreen Virology Ltd, Queen Mary s School of Medicine and Dentistry, 327 Mile End Road, London E1 4NS, UK
    J Antimicrob Chemother 53:133-6. 2004
    ....
  19. ncbi request reprint Human genetics and responses to influenza vaccination: clinical implications
    Robert Lambkin
    Department of Medical Microbiology and Retroscreen Virology, Queen Mary s School of Medicine and Dentistry, London, England
    Am J Pharmacogenomics 4:293-8. 2004
    ..Further investigation into the role of HLA polymorphisms and nonresponse to influenza virus vaccination, and vaccination against viruses in general, is clearly required...
  20. ncbi request reprint Rapid antibody response to influenza vaccination in "at risk" groups
    R Lambkin
    Retroscreen Ltd www retroscreen com, The Royal London and St Bartholomew s School of Medicine and Dentistry, 64 Turner Street, London, UK
    Vaccine 18:2307-11. 2000
    ..This is not a reason to modify present policy of routine vaccination in early winter well before epidemics are likely to occur...
  21. pmc The so-called Great Spanish Influenza Pandemic of 1918 may have originated in France in 1916
    J S Oxford
    Department of Medical Microbiology, Retroscreen Virology Ltd, St Bartholomew's and The London Queen Mary School of Medicine and Dentistry, 327 Mile End Road, London EC1 4NS, UK
    Philos Trans R Soc Lond B Biol Sci 356:1857-9. 2001
    ..Although more recent oubreaks of influenza have undoubtedly had an Oriental origin, the evidence indicates that future outbreaks could conceivably arise anywhere in the world...
  22. ncbi request reprint Lack of detection of influenza genes in archived formalin-fixed, paraffin wax-embedded brain samples of encephalitis lethargica patients from 1916 to 1920
    K C Lo
    Academic Virology, Department of Medical Microbiology, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Virchows Arch 442:591-6. 2003
    ..We conclude either that influenza was not the causative agent of encephalitis lethargica or, possibly, that the virus had a hit-and-run mechanism and was no longer present in the brain at the time of death of the patients...
  23. ncbi request reprint World War I may have allowed the emergence of "Spanish" influenza
    J S Oxford
    Department of Medical Microbiology and Retroscreen Virology, St Bartholomew s and The Royal London, Queen Mary, School of Medicine and Dentistry, University of London, London, UK
    Lancet Infect Dis 2:111-4. 2002
    ..We suggest that the pandemic had its origins on the Western Front, and that World War I was a contributor...
  24. ncbi request reprint In vitro anti-HIV-1 virucidal activity of tyrosine-conjugated tri- and dihydroxy bile salt derivatives
    A A Al-Jabri
    Department of Medical Microbiology and Retroscreen Virology, St Bartholomew s and the Royal London School of Medicine and Dentistry, 64 Turner Street, London, UK
    J Antimicrob Chemother 45:617-21. 2000
    ..Complexing of iodine to the bile salt derivative (as in DICGT) decreases virucidal potency...
  25. ncbi request reprint Flu: effect of vaccine in elderly care home residents: a randomized trial
    Fiona Gaughran
    Institute of Psychiatry, King s College London, London, United Kingdom
    J Am Geriatr Soc 55:1912-20. 2007
    ..To determine whether assessing seroprotection after influenza vaccine and administering booster vaccination where not achieved reduces hospitalization and death. To estimate the overall seroprotection rate of influenza vaccine...
  26. ncbi request reprint Preparing for the first influenza pandemic of the 21st century
    John S Oxford
    Retroscreen Virology Limited, Bart s and The London, Queen Mary s School of Medicine and Dentistry, 327 Mile End Road, London E1 4NS, UK
    Lancet Infect Dis 5:129-31. 2005
  27. ncbi request reprint New millennium antivirals against pandemic and epidemic influenza: the neuraminidase inhibitors
    John S Oxford
    Retroscreen Virology Ltd, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Antivir Chem Chemother 13:205-17. 2002
    ..Here we review older and newer neuraminidase inhibitors and the role that they will play in the fight against influenza in its epidemic and pandemic face...
  28. ncbi request reprint Influenza A: a threatening virus with two faces
    John S Oxford
    Department of Medical Microbiology, Queen Mary s School of Medicine and Dentistry, Retroscreen Virology, London, UK
    Biologist (London) 49:63-7. 2002
    ..The killer disease was flu. What was it that made this outbreak so deadly and would we be prepared if another pandemic struck?..
  29. ncbi request reprint Strong local and systemic protective immunity induced in the ferret model by an intranasal virosome-formulated influenza subunit vaccine
    Rob Lambkin
    Department of Medical Microbiology and Retroscreen Virology, St Bartholomew s and The Royal London, Queen Mary School of Medicine and Dentistry, University of London, 327 Mile End Road, London E1 4NS, UK
    Vaccine 22:4390-6. 2004
    ..The ease of application of an intranasal vaccine may have positive repercussions in the adoption of influenza vaccinations, particularly in 'at-risk' groups...
  30. ncbi request reprint Non-responders to egg grown influenza vaccine seroconvert after booster immunization with MDCK cell grown vaccine
    John S Oxford
    Department of Medical Microbiology and Retroscreen Virology, Queen Mary s School of Medicine and Dentistry, St Bart s and the London, 327 Mile End Road, London E1 4NS, UK
    Vaccine 21:2743-6. 2003
    ....
  31. ncbi request reprint Preclinical in vitro activity of QR-435 against influenza A virus as a virucide and in paper masks for prevention of viral transmission
    John S Oxford
    Retroscreen Virology, London, United Kingdom
    Am J Ther 14:455-61. 2007
    ..Masks impregnated with QR-435 were highly effective in blocking the passage of live H3N2 virus. These preclinical results warrant further evaluation of the prophylactic use of QR-435 against viral infection in humans...
  32. ncbi request reprint In vivo prophylactic activity of QR-435 against H3N2 influenza virus infection
    John S Oxford
    Retroscreen Virology, London, United Kingdom
    Am J Ther 14:462-8. 2007
    ..QR-435, an all-natural compound of green-tea extract and other agents, has been developed to protect against a range of viral infections, including the influenza subtype H3N2...
  33. ncbi request reprint Would you volunteer to be quarantined and infected with influenza virus?
    John S Oxford
    Expert Rev Anti Infect Ther 3:1-2. 2005
  34. pmc 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants
    Ann H Reid
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850 3125, USA
    Emerg Infect Dis 9:1249-53. 2003
  35. ncbi request reprint The prevalence of myocarditis and skeletal muscle injury during acute viral infection in adults: measurement of cardiac troponins I and T in 152 patients with acute influenza infection
    Kim Greaves
    Cardiology Department, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, England
    Arch Intern Med 163:165-8. 2003
    ..Using measurement of cardiac troponins I and T, this study sought to determine the prevalence of myocarditis in a large unselected cohort of patients with serologically confirmed acute influenza infection...