Affiliation: Queen Mary
Location: London, UK
- Schutters K, Kusters D, Chatrou M, Montero Melendez T, Donners M, Deckers N, et al. Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death Differ. 2013;20:49-56 pubmed publisher..We conclude that targeting cell surface-expressed PS is an attractive strategy for treatment of inflammatory diseases and that the rationally designed RGD-anxA5 is a promising therapeutic agent. ..
- Montero Melendez T, Dalli J, Perretti M. Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ. 2013;20:567-75 pubmed publisher..We propose non-genomic modulation of AnxA1 in immune cells as a novel mechanism of action for HDACIs, which may underlie their reported efficacy in models of chronic inflammatory pathologies. ..
- Al Kashi A, Montero Melendez T, Moradi Bidhendi N, Gilligan J, Mehta N, Perretti M. The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis. PLoS ONE. 2013;8:e54299 pubmed publisher..Substantial GC dose reduction, together with the absence of exacerbated adverse effects, indicated a significant clinical potential for this co-therapy in RA and beyond. ..
- Rhodes D, Pini M, Castellanos K, Montero Melendez T, Cooper D, Perretti M, et al. Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function. Obesity (Silver Spring). 2013;21:310-9 pubmed publisher..Obesity leads to differential modulation of Gal-1, 3, 9 and 12 in VAT and SAT, with Gal-1 acting as a modulator of adiposity. ..
- Montero Melendez T, Forfar R, Cook J, Jerman J, Taylor D, Perretti M. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017;74:1335-1345 pubmed publisher..In addition, MC3 PAMs emerged as a viable approach to the development of innovative therapeutics for joint diseases. ..