John P Monson

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Indications for GH replacement in adolescents and young adults
    J P Monson
    Centre for Clinical Endocrinology, William Harvey Research Institute, St Bartholomew s Hospital, Queen Mary, University of London, London, UK
    J Endocrinol Invest 28:52-5. 2005
  2. ncbi request reprint Long-term experience with GH replacement therapy: efficacy and safety
    John P Monson
    Department of Endocrinology, Division of General and Developmental Medicine, St Bartholomew s Hospital, West Smithfield, London ECIA 7BE, UK
    Eur J Endocrinol 148:S9-14. 2003
  3. ncbi request reprint Aspects of growth hormone (GH) replacement in elderly patients with GH deficiency: data from KIMS
    John P Monson
    Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Horm Res 60:112-20. 2003
  4. ncbi request reprint Monitoring of insulin-like growth factors during growth hormone treatment: adulthood growth hormone deficiency
    John P Monson
    Centre for Clinical Endocrinology, William Harvey Research Institute, St Bartholomew s and The Royal London Hospital, Queen Mary s School of Medicine and Dentistry, University of London, London EC1A 7BE, UK
    Endocr Dev 9:89-99. 2005
  5. ncbi request reprint Dehydroepiandrosterone (DHEA) replacement reduces growth hormone (GH) dose requirement in female hypopituitary patients on GH replacement
    Antonia M Brooke
    Centre for Clinical Endocrinology, William Harvey Research Institute, St Bartholomew s Hospital, QMUL, London, UK
    Clin Endocrinol (Oxf) 65:673-80. 2006
  6. doi request reprint Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours
    Umasuthan Srirangalingam
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Endocr Relat Cancer 16:515-25. 2009
  7. doi request reprint Adult GH deficiency throughout lifetime
    Julia D J Thomas
    Department of Endocrinology, St Bartholomew s Hospital, Queen Mary University of London, UK
    Eur J Endocrinol 161:S97-S106. 2009
  8. doi request reprint Long-term remission and recurrence rates in Cushing's disease: predictive factors in a single-centre study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, Barts and The London NHS Trust, Barts and the London School of Medicine, London, UK
    Eur J Endocrinol 168:639-48. 2013
  9. doi request reprint The prevalence and characteristic features of cyclicity and variability in Cushing's disease
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Eur J Endocrinol 160:1011-8. 2009
  10. pmc Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy
    John P Monson
    Centre for Clinical Endocrinology, St Bartholomew s Hospital, William Harvey Research Institute, Queen Mary University of London, UK
    Clin Endocrinol (Oxf) 67:623-8. 2007

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Indications for GH replacement in adolescents and young adults
    J P Monson
    Centre for Clinical Endocrinology, William Harvey Research Institute, St Bartholomew s Hospital, Queen Mary, University of London, London, UK
    J Endocrinol Invest 28:52-5. 2005
    ..Further studies are required to determine whether sabbatical periods off GH replacement are clinically appropriate and, if so, their reasonable duration...
  2. ncbi request reprint Long-term experience with GH replacement therapy: efficacy and safety
    John P Monson
    Department of Endocrinology, Division of General and Developmental Medicine, St Bartholomew s Hospital, West Smithfield, London ECIA 7BE, UK
    Eur J Endocrinol 148:S9-14. 2003
    ..Unlike mortality in untreated hypopituitary GH-deficient patients, mortality in the KIMS study is currently similar to that predicted for the normal population...
  3. ncbi request reprint Aspects of growth hormone (GH) replacement in elderly patients with GH deficiency: data from KIMS
    John P Monson
    Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Horm Res 60:112-20. 2003
    ..In conclusion, older patients with AO-GHD who receive GH replacement therapy achieve beneficial effects equivalent to those seen in younger patients in all age groups and require lower doses of GH...
  4. ncbi request reprint Monitoring of insulin-like growth factors during growth hormone treatment: adulthood growth hormone deficiency
    John P Monson
    Centre for Clinical Endocrinology, William Harvey Research Institute, St Bartholomew s and The Royal London Hospital, Queen Mary s School of Medicine and Dentistry, University of London, London EC1A 7BE, UK
    Endocr Dev 9:89-99. 2005
    ..In this respect, serum IGF-I is superior to other GH-dependent peptides. However, on present evidence, serum IGF-I should be regarded primarily as a safety marker rather than a specific therapeutic marker...
  5. ncbi request reprint Dehydroepiandrosterone (DHEA) replacement reduces growth hormone (GH) dose requirement in female hypopituitary patients on GH replacement
    Antonia M Brooke
    Centre for Clinical Endocrinology, William Harvey Research Institute, St Bartholomew s Hospital, QMUL, London, UK
    Clin Endocrinol (Oxf) 65:673-80. 2006
    ..This study aimed to determine the effect of dehydroepiandrosterone (DHEA) administration on GH dose requirements in hypopituitary adults...
  6. doi request reprint Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours
    Umasuthan Srirangalingam
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Endocr Relat Cancer 16:515-25. 2009
    ..VHL-related tumours tend to be adrenal phaeochromocytomas, frequently bilateral and associated with a milder phenotype...
  7. doi request reprint Adult GH deficiency throughout lifetime
    Julia D J Thomas
    Department of Endocrinology, St Bartholomew s Hospital, Queen Mary University of London, UK
    Eur J Endocrinol 161:S97-S106. 2009
    ..At all ages, accurate, safe diagnosis and appropriate GH dosing are necessary to provide the individual with the best possible outcome...
  8. doi request reprint Long-term remission and recurrence rates in Cushing's disease: predictive factors in a single-centre study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, Barts and The London NHS Trust, Barts and the London School of Medicine, London, UK
    Eur J Endocrinol 168:639-48. 2013
    ..To investigate the early and late outcomes of patients with Cushing's disease (CD) submitted to a neurosurgical procedure as first-line treatment...
  9. doi request reprint The prevalence and characteristic features of cyclicity and variability in Cushing's disease
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Eur J Endocrinol 160:1011-8. 2009
    ..The aim of the present study was to investigate the prevalence of cyclicity and variability in patients with Cushing's disease, and to identify putative distinctive features...
  10. pmc Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy
    John P Monson
    Centre for Clinical Endocrinology, St Bartholomew s Hospital, William Harvey Research Institute, Queen Mary University of London, UK
    Clin Endocrinol (Oxf) 67:623-8. 2007
    ....
  11. ncbi request reprint Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients
    Amar Agha
    William Harvey Research Institute, Queen Mary University of London, London, UK
    Clin Endocrinol (Oxf) 66:72-7. 2007
    ..The effect of GH replacement on thyroid function in hypopituitary patients has hitherto been studied in small groups of children and adults with conflicting results...
  12. ncbi request reprint Factors influencing cure by transsphenoidal selective adenomectomy in paediatric Cushing's disease
    Helen L Storr
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Eur J Endocrinol 152:825-33. 2005
    ..In our paediatric CD patient group we have assessed the possible factors which may influence cure by TSS...
  13. doi request reprint Imaging in covert ectopic ACTH secretion: a CT pictorial review
    Paul A Sookur
    Department of Academic Radiology, Dominion House, St Bartholomew s Hospital, West Smithfield, London, EC1A 7BE, UK
    Eur Radiol 19:1069-78. 2009
    ..Awareness of the imaging characteristics will aid identification of the source of ACTH production and allow potentially curative surgical resection...
  14. ncbi request reprint Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement
    Antonia M Brooke
    Department of Endocrinology, Harvey Research Institute, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 91:3773-9. 2006
    ..They are profoundly androgen deficient, and dehydroepiandrosterone (DHEA) has been shown to have a beneficial effect on well-being and mood in patients with adrenal failure and possibly in hypopituitarism...
  15. doi request reprint Endonasal endoscopic transsphenoidal pituitary surgery: early experience and outcome in paediatric Cushing's disease
    Helen L Storr
    Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Clin Endocrinol (Oxf) 80:270-6. 2014
    ..Endonasal transsphenoidal endoscopic surgery (ETES) is emerging as a novel, less invasive treatment for pituitary adenomas and has become the optimal surgical approach...
  16. ncbi request reprint Modulation of glucocorticoid metabolism by the growth hormone - IGF-1 axis
    Amar Agha
    Department of Endocrinology, St Bartholomew s Hospital William Harvey Research Institute, Queen Mary University of London, UK
    Clin Endocrinol (Oxf) 66:459-65. 2007
    ....
  17. ncbi request reprint Do all adults with growth hormone deficiency require growth hormone treatment?
    Antonia M Brooke
    Department of Endocrinology, St Bartholomew s and The Royal London, Queen Mary s School of Medicine and Dentistry, University of London, UK
    Ann Med 35:419-24. 2003
    ..Whether or not all patients with GHD should receive GH replacement remains a matter for debate: a selective approach to therapy based on psychological well being and quality of life has been adopted in many centres...
  18. doi request reprint Diagnosis and localisation of insulinoma: the value of modern magnetic resonance imaging in conjunction with calcium stimulation catheterisation
    Maralyn R Druce
    Department of Endocrinology, Barts and the London Medical School, St Bartholomew s Hospital, London, UK
    Eur J Endocrinol 162:971-8. 2010
    ..Preoperative localisation of insulinoma improves cure rate and reduces complications, but may be challenging...
  19. ncbi request reprint The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up
    Andrea M Isidori
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 91:371-7. 2006
    ..There are few large series of patients with ectopic, nonpituitary, corticotropin (ACTH) secretion (EAS)...
  20. doi request reprint A prospective evaluation of postural stimulation testing, computed tomography and adrenal vein sampling in the differential diagnosis of primary aldosteronism
    Jeshen H G Lau
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 76:182-8. 2012
    ..Various series have reported the utility of postural stimulation testing (PST), cross-sectional imaging and adrenal vein sampling (AVS) in the assessment of PA, but most of these studies were retrospective...
  21. ncbi request reprint 123I-metaiodobenzylguanidine (MIBG) scintigraphy for the detection of adrenal and extra-adrenal phaeochromocytomas: CT and MRI correlation
    Kunwar S S Bhatia
    Department of Academic Radiology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 69:181-8. 2008
    ..Evidence regarding the accuracy of [(123)I] metaiodobenzylguanidine (MIBG) imaging for phaeochromocytoma localization is currently limited to small series...
  22. ncbi request reprint Clinical and biochemical characteristics of adrenocorticotropin-secreting macroadenomas
    Y Sammy Woo
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 90:4963-9. 2005
    ..Cushing's disease as a result of a pituitary macroadenoma is an uncommon cause of Cushing's syndrome, and reports in the published literature are few and of limited size...
  23. ncbi request reprint Safety aspects of growth hormone replacement
    Mona Waterhouse
    Department of Endocrinology, St Bartholomew s Hospital, Queen Mary, University of London, London, UK
    Front Horm Res 33:209-21. 2005
  24. doi request reprint A single-center open-label study to investigate the efficacy and safety of repeated subcutaneous injections of lanreotide Autogel in patients with acromegaly previously treated with octreotide
    Phillip Kelly
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, EC1A 7BE, United Kingdom
    Endocr Pract 16:191-7. 2010
    ..To evaluate the efficacy of lanreotide Autogel, a depot preparation of a long-acting somatostatin analogue, in patients with acromegaly who were previously treated with octreotide...
  25. ncbi request reprint Adult growth hormone deficiency
    A M Brooke
    Department of Endocrinology, St Bartholomew s and the London, Queen Mary s, School of Medicine and Dentistry, University of London
    Clin Med 3:15-9. 2003
  26. ncbi request reprint Diagnosing unilateral primary aldosteronism - comparison of a clinical prediction score, computed tomography and adrenal venous sampling
    W C Candy Sze
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 81:25-30. 2014
    ..It has been suggested that a recently developed and published clinical prediction score (CPS) may correctly identify some patients as having unilateral disease, without recourse to adrenal venous sampling...
  27. doi request reprint Positron emission tomography in the diagnosis and management of intracranial germ cell tumours
    Philip A Kelly
    Department of Endocrinology, St Bartholomew s Hospital, London E1 5AG, UK
    Horm Res 72:190-6. 2009
    ..A cautionary note is introduced with respect to the interpretation of negative (18)F-FDG PET when investigating enhancing intracranial lesions...
  28. ncbi request reprint The management of differentiated thyroid cancer using 123I for imaging to assess the need for 131I therapy
    Nidhal Ali
    Department of Nuclear Medicine, St Bartholomew s Hospital, London, UK
    Nucl Med Commun 27:165-9. 2006
    ..Previous studies have suggested that, for scanning, 123I is more sensitive than 131I in identifying thyroid tissue, but its specificity when positive is less certain...
  29. ncbi request reprint CT and MR imaging of the adrenal glands in ACTH-independent cushing syndrome
    Andrea G Rockall
    Department of Academic Radiology, St Bartholomew s Hospital, Dominion House, St Bartholomew s Close, London EC1A 7ED, England
    Radiographics 24:435-52. 2004
    ..Familiarity with the range of imaging appearances of the adrenal glands in primary adrenal Cushing syndrome may help establish the underlying diagnosis...
  30. ncbi request reprint Markers of cell proliferation in a GH-producing adenoma of a patient treated with pegvisomant
    W M Drake
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, UK
    Eur J Endocrinol 153:203-5. 2005
    ....
  31. ncbi request reprint Computed tomography assessment of fat distribution in male and female patients with Cushing's syndrome
    A G Rockall
    Department of Diagnostic Radiology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Eur J Endocrinol 149:561-7. 2003
    ....
  32. doi request reprint Detection of neuroendocrine liver metastases with MnDPDP-enhanced MRI
    A G Rockall
    Department of Radiology, St Bartholomew s Hospital, London, UK
    Neuroendocrinology 89:288-95. 2009
    ..Our purpose was to assess the diagnostic performance of MRI, before and after administration of mangafodipir trisodium (MnDPDP), in the detection of neuroendocrine liver metastases...
  33. ncbi request reprint Growth hormone deficiency and replacement in patients with treated Cushing's Disease, prolactinomas and non-functioning pituitary adenomas: effects on body composition, glucose metabolism, lipid status and bone mineral density
    A Colson
    Centre for Clinical Endocrinology, St Bartholomew s Hospital, QMUL, London, UK
    Horm Res 66:257-67. 2006
    ..We report the effects of 5 years GH treatment in 124 GH deficiency adults; 42 patients with non-functioning pituitary adenomas (NFPA), 43 with treated PRL and 39 with treated CD...
  34. ncbi request reprint Comparison of continuation or cessation of growth hormone (GH) therapy on body composition and metabolic status in adolescents with severe GH deficiency at completion of linear growth
    P V Carroll
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 89:3890-5. 2004
    ....
  35. ncbi request reprint Transitional care of GH deficiency: when to stop GH therapy
    M O Savage
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London, UK
    Eur J Endocrinol 151:S61-5. 2004
    ..Quality of life does not appear to be decreased in adolescents with GHD who stop treatment, so achievement of satisfactory bone mass is a major determinant of the decision whether to continue therapy...
  36. ncbi request reprint Predicting therapeutic response and degree of pituitary tumour shrinkage during treatment of acromegaly with octreotide LAR
    P J Jenkins
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Horm Res 62:227-32. 2004
    ..This study prospectively determined the effects of the depot somatostatin analogue octreotide LAR on pituitary tumour size, GH and IGF-I levels and clinical symptoms in a cohort of previously untreated patients with acromegaly...
  37. ncbi request reprint Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography
    A G Rockall
    Department of Diagnostic Radiology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Eur J Endocrinol 149:543-8. 2003
    ....
  38. ncbi request reprint Disease activity in acromegaly may be assessed 6 weeks after discontinuation of pegvisomant
    W M Drake
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Eur J Endocrinol 152:47-51. 2005
    ..The purpose of this study was to assess the time for which it is necessary to discontinue pegvisomant prior to biochemical reassessment of acromegaly...
  39. ncbi request reprint Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant
    W M Drake
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Eur J Endocrinol 149:521-7. 2003
    ..IS was assessed by homeostatic model assessment (HOMA) using fasting glucose and insulin concentrations and by a short insulin tolerance test (sITT). Body composition was assessed by dual energy X-ray absorptiometry...
  40. ncbi request reprint Hypothalamo-pituitary surveillance imaging in hypopituitary patients receiving long-term GH replacement therapy
    G Frajese
    Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 86:5172-5. 2001
    ..Similar prospective longitudinal observation of patients who have not received postoperative irradiation and comparison with rates of tumor recurrence in control series are desirable...
  41. ncbi request reprint The effect of cessation of growth hormone (GH) therapy on bone mineral accretion in GH-deficient adolescents at the completion of linear growth
    W M Drake
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 88:1658-63. 2003
    ..This may predispose to clinically significant osteopenia in later adult life...
  42. ncbi request reprint Optimizing gh therapy in adults and children
    W M Drake
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    Endocr Rev 22:425-50. 2001
    ....
  43. ncbi request reprint Optimal dosage interval for depot somatostatin analogue therapy in acromegaly requires individual titration
    P J Jenkins
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 53:719-24. 2000
    ..However, it is uncertain whether the recommended dose intervals of 4 weeks and 10-14 days, respectively, are applicable to all patients...
  44. ncbi request reprint Growth in disorders of adrenal hyperfunction
    M O Savage
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Horm Res 58:39-43. 2002
    ..After cure by TSS or pituitary irradiation, GH deficiency was frequent and persisted for many years. Treatment with hGH induced significant long-term catch-up growth leading to reasonable final height...
  45. ncbi request reprint Stereotactic radiosurgery XVI: a treatment for previously irradiated pituitary adenomas
    F M Swords
    Department of Endocrinology, St Bartholomew s and The Royal London School of Medicine, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 88:5334-40. 2003
    ..Our data indicate that SMART is an effective complementary therapy for pituitary adenomas that have displayed a suboptimal response to conventional therapy including external irradiation...
  46. doi request reprint The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas
    Chrysanthia A Leontiou
    Department of Endocrinology, Barts and the London School of Medicine, London, United Kingdom
    J Clin Endocrinol Metab 93:2390-401. 2008
    ..Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this molecular chaperone is involved in tumorigenesis...
  47. ncbi request reprint Prepubertal Cushing's disease is more common in males, but there is no increase in severity at diagnosis
    Helen L Storr
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, West Smithfield, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 89:3818-20. 2004
    ..In conclusion, female preponderance of CD in adult patients was not present in childhood. In patients 18 yr of age or younger, there was no difference in the severity of hypercortisolemia or ACTH at diagnosis between males and females...
  48. ncbi request reprint Is there still a role for radiotherapy in acromegaly?
    John P Monson
    Centre for Clinical Endocrinology, St Bartholomew s Hospital, William Harvey Research Institute, Queen Mary University of London, London, UK
    Neuroendocrinology 83:269-73. 2006
    ..For these reasons, radiotherapy (both conventional external and stereotactic irradiation) continues to have a major role in controlling acromegaly in selected patients...
  49. ncbi request reprint Successful treatment of resistant acromegaly with a growth hormone receptor antagonist
    W M Drake
    Department of Endocrinology, St Bartholomew's Hospital, London, UK
    Eur J Endocrinol 145:451-6. 2001
    ..CONCLUSIONS: Treatment with pegvisomant is safe and efficacy is maintained after 2 years. Serum IGF-I may be normalised in patients who are refractory to conventional therapy...
  50. ncbi request reprint Insulin-like growth factor I and the development of colorectal neoplasia in acromegaly
    P J Jenkins
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    J Clin Endocrinol Metab 85:3218-21. 2000
    ..Serum IGF-I seems to be implicated in the development of colorectal neoplasia in acromegaly, although the exact mechanisms remain uncertain...
  51. ncbi request reprint Growth hormone deficiency and replacement in elderly hypopituitary adults. KIMS Study Group and the KIMS International Board. Pharmacia and Upjohn International Metabolic Database
    J P Monson
    St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 53:281-9. 2000
    ..KIMS is a physician-managed, open, long-term surveillance study of adult GH-deficient patients receiving GH replacement. Patients were entered and data provided by interested physicians...
  52. ncbi request reprint Influence of growth hormone on accretion of bone mass
    J P Monson
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Horm Res 58:52-6. 2002
    ..To date, this has been difficult to assess in adult GHD of childhood-onset because the relative contributions of low peak bone mass and increased loss of bone in later life could not be distinguished...
  53. ncbi request reprint Optimal strategy for management of pituitary disease in the growth hormone-deficient teenager
    J P Monson
    Department of Endocrinology, St Bartholomew s Hospital and the Royal London School of Medicine and Dentistry, UK
    J Pediatr Endocrinol Metab 13:1343-8. 2000
    ..The most important ingredient in this process is awareness of the situation by both pediatric and adult endocrinologists as well as the development of an agreed strategy within each clinical center...
  54. doi request reprint d3-GHR genotype does not explain heterogeneity in GH responsiveness in hypopituitary adults
    V J Moyes
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 72:807-13. 2010
    ..Deletion of exon 3 in the GH receptor (d3-GHR) has been linked to enhanced rhGH responsiveness in children. We investigated the role of the d3-GHR polymorphism in determining adult rhGH responsiveness...
  55. ncbi request reprint Predictors of the outcome of surgical treatment in acromegaly and the value of the mean growth hormone day curve in assessing postoperative disease activity
    G A Kaltsas
    Department of Endocrinology, St. Bartholomew's and the Royal London Hospitals, London ECIA 7BE, United Kingdom
    J Clin Endocrinol Metab 86:1645-52. 2001
    ....
  56. doi request reprint Gamma knife radiosurgery: a safe and effective salvage treatment for pituitary tumours not controlled despite conventional radiotherapy
    F M Swords
    Department of Oncology, Barts and The London NHS Trust, West Smithfield, London EC1A 7BE, UK
    Eur J Endocrinol 161:819-28. 2009
    ..We report the use of 'gamma knife' (GK) radiosurgery in 25 patients with pituitary adenomas not cured despite conventional therapy, including external beam radiotherapy...
  57. ncbi request reprint A rapid method for analyzing serum pro-insulin-like growth factor-II in patients with non-islet cell tumor hypoglycemia
    Farideh Miraki-Moud
    Department of Endocrinology, 51 53 Bartholomew Close, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 90:3819-23. 2005
    ..Non-islet cell tumor hypoglycemia (NICTH) results from the hypersecretion of pro-IGF-II by a large, usually mesenchymal tumor. Detection of pro-IGF-II in serum is a potential tumor marker in these patients...
  58. doi request reprint Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers
    Umasuthan Srirangalingam
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, UK
    Clin Endocrinol (Oxf) 69:587-96. 2008
    ..The aim of this study was to describe the clinical manifestations of subjects with SDH-B gene mutations...
  59. ncbi request reprint Modulation of cortisol metabolism during treatment of acromegaly is independent of body composition and insulin sensitivity
    Giovanni V Frajese
    Department of Endocrinology, St Bartholomew s Hospital, King s College Hospital, London, UK
    Horm Res 61:246-51. 2004
    ..Additionally, both fat mass and insulin may modulate 11beta-HSD1 and are both influenced by changes in GH status. This study examined the relative direct contribution of GH/IGF1 in modulating cortisol metabolism...
  60. ncbi request reprint CT and MR imaging of unusual locations of extra-adrenal paragangliomas (pheochromocytomas)
    Anju Sahdev
    Department of Radiology, St Bartholomew s Hospital, West Smithfield, London, EC1A 7BE, UK
    Eur Radiol 15:85-92. 2005
    ....
  61. ncbi request reprint Expression of the pituitary transcription factor Ptx-1, but not that of the trans-activating factor prop-1, is reduced in human corticotroph adenomas and is associated with decreased alpha-subunit secretion
    R H Skelly
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, United Kingdom
    J Clin Endocrinol Metab 85:2537-42. 2000
    ..Prop-1 expression was detected in all 34 pituitary adenomas, including 6 corticotroph adenomas and 5 gonadotroph adenomas. The expression of Prop-1 has not been described previously in these cell phenotypes...
  62. ncbi request reprint Sensitivity to growth hormone-the perspective. Round table discussion
    J P Monson
    Department of Endocrinology, St Bartholomew s Hospital and Royal London School of Medicine and Dentistry, West Smithfield, London, UK
    Horm Res 55:65-7. 2001
    ....
  63. ncbi request reprint Biochemical markers of individual response to growth hormone replacement in adults
    J P Monson
    Department of Endocrinology, St Bartholomew s Hospital and Royal London School of Medicine and Dentistry, West Smithfield, London, UK
    Horm Res 55:49-54. 2001
    ..Markers of bone remodelling are an important indicator of GH action within individuals, but exhibit wide inter-individual variation which limits their usefulness in defining relative GH responsiveness...
  64. ncbi request reprint Sexual dimorphism of cortisol metabolism is maintained in elderly subjects and is not oestrogen dependent
    A A Toogood
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 52:61-6. 2000
    ..The aim of this study is to determine whether the sexual dimorphism of cortisol metabolism persists between post-menopausal, oestrogen-deficient women and elderly men...
  65. doi request reprint Repeated colonoscopic screening of patients with acromegaly: 15-year experience identifies those at risk of new colonic neoplasia and allows for effective screening guidelines
    D Dworakowska
    Department of Endocrinology, Barts and the London School of Medicine, 68 Harley Street, London EC1A 7BE, UK
    Eur J Endocrinol 163:21-8. 2010
    ..It is suggested that patients with acromegaly have an increased risk of colorectal cancer and pre-malignant adenomatous polyps. However, the optimum frequency with which colonoscopic screening should be offered remains unclear...
  66. ncbi request reprint Comparison of somatostatin analog and meta-iodobenzylguanidine radionuclides in the diagnosis and localization of advanced neuroendocrine tumors
    G Kaltsas
    Department of Endocrinology, St. Bartholomew's Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 86:895-902. 2001
    ..These data have implications not only for staging such tumors, but also for identifying patients who might benefit from treatment using either [(131)I]MIBG or radioactive somatostatin analogs...
  67. ncbi request reprint Increased levels of insulin-like growth factor binding protein-2 in sera and tumours from patients with colonic neoplasia with and without acromegaly
    F Miraki-Moud
    Department of Endocrinology, St. Bartholomew's Hospital, London, UK
    Clin Endocrinol (Oxf) 54:499-508. 2001
    ....
  68. ncbi request reprint Safety of GH replacement in hypopituitary patients with nonirradiated pituitary and peripituitary tumours
    T T Chung
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Clin Endocrinol (Oxf) 68:965-9. 2008
    ..However, a preponderance of patients treated with external pituitary irradiation were included...
  69. ncbi request reprint The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas
    S J Aylwin
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 86:2476-83. 2001
    ..SF-1 expression is associated with the in vitro secretion of LH by NFPAs. A proportion of somatotroph tumors also express SF-1 and DAX-1 and secrete gonadotropin hormones in vitro...
  70. ncbi request reprint The effects of growth hormone deficiency and replacement on glucocorticoid exposure in hypopituitary patients on cortisone acetate and hydrocortisone replacement
    F M Swords
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, UK
    Clin Endocrinol (Oxf) 59:613-20. 2003
    ....
  71. ncbi request reprint The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas
    J A C Hunter
    Department of Clinical Biochemistry, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Eur J Endocrinol 148:203-11. 2003
    ....
  72. ncbi request reprint Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome)
    R K Lingam
    Department of Diagnostic Imaging, St Bartholomew s Hospital, West Smithfield, EC1A 7BE, London, UK
    Eur Radiol 14:1787-92. 2004
    ..There was good interobserver agreement on CT (k=0.71) and on MR (k=0.67). We have demonstrated comparable diagnostic performance and good interobserver agreement on CT and MR imaging for the detection of aldosterone-producing adenoma...
  73. ncbi request reprint The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism
    A M Isidori
    Department of Endocrinology, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 58:601-11. 2003
    ..This study examined the effects of GH replacement in GH-deficient adults on adrenal androgen secretion...
  74. ncbi request reprint Final adult height and body mass index after cure of paediatric Cushing's disease
    J H Davies
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Clin Endocrinol (Oxf) 62:466-72. 2005
    ..Linear growth data after cure of paediatric Cushing's disease (CD) have been reported infrequently. We evaluated final adult height (FH) and body mass index (BMI) in a cohort of paediatric patients treated successfully for CD...
  75. ncbi request reprint Pancreatic lesions in von Hippel-Lindau disease
    B Mukhopadhyay
    Departments of Endocrinology and Radiology, St Bartholomew s Hospital, West Smithfield, London, UK
    Clin Endocrinol (Oxf) 57:603-8. 2002
    ..The presence of pancreatic disease has also been variably reported. This study was undertaken to describe the prevalence, nature, natural history and clinical associations of pancreatic lesions in von Hippel-Lindau disease...
  76. ncbi request reprint Bone mineral density at diagnosis and following successful treatment of pediatric Cushing's disease
    S Scommegna
    Department of Endocrinology, St Bartholomew s Hospital, Birmingham, UK
    J Endocrinol Invest 28:231-5. 2005
    ..03 (-0.53-0.38). These findings show variability of BMD at diagnosis and near normal BMD after cure of pediatric CD, suggesting that with appropriate replacement of pituitary hormone deficiency normal peak bone mass is achievable...
  77. ncbi request reprint Growth hormone replacement does not increase serum prostate-specific antigen in hypopituitary men over 50 years
    C W le Roux
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, St Bartholomew s Hospital, London EC1A 7BE, UK
    Eur J Endocrinol 147:59-63. 2002
    ..The aim was to examine whether rhGH replacement in hypopituitary adults is associated with changes in serum prostate-specific antigen (PSA) as a surrogate marker of changes in prostatic growth...
  78. ncbi request reprint Tumour surveillance imaging in patients with extrapituitary tumours receiving growth hormone replacement
    T T Chung
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 63:274-9. 2005
    ..g. craniopharyngioma, glioma or germ cell tumours) might be anticipated to have a higher recurrence rate than secretory and nonsecretory anterior pituitary tumours...
  79. ncbi request reprint Skeletal consequences of discontinuation of growth hormone at final height
    William M Drake
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    J Pediatr Endocrinol Metab 15:1351-4. 2002
    ..This paper discusses the role of GH in the attainment of peak bone mass and some of the accumulating evidence that cessation of GH at final height may compromise bone mineral accretion in GH-deficient adolescent patients...
  80. ncbi request reprint Primary hyperaldosteronism (Conn syndrome): MR imaging findings
    S A Sohaib
    Department of Diagnostic Imaging, Dominion House, 59 Bartholomew s Close, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Radiology 214:527-31. 2000
    ..To describe the magnetic resonance (MR) imaging features of the adrenal glands in primary hyperaldosteronism and assess MR imaging in the detection and characterization of aldosterone-producing adenoma (APA)...
  81. ncbi request reprint A longitudinal study of markers of bone turnover in Graves' disease and their value in predicting bone mineral density
    A Siddiqi
    Department of Endocrinology, St Bartholomew s and The Royal London Hospital, England
    J Clin Endocrinol Metab 82:753-9. 1997
    ..Serum b-ALP indicates continuing bone formation and, at 1 yr, may provide a marker for low BMD. OC, Sdpd, and Spyr are less sensitive in documenting bone remodeling during treatment of thyrotoxicosis...
  82. ncbi request reprint Successful treatment of childhood-onset Cushing's disease is associated with persistent reduction in growth hormone secretion
    P V Carroll
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 60:169-74. 2004
    ..Whether recovery of spontaneous GH secretion occurs following treatment of childhood CD has yet to be established...
  83. ncbi request reprint Is ovarian and adrenal venous catheterization and sampling helpful in the investigation of hyperandrogenic women?
    G A Kaltsas
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 59:34-43. 2003
    ..We considered the technical success rate of catheterization, the extra information obtained in addition to the standard biochemical tests and imaging findings, and the impact of sampling on management decisions...
  84. doi request reprint Diagnosis, management and therapeutic outcome in prepubertal Cushing's disease
    R P Dias
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Eur J Endocrinol 162:603-9. 2010
    ..Cushing's disease (CD) in prepubertal children is very rare and presents important diagnostic and therapeutic challenges. We report experience of the management of this subpopulation of CD patients...
  85. ncbi request reprint The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11 beta-hydroxysteroid dehydrogenase activity
    S V Gelding
    Department of Endocrinology, Royal London Hospital, UK
    Clin Endocrinol (Oxf) 48:153-62. 1998
    ..To elucidate this, we examined the effect of GH on urinary cortisol, cortisone and cortisol metabolites in hypopituitary adults at increasing doses of hydrocortisone replacement...
  86. ncbi request reprint CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland
    R K Lingam
    Department of Diagnostic Imaging, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, United Kingdom
    AJR Am J Roentgenol 181:843-9. 2003
    ....
  87. ncbi request reprint FSH secretion predominates in vivo and in vitro in patients with non-functioning pituitary adenomas
    P L Hanson
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Eur J Endocrinol 152:363-70. 2005
    ..In this study, we aimed to examine the pattern of secretion of LH and FSH from a series of pituitary adenomas cultured in vitro and where data were available to relate the results to pre-operative serum gonadotrophin levels...
  88. ncbi request reprint Discriminatory value of the low-dose dexamethasone suppression test in establishing the diagnosis and differential diagnosis of Cushing's syndrome
    Andrea M Isidori
    Department of Endocrinology, St Bartholomew s Hospital, London ECIA 7BE, United Kingdom
    J Clin Endocrinol Metab 88:5299-306. 2003
    ..There does not appear to be any necessity for retaining the high-dose dexamethasone suppression test in this diagnostic work-up...
  89. ncbi request reprint A novel point mutation in P450c17 (CYP17) causing combined 17alpha-hydroxylase/17,20-lyase deficiency
    A M Brooke
    Center for Endocrinology, William Harvey Research Institute, St Bartholomew s Hospital, Queen Mary, University of London, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 91:2428-31. 2006
    ....
  90. ncbi request reprint Obstructive sleep apnea presenting as pseudopheochromocytoma: a case report
    L J Hoy
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 89:2033-8. 2004
    ..Pseudopheochromocytoma is therefore a rare, but treatable, presentation of obstructive sleep apnea...
  91. ncbi request reprint Optimal response criteria for the human CRH test in the differential diagnosis of ACTH-dependent Cushing's syndrome
    J Newell-Price
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 87:1640-5. 2002
    ....
  92. ncbi request reprint Abnormal puberty in paediatric Cushing's disease: relationship with adrenal androgen, sex hormone binding globulin and gonadotrophin concentrations
    C C Dupuis
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 66:838-43. 2007
    ..Paediatric Cushing's disease is frequently associated with abnormal puberty. We addressed the hypothesis that prepubertal patients show excessive virilization and pubertal patients show suppression of LH and FSH secretion...
  93. ncbi request reprint Treatment of metastatic carcinoid tumours, phaeochromocytoma, paraganglioma and medullary carcinoma of the thyroid with (131)I-meta-iodobenzylguanidine [(131)I-mIBG]
    J J Mukherjee
    Department of Endocrinology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK
    Clin Endocrinol (Oxf) 55:47-60. 2001
    ..It may be a valuable alternative or additional therapeutic option to the currently available conventional treatment modalities...
  94. ncbi request reprint Hexarelin as a test of pituitary reserve in patients with pituitary disease
    M Korbonits
    Departments of Endocrinology and Clinical Biochemistry, St Bartholomew s Hospital, London, United Kingdom
    Clin Endocrinol (Oxf) 51:369-75. 1999
    ..We therefore investigated whether it could be used to test GH and ACTH/cortisol reserve in patients with pituitary disease...
  95. ncbi request reprint Selective parathyroid venous sampling in patients with complicated hyperparathyroidism
    C M Ogilvie
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Eur J Endocrinol 155:813-21. 2006
    ..We report our experience of the use of selective parathyroid venous sampling (PVS) in the localisation of parathyroid disease in such patients...
  96. ncbi request reprint Seeking the optimal target range for insulin-like growth factor I during the treatment of adult growth hormone disorders
    Annice Mukherjee
    Department of Endocrinology, Christie Hospital, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 88:5865-70. 2003
    ....
  97. ncbi request reprint Does long-term GH replacement therapy in hypopituitary adults with GH deficiency normalise quality of life?
    Maria Koltowska-Haggstrom
    KIGS KIMS ACROSTUDY Medical Outcomes, Endocrine Care, Pfizer, Sollentuna, Sweden
    Eur J Endocrinol 155:109-19. 2006
    ..To determine whether impaired quality of life (QoL) in adults with GH deficiency (GHD) is reversible with long-term GH therapy and whether the responses in QoL dimensions differ from each other...
  98. ncbi request reprint Determinants of IGF-I status in a large cohort of growth hormone-deficient (GHD) subjects: the role of timing of onset of GHD
    Catherine A Lissett
    Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 59:773-8. 2003
    ..We have used the KIMS database to examine if a true difference exists between subjects who developed GHD in adult life (AO), and those who developed GHD in childhood (CO)...
  99. ncbi request reprint Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis
    Roger Abs
    Department of Endocrinology, University Hospital, Antwerp, Belgium
    Eur J Endocrinol 155:79-90. 2006
    ..The aim of the present study was to clarify the relationship between GH deficiency (GHD) and some cardiovascular risk factors and to analyse the effect of GH replacement therapy in a large number of patients over a prolonged period of time...
  100. ncbi request reprint Quality of life assessment of growth hormone deficiency in adults (QoL-AGHDA): comparison of normative reference data for the general population of England and Wales with results for adult hypopituitary patients with growth hormone deficiency
    Maria Kołtowska-Häggström
    KIGS KIMS ACROSTUDY Medical Outcomes, Endocrine Care, Pfizer, Stockholm, Sweden
    Horm Res 64:46-54. 2005
    ..The objective of this study was to develop such data for the QoL-AGHDA instrument for the population of England and Wales and to demonstrate the QoL deficit in patients with GHD...
  101. ncbi request reprint Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database
    Roger Abs
    Department of Endocrinology, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Growth Horm IGF Res 15:349-59. 2005
    ....