Adrian R Martineau
Affiliation: Queen Mary
- Vitamin D in the treatment of pulmonary tuberculosisAdrian R Martineau
Centre for Health Sciences, Institute of Health Sciences Education, Barts and the London School of Medicine and Dentistry, London E1 2AT, United Kingdom
J Steroid Biochem Mol Biol 103:793-8. 2007....
- Ethnic variation in inflammatory profile in tuberculosisAnna K Coussens
Division of Mycobacterial Research, MRC National Institute for Medical Research, London, United Kingdom
PLoS Pathog 9:e1003468. 2013..Candidate immunodiagnostics and immunological biomarkers of response to antimicrobial therapy should be derived and validated in tuberculosis patients of different ethnic origin. ..
- Old wine in new bottles: vitamin D in the treatment and prevention of tuberculosisAdrian R Martineau
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London E1 2AB, UK
Proc Nutr Soc 71:84-9. 2012..The conduct of such trials is a research priority, given the safety and low cost of vitamin D supplementation, and the potentially huge public health consequences of positive results...
- Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South AfricaAdrian R Martineau
Division of Mycobacterial Research, National Institute of Medical Research, Mill Hill NW7 1AA, United Kingdom
Proc Natl Acad Sci U S A 108:19013-7. 2011..Reciprocal seasonal variation in serum 25(OH)D concentration and TB notifications suggests that seasonal variations in vitamin D status and TB incidence in this setting are causally related...
- High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trialAdrian R Martineau
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
Lancet 377:242-50. 2011..Vitamin D was used to treat tuberculosis in the pre-antibiotic era, and its metabolites induce antimycobacterial immunity in vitro. Clinical trials investigating the effect of adjunctive vitamin D on sputum culture conversion are absent...
- Association between Gc genotype and susceptibility to TB is dependent on vitamin D statusA R Martineau
Wellcome Trust Centre for Research in Clinical Tropical Medicine, Division of Medicine, Imperial College London, London, UK
Eur Respir J 35:1106-12. 2010..02). No association between Gc genotype and susceptibility to TB was observed in other ethnic groups studied...
- Influence of a single oral dose of vitamin D(2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patientsA R Martineau
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, London, UK
Int J Tuberc Lung Dis 13:119-25. 2009..Newham Chest Clinic, London, UK...
- A single dose of vitamin D enhances immunity to mycobacteriaAdrian R Martineau
Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
Am J Respir Crit Care Med 176:208-13. 2007..Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity have not previously been performed...
- Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatmentAnna K Coussens
Division of Mycobacterial Research, Medical Research Council National Institute for Medical Research, London, United Kingdom
Proc Natl Acad Sci U S A 109:15449-54. 2012..Our findings suggest a potential role for adjunctive vitamin D supplementation in the treatment of pulmonary infections to accelerate resolution of inflammatory responses associated with increased risk of mortality...
- Neutrophil-mediated innate immune resistance to mycobacteriaAdrian R Martineau
Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College, London, UK
J Clin Invest 117:1988-94. 2007..Elucidation of the regulation of neutrophil antimicrobial peptides could facilitate prevention and treatment of TB...
- A novel assay of antimycobacterial activity and phagocytosis by human neutrophilsDavid M Lowe
Department of Medicine, Imperial College London, W2 1PG, UK
Tuberculosis (Edinb) 93:167-78. 2013..The same multiplicity of infection and serum conditions are optimal to demonstrate both internalisation and restriction of mycobacterial growth...
- Reduction of chemokine secretion in response to mycobacteria in infliximab-treated patientsSandra M Newton
Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Imperial College London, Wright Fleming Institute, United Kingdom
Clin Vaccine Immunol 15:506-12. 2008....
- Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosisKatalin A Wilkinson
National Institute for Medical Research, Mill Hill, London, UK
BMC Microbiol 9:93. 2009..We also reintroduced the 19 kDa gene in two modified forms that lacked motifs for acylation (Delta19::19NA) and O-glycosylation (Delta19::19NOG)...
- IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37Adrian R Martineau
Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College London, United Kingdom
J Immunol 178:7190-8. 2007..7%. These findings suggest that vitamin D contributes to protection against TB by "nonclassical" mechanisms that include the induction of antimicrobial peptides...
- 1alpha,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infectionAnna Coussens
Division of Mycobacterial Research, National Institute for Medical Research, London, UK
Immunology 127:539-48. 2009..1alpha,25(OH)(2)D(3) also induced secretion of IL-10 and PGE(2) from M. tuberculosis-infected PBMC. These findings represent a novel immunomodulatory role for 1alpha,25(OH)(2)D(3) in M. tuberculosis infection...
- DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudesValerie Kuan
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute, London, UK
BMC Evol Biol 13:144. 2013..We then explored the length of haplotypes in chromosomes to confirm recent positive selection...
- Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashionAlexandra M Nanzer
MRC and the Asthma UK Centre for Allergic Mechanisms in Asthma, King s College London, London, United Kingdom
J Allergy Clin Immunol 132:297-304.e3. 2013..We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10...
- Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studiesDavid A Jolliffe
Queen Mary University of London, Centre for Primary Care and Public Health, Barts and the London School of Medicine and Dentistry, London E1 2AB, UK
J Steroid Biochem Mol Biol 136:321-9. 2013..This article is part of a Special Issue entitled 'Vitamin D Workshop'...
- A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversionSandra M Newton
Wellcome Trust Center for Research in Clinical Tropical Medicine, Center for Molecular Microbiology and Infection, and Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London W2 1PG, United Kingdom
Proc Natl Acad Sci U S A 103:15594-8. 2006..The Rv1519 polymorphism in M. tuberculosis confers an immune subverting phenotype that contributes to the persistence and outbreak potential of this lineage...
- Neutrophils in tuberculosis: friend or foe?David M Lowe
Department of Medicine, Imperial College London, W2 1PG, UK
Trends Immunol 33:14-25. 2012..These activities may have clinical importance in terms of new treatments, targeted interventions and vaccine strategies...
- Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trialStephen T Goldring
Department of Paediatrics, Imperial College London, London, United Kingdom
PLoS ONE 8:e66627. 2013..Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study...
- Longitudinal study of vitamin D metabolites after long bone fractureAdam D M Briggs
Centre for Primary Care and Public Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, USA
J Bone Miner Res 28:1301-7. 2013..The latter finding contrasts with those of animal models reporting increases in serum 24R,25(OH)₂D concentration after long bone fracture...
- The effect of tenofovir on vitamin D metabolism in HIV-infected adults is dependent on sex and ethnicityKaren Klassen
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
PLoS ONE 7:e44845. 2012..The aim of this study was to carry out a detailed comparison of the effects of tenofovir versus non-tenofovir use on calcium, phosphate and, vitamin D, parathyroid hormone (PTH), and bone mineral density...
- Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methodsElisabeth Schölvinck
Department of Pediatrics Wellcome Centre for Research in Clinical Tropical Medicine, Faculty of Medicine, Imperial College London, London W2 1PG
J Clin Microbiol 42:829-31. 2004..The test results correlated well (r = 0.689, P < 0.0001). Its simple format and use of only small volumes of blood make the whole-blood assay suitable for pediatric practice and field trials...