A Malaspina

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration?
    Andrea Malaspina
    Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurochem 104:584-95. 2008
  2. pmc Spinal cord trauma and the molecular point of no return
    Ping K Yip
    Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Mol Neurodegener 7:6. 2012
  3. pmc The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression
    Natasa Jokic
    Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, UK
    BMC Genomics 11:633. 2010
  4. doi request reprint Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis
    A Malaspina
    Centre for Neuroscience and Trauma, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Blizard Institute, 4 Newark Street, London E1 2AT, UK
    Neuroscience 169:812-27. 2010
  5. pmc Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression
    Andrea Malaspina
    Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
    BMC Genomics 9:500. 2008
  6. ncbi request reprint A review of the functional role and of the expression profile of retinoid signaling and of nuclear receptors in human spinal cord
    Andrea Malaspina
    Neuroscience Centre, Institute of Cell and Molecular Science, Queen Mary University, 4 Newark Street, Whitechapel, London E1 2AT, UK
    Brain Res Bull 71:437-46. 2007
  7. ncbi request reprint Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays
    A Malaspina
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK
    J Neurochem 77:132-45. 2001
  8. ncbi request reprint A survey of trinucleotide/tandem repeat-containing transcripts (TNRTs) isolated from human spinal cord to identify genes containing unstable DNA regions as candidates for disorders of motor function
    A Malaspina
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK
    Brain Res Bull 56:299-306. 2001
  9. ncbi request reprint Clinical characteristics of SOD1 gene mutations in UK families with ALS
    R W Orrell
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    J Neurol Sci 169:56-60. 1999
  10. ncbi request reprint Nuclear hormone and orphan receptors: their role in neuronal differentiation and cytoprotection and in the pathogenesis of Parkinson's disease
    A Malaspina
    Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, London, UK
    Dev Neurosci 25:375-83. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration?
    Andrea Malaspina
    Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurochem 104:584-95. 2008
    ....
  2. pmc Spinal cord trauma and the molecular point of no return
    Ping K Yip
    Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Mol Neurodegener 7:6. 2012
    ..A better knowledge of the molecular signals activated in a state of increased vulnerability to trauma can inform future treatment strategies and the prediction of the neurological outcome after spinal cord injury...
  3. pmc The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression
    Natasa Jokic
    Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, UK
    BMC Genomics 11:633. 2010
    ....
  4. doi request reprint Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis
    A Malaspina
    Centre for Neuroscience and Trauma, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Blizard Institute, 4 Newark Street, London E1 2AT, UK
    Neuroscience 169:812-27. 2010
    ..In addition, factors previously described to be linked to ATF-3 activation under various experimental conditions of stress, become switched on in spinal cord from the end-stage transgenic rat model of ALS...
  5. pmc Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression
    Andrea Malaspina
    Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
    BMC Genomics 9:500. 2008
    ..Mechanical injury can also determine spinal cord degeneration and act as a risk factor for the development of ALS...
  6. ncbi request reprint A review of the functional role and of the expression profile of retinoid signaling and of nuclear receptors in human spinal cord
    Andrea Malaspina
    Neuroscience Centre, Institute of Cell and Molecular Science, Queen Mary University, 4 Newark Street, Whitechapel, London E1 2AT, UK
    Brain Res Bull 71:437-46. 2007
    ....
  7. ncbi request reprint Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays
    A Malaspina
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK
    J Neurochem 77:132-45. 2001
    ....
  8. ncbi request reprint A survey of trinucleotide/tandem repeat-containing transcripts (TNRTs) isolated from human spinal cord to identify genes containing unstable DNA regions as candidates for disorders of motor function
    A Malaspina
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK
    Brain Res Bull 56:299-306. 2001
    ..The potential role of the gene candidates identified is discussed in terms of their contribution to neurodegenerative processes...
  9. ncbi request reprint Clinical characteristics of SOD1 gene mutations in UK families with ALS
    R W Orrell
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    J Neurol Sci 169:56-60. 1999
    ..We have studied the neuropathology in patients with SOD1 mutations. We are also performing linkage studies to identify the genes involved in the 80% of families where an SOD1 mutation has not been identified...
  10. ncbi request reprint Nuclear hormone and orphan receptors: their role in neuronal differentiation and cytoprotection and in the pathogenesis of Parkinson's disease
    A Malaspina
    Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, London, UK
    Dev Neurosci 25:375-83. 2003
    ....
  11. ncbi request reprint Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization
    N Kaushik
    Department of Neuromuscular Diseases, Imperial College School of Medicine, London, UK
    DNA Cell Biol 19:265-73. 2000
    ..Characterization of polymorphic TNRs in novel and even known genes expressed in human spinal cord is likely to help in the identification of new candidates for genes involved in neurodegenerative disorders...
  12. ncbi request reprint Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis
    Andrea Malaspina
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London W14 8RF, UK
    Brain Res Brain Res Rev 45:213-29. 2004
    ....
  13. ncbi request reprint Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis
    Natasa Jokic
    Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurochem 103:1821-33. 2007
    ....
  14. ncbi request reprint Disease clustering: the example of ALS, PD, dementia and hereditary ataxias in Italy
    Andrea Malaspina
    Laboratory of Experimental Neurobiology, IRCCS C Mondino Institute of Neurology, University of Pavia, Italy
    Funct Neurol 17:177-82. 2002
    ..The organisation of national registers that record, in particular, the geographical distribution of neurological disorders, might represent a good research strategy...
  15. ncbi request reprint Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis
    Cristina Cereda
    Experimental Neurobiology, Neurological Institute IRCCS C Mondino, Pavia, Italy
    Amyotroph Lateral Scler 7:227-34. 2006
    ..01), suggesting that specific allelic variants of the FMO1 gene might be associated to susceptibility to develop ALS...