T T MacDonald

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Immunopathogenesis of Crohn's disease
    Thomas T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, United Kingdom
    JPEN J Parenter Enteral Nutr 29:S118-24; discussion S124-5, S184-8. 2005
  2. ncbi request reprint Immunity, inflammation, and allergy in the gut
    Thomas T MacDonald
    Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Science 307:1920-5. 2005
  3. ncbi request reprint Bacterial regulation of intestinal immune responses
    Thomas T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, Hampshire, United Kingdom
    Gastroenterol Clin North Am 34:401-12, vii-viii. 2005
  4. doi request reprint Probiotics and the immune response to vaccines
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Newark Street, London E1 4AT, UK
    Proc Nutr Soc 69:442-6. 2010
  5. doi request reprint What's the next best cytokine target in IBD?
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    Inflamm Bowel Dis 18:2180-9. 2012
  6. doi request reprint Reprogramming the immune system in IBD
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Dig Dis 30:392-5. 2012
  7. pmc Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system
    Anna Vossenkamper
    Centre for Immunology and Infectious Disease, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    J Inflamm (Lond) 8:11. 2011
  8. doi request reprint The immunologic basis for gastrointestinal food allergy
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    Curr Opin Gastroenterol 25:521-6. 2009
  9. ncbi request reprint Autistic enterocolitis; is it a histopathological entity?
    T T MacDonald
    Institute of Cell and Molecular Science and Health Sciences Education, Bart s and the London Queen Mary School of Medicine and Dentistry, London, UK
    Histopathology 50:371-9; discussion 380-4. 2007
  10. doi request reprint The opposing roles of IL-21 and TGFβ1 in chronic inflammatory bowel disease
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Barts and the London School of Medicine and Dentistry, 2 Newark Street, London E1 2AT, UK
    Biochem Soc Trans 39:1061-6. 2011

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Immunopathogenesis of Crohn's disease
    Thomas T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, United Kingdom
    JPEN J Parenter Enteral Nutr 29:S118-24; discussion S124-5, S184-8. 2005
    ....
  2. ncbi request reprint Immunity, inflammation, and allergy in the gut
    Thomas T MacDonald
    Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Science 307:1920-5. 2005
    ..This suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy...
  3. ncbi request reprint Bacterial regulation of intestinal immune responses
    Thomas T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, Hampshire, United Kingdom
    Gastroenterol Clin North Am 34:401-12, vii-viii. 2005
  4. doi request reprint Probiotics and the immune response to vaccines
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Newark Street, London E1 4AT, UK
    Proc Nutr Soc 69:442-6. 2010
    ..The effect when shown is modest and is not always seen in different studies to all vaccines, but there is enough of a trend to make the area worthy of further investigation, particularly to tease out the mechanisms involved...
  5. doi request reprint What's the next best cytokine target in IBD?
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    Inflamm Bowel Dis 18:2180-9. 2012
    ..An alternative approach is to try to target individual therapies to individual patients, to improve clinical efficacy in subsets of patients, but this has proven difficult. Here we try to evaluate the potential of each of these choices...
  6. doi request reprint Reprogramming the immune system in IBD
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Dig Dis 30:392-5. 2012
    ..We have also generated a mouse which over-expresses Smad7 in T cells. This animal develops more severe colitis in a number of different models, but the inflammation helps protect against colon cancer...
  7. pmc Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system
    Anna Vossenkamper
    Centre for Immunology and Infectious Disease, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    J Inflamm (Lond) 8:11. 2011
    ..This review addresses the multiple mechanisms by which the type III secretion system targets the intestinal immune response, with a special focus on pathogenic E. coli...
  8. doi request reprint The immunologic basis for gastrointestinal food allergy
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    Curr Opin Gastroenterol 25:521-6. 2009
    ..The purpose of this review is to determine the therapeutic potential and current treatments for these conditions by understanding and manipulating the immune response...
  9. ncbi request reprint Autistic enterocolitis; is it a histopathological entity?
    T T MacDonald
    Institute of Cell and Molecular Science and Health Sciences Education, Bart s and the London Queen Mary School of Medicine and Dentistry, London, UK
    Histopathology 50:371-9; discussion 380-4. 2007
    ..To review the literature on the histopathological diagnosis of the condition termed 'autistic enterocolitis'...
  10. doi request reprint The opposing roles of IL-21 and TGFβ1 in chronic inflammatory bowel disease
    Thomas T MacDonald
    Centre for Immunology and Infectious Disease, Barts and the London School of Medicine and Dentistry, 2 Newark Street, London E1 2AT, UK
    Biochem Soc Trans 39:1061-6. 2011
    ....
  11. doi request reprint Regulation of homeostasis and inflammation in the intestine
    Thomas T MacDonald
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Gastroenterology 140:1768-75. 2011
    ..We describe some aspects of gut immunity that could alter the delicate balance between inflammatory and tolerogenic responses and result in chronic gastrointestinal tract inflammation in patients...
  12. doi request reprint Antigen presenting cells and T cell interactions in the gastrointestinal tract
    Thomas T MacDonald
    Centre for Infectious Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Mol Nutr Food Res 53:947-51. 2009
    ..We present evidence that type I INF made by plasmacytoid dendritic cells may be important in coeliac disease...
  13. ncbi request reprint Interferon-alpha drives T cell-mediated immunopathology in the intestine
    G Monteleone
    Division of Infection, Inflammation and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, GB
    Eur J Immunol 31:2247-55. 2001
    ..Together these data indicate that IFN-alpha can facilitate activation of Th1-reactive cells in the gut and drive immunopathology...
  14. doi request reprint Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    L Rovedatti
    Institute of Cell and Molecular Science, London School of Medicine and Dentistry, London E1 2AT, UK
    Gut 58:1629-36. 2009
    ..Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear...
  15. ncbi request reprint Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease
    D Fina
    Dipartimento di Medicina Interna e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Universitè Tor Vergata, Rome, Italy
    Gut 57:887-92. 2008
    ..However, the molecular mechanisms which regulate T-bet and promote the Th1 cell response are unknown...
  16. pmc Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease
    G Docena
    Centre for Infectious Disease and Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Clin Exp Immunol 162:108-15. 2010
    ..Additionally, all the p38α selective inhibitory drugs significantly down-regulated the activation of the MAPK pathway and the secretion of proinflammatory cytokines...
  17. pmc Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
    G Monteleone
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, United Kingdom
    J Clin Invest 108:601-9. 2001
    ....
  18. doi request reprint Interleukin-25 production is differently regulated by TNF-α and TGF-β1 in the human gut
    D Fina
    Department of Internal Medicine, University Tor Vergata of Rome, Rome, Italy
    Mucosal Immunol 4:239-44. 2011
    ..Knockdown of Smad7 was accompanied by an increase in IL-25 production. Data show that IL-25 production is differently regulated by TNF-α and TGF-β1 in the human gut...
  19. pmc Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype
    S L Pender
    Centre for Infection, Allergy, Inflammation and Repair, University of Southampton School of Medicine, Southampton, United Kingdom
    Am J Pathol 157:1955-62. 2000
    ..Collectively these results suggest that alpha4ss1-induced up-regulation of MT1-MMP may be a crucial factor in the migration of mesenchymal cells into ulcer beds during restitution of diseased gut mucosa...
  20. doi request reprint IL-21 comes of age as a regulator of effector T cells in the gut
    M C Fantini
    Department of Internal Medicine, University Tor Vergata of Rome, Rome, Italy
    Mucosal Immunol 1:110-5. 2008
    ..Overall, there is now sufficient evidence to suggest that targeting IL-21 will be of therapeutic benefit in IBD...
  21. ncbi request reprint Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease
    J M Fell
    Chelsea and Westminster Hospital, London, UK
    Aliment Pharmacol Ther 14:281-9. 2000
    ..Although enteral nutrition is a recognized form of treatment for intestinal Crohn's disease, there are persisting problems with feed palatability and only limited data as to its mode of action...
  22. ncbi request reprint Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Gastroenterology 133:1175-87. 2007
    ..We examined mucosal DCs in celiac disease in terms of phenotype, activation/maturation state, cytokine production, and function...
  23. pmc Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis
    N S Goncalves
    School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Infect Immun 69:6651-9. 2001
    ..TNF-alpha is not obligatory for protective immunity to C. rodentium in mice; however, it appears to play some role in downregulating mucosal pathology and Th1 immune responses...
  24. doi request reprint Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa
    A Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts, London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    Gut 57:605-12. 2008
    ....
  25. doi request reprint Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London E12AT, UK
    Hum Pathol 40:699-704. 2009
    ..We conclude that mucosal addressin cell adhesion molecule 1 may represent an important determinant for the generation of mucosal damage in celiac disease...
  26. pmc Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease
    J N Gordon
    Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, UK
    Gut 54:1213-5. 2005
  27. doi request reprint TGF-beta1 and Smad7 in the regulation of IBD
    G Monteleone
    Department of Internal Medicine, University Tor Vergata of Rome, Rome, Italy
    Mucosal Immunol 1:S50-3. 2008
    ..These data support a role for Smad7 in maintaining intestinal inflammation, and suggest that blocking Smad7 could be a promising way to dampen the ongoing inflammation in IBD...
  28. ncbi request reprint CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-α and MMP-3 production in patients with inflammatory bowel disease
    J N Gordon
    Division of Infection, Inflammation and Repair, University of Southampton, School of Medicine, Southampton, UK Department of Gastroenterology, Royal Hampshire County Hospital, Winchester, UK
    J Crohns Colitis 3:175-82. 2009
    ....
  29. ncbi request reprint IL-12 and Th1 immune responses in human Peyer's patches
    T T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, UK SO16 6YD
    Trends Immunol 22:244-7. 2001
    ..This is caused by the high local levels of interleukin (IL)-12 in PPs...
  30. ncbi request reprint Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Gastroenterology 133:137-49. 2007
    ..We investigated the action of infliximab on apoptosis, the production of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMP)-1, and migration of Crohn's disease (CD) myofibroblasts...
  31. doi request reprint Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease
    Jenny Epstein
    Centre for Digestive Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary, University of London, London E1 2AT, UK
    Br J Nutr 103:824-32. 2010
    ..We demonstrate dose-dependent suppression of MMP-3 in CMF with curcumin. We conclude that curcumin, a naturally occurring food substance with no known human toxicity, holds promise as a novel therapy in IBD...
  32. doi request reprint Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies
    Jenny Epstein
    Centre for Digestive Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary, University of London, 4 Newark Street, London E1 2AT, UK
    Br J Nutr 103:1545-57. 2010
    ..We review the evidence for the therapeutic potential of curcumin from in vitro studies, animal models and human clinical trials...
  33. doi request reprint Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE
    Anna Vossenkamper
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London
    J Immunol 185:4118-27. 2010
    ..Thus, EPEC translocate effectors into human DCs to dampen the inflammatory response elicited by its own pathogen-associated molecular patterns...
  34. ncbi request reprint Host defences to Citrobacter rodentium
    Thomas T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Int J Med Microbiol 293:87-93. 2003
    ..Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut...
  35. ncbi request reprint Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells
    Laurens Kruidenier
    Research Centre in Gastroenterology, Institute of Cell and Molecular Science, Queen Mary s School of Medicine and Dentistry, University of London, London, England
    Gastroenterology 130:127-36. 2006
    ..However, their in vitro capacity to specifically cleave inflammatory mediators indicates that MMPs may have a profound immunoregulatory impact. We hypothesized that MMPs proteolytically modify intestinal epithelial chemokine signaling...
  36. doi request reprint Cow's milk protein-specific T-helper type I/II cytokine responses in infants with necrotizing enterocolitis
    S L Chuang
    Department of Neonatology, Chelsea and Westminster Hospital, London, UK
    Pediatr Allergy Immunol 20:45-52. 2009
    ..These novel findings provide a potential mechanism for a direct contributory role of CMP in the pathogenesis of NEC...
  37. ncbi request reprint Role of macrophage metalloelastase in gut inflammation
    Sylvia L F Pender
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Ann N Y Acad Sci 1072:386-8. 2006
    ..We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases...
  38. doi request reprint Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cellular and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Eur J Gastroenterol Hepatol 21:1049-55. 2009
    ..We focused on MMP-3 (stromelysin-1) and MMP-12 (macrophage metalloelastase) as these two enzymes have been linked to connective tissue destruction in CD...
  39. ncbi request reprint Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming
    C A Jones
    Infection, Inflammation and Repair, School of Medicine, University of Southampton, United Kingdom
    J Allergy Clin Immunol 108:235-41. 2001
    ..Antigen-specific responses can be detected in umbilical cord blood mononuclear cells. The fetal immune system must therefore attain a level of maturity compatible with the initiation of such responses as well as be exposed to antigen...
  40. pmc Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model
    S L F Pender
    Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, UK
    Gut 54:1114-20. 2005
    ....
  41. pmc Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa
    I Monteleone
    Dipartimento di Medicina Interna e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Universita Tor Vergata, Rome, Italy
    Gut 53:1090-5. 2004
    ..In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown...
  42. ncbi request reprint The pathophysiologic rationale for biological therapies in inflammatory bowel disease
    John N Gordon
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Curr Opin Gastroenterol 21:431-7. 2005
    ..This review summarises important new developments in understanding this immune response and the downstream mechanisms of intestinal injury, alongside their potential role in opening up new avenues of treatment...
  43. ncbi request reprint Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease
    John N Gordon
    Division of Infection, Inflammation and Repair, University of Southampton, School of Medicine, Southampton, UK
    Inflamm Bowel Dis 14:195-203. 2008
    ..In this study we isolated gut PCs from patients with IBD and normal controls and analyzed cytokine production, matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 production, and PC longevity ex vivo...
  44. doi request reprint Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    J Immunol 183:3454-62. 2009
    ....
  45. ncbi request reprint Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
    Shyam Prasad
    Division of Infection, Inflammation and Repair, Southampton General Hospital, University of Southampton School of Medicine, Southampton, UK
    Lab Invest 85:1139-62. 2005
    ..These results suggest that INFgamma/TNFalpha and IL-13 have differential effects on CL 2, 3 and 4 in tight junctions, which may lead to increased permeability via different mechanisms...
  46. ncbi request reprint Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma
    Cameron P Simmons
    Department of Biochemistry, Center for Molecular Microbiology and Infection, Imperial College, South Kensington, London, United Kingdom
    J Immunol 168:1804-12. 2002
    ..These studies are among the first to examine mechanisms of host resistance to an attaching-effacing pathogen and show an important role for IL-12 and IFN-gamma in limiting bacterial infection of the colonic epithelium...
  47. ncbi request reprint The biochemical basis of immune enteropathy
    Thomas T MacDonald
    Immunology, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, United Kingdom
    J Pediatr Gastroenterol Nutr 34:S27-30. 2002
  48. ncbi request reprint Biological therapy in Crohn's disease
    J N Gordon
    Division of Infection, Inflammation, and Repair, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD
    Hosp Med 64:708-12. 2003
    ..Advances in understanding of the immunopathological basis of Crohn's disease are leading to the development of new biological therapies which are likely to play an increasing role in future...
  49. doi request reprint Transcriptional regulation of the mucosal immune system mediated by T-bet
    N Powell
    National Institute for Health Research NIHR Comprehensive Biomedical Research Centre at Guy s and St Thomas NHS Foundation Trust, Guy s Hospital, King s College London, London, UK
    Mucosal Immunol 3:567-77. 2010
    ....
  50. ncbi request reprint The role of matrix metalloproteinases in stromal/epithelial interactions in the gut
    N Sengupta
    Centre for Academic Surgery, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London
    Physiology (Bethesda) 22:401-9. 2007
    ..Here, we review the role of matrix metalloproteonases (MMPs) in the gut in health, in gut inflammation, and in cancer...
  51. ncbi request reprint Activated STAT4 and a functional role for IL-12 in human Peyer's patches
    Giovanni Monteleone
    Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 170:300-7. 2003
    ..These data show that IL-12 in human PP is likely to be responsible for the Th1-dominated cytokine response of the human mucosal immune system...
  52. ncbi request reprint Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice
    Chris K F Li
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, UK
    J Immunol 173:5171-9. 2004
    ..These studies show that mucosal remodeling can occur in the absence of MMP3, but that MMP3 plays a role in the migration of CD4+ T lymphocytes to the intestinal mucosa...
  53. ncbi request reprint Matrix metalloproteinases and the gut - new roles for old enzymes
    Sylvia L F Pender
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Curr Opin Pharmacol 4:546-50. 2004
    ..MMP activity is important in diseases such as arthritis, atherosclerosis, periodontal diseases and cancer. Recent data suggest that MMPs are involved in tissue injury and healing in the human gut...
  54. ncbi request reprint The mucosal immune system
    Thomas T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, UK
    Parasite Immunol 25:235-46. 2003
    ....
  55. ncbi request reprint Microbial-gut interactions in health and disease. Immune responses
    Karen M Pickard
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Mailpoint 813, Level E, South Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Best Pract Res Clin Gastroenterol 18:271-85. 2004
    ..There is also a growing realization that the normal flora can also influence gene expression in antigen-presenting cells in the gut and so set the context in which T cells respond to food antigen and vaccines...
  56. doi request reprint Cancer immunoediting and "spontaneous" tumor regression
    Neel Sengupta
    Colorectal Cancer Genetics, Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
    Pathol Res Pract 206:1-8. 2010
    ..We also briefly summarize the history of immunotherapy and discuss the immunoediting process in the context of spontaneous tumor regression and whether this observation can be utilized in future treatment regimens...
  57. pmc The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium
    Alison Dennis
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street London E1 2AT, United Kingdom
    Infect Immun 76:4978-88. 2008
    ..These data also demonstrate that non-NF-kappaB-dependent defenses are insufficient to control C. rodentium infection, and hence, the NF-kappaB p50 subunit is critical for defense against this noninvasive pathogen...
  58. pmc Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences
    Nathalie S Goncalves
    School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Infect Immun 71:2960-5. 2003
    ..Intimin costimulates proliferation of spleen CD4 T cells and cells from organized lymphoid tissues but does not costimulate cells from the lamina propria of normal or inflamed colon...
  59. ncbi request reprint Autocrine regulation of IL-21 production in human T lymphocytes
    Flavio Caprioli
    Department of Internal Medicine, University Tor Vergata, Via Montpellier 1, Rome, Italy
    J Immunol 180:1800-7. 2008
    ..These data suggest the existence of a positive autocrine loop that could help to amplify and stabilize IL-21-driven, T cell-mediated responses...
  60. ncbi request reprint Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease
    Toshiki Mimura
    Department of Surgery, University of Teikyo, Tokyo, Japan
    Dis Colon Rectum 47:371-8; discussion 378-9. 2004
    ..This study was designed to investigate the role of collagens, matrix metalloproteinases, and tissue inhibitor of metalloproteinases in colonic diverticulosis...
  61. ncbi request reprint Smad7 in TGF-beta-mediated negative regulation of gut inflammation
    Giovanni Monteleone
    Department of Internal Medicine and Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, Cattedra di Gastroenterologia, University Tor Vergata of Rome, Italy
    Trends Immunol 25:513-7. 2004
    ....
  62. ncbi request reprint A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells
    Roberta Caruso
    Dipartimento di Medicina Interna e Centro di Eccellenza, Studio delle Malattie Complesse e Multifattoriali, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Gastroenterology 132:166-75. 2007
    ..In this study we examined whether intestinal epithelial cells express IL-21R and respond to IL-21 in IBD...
  63. ncbi request reprint Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease
    Daniel Lottaz
    Institute of Biochemistry and Molecular Medicine, University of Bern, CH 3012 Bern, Switzerland
    Biol Chem 388:337-41. 2007
    ..Meprin thereby gains access to the substrate repertoire present beneath the epithelium...
  64. pmc Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium
    Cameron P Simmons
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, South Kensington, London SW6 1SJ, United Kingdom
    Infect Immun 71:5077-86. 2003
    ..rodentium infection but that the mechanism through which this occurs requires further investigation. These data are relevant to understanding immunity to enteric attaching and effacing bacterial pathogens of humans...
  65. pmc Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions
    Giuseppe Mazzarella
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    Am J Pathol 162:1845-55. 2003
    ..Furthermore, inhibition of STAT-1 prevented the gliadin-mediated induction of ICAM-1 and B7-2. These data suggest that persistent STAT-1 activation can contribute to maintaining and expanding the local inflammatory response in CD...
  66. ncbi request reprint The exposure of infants to Lactobacillus rhamnosus GG in Finland
    Thomas T MacDonald
    J Pediatr Gastroenterol Nutr 42:476-8. 2006
  67. ncbi request reprint The significance of ileocolonic lymphoid nodular hyperplasia in children with autistic spectrum disorder
    Thomas T MacDonald
    Eur J Gastroenterol Hepatol 18:569-71; author reply 571-3. 2006
  68. ncbi request reprint Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease
    Giovanni Monteleone
    Department of Internal Medicine and Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, University of Tor Vergata, Rome, Italy
    Gastroenterology 129:1420-9. 2005
    ..In this study, we examined the molecular mechanism underlying the induction of Smad7 in the human gut...
  69. pmc Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon-gamma receptor
    Andrew M Veitch
    Digestive Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, London UK
    Int J Exp Pathol 84:107-13. 2003
    ..02). IFN-gamma has a partial, but not obligatory, role in the development of villous atrophy and crypt hyperplasia during T cell mediated rejection of intestinal allografts...
  70. ncbi request reprint A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts
    Mairi Brittan
    Histopathology Unit, Cancer Research UK, London Research Institute, United Kingdom
    Gastroenterology 128:1984-95. 2005
    ..To investigate the reparative capacity of BM in inflammatory bowel disease (IBD), a well-established model of experimental colitis was used...
  71. ncbi request reprint A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation
    Giovanni Monteleone
    Dipartimento di Medicina Interna e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Universita Tor Vergata, Rome 00133, Italy
    J Biol Chem 279:3925-32. 2004
    ..These data show that TGF-beta1 is a negative regulator of NF-kappaB activation in the gut and that Smad7 maintains high NF-kappaB activity in gut inflammation by blocking TGF-beta1 signaling...
  72. doi request reprint Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease
    Antonio Di Sabatino
    First Department of Medicine, Fondazione IRCCS Policlinico S Matteo, Centro per lo Studio e la Cura della Malattia Celiaca, University of Pavia, Pavia, Italy
    Am J Clin Pathol 130:34-42. 2008
    ..Paneth cell numbers and alpha-defensins are unchanged in the mucosa in uncomplicated CD. Further studies are needed to clarify the implications of reduction of numbers of Paneth cells in complicated CD...
  73. pmc Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut
    Cordula Hemrajani
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 76:4804-13. 2008
    ..Consistent with this, we found that the nleH mutant triggered a significantly lower tumor necrosis factor alpha response than the wild-type strain...
  74. doi request reprint IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa
    Roberta Caruso
    Department of Internal Medicine and Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, University Tor Vergata of Rome, Rome, Italy
    Eur J Immunol 38:470-8. 2008
    ..Data show that IL-23 is overexpressed in Hp-infected gastric mucosa where it could contribute to sustaining IL-17 production...
  75. ncbi request reprint Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells
    Ute Gunther
    Divisions of
    J Immunol 174:5414-22. 2005
    ..Thus, we demonstrate that the CD3(-)7(+) cells present in the human fetal gut display a distinct phenotype and are able to develop into CD3(+) T cells...
  76. ncbi request reprint Decoy receptor springs to life and eases fibrosis
    Thomas T MacDonald
    Nat Med 12:13-4. 2006
  77. ncbi request reprint Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
    Giovanni Monteleone
    Dipartimento di Medicina Interna e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Universita Tor Vergata, Rome, Italy
    Gastroenterology 128:687-94. 2005
    ..In this study, we examined the expression and role of IL-21, a T-cell-derived cytokine of the IL-2 family; in tissues and cells isolated from patients with inflammatory bowel disease...
  78. ncbi request reprint New players in the cytokine orchestra of inflammatory bowel disease
    Massimo C Fantini
    Department of Internal Medicine, University Tor Vergata of Rome, Rome, Italy
    Inflamm Bowel Dis 13:1419-23. 2007
    ..Two other cytokines, IL-27 and IL-32, may also be important in the inflammatory pathways that operate in IBD...
  79. doi request reprint Regulation of gut inflammation and th17 cell response by interleukin-21
    Daniele Fina
    Dipartimento di Medicina Interna e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Universita Tor Vergata, Rome
    Gastroenterology 134:1038-48. 2008
    ..We here examined whether IL-21 is necessary for the initiation and progress of experimental colitis and whether it regulates specific pathways of inflammation...
  80. ncbi request reprint Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease
    Virginia M Salvati
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Pediatr Res 54:312-8. 2003
    ....