Atholl Johnston

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Novel therapies in transplantation
    AnaMaria Jorga
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Expert Opin Investig Drugs 14:295-304. 2005
  2. doi request reprint Challenges of therapeutic substitution of drugs for economic reasons: focus on CVD prevention
    Atholl Johnston
    Clinical Pharmacology, Barts and the London School of Medicine and Dentistry, London, UK
    Curr Med Res Opin 26:871-8. 2010
  3. ncbi request reprint Potential clinical implications of substitution of generic cyclosporine formulations for cyclosporine microemulsion (Neoral) in transplant recipients
    Atholl Johnston
    Clinical Pharmacology, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, EC1M 6BQ, UK
    Eur J Clin Pharmacol 60:389-95. 2004
  4. pmc Effectiveness, safety and cost of drug substitution in hypertension
    Atholl Johnston
    Clinical Pharmacology, Barts and the London School of Medicine and Dentistry, London, UK
    Br J Clin Pharmacol 70:320-34. 2010
  5. ncbi request reprint Bioequivalence of enteric-coated mycophenolate sodium and mycophenolate mofetil: a meta-analysis of three studies in stable renal transplant recipients
    Atholl Johnston
    Clinical Pharmacology, Barts and The London, London, United Kingdom
    Transplantation 82:1413-8. 2006
  6. ncbi request reprint Monitoring cyclosporin in blood: between-assay differences at trough and 2 hours post-dose (C2)
    Atholl Johnston
    Clinical Pharmacology, Barts and The London, London, United Kingdom
    Ther Drug Monit 25:167-73. 2003
  7. ncbi request reprint Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements
    Salim Fredericks
    Analytical Unit, Cardiac and Vascular Science, St George s University of London, London, UK
    Clin Transplant 21:252-7. 2007
  8. doi request reprint First reported case in the UK of acute prolonged neuropsychiatric toxicity associated with analytically confirmed recreational use of phenazepam
    Paul I Dargan
    Clinical Toxicology Service, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Eur J Clin Pharmacol 69:361-3. 2013
  9. doi request reprint Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    Eur J Clin Pharmacol 68:853-6. 2012
  10. ncbi request reprint Risk factors for allograft failure in United kingdom renal transplant recipients treated with cyclosporine A
    Xiang He
    Clinical Pharmacology, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Transplantation 79:953-7. 2005

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Novel therapies in transplantation
    AnaMaria Jorga
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Expert Opin Investig Drugs 14:295-304. 2005
    ..The new drugs that are intended to be used in transplantation are mostly analogues of currently used drugs with improved safety and pharmaceutical profiles...
  2. doi request reprint Challenges of therapeutic substitution of drugs for economic reasons: focus on CVD prevention
    Atholl Johnston
    Clinical Pharmacology, Barts and the London School of Medicine and Dentistry, London, UK
    Curr Med Res Opin 26:871-8. 2010
    ..Whether the substitution improves patient and/or population outcomes must be appraised and this paper highlights the conditions under which therapeutic substitution may require additional thought and consideration...
  3. ncbi request reprint Potential clinical implications of substitution of generic cyclosporine formulations for cyclosporine microemulsion (Neoral) in transplant recipients
    Atholl Johnston
    Clinical Pharmacology, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, EC1M 6BQ, UK
    Eur J Clin Pharmacol 60:389-95. 2004
    ....
  4. pmc Effectiveness, safety and cost of drug substitution in hypertension
    Atholl Johnston
    Clinical Pharmacology, Barts and the London School of Medicine and Dentistry, London, UK
    Br J Clin Pharmacol 70:320-34. 2010
    ..Although the cost of treatment should always be considered, careful assessment of the human and economic costs and benefits of antihypertensive drug substitution is required before this practice is recommended...
  5. ncbi request reprint Bioequivalence of enteric-coated mycophenolate sodium and mycophenolate mofetil: a meta-analysis of three studies in stable renal transplant recipients
    Atholl Johnston
    Clinical Pharmacology, Barts and The London, London, United Kingdom
    Transplantation 82:1413-8. 2006
    ..In an effort to reduce the gastrointestinal effects of MMF, an enteric-coated formulation of the drug was developed, based on the sodium salt of MPA (EC-MPS, Myfortic)...
  6. ncbi request reprint Monitoring cyclosporin in blood: between-assay differences at trough and 2 hours post-dose (C2)
    Atholl Johnston
    Clinical Pharmacology, Barts and The London, London, United Kingdom
    Ther Drug Monit 25:167-73. 2003
    ..Thus, when adopting a C2 monitoring strategy, it is possible to use target therapeutic ranges that are independent of the assay system used...
  7. ncbi request reprint Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements
    Salim Fredericks
    Analytical Unit, Cardiac and Vascular Science, St George s University of London, London, UK
    Clin Transplant 21:252-7. 2007
    ..MDR-1 SNPs and haplotypes and also CYP3A5*1 genotype, do not appear to have a major influence on ciclosporin pharmacokinetics...
  8. doi request reprint First reported case in the UK of acute prolonged neuropsychiatric toxicity associated with analytically confirmed recreational use of phenazepam
    Paul I Dargan
    Clinical Toxicology Service, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Eur J Clin Pharmacol 69:361-3. 2013
    ..There is little information on the acute toxicity of these compounds; we describe here a case of analytically confirmed phenazepam-related acute toxicity...
  9. doi request reprint Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    Eur J Clin Pharmacol 68:853-6. 2012
    ..We report here a case series of three individuals with acute toxicity related to the analytically confirmed use of methoxetamine...
  10. ncbi request reprint Risk factors for allograft failure in United kingdom renal transplant recipients treated with cyclosporine A
    Xiang He
    Clinical Pharmacology, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Transplantation 79:953-7. 2005
    ..This study investigates the impact of a range of demographic and treatment factors on long-term graft survival in renal recipients treated with CsA from all renal transplant centers in the United Kingdom...
  11. ncbi request reprint Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?
    Sarah Wilson
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 M 6BQ, UK
    J Cardiovasc Risk 10:137-41. 2003
    ..It is important to quantify the impact of this advice if risk assessments are to be sufficiently accurate to guide treatment decisions...
  12. doi request reprint The relevance of factor VIII (FVIII) pharmacokinetics to TDM and hemophilia a treatment: is B domain-deleted FVIII equivalent to full-length FVIII?
    Atholl Johnston
    Center for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Ther Drug Monit 34:110-7. 2012
    ..This article predicts the impact that differences in the pharmacokinetic behavior between BDD- and FL-rFVIII may have on bleed prophylaxis in hemophilia A...
  13. ncbi request reprint Influence of donor C3 allotype on late renal-transplantation outcome
    Katherine M Brown
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London, United Kingdom
    N Engl J Med 354:2014-23. 2006
    ..In humans, C3 exists as two main allotypes, F (fast) and S (slow), which are known to affect the incidence of inflammatory disease. We conducted a study to address the influence of these alleles on late renal-graft outcome...
  14. doi request reprint Comparison of the predictive performance of eGFR formulae for mortality and graft failure in renal transplant recipients
    Xiang He
    Department of Clinical Pharmacology, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Transplantation 87:384-92. 2009
    ..However, a more appropriate clinical gold standard is one conveying a defined clinical disadvantage. In renal transplantation, these measures are mortality and graft failure...
  15. doi request reprint The value of monitoring ciclosporin concentration 2 hours post-dose (C2) in dermatology: a prospective cohort study
    Ai Lean Chew
    Skin Therapy Research Unit, St John s Institute of Dermatology, Guy s and St Thomas Hospital NHS Trust, London, UK
    J Dermatolog Treat 22:79-85. 2011
    ..Ciclosporin (CsA) is an effective treatment for several inflammatory dermatoses, including psoriasis and eczema. In contrast to transplantation medicine, dermatologists do not routinely use CsA blood concentrations to guide therapy...
  16. ncbi request reprint The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation
    Iain A M Macphee
    Cellular and Molecular Medicine Renal Medicine, St George s Hospital Medical School, London, UK
    Am J Transplant 4:914-9. 2004
    ....
  17. doi request reprint Plasma clozapine and norclozapine in patients prescribed different brands of clozapine (Clozaril, Denzapine, and Zaponex)
    Lewis Couchman
    Toxicology Unit, Department of Clinical Biochemistry, King s College Hospital, London, UK
    Ther Drug Monit 32:624-7. 2010
    ..Nevertheless, careful monitoring of mental state, smoking habit, adherence, and of possible life-threatening adverse effects is mandatory if the drug is to be used safely...
  18. doi request reprint A survey to determine the views of renal transplant patients on generic substitution in the UK
    Mubarak N Al Ameri
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, UK
    Transpl Int 24:770-9. 2011
    ....
  19. ncbi request reprint Analysis for identification in amnesty bin samples from dance venues
    Susannah L Kenyon
    King s College, St Georges Hospital Medical School, London, United Kingdom
    Ther Drug Monit 27:793-8. 2005
    ..The most common drugs found in powders in London and Manchester respectively were cocaine (29%, 40%), amphetamine (25%, 26%), ketamine (19%, 20%), and MDMA (19%, 11%)...
  20. doi request reprint A case series of individuals with analytically confirmed acute diphenyl-2-pyrrolidinemethanol (D2PM) toxicity
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    Eur J Clin Pharmacol 68:349-53. 2012
    ..There is limited information on the acute toxicity related to both D2PM and 2-DPMP. We report here a case series of five individuals with acute toxicity related to the use of D2PM...
  21. doi request reprint Generic and therapeutic substitutions: are they always ethical in their own terms?
    Mubarak Alameri
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Pharm World Sci 32:691-5. 2010
    ..Such substitutions are thus unethical in their very own terms...
  22. doi request reprint The impact of hemoglobin levels on patient and graft survival in renal transplant recipients
    Jason Moore
    Department of Nephrology and Renal Transplantation, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom
    Transplantation 86:564-70. 2008
    ..This study assessed the relationship of hemoglobin levels with patient and graft survival in 3859 patients with functioning renal transplants more than 6-months posttransplantation...
  23. ncbi request reprint CYP3A5 genotype does not influence the blood concentration of tacrolimus measured with the Abbott immunoassay
    Michelle Moreton
    Clin Chem 51:2214-5. 2005
  24. ncbi request reprint Recommendations for the implementation of Neoral C(2) monitoring in clinical practice
    Edward Cole
    University of Toronto, Toronto General Hospital, 621 University Ave, Toronto, Ontario M5G 2C4, Canada
    Transplantation 73:S19-22. 2002
  25. ncbi request reprint The TMC study
    Atholl Johnston
    Lancet 361:346-7; author reply 347. 2003
  26. ncbi request reprint A pharmacokinetic and clinical review of the potential clinical impact of using different formulations of cyclosporin A. Berlin, Germany, November 19, 2001
    Stephen Pollard
    Department of Organ Transplantation, St James s University Hospital, Leeds, United Kingdom
    Clin Ther 25:1654-69. 2003
    ..Any switch between CsA formulations in a particular patient should take place only in a controlled setting with adequate pharmacokinetic monitoring...
  27. ncbi request reprint Longitudinal evaluation of the pharmacokinetics of cyclosporin microemulsion (Neoral) in pediatric renal transplant recipients and assessment of C2 level as a marker for absorption
    Richard Trompeter
    Renal Unit, Great Ormond Street Hospital for Children, NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Transplant 7:282-8. 2003
    ....
  28. ncbi request reprint Patient management by cyclosporine C2 monitoring
    Anamarija Jorga
    Transplantation 77:323-4. 2004
  29. ncbi request reprint Monitoring immunosuppressive drugs: has it a future?
    David W Holt
    Analytical Unit, St Georges Hospital Medical School, London, England
    Ther Drug Monit 26:244-7. 2004
  30. ncbi request reprint Seeking optimal prescription of cyclosporine ME
    Matthias Buchler
    Department of Nephrology and Clinical Immunology, CHU Bretonneau, 37044 Tours, France
    Ther Drug Monit 27:3-6. 2005
    ..Pharmacogenetic studies of the MDR-1 gene as well as the CYP3A4 and CYP3A5 gene polymorphisms could not yet demonstrate any clear influence on the interindividual variations on the pharmacokinetic profile of CsA ME...
  31. ncbi request reprint Use of Neoral C monitoring: a European consensus
    Bjorn Nashan
    QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
    Transpl Int 18:768-78. 2005
    ....
  32. ncbi request reprint Influence of albumin supplementation on tacrolimus and cyclosporine therapy early after liver transplantation
    Andrew Trull
    Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Liver Transpl 8:224-32. 2002
    ..In addition, supplementary albumin may reduce the efficacy of TAC in liver transplant recipients at a time when the risk for rejection is greatest...
  33. ncbi request reprint Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians
    Iain A M Macphee
    Cellular and Molecular Medicine, Renal Medicine, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Transplantation 79:499-502. 2005
    ..Determination of the CYP3A5*1/*3 genotype could be used to predict the tacrolimus dose requirement and, given incomplete linkage, would be better than determination of the CYP3AP1 genotype...
  34. ncbi request reprint Pharmacokinetics of oral cyclosporine (Neoral) in heart transplant recipients during the immediate period after surgery
    Nicholas R Banner
    Heart Failure and Transplant Service, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex UB9 6JH, UK
    Transpl Int 15:649-54. 2002
    ..Oral administration of Neoral may result in inadequate immunosuppression immediately after heart transplantation unless it is supplemented either by intravenous cyclosporine or by the use of an induction agent...
  35. ncbi request reprint Genotyping cytochrome P450 3A5 using the Light Cycler
    Salim Fredericks
    Analytical Unit, Cardiac and Vascular Sciences, St George s Hospital Medical School, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Ann Clin Biochem 42:376-81. 2005
    ..This is a rapid and reliable method for genotyping the CYP3A5 polymorphism which may be used as an important adjunct to the TDM service offered by laboratories to optimize drug prescription...
  36. ncbi request reprint Therapeutic drug monitoring of immunosuppressant drugs in clinical practice
    Barry D Kahan
    Division of Immunology and Organ Transplantation, University of Texas Health Science Center at Houston Medical School, 77030, USA
    Clin Ther 24:330-50; discussion 329. 2002
    ..Therapeutic drug monitoring (TDM) is essential to maintain the efficacy of many immunosuppressant drugs while minimizing their toxicity. TDM has become more refined with the development of new monitoring techniques and more specific assays...
  37. ncbi request reprint Effective synthesis of 1beta-acyl glucuronides by selective acylation
    Jennifer A Perrie
    The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, UK
    Org Lett 7:2591-4. 2005
    ..The method is effective for a range of aryl and alkyl carboxylic acids, including important drugs...