Ian J Jacobs

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Progress and challenges in screening for early detection of ovarian cancer
    Ian J Jacobs
    Department of Gynaecological Oncology, Cancer Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6GR, United Kingdom
    Mol Cell Proteomics 3:355-66. 2004
  2. pmc Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma
    A N Rosenthal
    Department of Obstetrics and Gynaecology, The Gynecological Oncology Unit, Bart s and The London, Queen Mary School of Medicine and Dentistry, London University, UK
    Br J Cancer 88:251-6. 2003
  3. ncbi request reprint A molecular genetic and statistical approach for the diagnosis of dual-site cancers
    Dirk Brinkmann
    Gynaecology Cancer Research Unit, St Bartholomew s and the London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    J Natl Cancer Inst 96:1441-6. 2004
  4. ncbi request reprint Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis
    Philippe O Van Trappen
    Department of Gynaecological Oncology, Cancer Research UK Translational Oncology Laboratory, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    J Pathol 201:544-54. 2003
  5. ncbi request reprint Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer
    Andrea G Rockall
    FRCR, Department of Radiology, Dominion House, St Bartholomew s Hospital, W Smithfield, London EC1A 7ED, United Kingdom
    J Clin Oncol 23:2813-21. 2005
  6. doi request reprint HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer
    Heidi Fiegl
    Department of Gynecological Oncology, UCL EGA Institute for Women s Health, University College London, United Kingdom
    Int J Cancer 123:725-9. 2008
  7. ncbi request reprint Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions
    Steven J Skates
    Massachusetts General Hospital, 50 Stanford St, Suite 560, Boston, MA 02114, USA
    J Clin Oncol 22:4059-66. 2004
  8. ncbi request reprint Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the 'MALOVA' ovarian cancer study
    Estrid V S Høgdall
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Oncol Rep 18:1051-9. 2007
  9. ncbi request reprint Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer
    Zhen Zhang
    Department of Pathology, Biomarker Discovery Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 64:5882-90. 2004
  10. ncbi request reprint MSI-low, a real phenomenon which varies in frequency among cancer types
    Sarah E R Halford
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Pathol 201:389-94. 2003

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Progress and challenges in screening for early detection of ovarian cancer
    Ian J Jacobs
    Department of Gynaecological Oncology, Cancer Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6GR, United Kingdom
    Mol Cell Proteomics 3:355-66. 2004
    ..There is a sound basis for optimism that further developments in serum proteomic analysis will provide powerful methods for screening in ovarian cancer and many other diseases...
  2. pmc Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma
    A N Rosenthal
    Department of Obstetrics and Gynaecology, The Gynecological Oncology Unit, Bart s and The London, Queen Mary School of Medicine and Dentistry, London University, UK
    Br J Cancer 88:251-6. 2003
    ....
  3. ncbi request reprint A molecular genetic and statistical approach for the diagnosis of dual-site cancers
    Dirk Brinkmann
    Gynaecology Cancer Research Unit, St Bartholomew s and the London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    J Natl Cancer Inst 96:1441-6. 2004
    ..Concurrent tumors can be synchronous, independently derived, non-metastatic tumors or metastatic tumors. The prognosis and clinical management of patients with these different concurrent tumor types are different...
  4. ncbi request reprint Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis
    Philippe O Van Trappen
    Department of Gynaecological Oncology, Cancer Research UK Translational Oncology Laboratory, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    J Pathol 201:544-54. 2003
    ..These results suggest that in cervical carcinogenesis a switch to the lymphangiogenic phenotype may occur at the stage of CIN 3...
  5. ncbi request reprint Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer
    Andrea G Rockall
    FRCR, Department of Radiology, Dominion House, St Bartholomew s Hospital, W Smithfield, London EC1A 7ED, United Kingdom
    J Clin Oncol 23:2813-21. 2005
    ..Our aim was to compare the diagnostic performance of MRI with USPIO against standard size criteria...
  6. doi request reprint HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer
    Heidi Fiegl
    Department of Gynecological Oncology, UCL EGA Institute for Women s Health, University College London, United Kingdom
    Int J Cancer 123:725-9. 2008
    ..03)]. These findings support the view that the technical inability to optimally cytoreduce ovarian cancer is associated with particular molecular alterations in the tumor which per se define a subgroup of patients with poor outcome...
  7. ncbi request reprint Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions
    Steven J Skates
    Massachusetts General Hospital, 50 Stanford St, Suite 560, Boston, MA 02114, USA
    J Clin Oncol 22:4059-66. 2004
    ..For direct comparisons between marker panels, all sensitivity results correspond to a 98% fixed first-line specificity (referral rate 2%)...
  8. ncbi request reprint Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the 'MALOVA' ovarian cancer study
    Estrid V S Høgdall
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Oncol Rep 18:1051-9. 2007
    ..31-0.74) compared to patients with <10% expression for both receptors. In conclusion, our results predict that an elevated expression of ER and PR, alone and in combination, point to a favorable outcome for patients with OC...
  9. ncbi request reprint Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer
    Zhen Zhang
    Department of Pathology, Biomarker Discovery Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 64:5882-90. 2004
    ..These biomarkers demonstrated the potential to improve the detection of early stage ovarian cancer...
  10. ncbi request reprint MSI-low, a real phenomenon which varies in frequency among cancer types
    Sarah E R Halford
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Pathol 201:389-94. 2003
    ..PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem...
  11. ncbi request reprint Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis
    Farhad Alexander-Sefre
    ICRF Translational Oncology Laboratory, St Bartholomew s and the Royal London Medical and Dental School, Charterhouse Square, London, EC1M 6BQ, UK
    Gynecol Oncol 91:218-25. 2003
    ..Tumor cells can evade detection by light microscopy if they are vastly outnumbered by myometrial cells. Molecular techniques have a great potential in the detection of such isolated cells...
  12. ncbi request reprint Calculation of the risk of ovarian cancer from serial CA-125 values for preclinical detection in postmenopausal women
    Steven J Skates
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Oncol 21:206s-210s. 2003
    ..We conducted a study to assess the screening performance of the risk of ovarian cancer calculation based on serial CA-125 levels from prospectively collected serum samples compared with a fixed CA-125 cutoff...
  13. ncbi request reprint Screening for ovarian cancer
    Adam N Rosenthal
    Institute for Women s Health, University College London, Elizabeth Garrett Anderson Hospital, London, UK
    Clin Obstet Gynecol 49:433-47. 2006
    ..Current screening tests, clinical trials in the general and high-risk populations, screening acceptability and costs are reviewed in this article...
  14. ncbi request reprint Clinical value of immunohistochemically detected lymphovascular space invasion in early stage cervical carcinoma
    Chung Sim Lim
    Cancer Research United Kingdom Translational Oncology Laboratory, St Bartholomew s and the Royal London School of Medicine and Dentistry, John Vane Building, Charterhouse Square, London, EC1M 6BQ, UK
    Ann Surg Oncol 15:2581-8. 2008
    ..This study investigates the clinical significance of lymphovascular space invasion (LVSI) as detected by hematoxylin and eosin (LVSI-H&E) and immunohistochemistry (LVSI-IHC) in early stage cervical carcinoma...
  15. doi request reprint Distribution of p53 expression in tissue from 774 Danish ovarian tumour patients and its prognostic significance in ovarian carcinomas
    Estrid V S Høgdall
    Dept of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    APMIS 116:400-9. 2008
    ..00001). Multivariate Cox regression analysis found that less than 20% tissue expression of p53 was associated with longer OC disease-specific survival. Tissue p53 expression may be of prognostic value in women with OC...
  16. pmc Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer
    Zhen Zhang
    Center for Biomarker Discovery, Department of Pathology, Johns Hopkins Medical Institutions, CRB II 3M04, 1550 Orleans Street, Baltimore, MD 21231, USA
    Gynecol Oncol 107:526-31. 2007
    ..In this paper, an ANN model was evaluated for its performance in detecting early stage epithelial ovarian cancer using multiple serum markers...
  17. ncbi request reprint Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London UCL, Elizabeth Garrett Anderson EGA Institute for Women s Health, University College London, London, United Kingdom
    Hum Mutat 28:1207-15. 2007
    ..Finally, it is likely that these data will be of clinical importance for individuals in families with a history of epithelial ovarian cancer, in providing accurate estimates of their disease risks...
  18. ncbi request reprint Distribution of microsatellite instability in Danish ovarian tumor patients and the prognostic value in ovarian cancer patients
    Farah D Begum
    Gynaecologic Clinic, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen O, DK 2100, Denmark
    Oncol Res 17:43-9. 2008
    ..72). In conclusion, we found no association to any of the clinical parameters evaluated, although a tendency of a higher frequency of MSI was observed among serous OC...
  19. ncbi request reprint Loss of hMSH2 and hMSH6 expression is frequent in sporadic endometrial carcinomas with microsatellite instability: a population-based study
    Ingunn Stefansson
    Department of Pathology, The Gade Institute, Bergen, Norway
    Clin Cancer Res 8:138-43. 2002
    ..Our data indicate that the other mismatch repair genes hMSH2 and hMSH6 are also involved, especially in cases with intermediate MSI...
  20. ncbi request reprint BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark
    Marie Soegaard
    Institute of Cancer Epidemiology, Danish Cancer Society
    Clin Cancer Res 14:3761-7. 2008
    ..To evaluate the prevalence of BRCA1 and BRCA2 mutations and associations with clinical correlates of disease in a population-based series of ovarian cancer cases from Denmark...
  21. doi request reprint Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: from the Danish 'MALOVA'ovarian cancer study
    Estrid V S Høgdall
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Pathology 40:487-92. 2008
    ..To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease...
  22. pmc Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 3:e2656. 2008
    ..However, whether DNA methylation in normal unrelated cells is associated with BC risk and whether these imprints can be related to factors which can be modified by the environment, is unclear...
  23. ncbi request reprint Expression level of Wilms tumor 1 (WT1) protein has limited prognostic value in epithelial ovarian cancer: from the Danish "MALOVA" ovarian cancer study
    Estrid V S Høgdall
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Gynecol Oncol 106:318-24. 2007
    ..Secondly, to evaluate whether WT1 tissue expression levels correlate with clinico-pathological parameters and finally to investigate the prognostic value of WT1 expression levels in ovarian cancer (OC) patients...
  24. ncbi request reprint Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. Online
    Susan J Ramus
    Translational Research Laboratory, Institute for Women s Health, University College London, United Kingdom
    Hum Mutat 28:525-6. 2007
    ....
  25. ncbi request reprint CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients. From The Danish "MALOVA" Ovarian Cancer Study
    Estrid V S Høgdall
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Gynecol Oncol 104:508-15. 2007
    ....
  26. ncbi request reprint MR imaging of carcinoma of the vulva
    S A Aslam Sohaib
    Department of Diagnostic Imaging, St Bartholomew s Hospital, West Smithfield, London, EC1A 7BE, United Kingdom
    AJR Am J Roentgenol 178:373-7. 2002
    ..The aim of this study was to describe the MR imaging features of cancer of the vulva and to determine the accuracy of MR imaging in staging the disease...
  27. ncbi request reprint Molecular evidence of a common clonal origin and subsequent divergent clonal evolution in vulval intraepithelial neoplasia, vulval squamous cell carcinoma and lymph node metastases
    Adam N Rosenthal
    Gynaecological Oncology Unit, St Bartholomew s and Royal London Hospitals Medical College, Queen Mary and Westfield College, Charterhouse Square, London EC1M 6GM, UK
    Int J Cancer 99:549-54. 2002
    ....
  28. ncbi request reprint Ovarian cancer screening
    Farhad Alexander-Sefre
    Department of Gynaecological Oncology, St Bartholomew s and the Royal London Medical and Dental School, London EC1A 7BE
    Hosp Med 63:210-3. 2002
    ..However, the results so far do not justify routine screening until the impact of screening on mortality has been assessed in larger randomized trials...
  29. ncbi request reprint Loss of heterozygosity on the X chromosome is an independent prognostic factor in ovarian carcinoma: from the Danish "MALOVA" Ovarian Carcinoma Study
    Estrid V S Høgdall
    Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Cancer 100:2387-95. 2004
    ..Loss of heterozygosity (LOH) may be detected in individuals heterozygous for an allele and is associated with loss of function of tumor suppressor genes...
  30. ncbi request reprint STK15 polymorphisms and association with risk of invasive ovarian cancer
    Richard A Dicioccio
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 13:1589-94. 2004
    ..These results suggest a model of dominant inheritance of ovarian cancer risk by the I31 allele of F31I and that the I31 allele may be a common ovarian cancer susceptibility allele of low penetrance...
  31. ncbi request reprint Significance of PTEN alterations in endometrial carcinoma: a population-based study of mutations, promoter methylation and PTEN protein expression
    Helga B Salvesen
    Department of Gynaecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
    Int J Oncol 25:1615-23. 2004
    ..A pathway in endometrial carcinogenesis involving PTEN mutation and microsatellite instability is confirmed, and this study also indicates the importance of PTEN and hMLH1 methylation in this pathway...
  32. ncbi request reprint Low frequency of BRAF and CDKN2A mutations in endometrial cancer
    Helga B Salvesen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Int J Cancer 115:930-4. 2005
    ..However, the mechanism of p16 inactivation remains unclear for the majority of cases exhibiting loss of expression, but the interactions with K-ras and p53 should be further studied...
  33. ncbi request reprint Prospective study using the risk of ovarian cancer algorithm to screen for ovarian cancer
    Usha Menon
    Department of Gynecological Oncology, Institute of Women s Health, University College London
    J Clin Oncol 23:7919-26. 2005
    ..To evaluate prevalence screening in the first prospective trial of a new ovarian cancer screening (OCS) strategy (risk of ovarian cancer or ROC algorithm) on the basis of age and CA125 profile...
  34. ncbi request reprint 10th Biennial Helene Harris Memorial Trust meeting
    Frances R Balkwill
    Barts and The London Queen Mary s School of Medicine and Dentistry, UK
    Cancer Res 66:2904-6. 2006
    ....
  35. ncbi request reprint Common variants in RB1 gene and risk of invasive ovarian cancer
    Honglin Song
    Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
    Cancer Res 66:10220-6. 2006
    ..The possible associations of rs2854344 and rs4151620 with ovarian cancer risk warrant confirmation in independent case-control studies before studies on their biological mode of action...
  36. doi request reprint Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer
    Susan J Ramus
    Gynaecological Cancer Research Laboratory, University College London Elizabeth Garrett Anderson Institute for Women s Health, University College London, London, UK
    Clin Cancer Res 14:5840-8. 2008
    ..The diagnosis given will influence the patient's treatment and prognosis. Currently, a diagnosis of SPM or DP is made using histologic criteria, which are frequently unable to make a definitive diagnosis...