Marco Falasca

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials
    Marco Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London, UK
    Anticancer Agents Med Chem 11:455-63. 2011
  2. doi request reprint Regulation and cellular functions of class II phosphoinositide 3-kinases
    Marco Falasca
    Inositide Signalling Group, Centre for Diabetes, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Biochem J 443:587-601. 2012
  3. doi request reprint Investigational ABC transporter inhibitors
    Marco Falasca
    Queen Mary University of London, Blizard Institute, Barts and the London School of Medicine and Dentistry, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London, UK
    Expert Opin Investig Drugs 21:657-66. 2012
  4. ncbi request reprint Cancer chemoprevention by nuts: evidence and promises
    Marco Falasca
    Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    Front Biosci (Schol Ed) 4:109-20. 2012
  5. doi request reprint Boyden chamber
    Marco Falasca
    Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, London, UK
    Methods Mol Biol 769:87-95. 2011
  6. ncbi request reprint Targeting PDK1 in cancer
    C Raimondi
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London E1 2AT, UK
    Curr Med Chem 18:2763-9. 2011
  7. ncbi request reprint PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs
    Marco Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London E1 2AT, UK
    Curr Pharm Des 16:1410-6. 2010
  8. pmc A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate
    M Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London E1 2AT, UK
    Br J Cancer 102:104-14. 2010
  9. doi request reprint Rethinking phosphatidylinositol 3-monophosphate
    Marco Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London E1 2AT, UK
    Biochim Biophys Acta 1793:1795-803. 2009
  10. ncbi request reprint The role of phosphoinositide 3-kinase C2alpha in insulin signaling
    Marco Falasca
    Inositide Signalling Group, Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London E1 2AT, United Kingdom
    J Biol Chem 282:28226-36. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials
    Marco Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London, UK
    Anticancer Agents Med Chem 11:455-63. 2011
    ..In this review we will discuss how the PI3K/Akt/mTOR signaling network is altered in pancreatic cancer and further give an overview of preclinical and clinical studies where this pathway has been targeted...
  2. doi request reprint Regulation and cellular functions of class II phosphoinositide 3-kinases
    Marco Falasca
    Inositide Signalling Group, Centre for Diabetes, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Biochem J 443:587-601. 2012
    ..In the present review, we discuss the recent advances in our understanding of mammalian class II PI3Ks and the evidence suggesting their involvement in human diseases...
  3. doi request reprint Investigational ABC transporter inhibitors
    Marco Falasca
    Queen Mary University of London, Blizard Institute, Barts and the London School of Medicine and Dentistry, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London, UK
    Expert Opin Investig Drugs 21:657-66. 2012
    ..Evidence is also emerging of the role played by ABC transporters in cancer cell signalling that is likely to be important in disease progression and which is distinct from MDR...
  4. ncbi request reprint Cancer chemoprevention by nuts: evidence and promises
    Marco Falasca
    Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    Front Biosci (Schol Ed) 4:109-20. 2012
    ..Although the results are not conclusive, recent studies show possible cancer protective effects of nuts. This review will focus on the laboratory and clinical evidence of nuts chemopreventive and therapeutic properties...
  5. doi request reprint Boyden chamber
    Marco Falasca
    Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, London, UK
    Methods Mol Biol 769:87-95. 2011
    ..The method described in this chapter is intended specifically for measuring the migration or invasion of human endothelial and cancer cells...
  6. ncbi request reprint Targeting PDK1 in cancer
    C Raimondi
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London E1 2AT, UK
    Curr Med Chem 18:2763-9. 2011
    ..This review will focus on published data on the role of PDK1 in cancer and approaches used to inhibit PDK1...
  7. ncbi request reprint PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs
    Marco Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London E1 2AT, UK
    Curr Pharm Des 16:1410-6. 2010
    ..Therefore drugs designed to specifically target this pathway are under development to be used as single agent and in combination to chemotherapy to overcome therapeutic resistance...
  8. pmc A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate
    M Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London E1 2AT, UK
    Br J Cancer 102:104-14. 2010
    ..To further develop this compound we modified its structure to obtain more potent inhibitors of the PI3K/Akt pathway...
  9. doi request reprint Rethinking phosphatidylinositol 3-monophosphate
    Marco Falasca
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London E1 2AT, UK
    Biochim Biophys Acta 1793:1795-803. 2009
    ..Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years...
  10. ncbi request reprint The role of phosphoinositide 3-kinase C2alpha in insulin signaling
    Marco Falasca
    Inositide Signalling Group, Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London E1 2AT, United Kingdom
    J Biol Chem 282:28226-36. 2007
    ....
  11. pmc Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis
    Gianpaolo Tibolla
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute, Centre for Diabetes, Inositide Signalling Group, London, United Kingdom
    PLoS ONE 8:e53808. 2013
    ..Data further indicate that PI3K-C2β and p110γ control distinct steps involved in cell migration supporting the hypothesis that different PI3Ks regulate distinct cellular processes...
  12. doi request reprint Key role of phosphoinositide 3-kinase class IB in pancreatic cancer
    Charlotte E Edling
    Inositide Signalling Group, Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom
    Clin Cancer Res 16:4928-37. 2010
    ....
  13. pmc A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation
    Tania Maffucci
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London, United Kingdom
    PLoS ONE 4:e8285. 2009
    ..Here we investigated the basic FGF (FGF-2)-mediated activation of these enzymes in human umbilical vein endothelial cells (HUVECs) and defined their role in FGF-2-dependent cellular functions...
  14. pmc A novel regulatory mechanism links PLCγ1 to PDK1
    Claudio Raimondi
    Centre for Diabetes, Blizard Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    J Cell Sci 125:3153-63. 2012
    ..This is likely to have profound consequences for our understanding of several cellular functions that are dependent on phosphoinositides and controlled by PDK1 and PLCγ1...
  15. doi request reprint Phospholipase Cgamma1 is required for metastasis development and progression
    Gianluca Sala
    Inositide Signalling Group, Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom
    Cancer Res 68:10187-96. 2008
    ..These data show a critical role of PLCgamma1 in the metastatic potential of cancer cells, and they further indicate that PLCgamma1 inhibition has a therapeutic potential in the treatment of metastasis dissemination...
  16. ncbi request reprint Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger
    Marco Falasca
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK
    Arch Physiol Biochem 112:274-84. 2006
    ..In addition we describe the potential mechanism of switching on and off such signals. Taken together all this evidence suggest a novel, key role for PtdIns-3-P in signal transduction...
  17. pmc Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells
    Veronica Dominguez
    From the Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, London E1 2AT, United Kingdom
    J Biol Chem 286:4216-25. 2011
    ..Our results reveal a critical role for PI3K-C2α in β cells and suggest that down-regulation of PI3K-C2α may be a feature of type 2 diabetes...
  18. ncbi request reprint Genetic and epigenetic regulation of phosphoinositide 3-kinase isoforms
    Chanse Fyffe
    Inositide Signalling Group, Centre for Diabetes, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4Newark Street, London E1 2AT, UK
    Curr Pharm Des 19:680-6. 2013
    ..In this review, we summarize the genetic and epigenetic regulation of PI3Ks in physiology and the role played by their alterations in different diseases...
  19. doi request reprint Lysophosphatidylinositol signalling: new wine from an old bottle
    Roberto Piñeiro
    Queen Mary University of London, Barts and The Lodon School of Medicine and Dentistry, Blizard Istitute, Centre for Diabetes, Inositide Signalling Group, Lodon E1 2AT, UK
    Biochim Biophys Acta 1821:694-705. 2012
    ..Here we review the available data supporting the role of LPI in cell signalling and the pharmacology of its putative receptor GPR55...
  20. doi request reprint Analysis, regulation, and roles of endosomal phosphoinositides
    Tania Maffucci
    Inositide Signalling Group, Centre for Diabetes, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Methods Enzymol 535:75-91. 2014
    ..The use of specific tagged-PtdIns3P-binding domains later demonstrated that this constitutive PtdIns3P accumulates in endosomes where it critically regulates trafficking and membrane dynamics. ..
  21. ncbi request reprint Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3
    Tania Maffucci
    The Sackler Institute for Muscular Skeletal Research, Department of Medicine, University College London, London WC1E 6JJ, United Kingdom
    Mol Endocrinol 17:1568-79. 2003
    ..In particular, our data suggest that IRS3 intracellular localization at the plasma membrane and in the nucleus is the result of two different cooperative mechanisms both involving the PH domain...
  22. ncbi request reprint Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
    Tania Maffucci
    Department of Medicine, The Sackler Institute, University College London, United Kingdom
    Cancer Res 65:8339-49. 2005
    ..In this respect, Ins(1,3,4,5,6)P5, a water-soluble, natural compound with specific proapoptotic and antiangiogenic properties, might result in successful anticancer therapeutic strategies...
  23. pmc Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
    Tania Maffucci
    Department of Medicine, The Sackler Institute, University College London, London WC1E 6JJ, England, UK
    J Cell Biol 169:789-99. 2005
    ..Defining this novel PI3K-C2beta-PtdIns-3-P signaling pathway may help clarify the process of cell migration and may shed new light on PI3K-mediated intracellular events...
  24. ncbi request reprint Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway
    Enza Piccolo
    Department of Medicine, The Sackler Institute, University College London, 5, University Street, London WC1E 6JJ, UK
    Oncogene 23:1754-65. 2004
    ..These results support a role for Ins(1,3,4,5,6)P5 as a specific inhibitor of the PI 3-K/Akt signalling pathway, that may sensitize cancer cells to the action of commonly used anticancer drugs...
  25. pmc Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation
    Tania Maffucci
    The Sackler Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    EMBO J 22:4178-89. 2003
    ..These results give a new insight into the intracellular role of PtdIns-3-P and shed light on some aspects of insulin signalling so far not completely understood...
  26. ncbi request reprint The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration
    Enza Piccolo
    Department of Oncology and Neuroscience, Section of Medical Oncology, Universita G D Annunzio, Via dei Vestini 1, 66100 Chieti, Italy
    Oncogene 21:6520-9. 2002
    ..This may suggest that influence of PI 3-K on PLCgamma1 could be relevant in cell migration, where PLCgamma1 seems to play a key role by modulating a series of events involved in actin polymerization...