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Genomes and Genes | Maurice R ElphickSummaryAffiliation: Queen Mary Country: UK Publications
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Publications
The evolution and comparative neurobiology of endocannabinoid signallingMaurice R Elphick
School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
Philos Trans R Soc Lond B Biol Sci 367:3201-15. 2012..Thus, postsynaptic synthesis of 2-AG or anandamide may be a phylogenetically widespread phenomenon, and a variety of proteins may have evolved as presynaptic (or postsynaptic) receptors for endocannabinoids...- The protein precursors of peptides that affect the mechanics of connective tissue and/or muscle in the echinoderm Apostichopus japonicusMaurice R Elphick
Queen Mary University of London, School of Biological and Chemical Sciences, London, United Kingdom
PLoS ONE 7:e44492. 2012..This suggests that proteolysis of collagen may generate peptides (holokinins) that affect body wall stiffness in sea cucumbers, providing a novel perspective on mechanisms of mutable connective tissue in echinoderms... 
NG peptides: a novel family of neurophysin-associated neuropeptidesMaurice R Elphick
Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK
Gene 458:20-6. 2010....- NGFFFamide and echinotocin: structurally unrelated myoactive neuropeptides derived from neurophysin-containing precursors in sea urchinsMaurice R Elphick
School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
J Exp Biol 212:1067-77. 2009.... 
BfCBR: a cannabinoid receptor ortholog in the cephalochordate Branchiostoma floridae (Amphioxus)Maurice R Elphick
School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK
Gene 399:65-71. 2007....- Evolution of cannabinoid receptors in vertebrates: identification of a CB(2) gene in the puffer fish Fugu rubripesMaurice R Elphick
School of Biological Sciences, Queen Mary, University of London, London E1 4NS, UK
Biol Bull 202:104-7. 2002 - Molecular characterisation of SALMFamide neuropeptides in sea urchinsMaurice R Elphick
School of Biological and Chemical Sciences, Queen Mary, University of London, UK
J Exp Biol 208:4273-82. 2005.... - The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalisMaurice R Elphick
School of Biological Sciences, Queen Mary, University of London, E1 4NS, London, UK
Gene 302:95-101. 2003.... - MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor familyLi F Chan
Queen Mary University of London, Centre for Endocrinology, St Bartholomew s and Royal London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
Proc Natl Acad Sci U S A 106:6146-51. 2009..Collectively, our data identify MRAP and MRAP2 as unique bidirectional regulators of the MCR family... - Localization of CiCBR in the invertebrate chordate Ciona intestinalis: evidence of an ancient role for cannabinoid receptors as axonal regulators of neuronal signallingMichaela Egertová
School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
J Comp Neurol 502:660-72. 2007.... - Discovery of a second SALMFamide gene in the sea urchin Strongylocentrotus purpuratus reveals that L-type and F-type SALMFamide neuropeptides coexist in an echinoderm speciesMatthew L Rowe
Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK
Mar Genomics 3:91-7. 2010..We speculate that this feature of S. purpuratus may apply to other echinoderms and further insights on this issue will be possible if genomic and/or neural cDNA sequence data are obtained for other echinoderm species... - Identification of novel SALMFamide neuropeptides in the starfish Marthasterias glacialisSang Seon Yun
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK
Comp Biochem Physiol A Mol Integr Physiol 147:536-42. 2007..In particular, the identification of MagS3 and MagS4, in addition to S1 and the S2-like peptide MagS2, has revealed a greater diversity of SALMFamide neuropeptides occurring in a starfish species than any previous studies... - Enhanced fidelity of diffusive nitric oxide signalling by the spatial segregation of source and target neurones in the memory centre of an insect brainSwidbert R Ott
School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London, UK
Eur J Neurosci 25:181-90. 2007..In a neural structure that forms NO-dependent associations, these properties of the segregated architecture may reduce the likelihood of forming spurious memories... - Nitric oxide synthase histochemistry in insect nervous systems: Methanol/formalin fixation reveals the neuroarchitecture of formaldehyde-sensitive NADPH diaphorase in the cockroach Periplaneta americanaSwidbert R Ott
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
J Comp Neurol 448:165-85. 2002..These divergent architectures may result in different spatiotemporal dynamics of NO diffusion and suggest species differences in the role of NO in the mushroom bodies... - New techniques for whole-mount NADPH-diaphorase histochemistry demonstrated in insect gangliaSwidbert R Ott
School of Biological Sciences, Queen Mary, University of London, London, United Kingdom
J Histochem Cytochem 51:523-32. 2003..The new methods revealed the three-dimensional architecture of NADPHd expression in locust ganglia in unprecedented detail and may similarly improve whole-mount detection of NADPHd in other invertebrate and vertebrate preparations... - Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic painLeonardo Guasti
School of Biological and Chemical Sciences, Queen Mary University of London, UK
Mol Pain 5:35. 2009..01) increased levels of PEA in the ipsilateral spinal cord of SNL rats, compared to the contralateral spinal cord. Thus, activation of microglia affects spinal levels of endocannabinoids and related compounds in neuropathic pain states... - Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling moleculesMichaela Egertová
School of Biological and Chemical Sciences, Queen Mary, University of London, London, E1 4NS, United Kingdom
J Comp Neurol 506:604-15. 2008..We suggest that NAEs generated by NAPE-PLD in axons may act as anterograde synaptic signaling molecules that regulate the activity of postsynaptic neurons... - An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brainSwidbert R Ott
School of Biological Sciences, Queen Mary, University of London, Mile End Road, E1 4NS, UK
Eur J Neurosci 20:1231-44. 2004..Our findings add considerable momentum to the concept of an as yet unidentified endogenous ligand that regulates the gain of the NO-cGMP signalling pathway... - The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratusMatthew L Rowe
Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London E1 4NS, UK
Gen Comp Endocrinol 179:331-44. 2012..Looking ahead, the identification of these neuropeptide precursors in S. purpuratus has provided a strong basis for a comprehensive analysis of neuropeptide function in this model echinoderm species... - The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell lineSadani N Cooray
Centre for Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary University of London, West Smithfield, London, United Kingdom
Endocrinology 149:1935-41. 2008..1-kDa protein. Coimmunoprecipitation and mass spectroscopy suggests that MRAP exists as a homodimer that is resistant to dissociation by sodium dodecyl sulfate and reducing agents... - Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfishRichard Melarange
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
J Exp Biol 206:893-9. 2003..However, the mechanisms by which SALMFamides cause muscle relaxation in starfish remain unknown and, although our results do not rule out the involvement of cGMP or cAMP, other signalling pathways may now need to be investigated... - Nitric oxide synthase in crayfish walking leg ganglia: segmental differences in chemo-tactile centers argue against a generic role in sensory integrationSwidbert R Ott
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
J Comp Neurol 501:381-99. 2007..Our findings indicate that strong expression of NOS is not a universal feature of primary sensory centers but instead may subserve a specific requirement for sensory plasticity that arises only in particular behavioral contexts... - The genome of the sea urchin Strongylocentrotus purpuratusErica Sodergren
Science 314:941-52. 2006..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes... - Localization of nitric oxide synthase in the central complex and surrounding midbrain neuropils of the locust Schistocerca gregariaAngela E Kurylas
Fachbereich Biologie, Tierphysiologie, , D 35032 Marburg, Germany
J Comp Neurol 484:206-23. 2005..The results provide new insights into the neurochemical architecture of the central complex and suggest a prominent role for NO signaling in this brain area... - CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1aJason L Niehaus
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
Mol Pharmacol 72:1557-66. 2007..g., chronic pain, obesity, and epilepsy)... - The endocannabinoid system controls key epileptogenic circuits in the hippocampusKrisztina Monory
Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
Neuron 51:455-66. 2006..The direct endocannabinoid-mediated control of hippocampal glutamatergic neurotransmission may constitute a promising therapeutic target for the treatment of disorders associated with excessive excitatory neuronal activity...