Greg Elgar

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc Early evolution of conserved regulatory sequences associated with development in vertebrates
    Gayle K McEwen
    School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom
    PLoS Genet 5:e1000762. 2009
  2. pmc Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans
    Tanya Vavouri
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 8:R15. 2007
  3. pmc Persistence of duplicated PAC1 receptors in the teleost, Sparus auratus
    João C R Cardoso
    CCMAR, Molecular and Comparative Endocrinology, University of Algarve, 8005 139 Faro, Portugal
    BMC Evol Biol 7:221. 2007
  4. doi request reprint Pan-vertebrate conserved non-coding sequences associated with developmental regulation
    Greg Elgar
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Rd, London E1 4NS, UK
    Brief Funct Genomic Proteomic 8:256-65. 2009
  5. ncbi request reprint Different words, same meaning: understanding the languages of the genome
    Greg Elgar
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
    Trends Genet 22:639-41. 2006
  6. ncbi request reprint Tuning in to the signals: noncoding sequence conservation in vertebrate genomes
    Greg Elgar
    School of Biological and Chemical Sciences, Queen Mary, University of London, London, UK
    Trends Genet 24:344-52. 2008
  7. pmc CONDOR: a database resource of developmentally associated conserved non-coding elements
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    BMC Dev Biol 7:100. 2007
  8. doi request reprint Organization of conserved elements near key developmental regulators in vertebrate genomes
    Adam Woolfe
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Adv Genet 61:307-38. 2008
  9. pmc Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis
    Gayle K McEwen
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Genome Res 16:451-65. 2006
  10. pmc Comparative genomics using Fugu reveals insights into regulatory subfunctionalization
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, London, UK
    Genome Biol 8:R53. 2007

Collaborators

Detail Information

Publications35

  1. pmc Early evolution of conserved regulatory sequences associated with development in vertebrates
    Gayle K McEwen
    School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom
    PLoS Genet 5:e1000762. 2009
    ....
  2. pmc Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans
    Tanya Vavouri
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 8:R15. 2007
    ..Despite their extreme sequence conservation in vertebrates, sequences homologous to CNEs have not been identified in invertebrates...
  3. pmc Persistence of duplicated PAC1 receptors in the teleost, Sparus auratus
    João C R Cardoso
    CCMAR, Molecular and Comparative Endocrinology, University of Algarve, 8005 139 Faro, Portugal
    BMC Evol Biol 7:221. 2007
    ..These receptors belong to family 2 GPCRs and most of their members are duplicated in teleosts although the reason why both persist in the genome is unknown...
  4. doi request reprint Pan-vertebrate conserved non-coding sequences associated with developmental regulation
    Greg Elgar
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Rd, London E1 4NS, UK
    Brief Funct Genomic Proteomic 8:256-65. 2009
    ..I will also discuss the evolution of these elements, and examine their emerging and likely roles in disease. Together these analyses are starting to unravel how conserved non-coding regions function at the molecular level...
  5. ncbi request reprint Different words, same meaning: understanding the languages of the genome
    Greg Elgar
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
    Trends Genet 22:639-41. 2006
    ..It is as yet unclear whether these sequences are 'below the radar' of current sequence alignment tools or whether their functional homology is not sequence based...
  6. ncbi request reprint Tuning in to the signals: noncoding sequence conservation in vertebrate genomes
    Greg Elgar
    School of Biological and Chemical Sciences, Queen Mary, University of London, London, UK
    Trends Genet 24:344-52. 2008
    ....
  7. pmc CONDOR: a database resource of developmentally associated conserved non-coding elements
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    BMC Dev Biol 7:100. 2007
    ..Despite this, there remains little in the way of user-friendly access to a large dataset of such elements in conjunction with the analysis and the visualization tools needed to study them...
  8. doi request reprint Organization of conserved elements near key developmental regulators in vertebrate genomes
    Adam Woolfe
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Adv Genet 61:307-38. 2008
    ..This chapter describes the identification and characterization of these elements, with particular reference to their composition and organization...
  9. pmc Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis
    Gayle K McEwen
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Genome Res 16:451-65. 2006
    ..We propose a model whereby gene duplication and the evolution of cis-regulatory elements can be considered in the context of increased morphological diversity and the emergence of the modern vertebrate body plan...
  10. pmc Comparative genomics using Fugu reveals insights into regulatory subfunctionalization
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, London, UK
    Genome Biol 8:R53. 2007
    ..We have exploited fish-mammal genomic alignments to identify and compare more than 800 conserved non-coding elements (CNEs) that associate with genes that have undergone fish-specific duplication and retention...
  11. pmc Parallel evolution of chordate cis-regulatory code for development
    Laura Doglio
    Systems Biology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
    PLoS Genet 9:e1003904. 2013
    ..However, functional cross-talk still exists because the same repertoire of transcription factors has likely guided their parallel evolution, exploiting similar sets of binding sites but in different combinations. ..
  12. pmc A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes
    Mark Halling-Brown
    School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Nucleic Acids Res 32:2618-22. 2004
    ..The Fugu-human genome synteny views are available for each Fugu scaffold through the clonesearch web page located at the Fugu Genomics website (http://fugu.rfcgr.mrc.ac.uk/)...
  13. doi request reprint The PAX258 gene subfamily: a comparative perspective
    Debbie K Goode
    Queen Mary, University of London, School of Biological and Chemical Sciences, London, United Kingdom
    Dev Dyn 238:2951-74. 2009
    ..We also discuss their fundamental place within gene regulatory networks and the likely influence of cis-regulatory elements over their differential roles during early animal development...
  14. doi request reprint A reporter assay in lamprey embryos reveals both functional conservation and elaboration of vertebrate enhancers
    Hugo J Parker
    Division of Systems Biology, Medical Research Council National Institute for Medical Research, London, United Kingdom
    PLoS ONE 9:e85492. 2014
    ..We find instances of both functional conservation and lineage-specific functional evolution of CNEs across vertebrates, emphasising the utility of functionally testing homologous CNEs in their host species. ..
  15. doi request reprint Capturing the regulatory interactions of eukaryote genomes
    Debbie K Goode
    Cambridge Institute for Medical Research, Deptartment of Haematology, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Brief Funct Genomics 12:142-60. 2013
    ..While we are only at the advent of making these discoveries, the next decade promises to be a very exciting and rewarding time for genome researchers...
  16. ncbi request reprint Molecular evolution of the vertebrate blood coagulation network
    Colin J Davidson
    Haemostasis Group, MRC Clinical Sciences Centre, The Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Thromb Haemost 89:420-8. 2003
    ..Comparative sequence analyses of amino acid residues in the active site region suggest these additional sequences have evolved new and as yet unknown functions...
  17. pmc Analyses of the extent of shared synteny and conserved gene orders between the genome of Fugu rubripes and human 20q
    Sarah F Smith
    Fugu Genomics, United Kingdom Human Genome Mapping Project Resource Centre, Wellcome Genome Campus, Hinxton Hall, Hinxton, Cambridgeshire, CB10 1SB, United Kingdom
    Genome Res 12:776-84. 2002
    ....
  18. ncbi request reprint Ultraconserved non-coding sequence element controls a subset of spatiotemporal GLI3 expression
    Zissis Paparidis
    Institute of Human Genetics, Philipps University, Bahnhofstrasse 7, D35037 Marburg, Germany
    Dev Growth Differ 49:543-53. 2007
    ..Time, location, and quantity of reporter gene expression are congruent with part of the pattern previously reported for endogenous GLI3 transcription...
  19. ncbi request reprint Prediction of cis-regulatory elements using binding site matrices--the successes, the failures and the reasons for both
    Tanya Vavouri
    Comparative Genomics Group, MRC Rosalind Franklin Centre for Genomics Research, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SB, UK
    Curr Opin Genet Dev 15:395-402. 2005
    ..Nonetheless, a combination of experimental, computational and comparative data is likely to reveal aspects of complex regulatory networks in vertebrates, just as it has already done for simple eukaryotic genomes...
  20. ncbi request reprint Highly conserved regulatory elements around the SHH gene may contribute to the maintenance of conserved synteny across human chromosome 7q36.3
    Debbie K Goode
    Comparative Genomics Group, MRC Rosalind Franklin Centre for Genomics Research, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SB, UK
    Genomics 86:172-81. 2005
    ....
  21. ncbi request reprint Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes
    Samuel Aparicio
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Science 297:1301-10. 2002
    ..Conserved linkages between Fugu and human genes indicate the preservation of chromosomal segments from the common vertebrate ancestor, but with considerable scrambling of gene order...
  22. pmc Highly conserved non-coding sequences are associated with vertebrate development
    Adam Woolfe
    Medical Research Council Rosalind Franklin Centre for Genomics Research Hinxton, Cambridge, United Kingdom
    PLoS Biol 3:e7. 2005
    ..These highly conserved non-coding sequences are likely to form part of the genomic circuitry that uniquely defines vertebrate development...
  23. ncbi request reprint Identification and analysis of cis-regulatory elements in development using comparative genomics with the pufferfish, Fugu rubripes
    Greg Elgar
    MRC Rosalind Franklin Centre for Genomics Research, Genome Campus, Hinxton, Cambridgeshire CB10 1SB, UK
    Semin Cell Dev Biol 15:715-9. 2004
    ..This review describes progress made in this kind of comparison, from small regions of individual genes, to whole genome alignments...
  24. ncbi request reprint Plenty more fish in the sea: comparative and functional genomics using teleost models
    Greg Elgar
    MRC Rosalind Franklin Centre for Genomics Research, Genome Campus, Hinxton Hinxton, Cambridge, CB10 1SB, UK
    Brief Funct Genomic Proteomic 3:15-25. 2004
    ..In this review, the relationship between fish species is examined along with the role of different fish models in a wide range of biological disciplines...
  25. pmc Fugu ESTs: new resources for transcription analysis and genome annotation
    Melody S Clark
    MRC Rosalind Franklin Centre for Genomics Research, formerly known as the MRC UK HGMP Resource Centre, Genome Campus, Hinxton, Cambridge, CB10 1SB, UK
    Genome Res 13:2747-53. 2003
    ..This is particularly timely with the increasing availability of draft genome sequence from different organisms and the mounting emphasis on gene function and regulation...
  26. pmc Faithful expression of a tagged Fugu WT1 protein from a genomic transgene in zebrafish: efficient splicing of pufferfish genes in zebrafish but not mice
    Colin G Miles
    Medical Research Council Human Genetics Unit, Western General Hospital, Creve Road, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 31:2795-802. 2003
    ..These data demonstrate that the zebrafish:Fugu system is a powerful and convenient tool for dissecting both vertebrate gene regulation and gene function in vivo...
  27. ncbi request reprint Fugu orthologues of human major histocompatibility complex genes: a genome survey
    Jennifer G Sambrook
    Fugu Genomics, HGMP Resource Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SB, UK
    Immunogenetics 54:367-80. 2002
    ..Comparison with zebrafish substantiates previously observed linkages between class III region orthologues and hints at an ancient conserved class III region...
  28. ncbi request reprint Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis
    Daisuke Ikeda
    Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan
    Physiol Genomics 32:1-15. 2007
    ..Phylogenetic analysis suggests that fast skeletal MYHs evolved independently in teleosts and tetrapods after fast skeletal MYHs had diverged from four ancestral MYHs...
  29. ncbi request reprint Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key
    Tanya Vavouri
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA
    Trends Genet 22:5-10. 2006
    ..This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene...
  30. ncbi request reprint Striking nucleotide frequency pattern at the borders of highly conserved vertebrate non-coding sequences
    Klaudia Walter
    MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge CB10 1SB, UK
    Trends Genet 21:436-40. 2005
    ..The analysis reveals a novel, sharp and distinct signal of nucleotide frequency bias precisely at the border between CNEs and flanking regions...
  31. ncbi request reprint A genomic approach to reveal novel genes associated with myotube formation in the model teleost, Takifugu rubripes
    Jorge M O Fernandes
    Gatty Marine Laboratory, School of Biology, University of St Andrews, St Andrews, Fife, United Kingdom
    Physiol Genomics 22:327-38. 2005
    ..The novel genes identified, which are also present in other vertebrate genomes, may play a role in inhibiting myotube formation in vertebrate muscle...
  32. ncbi request reprint Effect of cryopreservation on mitochondrial DNA of zebrafish (Danio rerio) blastomere cells
    Julia Kopeika
    Luton Institute of Research in the Applied Natural Sciences, University of Luton, The Spires, 2 Adelaide Street, Luton LU1 5DU, UK
    Mutat Res 570:49-61. 2005
    ..Meanwhile, it is important to be cautious in making judgements of the effect of cryopreservation technique in assisted reproduction. This is the first report on the effect of cryopreservation on mtDNA...
  33. pmc Comparative analysis of vertebrate dystrophin loci indicate intron gigantism as a common feature
    Uberto Pozzoli
    IRCCS E Medea, Associazione La Nostra Famiglia, 23842 Bosisio Parini LC, Italy
    Genome Res 13:764-72. 2003
    ..The hypothesis that intron length might be functionally relevant to the DMD gene regulation is proposed and substantiated by the finding that dystrophin intron gigantism is common to the three vertebrate genes...
  34. ncbi request reprint Comparative analysis of vertebrate Shh genes identifies novel conserved non-coding sequence
    Debbie K Goode
    Comparative Genomics Group, HGMP Resource Centre, Hinxton, Cambridge, CB10 1SB, UK
    Mamm Genome 14:192-201. 2003
    ..This work demonstrates the value of using Fugu in comparative genomics, which has allowed identification of new putative regulatory elements, as well as corroborating enhancers identified by the more traditional deletion mapping method...
  35. ncbi request reprint Xena, a full-length basal retroelement from tetraodontid fish
    Damian E Dalle Nogare
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Mol Biol Evol 19:247-55. 2002
    ..The Penelope-Xena lineage is apparently a basal group within the retrotransposons and therefore represents an evolutionarily important class of retroelement...