Stephen W Duffy

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc Mammographic density and its interaction with other breast cancer risk factors in an Asian population
    C S Wong
    Centre for Molecular Epidemiology, National University of Singapore, Blk MD3, 16 Medical Drive, Singapore 117597, Singapore
    Br J Cancer 104:871-4. 2011
  2. pmc An ongoing case-control study to evaluate the NHS breast screening programme
    Nathalie J Massat
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine Room 009, Queen Mary University of London, London EC1M 6BQ, UK
    BMC Cancer 13:596. 2013
  3. pmc Assessing risk of breast cancer in an ethnically South-East Asia population (results of a multiple ethnic groups study)
    Fei Gao
    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610
    BMC Cancer 12:529. 2012
  4. doi request reprint Evaluation of mammographic surveillance services in women aged 40-49 years with a moderate family history of breast cancer: a single-arm cohort study
    S W Duffy
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Health Technol Assess 17:vii-xiv, 1-95. 2013
  5. ncbi request reprint Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer
    Stephen W Duffy
    Cancer Research UK Centre for EMS, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Expert Rev Anticancer Ther 9:1467-72. 2009
  6. pmc Using mammographic density to predict breast cancer risk: dense area or percentage dense area
    Jennifer Stone
    Centre for Molecular, Environmental, Genetic and Analytical MEGA Epidemiology, The University of Melbourne, School of Population Health, Victoria, 3010, Australia
    Breast Cancer Res 12:R97. 2010
  7. doi request reprint Tamoxifen-induced reduction in mammographic density and breast cancer risk reduction: a nested case-control study
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Natl Cancer Inst 103:744-52. 2011
  8. pmc Overdiagnosis and overtreatment of breast cancer: estimates of overdiagnosis from two trials of mammographic screening for breast cancer
    Stephen W Duffy
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary College, University of London, London, UK
    Breast Cancer Res 7:258-65. 2005
  9. ncbi request reprint Some current issues in breast cancer screening
    Stephen W Duffy
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London EC1M 6BQ, UK
    J Med Screen 12:128-33. 2005
  10. pmc Absolute numbers of lives saved and overdiagnosis in breast cancer screening, from a randomized trial and from the Breast Screening Programme in England
    Stephen W Duffy
    CR UK Centre for Epidemiology, Statistics and Mathematics, Wolfson Institute for Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 17:25-30. 2010

Collaborators

Detail Information

Publications30

  1. pmc Mammographic density and its interaction with other breast cancer risk factors in an Asian population
    C S Wong
    Centre for Molecular Epidemiology, National University of Singapore, Blk MD3, 16 Medical Drive, Singapore 117597, Singapore
    Br J Cancer 104:871-4. 2011
    ..Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear...
  2. pmc An ongoing case-control study to evaluate the NHS breast screening programme
    Nathalie J Massat
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine Room 009, Queen Mary University of London, London EC1M 6BQ, UK
    BMC Cancer 13:596. 2013
    ..We propose innovative selection of cases and controls and gathering of additional variables to address new outcomes of interest and develop new methodologies to control for potential sources of bias...
  3. pmc Assessing risk of breast cancer in an ethnically South-East Asia population (results of a multiple ethnic groups study)
    Fei Gao
    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610
    BMC Cancer 12:529. 2012
    ..However, the validity of the model for projecting risk in South-East Asian women is uncertain. We evaluated GAIL and attempted to improve its performance for Singapore women of Chinese, Malay and Indian origins...
  4. doi request reprint Evaluation of mammographic surveillance services in women aged 40-49 years with a moderate family history of breast cancer: a single-arm cohort study
    S W Duffy
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Health Technol Assess 17:vii-xiv, 1-95. 2013
    ..Up to now, this strategy has not been fully evaluated...
  5. ncbi request reprint Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer
    Stephen W Duffy
    Cancer Research UK Centre for EMS, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Expert Rev Anticancer Ther 9:1467-72. 2009
    ....
  6. pmc Using mammographic density to predict breast cancer risk: dense area or percentage dense area
    Jennifer Stone
    Centre for Molecular, Environmental, Genetic and Analytical MEGA Epidemiology, The University of Melbourne, School of Population Health, Victoria, 3010, Australia
    Breast Cancer Res 12:R97. 2010
    ..Mammographic density (MD) is one of the strongest risk factors for breast cancer. It is not clear whether this association is best expressed in terms of absolute dense area or percentage dense area (PDA)...
  7. doi request reprint Tamoxifen-induced reduction in mammographic density and breast cancer risk reduction: a nested case-control study
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Natl Cancer Inst 103:744-52. 2011
    ..However, it is not known if tamoxifen-induced reductions in breast density can be used to identify women who will benefit the most from prophylactic treatment with this drug...
  8. pmc Overdiagnosis and overtreatment of breast cancer: estimates of overdiagnosis from two trials of mammographic screening for breast cancer
    Stephen W Duffy
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary College, University of London, London, UK
    Breast Cancer Res 7:258-65. 2005
    ..Our results suggest that overdiagnosis in mammography screening is a minor phenomenon, but further studies with very large numbers are required for more precise estimation...
  9. ncbi request reprint Some current issues in breast cancer screening
    Stephen W Duffy
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London EC1M 6BQ, UK
    J Med Screen 12:128-33. 2005
    ..This paper describes examples of approaches to the above issues, along with some important results...
  10. pmc Absolute numbers of lives saved and overdiagnosis in breast cancer screening, from a randomized trial and from the Breast Screening Programme in England
    Stephen W Duffy
    CR UK Centre for Epidemiology, Statistics and Mathematics, Wolfson Institute for Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 17:25-30. 2010
    ..To estimate the absolute numbers of breast cancer deaths prevented and the absolute numbers of tumours overdiagnosed in mammographic screening for breast cancer at ages 50-69 years...
  11. doi request reprint Clinical and epidemiological issues in mammographic density
    Valentina Assi
    Center for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Clin Oncol 9:33-40. 2012
    ....
  12. doi request reprint A deterministic model for estimating the reduction in colorectal cancer incidence due to endoscopic surveillance
    Fay H Cafferty
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Stat Methods Med Res 18:163-82. 2009
    ..They indicate that polypectomy and follow-up surveillance can lead to large reductions in cancer incidence which may have been under-estimated in previous studies...
  13. ncbi request reprint Tamoxifen and breast density in women at increased risk of breast cancer
    Jack Cuzick
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary College, University of London, London, UK
    J Natl Cancer Inst 96:621-8. 2004
    ..We investigated mammographic breast density in healthy women with an increased risk of breast cancer at baseline and during 54 months of tamoxifen treatment...
  14. pmc Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view
    Stephen W Duffy
    Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Breast Cancer Res 10:R64. 2008
    ..A particularly strong association with risk has been observed when density is measured using interactive threshold software. This, however, is a labour-intensive process for large-scale studies...
  15. ncbi request reprint Overdiagnosis, sojourn time, and sensitivity in the Copenhagen mammography screening program
    Anne Helene Olsen
    Cancer Research UK, Department of Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, United Kingdom
    Breast J 12:338-42. 2006
    ..A modest overdiagnosis was estimated for the Copenhagen screening program, deriving almost exclusively from the first screen. The CIs were very broad, however, and estimates from larger datasets are warranted...
  16. ncbi request reprint Tumor size and breast cancer detection: what might be the effect of a less sensitive screening tool than mammography?
    Stephen W Duffy
    Cancer Research UK Center for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Breast J 12:S91-5. 2006
    ..Our findings suggest that a less sensitive tool might be expected to confer a breast cancer mortality reduction about half of that observed with mammography...
  17. ncbi request reprint Some issues in screening for breast and other cancers
    Stephen W Duffy
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London
    J Med Screen 13:S28-34. 2006
    ..There are some issues in screening for cancer, especially breast cancer, which are worthy of further study...
  18. ncbi request reprint Screening and primary prevention of colorectal cancer: a review of sex-specific and site-specific differences
    Nathalie J Massat
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Med Screen 20:125-48. 2013
    ..Incidence rates for colorectal adenomas and advanced colorectal neoplasia are higher in men than in women of all age groups. The male-to-female ratio for CRC incidence rates differs for different parts of the large bowel...
  19. ncbi request reprint Prospective estimation of rates of change in mammographic parenchymal patterns: influence of age and of hormone replacement therapy
    Jonathan P Myles
    Cancer Research UK, Department of Mathematics, Statistics and Epidemiology, Wolfson Institute of Preventitive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Breast 13:56-60. 2004
    ..The probability of non-dense patterns and the rate of change to non-dense patterns are reduced with HRT use. Errors of classification are relatively rare, but are dependent on the age of the subject...
  20. pmc Avoiding bias from aggregate measures of exposure
    Stephen W Duffy
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Epidemiol Community Health 61:461-3. 2007
    ..To show how the individual level effect can be correctly estimated by excess relative risk models. METHODS: The problem and solution are demonstrated using data on prostate-specific antigen testing and prostate cancer incidence...
  21. ncbi request reprint Screening for breast cancer
    Stephen W Duffy
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Surg Oncol Clin N Am 14:671-97. 2005
    ....
  22. ncbi request reprint Bayesian evaluation of breast cancer screening using data from two studies
    Jonathan P Myles
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London, UK
    Stat Med 22:1661-74. 2003
    ..The method is applied to the synthesis of two studies of mammographic screening in women with a family history of breast cancer, one in Manchester and one in Kopparberg, Sweden...
  23. ncbi request reprint Misclassification in a matched case-control study with variable matching ratio: application to a study of c-erbB-2 overexpression and breast cancer
    Stephen W Duffy
    Department of Epidemiology, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Stat Med 22:2459-68. 2003
    ..An example is given from a study of risk factors for progression of benign breast disease to breast cancer, in which the risk factor is a biological marker measured with poor sensitivity...
  24. ncbi request reprint Surrogate endpoints for cancer screening trials: general principles and an illustration using the UK Flexible Sigmoidoscopy Screening Trial
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Med Screen 14:178-85. 2007
    ..Surrogate endpoints should not replace a long-term analysis based directly on mortality, but can provide reliable early indicators which can be useful both for monitoring ongoing screening programmes and for making policy decisions...
  25. ncbi request reprint Time-dependent effects on survival in breast carcinoma: results of 20 years of follow-up from the Swedish Two-County Study
    Jane Warwick
    Department of Epidemiology, Mathematics, and Statistics, Cancer Research UK, Wolfson Institute of Preventive Medicine, London, UK
    Cancer 100:1331-6. 2004
    ..However, to the authors' knowledge, the effect of these factors in the longer term (>10 years after diagnosis) is not yet clear...
  26. pmc Commentary on 'what is the point: will screening mammography save my life?' by Keen and Keen
    Stephen W Duffy
    Cancer Research UK Centre for EMS, Wolfson Institute of Preventive Medicine, Barts and London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    BMC Med Inform Decis Mak 9:19. 2009
    ..Commentary on Keen and Keen 'What is the point: will screening mammography save my life?' BMC Medical Informatics and Decision Making, 2009...
  27. doi request reprint Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial
    Wendy S Atkin
    Department of Surgery and Cancer, Imperial College London, London, UK
    Lancet 375:1624-33. 2010
    ..We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality...
  28. ncbi request reprint What information should be given to women invited for mammographic screening for breast cancer?
    Stephen W Duffy
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, London, UK
    Womens Health (Lond Engl) 2:829-33. 2006
    ..We suggest a few simple and clear points that should be made to the invited women, summarizing the positive and negative aspects without a mass of confusing statistics...