Affiliation: Queen Mary
- WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathwaysGiovanna Nalesso
Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London EC1M6BQ, England, UK
J Cell Biol 193:551-64. 2011..We propose a novel model in which a single WNT can simultaneously activate different pathways with distinct and independent outcomes and with reciprocal regulation. This offers an opportunity for selective pharmacological targeting...
- A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injuryN M Eltawil
William Harvey Research Institute, Barts and The London Queen Mary s School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, UK
Osteoarthritis Cartilage 17:695-704. 2009..To generate and validate a murine model of joint surface repair following acute mechanical injury...
- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritisFrancesco Dell'accio
Barts and the London School of Medicine and Dentistry, London, UK
Arthritis Rheum 58:1410-21. 2008..To characterize the molecular response of adult human articular cartilage to acute mechanical injury...
- Joint surface defects: clinical course and cellular response in spontaneous and experimental lesionsF Dell'accio
Centre of Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, II floor John Vane Building, Charterhouse Square, London EC1M 6BQ, UK
Eur Cell Mater 20:210-7. 2010..In the second part we will summarize the data coming from in vitro and in vivo models of cartilage injury and regeneration, focussing on the molecular control of cartilage homeostasis after creation of cartilage surface defects...
- High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agentsK V Greco
William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
Biochem Pharmacol 82:1919-29. 2011....
- Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in miceJ Bertrand
Department of Experimental Medicine and Rheumatology, Barts and The London, Queen Mary School of Medicine and Dentistry, William Harvey Research Institute, London, UK
Ann Rheum Dis 71:1249-53. 2012..To analyse the function of nucleotide pyrophosphatase phosphodiesterase (NPP1), a member of the pyrophosphate pathway, in osteoarthritis (OA)...
- Mesenchymal differentiation propensity of a human embryonic stem cell lineS Pringle
Stem Cell Laboratory, King s College London, London, UK
Cell Prolif 44:120-7. 2011..To characterize basal differentiation tendencies of a human embryonic stem (hES) cell line, KCL-002...