Fulvio D'Acquisto

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. doi request reprint Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation
    Anthony Huggins
    William Harvey Research Institute, Barts and the London School of Medicine, London, UK
    FASEB J 23:985-96. 2009
  2. doi request reprint Pro-inflammatory and pathogenic properties of Annexin-A1: the whole is greater than the sum of its parts
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Biochem Pharmacol 85:1213-8. 2013
  3. ncbi request reprint From willow bark to peptides: the ever widening spectrum of NF-kappaB inhibitors
    Fulvio D'Acquisto
    William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Curr Opin Pharmacol 6:387-92. 2006
  4. pmc Annexin-1 modulates T-cell activation and differentiation
    Fulvio D'Acquisto
    William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, UK
    Blood 109:1095-102. 2007
  5. doi request reprint Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells
    F D'Acquisto
    The William Harvey Research Institute, Centre for Biochemical Pharmacology, Barts and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Rheumatology (Oxford) 47:636-9. 2008
  6. doi request reprint On the adaptive nature of annexin-A1
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Curr Opin Pharmacol 9:521-8. 2009
  7. ncbi request reprint Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and The London, London, UK
    Eur J Immunol 37:3131-42. 2007
  8. doi request reprint From IL-15 to IL-33: the never-ending list of new players in inflammation. Is it time to forget the humble aspirin and move ahead?
    Fulvio D'Acquisto
    The William Harvey Research Institute, Queen Mary University of London, Barts and the London Medical School, Charterhouse Square, London EC1 M 6BQ, UK
    Biochem Pharmacol 79:525-34. 2010
  9. doi request reprint CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response?
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
    Biochem Pharmacol 82:333-40. 2011
  10. doi request reprint Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
    Mauro Perretti
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Nat Rev Immunol 9:62-70. 2009

Collaborators

Detail Information

Publications49

  1. doi request reprint Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation
    Anthony Huggins
    William Harvey Research Institute, Barts and the London School of Medicine, London, UK
    FASEB J 23:985-96. 2009
    ..Together, these findings suggest that inhibition of Anx-A1 expression or function in dendritic cells might represent a useful way to modulate the adaptive immune response and pathogen-induced T-cell-driven immune diseases...
  2. doi request reprint Pro-inflammatory and pathogenic properties of Annexin-A1: the whole is greater than the sum of its parts
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Biochem Pharmacol 85:1213-8. 2013
    ..Most importantly, we hope that this commentary will provide scientific support to "controversial" findings one might encounter while studying this fascinating protein...
  3. ncbi request reprint From willow bark to peptides: the ever widening spectrum of NF-kappaB inhibitors
    Fulvio D'Acquisto
    William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Curr Opin Pharmacol 6:387-92. 2006
    ..Therefore, it is possible to hypothesize that these molecules might represent the future class of drugs for the treatment of inflammatory diseases...
  4. pmc Annexin-1 modulates T-cell activation and differentiation
    Fulvio D'Acquisto
    William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, UK
    Blood 109:1095-102. 2007
    ....
  5. doi request reprint Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells
    F D'Acquisto
    The William Harvey Research Institute, Centre for Biochemical Pharmacology, Barts and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Rheumatology (Oxford) 47:636-9. 2008
    ..Here, we investigated the effects of glucocorticoids (GCs) on Anx-A1 expression in T cells in vitro and in vivo...
  6. doi request reprint On the adaptive nature of annexin-A1
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Curr Opin Pharmacol 9:521-8. 2009
    ..This review will be focusing on these recent findings providing further evidences for the promising therapeutic potential of drugs targeting Annexin-1...
  7. ncbi request reprint Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and The London, London, UK
    Eur J Immunol 37:3131-42. 2007
    ..These results demonstrate a novel modulatory role of endogenous Annexin-1 in TCR signaling and T cell differentiation and suggest this protein might play a dual and complementary role in the innate and adaptive immune response...
  8. doi request reprint From IL-15 to IL-33: the never-ending list of new players in inflammation. Is it time to forget the humble aspirin and move ahead?
    Fulvio D'Acquisto
    The William Harvey Research Institute, Queen Mary University of London, Barts and the London Medical School, Charterhouse Square, London EC1 M 6BQ, UK
    Biochem Pharmacol 79:525-34. 2010
    ....
  9. doi request reprint CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response?
    Fulvio D'Acquisto
    William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
    Biochem Pharmacol 82:333-40. 2011
    ....
  10. doi request reprint Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
    Mauro Perretti
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Nat Rev Immunol 9:62-70. 2009
    ..In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation...
  11. ncbi request reprint Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection
    Nikolaos Paschalidis
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Cell Cycle 9:784-93. 2010
    ..These results suggest that targeting AnxA1 expression or function in T cells could represent a useful approach for the development of novel therapies for the treatment of autoimmune diseases...
  12. pmc The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis
    Hetal B Patel
    William Harvey Research Institute, Barts and the London School of Medicine, London UK
    Ann Rheum Dis 71:1872-80. 2012
    ..To establish the role and effect of glucocorticoids and the endogenous annexin A1 (AnxA1) pathway in inflammatory arthritis...
  13. pmc Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1
    Nikolaos Paschalidis
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M6BQ, UK
    J Neuroinflammation 6:33. 2009
    ..In this study, we investigated the potential modulatory role of Annexin A1 in the development of experimental autoimmune encephalomyelitis, a model of multiple sclerosis...
  14. doi request reprint Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation
    Neil Dufton
    The William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London
    J Immunol 184:2611-9. 2010
    ..We conclude that Fpr2 is an anti-inflammatory receptor that serves varied regulatory functions during the host defense response. These data support the development of Fpr2 agonists as novel anti-inflammatory therapeutics...
  15. doi request reprint Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature
    Magali Pederzoli-Ribeil
    William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Blood 116:4288-96. 2010
    ....
  16. doi request reprint Interleukin 17 sustains rather than induces inflammation
    Francesco Maione
    William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M6BQ, UK
    Biochem Pharmacol 77:878-87. 2009
    ....
  17. doi request reprint Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells
    Tanya Leger
    Wolfson Centre for Age Related Disease, Kings College London, London, UK
    J Neuroimmunol 234:19-26. 2011
    ..These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention...
  18. pmc Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression
    Andre L F Sampaio
    The William Harvey Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Mediators Inflamm 2013:741804. 2013
    ..However, there has been no in vivo investigation of the (in vitro) •NO scavenger, cobalamin's (Cbl) endogenous effects on NOS/•NO/inflammatory mediators during the immune response to sepsis...
  19. doi request reprint Distinct localization of T cell Agrin during antigen presentation--evidence for the expression of Agrin receptor(s) in antigen-presenting cells
    Panagiotis S Kabouridis
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    FEBS J 279:2368-80. 2012
    ..Collectively, these results confirm the location of Agrin at the immunological synapse between T cells and antigen-presenting cells and justify further characterization of its receptors in the immune system...
  20. doi request reprint Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
    Hetal B Patel
    William Harvey Research Institute, Barts and London School of Medicine, Queen Mary University of London, London, UK
    FASEB J 24:4835-43. 2010
    ..Overall, these findings identify MC(3)-mediated signaling as a beneficial pathway in experimental arthritis; hence this receptor is a novel target for the development of therapeutics for arthritis...
  21. pmc Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3
    Linda Vong
    William Harvey Research Institute, Barts and The London, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 282:29998-30004. 2007
    ....
  22. doi request reprint Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets
    Lydia Spurr
    William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Int Immunopharmacol 11:55-66. 2011
    ....
  23. pmc Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation
    Amilcar S Damazo
    The William Harvey Research Institute, Centre of Biochemical Pharmacology, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Am J Pathol 166:1607-17. 2005
    ....
  24. ncbi request reprint Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor
    Mauro Perretti
    The William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Inflamm Allergy Drug Targets 5:107-14. 2006
    ..The two mediators/targets here illustrated are to be taken as examples of the clues that the study of anti-inflammation might give to the pharmaceutical industry for innovative drug discovery...
  25. doi request reprint Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells
    Francesco Maione
    William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London, EC1M 6BQ, UK
    Autoimmunity 43:672-81. 2010
    ....
  26. pmc Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo
    Doris Proebstl
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    J Exp Med 209:1219-34. 2012
    ..The findings identify previously unknown roles for pericytes in neutrophil transmigration in vivo and add additional steps to the leukocyte adhesion cascade that supports leukocyte trafficking into sites of inflammation...
  27. doi request reprint Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice
    Amelia A Staniland
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 114:1143-57. 2010
    ..Loss of FKN/CX3CR1 neuroimmune communication attenuates hyperalgesia and allodynia in a modality-dependent fashion highlighting the complex nature of microglial response in pathological pain models...
  28. pmc IL-17A increases ADP-induced platelet aggregation
    Francesco Maione
    William Harvey Research Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
    Biochem Biophys Res Commun 408:658-62. 2011
    ....
  29. pmc TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons
    Yasunori Shintani
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 110:5109-14. 2013
    ..These data propose an intriguing model that the same ligand-receptor can concomitantly increase the stress tolerance in cardiomyocytes and neurons, whereas immune cells induce inflammation upon tissue injury...
  30. pmc Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB
    Veronika Souslova
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 5:e9902. 2010
    ..In the present study, we sought to investigate whether MMP3 and NFkappaB were co-localized in atherosclerotic lesions and whether NFkappaB had differential effects on the two alleles of the MMP3 5A/6A polymorphism...
  31. ncbi request reprint Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation
    Paola Di Meglio
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Arthritis Rheum 52:951-8. 2005
    ..We used an experimental model of inflammation in mice, carrageenan-induced paw edema, to study the antiinflammatory effects of the NEMO-binding domain (NBD) peptide, which blocks activation of the inducible transcription factor NF-kappaB...
  32. pmc Beneficial effects of caffeic acid phenethyl ester in a rat model of vascular injury
    Pasquale Maffia
    Department of Pharmaceutical Science, University of Salerno, via Ponte Don Melillo Fisciano, Salerno, Italy
    Br J Pharmacol 136:353-60. 2002
    ..4. These results indicate that treatment with CAPE may lead to a reduction of neointima formation by inhibiting NF-kappaB activation and suggest that this agent may have therapeutic relevance for the prevention of human restenosis...
  33. ncbi request reprint Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    Eur J Pharmacol 509:89-96. 2005
    ..e. by preventing the activation of nuclear factor-kappaB, and provide additional information about mechanism(s) underlying the anti-inflammatory effect of the heat shock proteins...
  34. ncbi request reprint Inhibition of activated murine T-lymphocytes by synthetic glycoglycerolipid analogues
    Diego Colombo
    Dipartimento di Chimica e Biochimica Medica, Universita di Milano, Milan, Italy
    Farmaco 57:337-9. 2002
    ..Vice versa, when the acyl chain is located on the sugar unit, no immunomodulating activity is observed, suggesting a strict relationship between the activity and the location of the acyl chain...
  35. ncbi request reprint Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response
    Angela Ianaro
    Department of Experimental Pharmacology, University of Naples Federico II, Via D Montesano 4, 80131, Naples, Italy
    Mol Pharmacol 64:85-93. 2003
    ....
  36. ncbi request reprint Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
    Eur J Pharmacol 483:79-93. 2004
    ..We propose that rosiglitazone and other potent PPAR-gamma agonists may be useful in the therapy of inflammation...
  37. ncbi request reprint Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, Torre Biologicala, Policlinico Universitario, University of Messina, Via C Valeria Gazzi, 98100, Messina, Italy
    Intensive Care Med 29:2016-25. 2003
    ..Dithiocarbamates are anti-oxidants which are potent inhibitors of NF-kappaB. We postulated that pyrrolidine dithiocarbamate (PDTC) would attenuate multiple-organ failure (MOF)...
  38. ncbi request reprint 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB
    Angela Ianaro
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    FEBS Lett 553:21-7. 2003
    ..Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis...
  39. ncbi request reprint New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production
    Simona De Marino
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, Napoli, Italy
    Planta Med 71:706-10. 2005
    ..The most active compound 2 potently inhibited NO (2)(-) release with an IC (50) value of 0.8 microM...
  40. ncbi request reprint Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury
    Pasquale Maffia
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Circulation 114:430-7. 2006
    ..We investigated the effective role of IL-18 in neointimal formation in a balloon-induced rat model of vascular injury...
  41. ncbi request reprint Paraliane and pepluane diterpenes as anti-inflammatory agents: first insights in structure-activity relationships
    Elisa Barile
    DISTAAM, Università degli Studi del Molise, Via F De Sanctis, I 86100 Campobasso, Italy
    Bioorg Med Chem Lett 17:4196-200. 2007
    ..The data obtained provided first insights towards the structure-activity relationship of this class of compounds highlighting the key role of D-ring structure...
  42. ncbi request reprint The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells
    Daniela Bernasconi
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy
    J Biol Chem 280:24127-34. 2005
    ..The results identify IKK as an important factor in triggering influenza virus-induced inflammatory reactions in pulmonary epithelium, suggesting novel therapeutic approaches in the treatment of influenza...
  43. ncbi request reprint Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis
    Pasquale Maffia
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Arterioscler Thromb Vasc Biol 22:263-7. 2002
    ..In conclusion, HCT-1026 caused a significant reduction in restenosis that appears to be directly related to NO release. HCT-1026 may prove to be beneficial in preventing or delaying restenosis in humans...
  44. ncbi request reprint Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Mol Pharmacol 67:1620-8. 2005
    ....
  45. ncbi request reprint Megastigmane and phenolic components from Laurus nobilis L. leaves and their inhibitory effects on nitric oxide production
    Simona De Marino
    Dipartimento di Chimica delle Sostanze Naturali and Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, I 80131 Naples, Italy
    J Agric Food Chem 52:7525-31. 2004
    ..The effect of isolated compounds on nitric oxide production in lipopolysaccharide-activated murine macrophages were examined...
  46. ncbi request reprint Tempol reduces the activation of nuclear factor-kappaB in acute inflammation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Free Radic Res 38:813-9. 2004
    ..These data confirm that Tempol exerts potent anti-inflammatory properties and clearly demonstrates for the first time that Tempol reduces the activation of NF-kappaB in vivo...
  47. ncbi request reprint Superoxide-related signaling cascade mediates nuclear factor-kappaB activation in acute inflammation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Antioxid Redox Signal 6:699-704. 2004
    ..These data confirm that M40403 exerts a potent antiinflammatory activity and clearly demonstrate that the reduction of the inflammatory process is associated with modification of the activation of signal transduction pathways...
  48. ncbi request reprint Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells
    Pasquale Maffia
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow, Scotland G11 6NT, UK
    J Immunol 173:151-6. 2004
    ..Furthermore, the ability to track these cells in vivo will make feasible studies revealing the dynamic role of T cells in arthritis...
  49. ncbi request reprint Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent
    Gabriella Corea
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    J Med Chem 48:7055-62. 2005
    ....