Research Topics
Genomes and Genes | Fulvio D'AcquistoSummaryAffiliation: Queen Mary Country: UK Publications
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Publications
Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiationAnthony Huggins
William Harvey Research Institute, Barts and the London School of Medicine, London, UK
FASEB J 23:985-96. 2009..Together, these findings suggest that inhibition of Anx-A1 expression or function in dendritic cells might represent a useful way to modulate the adaptive immune response and pathogen-induced T-cell-driven immune diseases...- Pro-inflammatory and pathogenic properties of Annexin-A1: the whole is greater than the sum of its partsFulvio D'Acquisto
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Biochem Pharmacol 85:1213-8. 2013..Most importantly, we hope that this commentary will provide scientific support to "controversial" findings one might encounter while studying this fascinating protein... 
Annexin-1 modulates T-cell activation and differentiationFulvio D'Acquisto
William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, UK
Blood 109:1095-102. 2007....
From willow bark to peptides: the ever widening spectrum of NF-kappaB inhibitorsFulvio D'Acquisto
William Harvey Research Institute, Bart s and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
Curr Opin Pharmacol 6:387-92. 2006..Therefore, it is possible to hypothesize that these molecules might represent the future class of drugs for the treatment of inflammatory diseases...- From IL-15 to IL-33: the never-ending list of new players in inflammation. Is it time to forget the humble aspirin and move ahead?Fulvio D'Acquisto
The William Harvey Research Institute, Queen Mary University of London, Barts and the London Medical School, Charterhouse Square, London EC1 M 6BQ, UK
Biochem Pharmacol 79:525-34. 2010.... - On the adaptive nature of annexin-A1Fulvio D'Acquisto
William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
Curr Opin Pharmacol 9:521-8. 2009..This review will be focusing on these recent findings providing further evidences for the promising therapeutic potential of drugs targeting Annexin-1... - Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cellsF D'Acquisto
The William Harvey Research Institute, Centre for Biochemical Pharmacology, Barts and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
Rheumatology (Oxford) 47:636-9. 2008..Here, we investigated the effects of glucocorticoids (GCs) on Anx-A1 expression in T cells in vitro and in vivo... - Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cellsFulvio D'Acquisto
William Harvey Research Institute, Barts and The London, London, UK
Eur J Immunol 37:3131-42. 2007..These results demonstrate a novel modulatory role of endogenous Annexin-1 in TCR signaling and T cell differentiation and suggest this protein might play a dual and complementary role in the innate and adaptive immune response... - CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response?Fulvio D'Acquisto
William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
Biochem Pharmacol 82:333-40. 2011.... - Annexin A1 and glucocorticoids as effectors of the resolution of inflammationMauro Perretti
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
Nat Rev Immunol 9:62-70. 2009..In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation... - Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selectionNikolaos Paschalidis
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Cell Cycle 9:784-93. 2010..These results suggest that targeting AnxA1 expression or function in T cells could represent a useful approach for the development of novel therapies for the treatment of autoimmune diseases... - The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritisHetal B Patel
William Harvey Research Institute, Barts and the London School of Medicine, London UK
Ann Rheum Dis 71:1872-80. 2012..To establish the role and effect of glucocorticoids and the endogenous annexin A1 (AnxA1) pathway in inflammatory arthritis... - Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1Nikolaos Paschalidis
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M6BQ, UK
J Neuroinflammation 6:33. 2009..In this study, we investigated the potential modulatory role of Annexin A1 in the development of experimental autoimmune encephalomyelitis, a model of multiple sclerosis... - Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammationNeil Dufton
The William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London
J Immunol 184:2611-9. 2010..We conclude that Fpr2 is an anti-inflammatory receptor that serves varied regulatory functions during the host defense response. These data support the development of Fpr2 agonists as novel anti-inflammatory therapeutics... - Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculatureMagali Pederzoli-Ribeil
William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Blood 116:4288-96. 2010.... - Interleukin 17 sustains rather than induces inflammationFrancesco Maione
William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M6BQ, UK
Biochem Pharmacol 77:878-87. 2009.... - Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cellsTanya Leger
Wolfson Centre for Age Related Disease, Kings College London, London, UK
J Neuroimmunol 234:19-26. 2011..These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention... - Distinct localization of T cell Agrin during antigen presentation--evidence for the expression of Agrin receptor(s) in antigen-presenting cellsPanagiotis S Kabouridis
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
FEBS J 279:2368-80. 2012..Collectively, these results confirm the location of Agrin at the immunological synapse between T cells and antigen-presenting cells and justify further characterization of its receptors in the immune system... - Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3Linda Vong
William Harvey Research Institute, Barts and The London, Charterhouse Square, London EC1M 6BQ, United Kingdom
J Biol Chem 282:29998-30004. 2007.... - Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritisHetal B Patel
William Harvey Research Institute, Barts and London School of Medicine, Queen Mary University of London, London, UK
FASEB J 24:4835-43. 2010..Overall, these findings identify MC(3)-mediated signaling as a beneficial pathway in experimental arthritis; hence this receptor is a novel target for the development of therapeutics for arthritis... - Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptorMauro Perretti
The William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
Inflamm Allergy Drug Targets 5:107-14. 2006..The two mediators/targets here illustrated are to be taken as examples of the clues that the study of anti-inflammation might give to the pharmaceutical industry for innovative drug discovery... - Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculationAmilcar S Damazo
The William Harvey Research Institute, Centre of Biochemical Pharmacology, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
Am J Pathol 166:1607-17. 2005.... - Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsetsLydia Spurr
William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom
Int Immunopharmacol 11:55-66. 2011.... - Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cellsFrancesco Maione
William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London, EC1M 6BQ, UK
Autoimmunity 43:672-81. 2010.... - Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivoDoris Proebstl
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
J Exp Med 209:1219-34. 2012..The findings identify previously unknown roles for pericytes in neutrophil transmigration in vivo and add additional steps to the leukocyte adhesion cascade that supports leukocyte trafficking into sites of inflammation... - Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout miceAmelia A Staniland
Wolfson Centre for Age Related Diseases, King s College London, London, UK
J Neurochem 114:1143-57. 2010..Loss of FKN/CX3CR1 neuroimmune communication attenuates hyperalgesia and allodynia in a modality-dependent fashion highlighting the complex nature of microglial response in pathological pain models... - IL-17A increases ADP-induced platelet aggregationFrancesco Maione
William Harvey Research Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
Biochem Biophys Res Commun 408:658-62. 2011.... - TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neuronsYasunori Shintani
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom
Proc Natl Acad Sci U S A 110:5109-14. 2013..These data propose an intriguing model that the same ligand-receptor can concomitantly increase the stress tolerance in cardiomyocytes and neurons, whereas immune cells induce inflammation upon tissue injury... - Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaBVeronika Souslova
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
PLoS ONE 5:e9902. 2010..In the present study, we sought to investigate whether MMP3 and NFkappaB were co-localized in atherosclerotic lesions and whether NFkappaB had differential effects on the two alleles of the MMP3 5A/6A polymorphism... - Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophagesArmando Ialenti
Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Eur J Pharmacol 509:89-96. 2005..e. by preventing the activation of nuclear factor-kappaB, and provide additional information about mechanism(s) underlying the anti-inflammatory effect of the heat shock proteins... - Beneficial effects of caffeic acid phenethyl ester in a rat model of vascular injuryPasquale Maffia
Department of Pharmaceutical Science, University of Salerno, via Ponte Don Melillo Fisciano, Salerno, Italy
Br J Pharmacol 136:353-60. 2002..4. These results indicate that treatment with CAPE may lead to a reduction of neointima formation by inhibiting NF-kappaB activation and suggest that this agent may have therapeutic relevance for the prevention of human restenosis... - Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activationPaola Di Meglio
Yale University School of Medicine, New Haven, Connecticut 06520, USA
Arthritis Rheum 52:951-8. 2005..CONCLUSION: These studies further establish NF-kappaB as a target for antiinflammatory therapy and provide support for the use of the NBD peptide as a possible therapeutic agent for inflammatory diseases... - Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injuryPasquale Maffia
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
Circulation 114:430-7. 2006..We investigated the effective role of IL-18 in neointimal formation in a balloon-induced rat model of vascular injury... - 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaBAngela Ianaro
Department of Experimental Pharmacology, University of Naples Federico II, Italy
FEBS Lett 553:21-7. 2003..Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis... - Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammationSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
Eur J Pharmacol 483:79-93. 2004..We propose that rosiglitazone and other potent PPAR-gamma agonists may be useful in the therapy of inflammation... - Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in miceSalvatore Cuzzocrea
Institute of Pharmacology, School of Medicine, Torre Biologicala, Policlinico Universitario, University of Messina, Via C Valeria Gazzi, 98100, Messina, Italy
Intensive Care Med 29:2016-25. 2003..Dithiocarbamates are anti-oxidants which are potent inhibitors of NF-kappaB. We postulated that pyrrolidine dithiocarbamate (PDTC) would attenuate multiple-organ failure (MOF)... - Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock responseAngela Ianaro
Department of Experimental Pharmacology, University of Naples Federico II, Via D Montesano 4, 80131, Naples, Italy
Mol Pharmacol 64:85-93. 2003.... - Inhibition of activated murine T-lymphocytes by synthetic glycoglycerolipid analoguesDiego Colombo
Dipartimento di Chimica e Biochimica Medica, , Milan, Italy
Farmaco 57:337-9. 2002..Vice versa, when the acyl chain is located on the sugar unit, no immunomodulating activity is observed, suggesting a strict relationship between the activity and the location of the acyl chain... - Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cellsPasquale Maffia
Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow, Scotland G11 6NT, UK
J Immunol 173:151-6. 2004..Furthermore, the ability to track these cells in vivo will make feasible studies revealing the dynamic role of T cells in arthritis... - Superoxide-related signaling cascade mediates nuclear factor-kappaB activation in acute inflammationSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
Antioxid Redox Signal 6:699-704. 2004..These data confirm that M40403 exerts a potent antiinflammatory activity and clearly demonstrate that the reduction of the inflammatory process is associated with modification of the activation of signal transduction pathways... - Paraliane and pepluane diterpenes as anti-inflammatory agents: first insights in structure-activity relationshipsElisa Barile
DISTAAM, Università degli Studi del Molise, Via F De Sanctis, I 86100 Campobasso, Italy
Bioorg Med Chem Lett 17:4196-200. 2007..The data obtained provided first insights towards the structure-activity relationship of this class of compounds highlighting the key role of D-ring structure... - Megastigmane and phenolic components from Laurus nobilis L. leaves and their inhibitory effects on nitric oxide productionSimona De Marino
Dipartimento di Chimica delle Sostanze Naturali and Dipartimento di Farmacologia Sperimentale, , Via D. Montesano 49, I-80131 Naples, Italy
J Agric Food Chem 52:7525-31. 2004..The effect of isolated compounds on nitric oxide production in lipopolysaccharide-activated murine macrophages were examined... - Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathwayArmando Ialenti
Department of Experimental Pharmacology, University of Naples Federico II, Italy
Mol Pharmacol 67:1620-8. 2005.... - Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosisPasquale Maffia
Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
Arterioscler Thromb Vasc Biol 22:263-7. 2002..In conclusion, HCT-1026 caused a significant reduction in restenosis that appears to be directly related to NO release. HCT-1026 may prove to be beneficial in preventing or delaying restenosis in humans... - The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cellsDaniela Bernasconi
Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy
J Biol Chem 280:24127-34. 2005..The results identify IKK as an important factor in triggering influenza virus-induced inflammatory reactions in pulmonary epithelium, suggesting novel therapeutic approaches in the treatment of influenza... - New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide productionSimona De Marino
Dipartimento di Chimica delle Sostanze Naturali, , Napoli, Italy
Planta Med 71:706-10. 2005..The most active compound 2 potently inhibited NO (2)(-) release with an IC (50) value of 0.8 microM... - Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agentGabriella Corea
Dipartimento di Chimica delle Sostanze Naturali, , Via D. Montesano 49, 80131 Naples, Italy
J Med Chem 48:7055-62. 2005.... - Tempol reduces the activation of nuclear factor-kappaB in acute inflammationSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
Free Radic Res 38:813-9. 2004..These data confirm that Tempol exerts potent anti-inflammatory properties and clearly demonstrates for the first time that Tempol reduces the activation of NF-kappaB in vivo...