Jack Cuzick

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. doi request reprint Controversies in design and interpretation of adjuvant clinical trials
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, UK
    Cancer Invest 28:28-34. 2010
  2. doi request reprint Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK Electronic address
    Lancet 383:1041-8. 2014
  3. doi request reprint Prognostic value of a cell cycle progression score for men with prostate cancer
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, EC1M 6BQ, UK
    Recent Results Cancer Res 202:133-40. 2014
  4. pmc Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study
    Katja Lundgren
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Breast Cancer Res 14:R57. 2012
  5. pmc Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, EC1M 6BQ, UK
    Br J Cancer 108:2582-9. 2013
  6. pmc Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet 381:1827-34. 2013
  7. doi request reprint Human papillomavirus testing for triage of women with low-grade squamous intraepithelial lesions
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    Int J Cancer 132:959-66. 2013
  8. doi request reprint New technologies and procedures for cervical cancer screening
    Jack Cuzick
    Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom
    Vaccine 30:F107-16. 2012
  9. pmc Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London EC1 M 6BQ, UK
    Br J Cancer 106:1095-9. 2012
  10. doi request reprint Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics, and Statistics, Queen Mary University of London, London UK
    Lancet Oncol 10:501-7. 2009

Detail Information

Publications84

  1. doi request reprint Controversies in design and interpretation of adjuvant clinical trials
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, UK
    Cancer Invest 28:28-34. 2010
    ..Distant metastasis is an excellent surrogate for breast cancer death and is available a few years earlier. These changes should lead to more rapid and reliable introduction of improved therapeutic strategies...
  2. doi request reprint Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK Electronic address
    Lancet 383:1041-8. 2014
    ..We assessed the efficacy and safety of the aromatase inhibitor anastrozole for prevention of breast cancer in postmenopausal women who are at high risk of the disease...
  3. doi request reprint Prognostic value of a cell cycle progression score for men with prostate cancer
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, EC1M 6BQ, UK
    Recent Results Cancer Res 202:133-40. 2014
    ..In all cases a unit change in CCP score was associated with an approximate doubling of risk of an event. These data provide strong event to support use of the CCP score to help guide clinical management. ..
  4. pmc Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study
    Katja Lundgren
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Breast Cancer Res 14:R57. 2012
    ..CCND1 amplification and protein overexpression have also been associated with resistance to treatment with tamoxifen or even to a potentially detrimental effect of tamoxifen...
  5. pmc Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, EC1M 6BQ, UK
    Br J Cancer 108:2582-9. 2013
    ..We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate...
  6. pmc Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet 381:1827-34. 2013
    ..We assessed the effectiveness of selective oestrogen receptor modulators (SERMs) on breast cancer incidence...
  7. doi request reprint Human papillomavirus testing for triage of women with low-grade squamous intraepithelial lesions
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    Int J Cancer 132:959-66. 2013
    ....
  8. doi request reprint New technologies and procedures for cervical cancer screening
    Jack Cuzick
    Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom
    Vaccine 30:F107-16. 2012
    ..This article forms part of a special supplement entitled "Comprehensive Control of HPV Infections and Related Diseases" Vaccine Volume 30, Supplement 5, 2012...
  9. pmc Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London EC1 M 6BQ, UK
    Br J Cancer 106:1095-9. 2012
    ..A greater need is to predict outcome in patients diagnosed by needle biopsy...
  10. doi request reprint Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics, and Statistics, Queen Mary University of London, London UK
    Lancet Oncol 10:501-7. 2009
    ..The main side-effect of aspirin is peptic ulcers; therefore coadministration of aspirin with a proton-pump inhibitor is an attractive option and is under investigation in the AspECT trial...
  11. doi request reprint Long-term cervical cancer prevention strategies across the globe
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary University of London, Wolfson Institute of Preventive Medicine, UK
    Gynecol Oncol 117:S11-4. 2010
    ..However, a significant HPV vaccination-induced reduction in cervical cancer burden is not likely to be realized for at least 10 to 15 years...
  12. doi request reprint Performance of the Abbott RealTime high-risk HPV test in women with abnormal cervical cytology smears
    Jack Cuzick
    Wolfson Institute of Preventive Medicine, Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary University of London, London, United Kingdom
    J Med Virol 82:1186-91. 2010
    ..Differences between these tests appeared to be related mostly to the choice of cutoff level. An added feature of the Abbott test was the provision of type specific results for HPV 16 and 18...
  13. pmc Long-term follow-up in cancer prevention trials (It ain't over 'til it's over)
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, United Kingdom
    Cancer Prev Res (Phila) 3:689-91. 2010
    ....
  14. doi request reprint Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Lancet Oncol 11:1135-41. 2010
    ..In this analysis, we assess the long-term outcomes after a median follow-up of 120 months...
  15. pmc Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study
    Jack Cuzick
    Cancer Research UK Centre of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, St Bartholomew s Medical School, Queen Mary University of London, London, UK
    Lancet Oncol 12:245-55. 2011
    ..We assessed the prognostic value of a predefined cell cycle progression (CCP) score in two cohorts of patients with prostate cancer...
  16. doi request reprint Preventive therapy for breast cancer: a consensus statement
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet Oncol 12:496-503. 2011
    ..If valid such a model would facilitate the design of simpler, cheaper, and better-focused trials for assessing new agents...
  17. doi request reprint Tamoxifen-induced reduction in mammographic density and breast cancer risk reduction: a nested case-control study
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Natl Cancer Inst 103:744-52. 2011
    ..However, it is not known if tamoxifen-induced reductions in breast density can be used to identify women who will benefit the most from prophylactic treatment with this drug...
  18. pmc Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Lancet Oncol 12:21-9. 2011
    ..Here, we report long-term results of this trial...
  19. doi request reprint Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer
    Jack Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 29:4273-8. 2011
    ..The aim of this article is to determine how much of this information is contained in standard immunohistochemical (IHC) markers...
  20. doi request reprint Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-Results from the Hammersmith study
    Jack Cuzick
    Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Int J Cancer 122:2294-300. 2008
    ..52, p = 0.001), whereas there was little difference according to initial cytology (HR = 1.64, p = 0.51)...
  21. doi request reprint Treatment-emergent endocrine symptoms and the risk of breast cancer recurrence: a retrospective analysis of the ATAC trial
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Lancet Oncol 9:1143-8. 2008
    ..In this retrospective analysis, the relation between the reported incidence of vasomotor or joint symptoms and breast cancer recurrence in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial is assessed...
  22. doi request reprint Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008
    ..This study compared the sensitivity and specificity of several adjunctive tests for the detection of high-grade CIN in a population referred to colposcopy because of abnormal cytology...
  23. ncbi request reprint Long-term results of tamoxifen prophylaxis for breast cancer--96-month follow-up of the randomized IBIS-I trial
    Jack Cuzick
    Centre for Epidemiology, Mathematics, and Statistics, Cancer Research UK, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Natl Cancer Inst 99:272-82. 2007
    ..We report an updated analysis of IBIS-I that focuses on the period after active treatment was completed, a time for which little evidence from other trials is available...
  24. pmc An improved prognostic model for stage T1a and T1b prostate cancer by assessments of cancer extent
    Ramzi Rajab
    Centre for Molecular Oncology and Imaging, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Mod Pathol 24:58-63. 2011
    ..Staging by a four-group subdivision would substantially improve prognostication in patients with early stage disease and also may help to refine management decisions in patients who would do well with conservative treatments...
  25. ncbi request reprint Tamoxifen and breast density in women at increased risk of breast cancer
    Jack Cuzick
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary College, University of London, London, UK
    J Natl Cancer Inst 96:621-8. 2004
    ..We investigated mammographic breast density in healthy women with an increased risk of breast cancer at baseline and during 54 months of tamoxifen treatment...
  26. pmc Factors predicting late recurrence for estrogen receptor-positive breast cancer
    Ivana Sestak
    Affiliations of authors Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University, London, UK IS, JC Academic Department of Biochemistry, Royal Marsden Hospital, London, UK MD, LZ, EL K NanoString Technologies, Seattle, WA SF, JWC
    J Natl Cancer Inst 105:1504-11. 2013
    ....
  27. doi request reprint Effect of baseline serum vitamin D levels on aromatase inhibitors induced musculoskeletal symptoms: results from the IBIS-II, chemoprevention study using anastrozole
    Shalini Singh
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Breast Cancer Res Treat 132:625-9. 2012
    ..75 ng/ml [-0.35, 1.85; P = 0.18]). Only a small and a nonsignificant effect of baseline vitamin D levels were seen on the risk of musculoskeletal symptoms. This does not appear to be a major determinant of risk for these symptoms...
  28. doi request reprint Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial
    Ivana Sestak
    Cancer Research UK UK, Queen Mary University of London, London, United Kingdom
    J Clin Oncol 28:3411-5. 2010
    ..As aromatase inhibitors work by inhibiting the conversion of androgens to estrogens in adipose tissue, we hypothesized that anastrozole may be more effective in women with a high body mass index (BMI)...
  29. doi request reprint The retinoblastoma protein/p16 INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma
    Elzbieta Stankiewicz
    Queen Mary University of London, Centre for Molecular Oncology and Imaging, Barts and the London School of Medicine and Dentistry, London, UK
    Histopathology 58:433-9. 2011
    ..The aim was to determine the extent of HPV infection in different histological subtypes of PSCC and its impact on the expression of key cell-cycle proteins: p53, p21, p16(INK4A) and retinoblastoma (RB) protein...
  30. doi request reprint Comparison of human papillomavirus testing strategies for triage of women referred with low-grade cytological abnormalities
    David Mesher
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Eur J Cancer 49:2179-86. 2013
    ..To compare triage strategies using different human papillomavirus (HPV) consensus and genotyping tests and a p16(INK4a) test...
  31. doi request reprint Risk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysis
    Ivana Sestak
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, London, UK
    Lancet Oncol 9:866-72. 2008
    ..The aim of this study was to assess the relative importance of different risk factors for treatment-emergent joint symptoms in patients assigned to anastrozole or tamoxifen as adjuvant treatment for postmenopausal breast cancer...
  32. doi request reprint Aromatase inhibitor-induced carpal tunnel syndrome: results from the ATAC trial
    Ivana Sestak
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, UK
    J Clin Oncol 27:4961-5. 2009
    ..Aromatase inhibitors lead to profound estrogen suppression and may be expected to increase the risk of CTS in postmenopausal women receiving adjuvant therapy for early breast cancer...
  33. pmc Measurements of cancer extent in a conservatively treated prostate cancer biopsy cohort
    Ramzi Rajab
    Centre for Molecular Oncology and Imaging, Queen Mary University of London, UK
    Virchows Arch 457:547-53. 2010
    ..The percentage of positive cores appeared the strongest predictor and was stronger than percentage length of cancer in the cores...
  34. pmc HPV16 L1 and L2 DNA methylation predicts high-grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology
    Attila T Lorincz
    Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, London, EC1M 6BQ, United Kingdom
    Int J Cancer 133:637-44. 2013
    ..We conclude that quantitative DNA methylation assays could help to improve triage among HPV16 positive women...
  35. doi request reprint Preventive therapy for breast cancer
    Ivana Sestak
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Curr Oncol Rep 14:568-73. 2012
    ..The IBIS-II trial is currently investigating anastrozole in healthy postmenopausal women. New agents are needed for receptor negative breast cancer and premenopausal women, and several possibilities are currently under investigation...
  36. doi request reprint Immunohistochemical BAG1 expression improves the estimation of residual risk by IHC4 in postmenopausal patients treated with anastrazole or tamoxifen: a TransATAC study
    Maria Afentakis
    Department of Academic Biochemistry, The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK
    Breast Cancer Res Treat 140:253-62. 2013
    ..Similar results were seen if all recurrences were the endpoints. BAG1 expression provides significant prognostic information when added to the classical clinicopathological parameters and IHC4, particularly in node-positive patients. ..
  37. pmc Comparison of seven tests for high-grade cervical intraepithelial neoplasia in women with abnormal smears: the Predictors 2 study
    Anne Szarewski
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, United Kingdom
    J Clin Microbiol 50:1867-73. 2012
    ..7% PPV. Our study confirms that, in a referral setting, HPV testing by a number of different tests provides high sensitivity for high-grade disease. Further work is needed to confirm these findings in a routine screening setting...
  38. ncbi request reprint The ATAC trial: the vanguard trial for use of aromatase inhibitors in early breast cancer
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, EC1M 6BQ, UK
    Expert Rev Anticancer Ther 7:1089-94. 2007
    ....
  39. ncbi request reprint Anastrozole
    Jack Cuzick
    Wolfson Institute of Preventive Medicine, St Bartholomew s Medical School, London, UK
    Drugs Today (Barc) 41:227-39. 2005
    ..Similarly, the use of anastrozole in the adjuvant setting has shown a significantly prolonged disease-free survival time and improved tolerability compared to tamoxifen in postmenopausal breast cancer survivors...
  40. ncbi request reprint Human papillomavirus DNA detection in the management of women with twice mildly abnormal cytological smears
    Linda Ho
    Department of Molecular Pathology, University College London, London, United Kingdom
    J Med Virol 69:118-21. 2003
    ..The utility of high-risk HPV detection in the management of women presenting with mild cytological abnormalities is discussed...
  41. ncbi request reprint Surrogate endpoints for cancer screening trials: general principles and an illustration using the UK Flexible Sigmoidoscopy Screening Trial
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Med Screen 14:178-85. 2007
    ..Surrogate endpoints should not replace a long-term analysis based directly on mortality, but can provide reliable early indicators which can be useful both for monitoring ongoing screening programmes and for making policy decisions...
  42. doi request reprint Weight change associated with anastrozole and tamoxifen treatment in postmenopausal women with or at high risk of developing breast cancer
    Ivana Sestak
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University, Charterhouse Square, London, EC1M 6BQ, UK
    Breast Cancer Res Treat 134:727-34. 2012
    ..In the prevention trials, weight gain does not differ between anastrozole, tamoxifen and placebo and also did not differ between anastrozole and tamoxifen in the treatment trial...
  43. doi request reprint Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
    ..These psychosocial aspects and the need for more information and educational programmes about HPV are also discussed in this article...
  44. doi request reprint The prognostic value of Ki-67 expression in penile squamous cell carcinoma
    Elzbieta Stankiewicz
    Department of Molecular Oncology, Barts Cancer Institute, London, UK
    J Clin Pathol 65:534-7. 2012
    ..To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival...
  45. doi request reprint Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer
    Sakunthala C Kudahetti
    Centre for Molecular Oncology and Imaging, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Pathology 42:519-23. 2010
    ....
  46. doi request reprint Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen
    Mitch Dowsett
    Academic Department of Biochemistry, Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 28:509-18. 2010
    ..To conduct meta-analyses of randomized trials of aromatase inhibitors (AIs) compared with tamoxifen either as initial monotherapy (cohort 1) or after 2 to 3 years of tamoxifen (cohort 2)...
  47. doi request reprint Screening and adenocarcinoma of the cervix
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    Int J Cancer 125:525-9. 2009
    ..The impact of screening on adenosquamous carcinoma is similar to its impact on squamous carcinoma...
  48. pmc Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas
    Elzbieta Stankiewicz
    Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 6:e17517. 2011
    ..We investigated HER family receptors and phosphatase and tension homolog (PTEN) in HPV-positive and negative PSCC and its impact on Akt activation using immunohistochemistry and fluorescent in situ hybridisation (FISH)...
  49. doi request reprint Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy
    Mitch Dowsett
    Academic Department of Biochemistry, Royal Marsden Hospital, and Breakthrough Breast Cancer Centre, Institute of Cancer Research, London, SW3 6JJ, United Kingdom
    J Clin Oncol 31:2783-90. 2013
    ..It is frequently estimated using the Oncotype DX recurrence score (RS). The PAM50 risk of recurrence (ROR) score provides an alternative approach, which also identifies intrinsic subtypes...
  50. doi request reprint IBIS II: a breast cancer prevention trial in postmenopausal women using the aromatase inhibitor anastrozole
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, UK
    Expert Rev Anticancer Ther 8:1377-85. 2008
    ..The primary end point is breast cancer incidence, but major efforts are also being directed at minimizing any fracture risk...
  51. pmc Effectiveness of cervical screening with age: population based case-control study of prospectively recorded data
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 339:b2968. 2009
    ..To study the effect of cervical screening on incidence of cervical cancer as a function of age with particular focus on women screened under the age of 25...
  52. ncbi request reprint Influence of hormone replacement therapy on tamoxifen-induced vasomotor symptoms
    Ivana Sestak
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    J Clin Oncol 24:3991-6. 2006
    ..Vasomotor symptoms were evaluated according to follow-up time, severity, and use of hormone replacement therapy (HRT) in a retrospective analysis...
  53. ncbi request reprint Major shifts in the treatment and prognosis of prostate cancer due to changes in pathological diagnosis and grading
    Daniel M Berney
    Department of Histopathology, St Bartholomew s Hospital, Queen Mary University of London, London, UK
    BJU Int 100:1240-4. 2007
    ..To examine data on the changes in the accuracy of the diagnosis of prostate cancer and of Gleason grading in the modern era...
  54. doi request reprint Clinical and epidemiological issues in mammographic density
    Valentina Assi
    Center for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Clin Oncol 9:33-40. 2012
    ....
  55. doi request reprint Incorporating human papillomavirus testing into cytological screening in the era of prophylactic vaccines
    Maribel Almonte
    Centre for Cancer Prevention, Queen Mary University of London, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, UK
    Best Pract Res Clin Obstet Gynaecol 25:617-29. 2011
    ..The screening characteristics of HPV testing make it the preferred choice for primary screening. However, questions regarding how to use HPV testing to screen vaccinated and unvaccinated women in the future remain unanswered...
  56. ncbi request reprint Aromatase inhibitors in prevention--data from the ATAC (arimidex, tamoxifen alone or in combination) trial and the design of IBIS-II (the second International Breast Cancer Intervention Study)
    Jack Cuzick
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London ECIM 6BQ
    Recent Results Cancer Res 163:96-103; discussion 264-6. 2003
    ..A parallel trial will compare anastrozole against tamoxifen in 4,000 women with locally excised DCIS...
  57. ncbi request reprint Human papillomavirus testing by self-sampling: assessment of accuracy in an unsupervised clinical setting
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    J Med Screen 14:34-42. 2007
    ..To compare the performance and acceptability of unsupervised self-sampling with clinician sampling for high-risk human papillomavirus (HPV) types for the first time in a UK screening setting...
  58. doi request reprint Aromatase inhibitors in early breast-cancer treatment: The story so far
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Breast 17:S2-8. 2008
    ..Further clinical trials are needed to ascertain the optimal length of treatment with an AI...
  59. pmc Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view
    Stephen W Duffy
    Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Breast Cancer Res 10:R64. 2008
    ..A particularly strong association with risk has been observed when density is measured using interactive threshold software. This, however, is a labour-intensive process for large-scale studies...
  60. pmc ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer
    Isabel Pinhel
    Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK
    Breast Cancer Res 14:R46. 2012
    ..However, we investigated the quantitative relation between ER and HER2 expression at both RNA and protein levels in HER2+ve and HER2-ve breast carcinomas...
  61. doi request reprint Risk factors for high-risk human papillomavirus infection and cofactors for high-grade cervical disease in Peru
    Maribel Almonte
    Centre for Cancer Prevention, Queen Mary University of London Wolfson Institute of Preventive Medicine, London, UK
    Int J Gynecol Cancer 21:1654-63. 2011
    ....
  62. doi request reprint Chemoprevention of breast cancer
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Breast Cancer 15:10-6. 2008
    ..3). New agents are needed, for receptor negative breast cancer and several possibilities are currently under investigation...
  63. ncbi request reprint Treatment of DCIS--results from clinical trials
    Jack Cuzick
    Department of Epidemiology, Mathematics and Statistics, Cancer Research UK, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, EC1M 6BQ, UK
    Surg Oncol 12:213-9. 2003
  64. doi request reprint HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis
    Elzbieta Stankiewicz
    Centre for Molecular Oncology and Imaging, Barts and the London School of Medicine and Dentistry, London, UK
    Mod Pathol 22:1160-8. 2009
    ....
  65. ncbi request reprint Aromatase inhibitors for breast cancer prevention
    Jack Cuzick
    Centre of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 23:1636-43. 2005
  66. ncbi request reprint Chapter 10: New dimensions in cervical cancer screening
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, United Kingdom
    Vaccine 24:S3/90-7. 2006
    ..The fact that HPV is a sexually transmitted infection may lead to anxiety and concerns about sexual relationships and these issues are also discussed. Ongoing HPV studies are identified and briefly reviewed...
  67. ncbi request reprint International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate: a meta-analysis of 1446 patients
    Greg L Shaw
    St Bartholemew s Hospital, London, UK, and University of Western Australia, Perth, Australia
    BJU Int 99:1056-65. 2007
    ....
  68. ncbi request reprint Role of HPV testing in clinical practice
    Jack Cuzick
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, 61 Lincoln s Inn Fields, London, UK
    Virus Res 89:263-9. 2002
  69. pmc Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing
    Natasa Vasiljevic
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and the London School of Dentistry and Medicine, Queen Mary University of London, London, UK
    Dis Markers 30:151-61. 2011
    ....
  70. doi request reprint Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial
    Wendy S Atkin
    Department of Surgery and Cancer, Imperial College London, London, UK
    Lancet 375:1624-33. 2010
    ..We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality...
  71. pmc Early stopping of clinical trials
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, UK
    Breast Cancer Res 7:181-3. 2005
    ....
  72. pmc Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group
    Mitch Dowsett
    Department of Biochemistry, Royal Marsden Hospital and Breakthrough Breast Cancer Centre, Fulham Road, London, UK
    J Natl Cancer Inst 103:1656-64. 2011
    ..These recommendations are geared toward achieving a harmonized methodology, create greater between-laboratory and between-study comparability, and allow earlier valid applications of this marker in clinical practice...
  73. ncbi request reprint Overview of the European and North American studies on HPV testing in primary cervical cancer screening
    Jack Cuzick
    Cancer Research UK, Wolfson Institute of Preventive Medicine, London
    Int J Cancer 119:1095-101. 2006
    ..These results support the use of HPV testing as the sole primary screening test, with cytology reserved for women who test HPV positive. Large demonstration projects are needed to fully evaluate this strategy...
  74. doi request reprint Human papillomavirus genotype detection and viral load in paired genital and urine samples from both females and males
    Sara L Bissett
    Virus Reference Department, Centre for Infections, Health Protection Agency, London, United Kingdom
    J Med Virol 83:1744-51. 2011
    ..The utility of urine for type-specific detection in males is less certain...
  75. ncbi request reprint Inherited and acquired risk factors for venous thromboembolic disease among women taking tamoxifen to prevent breast cancer
    Catherine Duggan
    Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 21:3588-93. 2003
    ..We investigate the association between acquired and inherited risk factors for VTE in the International Breast Cancer Intervention Study (IBIS-I) trial of tamoxifen prophylaxis for women at increased risk of breast cancer...
  76. ncbi request reprint Wide variation in adenoma detection rates at screening flexible sigmoidoscopy
    Wendy Atkin
    Colorectal Unit, Cancer Research UK, St Mark s Hospital, Northwick Park, Harrow, Middlesex HA1 3UJ, England, UK
    Gastroenterology 126:1247-56. 2004
    ....
  77. doi request reprint Primary endpoints for randomised trials of cancer therapy
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London EC1M 6BQ, UK
    Lancet 371:2156-8. 2008
  78. pmc Bone versus breast density
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Breast Cancer Res 8:104. 2006
    ..Overall, the relationship is very weak, if it exists at all. Other factors such as weight-bearing exercise, which have opposing impacts on these variables, may have a more dominant effect...
  79. ncbi request reprint Prostate cancer prevention by short-term anti-androgens: the rationale behind design of pilot studies
    Tim Oliver
    Wolfson Institute of Preventive Medicine, Queen Mary University London, UK
    Recent Results Cancer Res 181:195-205. 2009
    ....
  80. ncbi request reprint Epidemiology of breast cancer--selected highlights
    Jack Cuzick
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, UK
    Breast 12:405-11. 2003
    ..A computer programme for combining them to produce individualized risk profiles is described. The ongoing IBIS-II trial of chemoprevention for high risk postmenopausal women is presented as one approach to managing high risk women...
  81. doi request reprint Hormone replacement therapy and the risk of breast cancer
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, Charterhouse Square, London, UK
    Eur J Cancer 44:2344-9. 2008
    ..Recent sharp reductions in HRT use have been correlated with declines in breast cancer incidence in the USA, but not so clearly elsewhere...
  82. ncbi request reprint A breast cancer prediction model incorporating familial and personal risk factors
    Jonathan Tyrer
    Department of Epidemiology, Mathematics and Statistics, Cancer Research UK
    Stat Med 23:1111-30. 2004
    ..This risk was further refined based on the woman's personal history. The model has been incorporated into a computer program that gives a personalised risk estimate...
  83. ncbi request reprint Cervical screening by visual inspection, HPV testing, liquid-based and conventional cytology in Amazonian Peru
    Maribel Almonte
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Int J Cancer 121:796-802. 2007
    ..VIA gives immediate results, but will require investment in regular training and supervision. Further work is needed to determine whether screened-positive women should all be treated or triaged with a more specific test...
  84. ncbi request reprint A multicentre epidemiological study on sunbed use and cutaneous melanoma in Europe
    Veronique Bataille
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, London, UK
    Eur J Cancer 41:2141-9. 2005
    ..Sunbed exposure has become increasingly prevalent over the last 20 years, especially in Northern Europe but the full impact of this exposure on skin cancers may not become apparent for many years...