MICHAEL ANTHONY CURTIS

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. doi request reprint The oral commensal microbiota bites back through Nod1
    Mike Curtis
    Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London E1 2AT, UK
    Cell Host Microbe 13:503-5. 2013
  2. pmc Clustering of Pseudomonas aeruginosa transcriptomes from planktonic cultures, developing and mature biofilms reveals distinct expression profiles
    Richard D Waite
    MRC Molecular Pathogenesis Research Unit, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, UK
    BMC Genomics 7:162. 2006
  3. pmc Temperature-dependent modulation of Porphyromonas gingivalis lipid A structure and interaction with the innate host defenses
    Michael A Curtis
    Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London E1 2AT, United Kingdom
    Infect Immun 79:1187-93. 2011
  4. pmc Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor
    M A Curtis
    MRC Molecular Pathogenesis Group, Medical Microbiology, Bart s and The London, Queen Mary s School of Medicine and Dentistry, United Kingdom
    Infect Immun 70:6968-75. 2002
  5. ncbi request reprint Summary: microbiological perspective
    Michael A Curtis
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 32 Newark St, London E1 2AA, UK
    Mol Immunol 40:477-9. 2003
  6. ncbi request reprint Critical pathways in microbial virulence
    M A Curtis
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, London, UK
    J Clin Periodontol 32:28-38. 2005
  7. ncbi request reprint Recognition of the carbohydrate modifications to the RgpA protease of Porphyromonas gingivalis by periodontal patient serum IgG
    Jennifer M Slaney
    Department of Medical Microbiology, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, UK
    J Periodontal Res 37:215-22. 2002
  8. pmc Expression of Arg-Gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50
    Minnie Rangarajan
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    Infect Immun 73:4864-78. 2005
  9. pmc The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction
    Xiaoju Shi
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    Infect Immun 75:2071-4. 2007
  10. pmc Sequence diversity and antigenic variation at the rag locus of Porphyromonas gingivalis
    Lucinda M C Hall
    Centre for Infectious Disease, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, Turner Street, London E1 2AD, United Kingdom
    Infect Immun 73:4253-62. 2005

Research Grants

Collaborators

Detail Information

Publications27

  1. doi request reprint The oral commensal microbiota bites back through Nod1
    Mike Curtis
    Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London E1 2AT, UK
    Cell Host Microbe 13:503-5. 2013
    ..Jiao et al. (2013) demonstrate that, in the case of inflammatory disease in the mouth, stimulation of the intracellular pattern recognition receptor Nod1 is a critical determinant...
  2. pmc Clustering of Pseudomonas aeruginosa transcriptomes from planktonic cultures, developing and mature biofilms reveals distinct expression profiles
    Richard D Waite
    MRC Molecular Pathogenesis Research Unit, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, UK
    BMC Genomics 7:162. 2006
    ....
  3. pmc Temperature-dependent modulation of Porphyromonas gingivalis lipid A structure and interaction with the innate host defenses
    Michael A Curtis
    Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London E1 2AT, United Kingdom
    Infect Immun 79:1187-93. 2011
    ..gingivalis, which will influence the interaction of this organism with the innate host defense...
  4. pmc Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor
    M A Curtis
    MRC Molecular Pathogenesis Group, Medical Microbiology, Bart s and The London, Queen Mary s School of Medicine and Dentistry, United Kingdom
    Infect Immun 70:6968-75. 2002
    ..gingivalis infections. Protease inhibitors may be a potentially novel class of antimicrobial agents with relevance to the control of other bacterial pathogens...
  5. ncbi request reprint Summary: microbiological perspective
    Michael A Curtis
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 32 Newark St, London E1 2AA, UK
    Mol Immunol 40:477-9. 2003
  6. ncbi request reprint Critical pathways in microbial virulence
    M A Curtis
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, London, UK
    J Clin Periodontol 32:28-38. 2005
    ....
  7. ncbi request reprint Recognition of the carbohydrate modifications to the RgpA protease of Porphyromonas gingivalis by periodontal patient serum IgG
    Jennifer M Slaney
    Department of Medical Microbiology, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, UK
    J Periodontal Res 37:215-22. 2002
    ..Therefore, glycosylation of the RgpAcat protease may play an important role in immune evasion by shielding the primary structure from immune recognition...
  8. pmc Expression of Arg-Gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50
    Minnie Rangarajan
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    Infect Immun 73:4864-78. 2005
    ..These data suggest that RgpB is required for the normal posttranslational glycosylation of Arg-gingipains derived from rgpA and that this process is required for enzyme stabilization...
  9. pmc The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction
    Xiaoju Shi
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    Infect Immun 75:2071-4. 2007
    ..Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection...
  10. pmc Sequence diversity and antigenic variation at the rag locus of Porphyromonas gingivalis
    Lucinda M C Hall
    Centre for Infectious Disease, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, Turner Street, London E1 2AD, United Kingdom
    Infect Immun 73:4253-62. 2005
    ..L. Laine and A. J. van Winkelhoff, Oral Microbiol. Immunol. 13:322-325, 1998), isolates that caused serious disease in mice were significantly more likely to carry rag-1 than other rag alleles...
  11. pmc Nuclear targeting of Porphyromonas gingivalis W50 protease in epithelial cells
    Margaret A Scragg
    Department of Clinical and Diagnostic Oral Sciences Oral Pathology Queen Mary, University of London, London, United Kingdom
    Infect Immun 70:5740-50. 2002
    ..These effects were seen with both active and TLCK-inactivated protease, confirming that they were not dependent on proteolytic activity, and thus provide new insights into the functioning of this P. gingivalis protease...
  12. pmc Pseudomonas aeruginosa PAO1 pyocin production affects population dynamics within mixed-culture biofilms
    Richard D Waite
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Centre for Infectious Disease, Institute of Cell and Molecular Science, 4 Newark Street, London E1 2AT, United Kingdom
    J Bacteriol 191:1349-54. 2009
    ..Biofilm coculture of strain PAO1 and a pyocin-sensitive isolate showed that pyocin production had a significant impact on bacterial population dynamics, particularly under anaerobic conditions...
  13. pmc Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50
    Minnie Rangarajan
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    J Bacteriol 190:2920-32. 2008
    ..gingivalis has dual specificity for both O-antigen and APS repeating units...
  14. ncbi request reprint Regulation of RANKL and OPG gene expression in human gingival fibroblasts and periodontal ligament cells by Porphyromonas gingivalis: a putative role of the Arg-gingipains
    Georgios N Belibasakis
    Centre for Adult Oral Health, Bart s and The London School of Medicine and Dentistry, Queen Mary s University of London, London E1 2AT, UK
    Microb Pathog 43:46-53. 2007
    ..The component mainly responsible for RANKL induction appears to be proteinaceous, and it may be regulated by the Arg-gingipains...
  15. ncbi request reprint A genotypic and phenotypic comparison of type III secretion profiles of Pseudomonas aeruginosa cystic fibrosis and bacteremia isolates
    David W Wareham
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London E1 2AT, UK
    Int J Med Microbiol 297:227-34. 2007
    ..Detection of TTSS toxins in clinical material may be useful in targeting antimicrobial therapy or identifying individuals infected with aggressive strains of P. aeruginosa...
  16. ncbi request reprint Prognostic factors in the treatment of generalized aggressive periodontitis: I. Clinical features and initial outcome
    Francis J Hughes
    Collaborative Group in Risk Factors for Periodontal Disease, Institute of Dentistry, Queen Mary s School of Medicine, London, UK
    J Clin Periodontol 33:663-70. 2006
    ..The aims of this study were to investigate prognostic factors for initial response to non-surgical periodontal treatment for generalized aggressive periodontitis...
  17. ncbi request reprint Prognostic factors in the treatment of generalized aggressive periodontitis: II. Effects of smoking on initial outcome
    Francis J Hughes
    Collaborative Group in Risk Factors for Periodontal Disease, Centre for Adult Oral Health, Institute of Dentistry, London, UK
    J Clin Periodontol 33:671-6. 2006
    ..The aim of this study was to investigate the effects of smoking on the response to non-surgical treatment for aggressive periodontitis...
  18. ncbi request reprint Glycosylation of the Arg-gingipains of Porphyromonas gingivalis and comparison with glycoconjugate structure and synthesis in other bacteria
    Alexandra Gallagher
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, 32 Newark Street, London E1 2AA, UK
    Curr Protein Pept Sci 4:427-41. 2003
    ....
  19. ncbi request reprint The Pseudomonas aeruginosa PA14 type III secretion system is expressed but not essential to virulence in the Caenorhabditis elegans-P. aeruginosa pathogenicity model
    David W Wareham
    MRC Molecular Pathogenesis Research Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, University of London, London E1 2AA, UK
    FEMS Microbiol Lett 242:209-16. 2005
    ..A fuller understanding of the mechanism of resistance to type III attack in C. elegans may lead to the identification and development of novel therapeutic targets affording protection to TTSS products in man...
  20. pmc Transcriptome analysis of Pseudomonas aeruginosa growth: comparison of gene expression in planktonic cultures and developing and mature biofilms
    Richard D Waite
    MRC Molecular Pathogenesis Research Unit, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, United Kingdom
    J Bacteriol 187:6571-6. 2005
    ..In addition, a number of novel genes were up-regulated in developing and confluent biofilms, including genes encoding putative solute transport proteins and transcriptional regulators, respectively...
  21. pmc Structural analysis of the core region of O-lipopolysaccharide of Porphyromonas gingivalis from mutants defective in O-antigen ligase and O-antigen polymerase
    Nikolay A Paramonov
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Centre for Infectious Disease, Institute of Cell and Molecular Science, 4 Newark Street, London E1 2AT, United Kingdom
    J Bacteriol 191:5272-82. 2009
    ..The core OS of P. gingivalis O-LPS is therefore a highly unusual structure, and it is the basis for further investigation of the mechanism of assembly of the outer membrane of this important periodontal bacterium...
  22. ncbi request reprint Structural analysis of a novel anionic polysaccharide from Porphyromonas gingivalis strain W50 related to Arg-gingipain glycans
    Nikolay Paramonov
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Mol Microbiol 58:847-63. 2005
    ..This phosphorylated branched mannan represents a novel polysaccharide that is immunologically related to the post-translational additions of Arg-gingipains...
  23. pmc Identification and characterization of the capsular polysaccharide (K-antigen) locus of Porphyromonas gingivalis
    Joseph Aduse-Opoku
    MRC Molecular Pathogenesis Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    Infect Immun 74:449-60. 2006
    ..gingivalis is independent of the capsule biosynthetic machinery...
  24. ncbi request reprint Mechanisms of evasion of complement by Porphyromonas gingivalis
    Jennifer M Slaney
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Front Biosci 13:188-96. 2008
    ..Instead, complement resistance in P. gingivalis is associated with the presence on the cell surface of an anionic branched mannan and appears independent of capsule serotype...
  25. pmc Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement
    Jennifer M Slaney
    MRC Molecular Pathogenesis Group, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    Infect Immun 74:5352-61. 2006
    ..We conclude that the production of APS at the surface of P. gingivalis rather than Arg- and Lys-gingipain synthesis is the principal mechanism of serum resistance in P. gingivalis...
  26. pmc A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro
    Y K Stella Man
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Queen Mary University of London, 4 Newark Street, Whitechapel, London, UK
    J Membr Biol 218:29-37. 2007
    ..These in vitro studies suggest an advantageous effect of (R143W)Cx26 in epithelial cells...
  27. doi request reprint Porphyromonas gingivalis regulates the RANKL-OPG system in bone marrow stromal cells
    Durga Reddi
    Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AD, UK
    Microbes Infect 10:1459-68. 2008
    ..A non-proteolytic and non-proteinaceous P. gingivalis component is involved in these events, most probably its lipopolysaccharide. This activity may contribute to the bone loss characteristic of periodontitis...

Research Grants1

  1. 2006 Periodontal Diseases Gordon Research Conference
    Michael Curtis; Fiscal Year: 2006
    ..Funding is requested in order to support the travel costs and meeting expenses of speakers and to provide meeting grants for junior research workers at the beginning of their research careers. ..