D Curtis

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc A simple method for assessing the strength of evidence for association at the level of the whole gene
    David Curtis
    Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Adv Appl Bioinform Chem 1:115-20. 2008
  2. pmc Approaches to the detection of recessive effects using next generation sequencing data from outbred populations
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Adv Appl Bioinform Chem 6:29-35. 2013
  3. pmc A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Adv Appl Bioinform Chem 5:1-9. 2012
  4. doi request reprint Consideration of plausible genetic architectures for schizophrenia and implications for analytic approaches in the era of next generation sequencing
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Psychiatr Genet 23:1-10. 2013
  5. pmc Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
    Susmita R Datta
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
    Behav Brain Funct 3:50. 2007
  6. pmc Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
    Nicholas J Bass
    Molecular Psychiatry Laboratory, Research Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
    Behav Brain Funct 5:28. 2009
  7. pmc Case report: rapidly fatal bowel ischaemia on clozapine treatment
    Giles Townsend
    East London and City Mental Health Trust, Department of Adult Psychiatry, Royal London Hospital, Whitechapel, London E1 1BB, UK
    BMC Psychiatry 6:43. 2006
  8. pmc Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2
    Irene Guerrini
    Molecular Psychiatry Laboratory, Windeyer Institute for Medical Sciences, Department of Mental Health Sciences, Royal Free and University College London Medical School, 46 Cleveland Street, London, W1T 4JF, UK
    BMC Genet 6:11. 2005
  9. ncbi request reprint A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees
    David Curtis
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Psychiatr Genet 15:181-7. 2005
  10. pmc Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations
    D Curtis
    Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
    Ann Hum Genet 72:261-78. 2008

Collaborators

Detail Information

Publications61

  1. pmc A simple method for assessing the strength of evidence for association at the level of the whole gene
    David Curtis
    Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Adv Appl Bioinform Chem 1:115-20. 2008
    ..Doing this is complicated by the fact that different markers do not represent independent sources of information...
  2. pmc Approaches to the detection of recessive effects using next generation sequencing data from outbred populations
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Adv Appl Bioinform Chem 6:29-35. 2013
    ..The procedure is simple and quick to apply so can be used in the context of whole genome or exome sequencing studies and is implemented in the SCOREASSOC program. ..
  3. pmc A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Adv Appl Bioinform Chem 5:1-9. 2012
    ..20,000 analyses of a gene containing 62 variants could be performed in 80 minutes on a laptop. This approach shows promise for the analysis of data currently emerging from genome wide sequencing studies...
  4. doi request reprint Consideration of plausible genetic architectures for schizophrenia and implications for analytic approaches in the era of next generation sequencing
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Psychiatr Genet 23:1-10. 2013
    ..It is recommended that analytic approaches aim to detect very rare variants with major effect and that specific attempts are made to detect recessively acting loci...
  5. pmc Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
    Susmita R Datta
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
    Behav Brain Funct 3:50. 2007
    ..abstract:..
  6. pmc Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
    Nicholas J Bass
    Molecular Psychiatry Laboratory, Research Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
    Behav Brain Funct 5:28. 2009
    ..abstract:..
  7. pmc Case report: rapidly fatal bowel ischaemia on clozapine treatment
    Giles Townsend
    East London and City Mental Health Trust, Department of Adult Psychiatry, Royal London Hospital, Whitechapel, London E1 1BB, UK
    BMC Psychiatry 6:43. 2006
    ..There have been previous reported deaths due to clozapine-induced constipation. In all these cases patients have experienced prior abdominal symptoms over a period of weeks or months...
  8. pmc Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2
    Irene Guerrini
    Molecular Psychiatry Laboratory, Windeyer Institute for Medical Sciences, Department of Mental Health Sciences, Royal Free and University College London Medical School, 46 Cleveland Street, London, W1T 4JF, UK
    BMC Genet 6:11. 2005
    ..In order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study...
  9. ncbi request reprint A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees
    David Curtis
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Psychiatr Genet 15:181-7. 2005
    ..Here, we describe a new method for LOD score analysis of quantitative traits which does not require specification of a mode of inheritance...
  10. pmc Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations
    D Curtis
    Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
    Ann Hum Genet 72:261-78. 2008
    ..The haplotypes involved are sometimes markedly disparate from each other. These regions offer a valuable opportunity for further investigation, in particular with regard to their ancestral history...
  11. pmc Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus
    D Curtis
    Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Ann Hum Genet 72:547-56. 2008
    ..Microsatellites seem ill-suited for systematic studies to detect association...
  12. pmc A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies
    David Curtis
    Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
    BMC Genet 8:20. 2007
    ..However if hundreds of thousands of markers are typed then inevitably very large numbers of such results will occur by chance and those from candidate regions may attract no special attention...
  13. pmc Extended homozygosity is not usually due to cytogenetic abnormality
    David Curtis
    Academic Centre for Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London E1 1BB, UK
    BMC Genet 8:67. 2007
    ..Previous studies have reported frequent stretches of homozygosity in human subjects but have failed to clarify whether these are due to cytogenetic abnormalities or to autozygosity...
  14. ncbi request reprint Re-analysis of collaborative study on the genetics of alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299
    David Curtis
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry
    Psychiatr Genet 14:151-5. 2004
    ..Additional samples will need to be studied in order to discover which regions truly harbour genetic polymorphisms influencing personality traits...
  15. pmc Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test statistics
    David Curtis
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
    BMC Genet 8:38. 2007
    ..We also carried out permutation testing to assess the empirical significance of the results obtained...
  16. pmc Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association
    David Curtis
    Academic Centre for Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London, UK
    BMC Genet 8:49. 2007
    ..Here, the performance of ANN analysis is compared with other multi-marker methods, comprising different haplotype-based analyses and locus-based analyses...
  17. ncbi request reprint Assessing the contribution family data can make to case-control studies of rare variants
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Ann Hum Genet 75:630-8. 2011
    ..Affected relatives offer a valuable resource to assist the interpretation of case-control studies of rare variants. The method is capable of including other relative types and can deal with complex pedigrees...
  18. pmc Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes
    David Curtis
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
    Psychiatr Genet 21:1-4. 2011
    ..The samples may be better matched, especially for background risk factors common to both diseases. Genetic loci may also be detected which influence which of the two diseases occurs if common risk factors are present...
  19. doi request reprint Yin yang haplotypes revisited - long, disparate haplotypes observed in European populations in regions of increased homozygosity
    David Curtis
    Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
    Hum Hered 69:184-92. 2010
    ..Here, we formally assess whether haplotypes from these regions provide evidence for the yin yang effect...
  20. pmc Allelic association studies of genome wide association data can reveal errors in marker position assignments
    David Curtis
    Academic Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
    BMC Genet 8:30. 2007
    ..Analysing pairs of markers from separate regions might lead to the detection of allelic association which might indicate an interaction between nearby genes...
  21. pmc Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibrium
    Anna E Vine
    Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, E1 1BB, UK
    BMC Res Notes 2:29. 2009
    ..CONCLUSION: The human genome contains regions which deviate markedly from HWE and these might harbour genes influencing embryonic survival...
  22. doi request reprint Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders
    A McQuillin
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London, UK
    Mol Psychiatry 14:614-20. 2009
    ....
  23. ncbi request reprint Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility loci
    B V North
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Ann Hum Genet 68:240-8. 2004
    ..We conclude that one may need to use very dense SNP maps in order to avoid overlooking polymorphisms affecting susceptibility to a common phenotype...
  24. ncbi request reprint Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3
    A McQuillin
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, and Royal London Hospital, London, UK
    Mol Psychiatry 11:134-42. 2006
    ..A third nonconservative change from histidine to glutamic acid was found in exon 8 of TSPEAR. These changes need further investigation to establish any aetiological role in bipolar disorder...
  25. ncbi request reprint Coeliac disease: follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11
    A L King
    Gastroenterology Unit, GKT, The Rayne Institute, St. Thomas' Hospital, London, UK
    Ann Hum Genet 65:377-86. 2001
    ..6 at D11S914 on chromosome 11p11. This marker maps to a position implicated in one of the two previous genome scans and taken together these results provide strong support for the existence of a susceptibility locus in this region...
  26. doi request reprint A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia
    S R Datta
    Molecular Psychiatry Laboratory, Research Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
    Mol Psychiatry 15:615-28. 2010
    ..However, the DNA changes we have found deserve widespread genotyping in multiple case-control populations...
  27. ncbi request reprint Use of an artificial neural network to detect association between a disease and multiple marker genotypes
    D Curtis
    Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Ann Hum Genet 65:95-107. 2001
    ..The application of neural networks to such problems shows considerable promise and further work could usefully be directed towards optimising the design and implementation of such networks...
  28. ncbi request reprint Coeliac disease: investigation of proposed causal variants in the CTLA4 gene region
    A L King
    Gastroenterology Unit, GKT, The Rayne Institute, St Thomas Hospital, London, UK
    Eur J Immunogenet 30:427-32. 2003
    ..MH30, CT60, and other SNPs in the region may still warrant further investigation in other CD samples...
  29. ncbi request reprint Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes
    B V North
    Academic Department of Psychiatry, Barts and The London Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Ann Hum Genet 67:348-56. 2003
    ..Permuting only the marker genotypes relative to affection status and these risk factors would allow the contribution of the markers to disease risk to be independently assessed...
  30. ncbi request reprint Model-free analysis and permutation tests for allelic associations
    J H Zhao
    Department of Psychological Medicine, Institute of Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Hum Hered 50:133-9. 2000
    ..A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed...
  31. ncbi request reprint Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, London, UK
    Biol Psychiatry 61:873-9. 2007
    ..Tests of allelic association with both of these genes in our case control sample were negative. Therefore, we carried out further fine mapping between the RGS4 and CAPON genes...
  32. ncbi request reprint CLUMPHAP: a simple tool for performing haplotype-based association analysis
    Jo Knight
    Social Genetic and Developmental Psychiatry MRC Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
    Genet Epidemiol 32:539-45. 2008
    ..Our results show that CLUMPHAP tends to have greater power than the omnibus haplotype test and is comparable in power to multiple regression locus-coding approaches...
  33. ncbi request reprint Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13
    D Curtis
    Department of Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Psychiatr Genet 14:83-7. 2004
    ..To localize genes influencing the susceptibility to Gilles de la Tourette syndrome (GTS) and associated chronic multiple tics (CMT)...
  34. pmc Meta-analysis of 32 genome-wide linkage studies of schizophrenia
    M Y M Ng
    King s College London, Department of Medical and Molecular Genetics, London, UK
    Mol Psychiatry 14:774-85. 2009
    ..Therefore, the regions supported by this meta-analysis deserve close attention in future studies...
  35. ncbi request reprint Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q
    David Curtis
    Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Psychiatr Genet 13:77-84. 2003
    ..To localize genes conferring susceptibility to bipolar affective disorder...
  36. ncbi request reprint A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease
    D Curtis
    Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Ann Hum Genet 65:473-81. 2001
    ..The results provide support for the existence of additional susceptibility loci linked to D10S1211 and to D12S358...
  37. ncbi request reprint Linkage analysis between bipolar affective disorder and markers on chromosome X
    H P Vallada
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatr Genet 8:183-6. 1998
    ..We conclude that there is no evidence of a common major gene for bipolar affective disorder at Xq25-q27 in our set of families...
  38. ncbi request reprint Extension of conditional model-free likelihood-based linkage analysis to additive and other models
    D Curtis
    Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London, UK
    Ann Hum Genet 66:157-67. 2002
    ..Nevertheless, the new method allows researchers greater flexibility in analysing linkage data for diseases in which one or more risk polymorphisms have already been identified...
  39. ncbi request reprint Program report: GENECOUNTING support programs
    D Curtis
    Department of Adult Psychiatry, Royal London Hospital, Whitechapel, London E1 1BB, UK
    Ann Hum Genet 70:277-9. 2006
    ....
  40. pmc A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia
    Khalid Choudhury
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK
    Am J Hum Genet 80:664-72. 2007
    ..Etiological base-pair changes in FXYD6 or in associated promoter/control regions are likely to cause abnormal function or expression of phosphohippolin and to increase genetic susceptibility to schizophrenia...
  41. doi request reprint Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
    Eur J Hum Genet 16:1275-82. 2008
    ..3 region have lacked accuracy or may have suffered from methodological flaws...
  42. ncbi request reprint Association between clozapine response and allelic variation in the 5-HT2C receptor gene
    M S Sodhi
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Neuroreport 7:169-72. 1995
    ..There was no association between schizophrenia and the 5-HT2Cser allele, but our results indicate that the 5-HT2C receptor may contain the major site of action through which clozapine mediates its antipsychotic effects...
  43. ncbi request reprint Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK
    Biol Psychiatry 59:195-7. 2006
    ..A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia...
  44. ncbi request reprint Application of logistic regression to case-control association studies involving two causative loci
    Bernard V North
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Hum Hered 59:79-87. 2005
    ..Hence we conclude that in general both conditional and unconditional analyses should be performed when searching for additional loci...
  45. ncbi request reprint Chromosome 21 workshop
    D Curtis
    Department of Psychological Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Royal London Hospital, UK
    Am J Med Genet 88:272-5. 1999
    ..Participants concluded that the evidence implicating this region remains as strong as any, and were optimistic that further investigation would eventually lead to the identification of a susceptibility gene...
  46. ncbi request reprint The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations
    P C Sham
    Department of Psychiatry, Institute of Psychiatry, London, UK
    Ann Hum Genet 64:161-9. 2000
    ..They also show that multiple ancestral disease mutations do not necessarily preclude linkage disequilibrium mapping, if highly polymorphic markers or multi-locus haplotypes are used...
  47. doi request reprint No evidence for excess runs of homozygosity in bipolar disorder
    Anna E Vine
    Centre for Psychiatry, University College London, UK
    Psychiatr Genet 19:165-70. 2009
    ..Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3)...
  48. ncbi request reprint Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters
    S J Moodie
    Gastroenteroly Unit, GKT, The Rayne Institute, St Trhomas Hospital, London, UK
    Eur J Immunogenet 29:287-91. 2002
    ..A transmission disequilibrium test also found no association of the A and B KIR haplotypes or the LILRA3 gene deletion with coeliac disease...
  49. ncbi request reprint A novel polymorphism in exon 11 of the WKL1 gene, shows no association with schizophrenia
    Andrew McQuillin
    Molecular Psychiatry Laboratory, University College London, Department of Psychiatry and Behavioural Sciences, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London W1T 4JF, UK
    Eur J Hum Genet 10:491-4. 2002
    ..The insertion/deletion is composed of repeated sequence from exon 11 and intron 11 and is predicted to affect WKL1 protein structure...
  50. ncbi request reprint Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14
    Nichole L Taske
    Department of Paediatrics and Child Health, Royal Free and University College Medical School, University College London, Gower Street Campus, 5 University Street, London WC1E 6JJ, UK
    Epilepsy Res 49:157-72. 2002
    ..Causal sequence variants in the positional candidate CHRNA7 have not been identified but the presence of multiple segmental duplications in this region raises the possibility of undetected disease-causing genomic rearrangements...
  51. ncbi request reprint Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians
    Paul G Cassell
    Department of Diabetes and Metabolic Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, University of London, London
    Diabetes 51:1622-8. 2002
    ..However, the relative infrequency of the "at-risk" combinations in the South Indian population suggests that calpain 10 is not a common determinant of susceptibility to type 2 diabetes...
  52. pmc Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia
    Hugh M D Gurling
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
    Arch Gen Psychiatry 63:844-54. 2006
    ..There is evidence of linkage to a schizophrenia susceptibility locus on chromosome 8p21-22 found by several family linkage studies...
  53. pmc Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
    Jo Knight
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
    BMC Genet 4:S74. 2003
    ....
  54. ncbi request reprint Identification of the Slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24
    Gursharan Kalsi
    Molecular Psychiatry Laboratory, Windeyer Institute for Medical Science, Department of Psychiatry and Behavioral Sciences, Royal Free and University College Medical School, University College London, 46 Cleveland St, London W1T 4JF, United Kingdom
    Am J Psychiatry 163:1767-76. 2006
    ..00 and 3.00. In order to identify which gene on this chromosome is responsible, the authors carried out tests of allelic association with bipolar disorder in order to fine map an affective disorder susceptibility gene...
  55. ncbi request reprint Estimation of haplotypes at DRD2 may have produced misleading results
    David Curtis
    Arch Gen Psychiatry 63:939; author reply 939-40. 2006
  56. pmc The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia
    Jonathan Pimm
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
    Am J Hum Genet 76:902-7. 2005
    ..A genetically determined abnormality in the structure, function, or expression of enthoprotin is likely to be responsible for genetic susceptibility to a subtype of schizophrenia on chromosome 5q33.3...
  57. ncbi request reprint Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region
    John B Vincent
    Molecular Psychiatry Laboratory, Department of Psychiatry and Behavioural Sciences, Windeyer Institute of Medical Science, University College London, London
    Psychiatr Genet 15:83-90. 2005
    ..1 for a broad phenotype diagnostic model. Thus, this study offers modest support for a susceptibility locus for autism within the Xq27-q28 region. Further genetic investigations of this region are warranted...
  58. ncbi request reprint Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4)
    Mie A Rizig
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:296-300. 2006
    ..The finding weakens the evidence that mutations or variation in the RGS4 gene have an effect on schizophrenia susceptibility...
  59. pmc Estimated haplotype counts from case-control samples cannot be treated as observed counts
    David Curtis
    Am J Hum Genet 78:729-30; author reply 728-9. 2006
  60. pmc SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent
    Zahid Hassan
    Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Hum Genet 71:964-8. 2002
    ..02 compared with the ethnically matched control group). These results suggest that the N34S variant of SPINK1 is a susceptibility gene for FCPD in the Indian subcontinent, although, by itself, it is not sufficient to cause disease...