Research Topics
Genomes and Genes | D CurtisSummaryAffiliation: Queen Mary Country: UK Publications
| Collaborators
|
Detail Information
Publications
Consideration of plausible genetic architectures for schizophrenia and implications for analytic approaches in the era of next generation sequencingDavid Curtis
Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
Psychiatr Genet 23:1-10. 2013..It is recommended that analytic approaches aim to detect very rare variants with major effect and that specific attempts are made to detect recessively acting loci...
Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophreniaSusmita R Datta
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
Behav Brain Funct 3:50. 2007..abstract:..- Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophreniaNicholas J Bass
Molecular Psychiatry Laboratory, Research Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
Behav Brain Funct 5:28. 2009..abstract:.. - Case report: rapidly fatal bowel ischaemia on clozapine treatmentGiles Townsend
East London and City Mental Health Trust, Department of Adult Psychiatry, Royal London Hospital, Whitechapel, London E1 1BB, UK
BMC Psychiatry 6:43. 2006..There have been previous reported deaths due to clozapine-induced constipation. In all these cases patients have experienced prior abdominal symptoms over a period of weeks or months... - Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2Irene Guerrini
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Sciences, Department of Mental Health Sciences, Royal Free and University College London Medical School, 46 Cleveland Street, London, W1T 4JF, UK
BMC Genet 6:11. 2005..In order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study... - Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test statisticsDavid Curtis
Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
BMC Genet 8:38. 2007..We also carried out permutation testing to assess the empirical significance of the results obtained... - Allelic association studies of genome wide association data can reveal errors in marker position assignmentsDavid Curtis
Academic Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
BMC Genet 8:30. 2007..Analysing pairs of markers from separate regions might lead to the detection of allelic association which might indicate an interaction between nearby genes... 
Re-analysis of collaborative study on the genetics of alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299David Curtis
Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry
Psychiatr Genet 14:151-5. 2004..Additional samples will need to be studied in order to discover which regions truly harbour genetic polymorphisms influencing personality traits...- Extended homozygosity is not usually due to cytogenetic abnormalityDavid Curtis
Academic Centre for Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London E1 1BB, UK
BMC Genet 8:67. 2007..Previous studies have reported frequent stretches of homozygosity in human subjects but have failed to clarify whether these are due to cytogenetic abnormalities or to autozygosity... - Comparison of artificial neural network analysis with other multimarker methods for detecting genetic associationDavid Curtis
Academic Centre for Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London, UK
BMC Genet 8:49. 2007..Here, the performance of ANN analysis is compared with other multi-marker methods, comprising different haplotype-based analyses and locus-based analyses... - A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigreesDavid Curtis
Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
Psychiatr Genet 15:181-7. 2005..Here, we describe a new method for LOD score analysis of quantitative traits which does not require specification of a mode of inheritance... - Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locusD Curtis
Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
Ann Hum Genet 72:547-56. 2008..Microsatellites seem ill-suited for systematic studies to detect association... - A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studiesDavid Curtis
Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
BMC Genet 8:20. 2007..However if hundreds of thousands of markers are typed then inevitably very large numbers of such results will occur by chance and those from candidate regions may attract no special attention... - Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populationsD Curtis
Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
Ann Hum Genet 72:261-78. 2008..The haplotypes involved are sometimes markedly disparate from each other. These regions offer a valuable opportunity for further investigation, in particular with regard to their ancestral history... - Yin yang haplotypes revisited - long, disparate haplotypes observed in European populations in regions of increased homozygosityDavid Curtis
Centre for Psychiatry, Queen Mary s School of Medicine and Dentistry, London, UK
Hum Hered 69:184-92. 2010..Here, we formally assess whether haplotypes from these regions provide evidence for the yin yang effect... - Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibriumAnna E Vine
Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, E1 1BB, UK
BMC Res Notes 2:29. 2009..CONCLUSION: The human genome contains regions which deviate markedly from HWE and these might harbour genes influencing embryonic survival... - Assessing the contribution family data can make to case-control studies of rare variantsDavid Curtis
Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
Ann Hum Genet 75:630-8. 2011..Affected relatives offer a valuable resource to assist the interpretation of case-control studies of rare variants. The method is capable of including other relative types and can deal with complex pedigrees... - Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genesDavid Curtis
Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, London, UK
Psychiatr Genet 21:1-4. 2011..The samples may be better matched, especially for background risk factors common to both diseases. Genetic loci may also be detected which influence which of the two diseases occurs if common risk factors are present... - Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disordersA McQuillin
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London, UK
Mol Psychiatry 14:614-20. 2009.... - Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility lociB V North
Academic Department of Psychiatry, Queen Mary's School of Medicine and Dentistry, London E1 1BB, UK
Ann Hum Genet 68:240-8. 2004..We conclude that one may need to use very dense SNP maps in order to avoid overlooking polymorphisms affecting susceptibility to a common phenotype... - Coeliac disease: follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11A L King
Gastroenterology Unit, GKT, The Rayne Institute, St. Thomas' Hospital, London, UK
Ann Hum Genet 65:377-86. 2001..6 at D11S914 on chromosome 11p11. This marker maps to a position implicated in one of the two previous genome scans and taken together these results provide strong support for the existence of a susceptibility locus in this region... - Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3A McQuillin
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, and Royal London Hospital, London, UK
Mol Psychiatry 11:134-42. 2006..A third nonconservative change from histidine to glutamic acid was found in exon 8 of TSPEAR. These changes need further investigation to establish any aetiological role in bipolar disorder... - A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophreniaS R Datta
Molecular Psychiatry Laboratory, Research Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
Mol Psychiatry 15:615-28. 2010..However, the DNA changes we have found deserve widespread genotyping in multiple case-control populations... - Use of an artificial neural network to detect association between a disease and multiple marker genotypesD Curtis
Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
Ann Hum Genet 65:95-107. 2001..The application of neural networks to such problems shows considerable promise and further work could usefully be directed towards optimising the design and implementation of such networks... - Coeliac disease: investigation of proposed causal variants in the CTLA4 gene regionA L King
Gastroenterology Unit, GKT, The Rayne Institute, St Thomas Hospital, London, UK
Eur J Immunogenet 30:427-32. 2003..MH30, CT60, and other SNPs in the region may still warrant further investigation in other CD samples... - Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetesB V North
Academic Department of Psychiatry, Barts and The London Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
Ann Hum Genet 67:348-56. 2003..Permuting only the marker genotypes relative to affection status and these risk factors would allow the contribution of the markers to disease risk to be independently assessed... - Model-free analysis and permutation tests for allelic associationsJ H Zhao
Department of Psychological Medicine, Institute of Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
Hum Hered 50:133-9. 2000..A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed... - Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility geneVinay Puri
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, London, UK
Biol Psychiatry 61:873-9. 2007..Tests of allelic association with both of these genes in our case control sample were negative. Therefore, we carried out further fine mapping between the RGS4 and CAPON genes... - CLUMPHAP: a simple tool for performing haplotype-based association analysisJo Knight
Social Genetic and Developmental Psychiatry MRC Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
Genet Epidemiol 32:539-45. 2008..Our results show that CLUMPHAP tends to have greater power than the omnibus haplotype test and is comparable in power to multiple regression locus-coding approaches... - Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13D Curtis
Department of Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
Psychiatr Genet 14:83-7. 2004..To localize genes influencing the susceptibility to Gilles de la Tourette syndrome (GTS) and associated chronic multiple tics (CMT)... - Meta-analysis of 32 genome-wide linkage studies of schizophreniaM Y M Ng
King s College London, Department of Medical and Molecular Genetics, London, UK
Mol Psychiatry 14:774-85. 2009..Therefore, the regions supported by this meta-analysis deserve close attention in future studies... - Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1qDavid Curtis
Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
Psychiatr Genet 13:77-84. 2003..To localize genes conferring susceptibility to bipolar affective disorder... - Linkage analysis between bipolar affective disorder and markers on chromosome XH P Vallada
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Psychiatr Genet 8:183-6. 1998..We conclude that there is no evidence of a common major gene for bipolar affective disorder at Xq25-q27 in our set of families... - Extension of conditional model-free likelihood-based linkage analysis to additive and other modelsD Curtis
Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London, UK
Ann Hum Genet 66:157-67. 2002..Nevertheless, the new method allows researchers greater flexibility in analysing linkage data for diseases in which one or more risk polymorphisms have already been identified... - A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's diseaseD Curtis
Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
Ann Hum Genet 65:473-81. 2001..The results provide support for the existence of additional susceptibility loci linked to D10S1211 and to D12S358... - Program report: GENECOUNTING support programsD Curtis
Department of Adult Psychiatry, Royal London Hospital, Whitechapel, London E1 1BB, UK
Ann Hum Genet 70:277-9. 2006.... - Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3Vinay Puri
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
Eur J Hum Genet 16:1275-82. 2008..3 region have lacked accuracy or may have suffered from methodological flaws... - A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophreniaKhalid Choudhury
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK
Am J Hum Genet 80:664-72. 2007..Etiological base-pair changes in FXYD6 or in associated promoter/control regions are likely to cause abnormal function or expression of phosphohippolin and to increase genetic susceptibility to schizophrenia... - Association between clozapine response and allelic variation in the 5-HT2C receptor geneM S Sodhi
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Neuroreport 7:169-72. 1995..There was no association between schizophrenia and the 5-HT2Cser allele, but our results indicate that the 5-HT2C receptor may contain the major site of action through which clozapine mediates its antipsychotic effects... - Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sampleVinay Puri
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK
Biol Psychiatry 59:195-7. 2006..A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia... - Application of logistic regression to case-control association studies involving two causative lociBernard V North
Academic Department of Psychiatry, Queen Mary's School of Medicine and Dentistry, London E1 1BB, UK
Hum Hered 59:79-87. 2005..Hence we conclude that in general both conditional and unconditional analyses should be performed when searching for additional loci... - The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutationsP C Sham
Department of Psychiatry, Institute of Psychiatry, London, UK
Ann Hum Genet 64:161-9. 2000..They also show that multiple ancestral disease mutations do not necessarily preclude linkage disequilibrium mapping, if highly polymorphic markers or multi-locus haplotypes are used... - Chromosome 21 workshopD Curtis
Department of Psychological Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Royal London Hospital, UK
Am J Med Genet 88:272-5. 1999..Participants concluded that the evidence implicating this region remains as strong as any, and were optimistic that further investigation would eventually lead to the identification of a susceptibility gene... - No evidence for excess runs of homozygosity in bipolar disorderAnna E Vine
Centre for Psychiatry, University College London, UK
Psychiatr Genet 19:165-70. 2009..Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3)... - Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clustersS J Moodie
Gastroenteroly Unit, GKT, The Rayne Institute, St Trhomas Hospital, London, UK
Eur J Immunogenet 29:287-91. 2002..A transmission disequilibrium test also found no association of the A and B KIR haplotypes or the LILRA3 gene deletion with coeliac disease... - A novel polymorphism in exon 11 of the WKL1 gene, shows no association with schizophreniaAndrew McQuillin
Molecular Psychiatry Laboratory, University College London, Department of Psychiatry and Behavioural Sciences, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London W1T 4JF, UK
Eur J Hum Genet 10:491-4. 2002..The insertion/deletion is composed of repeated sequence from exon 11 and intron 11 and is predicted to affect WKL1 protein structure... - Estimated haplotype counts from case-control samples cannot be treated as observed countsDavid Curtis
Am J Hum Genet 78:729-30; author reply 728-9. 2006 - Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14Nichole L Taske
Department of Paediatrics and Child Health, Royal Free and University College Medical School, University College London, Gower Street Campus, 5 University Street, London WC1E 6JJ, UK
Epilepsy Res 49:157-72. 2002..Causal sequence variants in the positional candidate CHRNA7 have not been identified but the presence of multiple segmental duplications in this region raises the possibility of undetected disease-causing genomic rearrangements... - Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South IndiansPaul G Cassell
Department of Diabetes and Metabolic Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, University of London, London
Diabetes 51:1622-8. 2002..However, the relative infrequency of the "at-risk" combinations in the South Indian population suggests that calpain 10 is not a common determinant of susceptibility to type 2 diabetes... - Rare chromosomal deletions and duplications increase risk of schizophreniaJennifer L Stone
Nature 455:237-41. 2008..Our results provide strong support for a model of schizophrenia pathogenesis that includes the effects of multiple rare structural variants, both genome-wide and at specific loci... - Estimation of haplotypes at DRD2 may have produced misleading resultsDavid Curtis
Arch Gen Psychiatry 63:939; author reply 939-40. 2006 - Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative traitJo Knight
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
BMC Genet 4:S74. 2003.... - Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X regionJohn B Vincent
Molecular Psychiatry Laboratory, Department of Psychiatry and Behavioural Sciences, Windeyer Institute of Medical Science, University College London, London
Psychiatr Genet 15:83-90. 2005..1 for a broad phenotype diagnostic model. Thus, this study offers modest support for a susceptibility locus for autism within the Xq27-q28 region. Further genetic investigations of this region are warranted... - Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4)Mie A Rizig
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 141:296-300. 2006..The finding weakens the evidence that mutations or variation in the RGS4 gene have an effect on schizophrenia susceptibility... - The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophreniaJonathan Pimm
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
Am J Hum Genet 76:902-7. 2005..A genetically determined abnormality in the structure, function, or expression of enthoprotin is likely to be responsible for genetic susceptibility to a subtype of schizophrenia on chromosome 5q33.3... - Identification of the Slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24Gursharan Kalsi
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Science, Department of Psychiatry and Behavioral Sciences, Royal Free and University College Medical School, University College London, 46 Cleveland St, London W1T 4JF, United Kingdom
Am J Psychiatry 163:1767-76. 2006..Sequencing of expressed sequences and control regions in the area should identify etiological base pair changes that increase susceptibility to bipolar disorder... - Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophreniaHugh M D Gurling
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
Arch Gen Psychiatry 63:844-54. 2006..There is evidence of linkage to a schizophrenia susceptibility locus on chromosome 8p21-22 found by several family linkage studies... - SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinentZahid Hassan
Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
Am J Hum Genet 71:964-8. 2002..02 compared with the ethnically matched control group). These results suggest that the N34S variant of SPINK1 is a susceptibility gene for FCPD in the Indian subcontinent, although, by itself, it is not sufficient to cause disease...