Research Topics
| R CorderSummaryAffiliation: Queen Mary Country: UK Publications
| Collaborators
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Detail Information
Publications
Oenology: red wine procyanidins and vascular healthR Corder
William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6BQ, UK
Nature 444:566. 2006..These regions also happen to be associated with increased longevity in the population...
Endothelin-1 synthesis reduced by red wineR Corder
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
Nature 414:863-4. 2001..Our findings indicate that components specific to red wine may help to prevent coronary heart disease...
Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRFT D Warner
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 110:777-82. 1993..Thus, the receptor present on the endothelium responsible for the release of nitric oxide in response to the ET/SX peptides is most probably different from that present on smooth muscle that mediates BQ-123-insensitive contractions...
Rapid degradation of endothelin-1 by an enzyme released by the rat isolated perfused mesenteryF Perez-Vizcaino
William Harvey Research Institute, Medical College of Saint Bartholomews Hospital, London
Br J Pharmacol 114:867-71. 1995..It is tempting, therefore, to speculate that the endothelin degrading enzyme active at neutral pH that- we have found is important in the metabolism of ET-1 throughout the vasculature...
Effect of an antisense oligodeoxynucleotide to endothelin-converting enzyme-1c (ECE-1c) on ECE-1c mRNA, ECE-1 protein and endothelin-1 synthesis in bovine pulmonary artery smooth muscle cellsS Barker
Department of Experimental Therapeutics, William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, Charterhouse Square Campus, London, EC1M 6BQ, UK
Mol Pharmacol 59:163-9. 2001..Hence, an endopeptidase distinct from ECE-1 is mainly responsible big ET-1 processing in BPASMC...
Endothelin-2 synthesis is stimulated by the type-1 tumour necrosis factor receptor and cAMP: comparison with endothelin-converting enzyme-1 expressionG L Lambert
The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, Charterhouse Square Campus, London EC1M 6BQ, UK
J Mol Endocrinol 24:273-83. 2000..Forskolin had no effect on ECE-1b/c/d mRNA levels. Thus, expression of ET-2 and ECE-1b/c/d mRNAs in ACHN cells do not display the co-ordinated regulation observed with typical peptide prohormone processing enzymes and their substrates...
Incomplete inhibition of the pressor effects of endothelin-1 and related peptides in the anaesthetized rat with BQ-123 provides evidence for more than one vasoconstrictor receptorL Mcmurdo
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 108:557-61. 1993..Complete inhibition of the pressor responses could not be achieved, suggesting that a component of the pressor response is not mediated via the ETA receptor...
Contractile activity of endothelin precursors in the isolated gallbladder of the guinea-pig: presence of an endothelin-converting enzymeB Battistini
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 114:1383-90. 1995..11) and not located on the epithelium, converts big ET-1 into ET-1 in the gallbladder of the guinea-pig. This ECE appears to act preferentially on big ET-1 or big ET-2 over bigET-3...
Cloning of bovine preproadrenomedullin and inhibition of its basal expression in vascular endothelial cells by staurosporineS Barker
Cellular Pharmacology Group, The William Harvey Research Institute, London, UK
Life Sci 62:1407-15. 1998..These observations suggest that activation of a novel staurosporine-sensitive protein kinase is necessary for basal expression of the preproAM gene in these cells...
Effect of lisinopril on tissue levels of neuropeptide Y in normotensive and spontaneously hypertensive ratsR Corder
The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, Charterhouse Square, London, EC1M 6BQ, UK
J Hum Hypertens 14:381-4. 2000..Journal of Human Hypertension (2000) 14, 381-384..
