Adrian J L Clark
Affiliation: Queen Mary
Clark A. 60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease. J Mol Endocrinol. 2016;56:T27-37 pubmed publisher
..This article reviews each of these aspects of POMC with the benefit of several decades of hindsight and informed by more recent genomic and transcriptomic data. ..
Clark A, Metherell L, Cheetham M, Huebner A. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. Trends Endocrinol Metab. 2005;16:451-7 pubmed
..Molecular defects underlying other causes of ACTH insensitivity syndromes will probably contribute further to our understanding of these pathways. ..
Novoselova T, Larder R, Rimmington D, Lelliott C, Wynn E, Gorrigan R, et al
. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. J Endocrinol. 2016;230:13-26 pubmed publisher
..Taken together, these data corroborate the role of MRAP2 in metabolic regulation and indicate that, at least in part, this may be due to defective central melanocortin signalling. ..
Clark A, Chan L. Promiscuity among the MRAPs. J Mol Endocrinol. 2017;58:F1-F4 pubmed publisher
..Evidence for other receptor interactions and aspects of the tissue distribution of MRAP and MRAP2 gene expression may indicate that these accessory proteins have a wider role than with the melanocortin receptors alone. ..