Tina T Chowdhury

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi Purinergic pathway suppresses the release of .NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression
    T T Chowdhury
    Medical Engineering Division, Department of Engineering, Queen Mary, University of London, Mile End Road, London, UK
    J Cell Physiol 209:845-53. 2006
  2. ncbi Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression
    T T Chowdhury
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, E1 4NS London, UK
    Inflamm Res 57:306-13. 2008
  3. ncbi Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs
    Tina T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Biorheology 43:413-29. 2006
  4. ncbi Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes
    T T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Biomech Model Mechanobiol 5:192-201. 2006
  5. ncbi Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes
    T T Chowdhury
    Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 339:241-7. 2006
  6. ncbi Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes
    T T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 318:873-81. 2004
  7. ncbi Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs
    Tina T Chowdhury
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
    Arthritis Res Ther 12:R82. 2010
  8. ncbi Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs
    T T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London, UK
    Osteoarthritis Cartilage 11:688-96. 2003
  9. ncbi Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression
    Tina T Chowdhury
    Medical Engineering Division, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Arch Biochem Biophys 417:105-11. 2003
  10. ncbi Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs
    T T Chowdhury
    School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Arthritis Res Ther 10:R35. 2008

Collaborators

Detail Information

Publications17

  1. ncbi Purinergic pathway suppresses the release of .NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression
    T T Chowdhury
    Medical Engineering Division, Department of Engineering, Queen Mary, University of London, Mile End Road, London, UK
    J Cell Physiol 209:845-53. 2006
    ..The current study demonstrates for the first time the importance of a purinergic pathway in mediating the metabolic response to dynamic compression and suppressing an inflammatory effect...
  2. ncbi Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression
    T T Chowdhury
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, E1 4NS London, UK
    Inflamm Res 57:306-13. 2008
    ..To examine whether inhibitors of the MAPK pathways will influence the response of bovine chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression...
  3. ncbi Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs
    Tina T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Biorheology 43:413-29. 2006
    ..These data indicate interactions exist between the NOS and COX pathways, a finding which will provide new insights in the development of pharmacological or biophysical treatments for cartilage disorders such as OA...
  4. ncbi Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes
    T T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Biomech Model Mechanobiol 5:192-201. 2006
    ..The non-binding control peptide, GRADSP, had no effect. These data clearly demonstrate that the metabolic response of the chondrocytes to dynamic compression in the presence and absence of IL-1 beta, are integrin mediated...
  5. ncbi Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes
    T T Chowdhury
    Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 339:241-7. 2006
    ..IL-4 and mechanical loading may therefore provide a potential protective mechanism for cartilage destruction as observed in OA...
  6. ncbi Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes
    T T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 318:873-81. 2004
    ..The current data clearly demonstrate that the dynamic compression-induced changes observed in cell metabolism for human monolayer-expanded chondrocytes were dependent on the presence of TGFbeta3 and are integrin-mediated...
  7. ncbi Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs
    Tina T Chowdhury
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
    Arthritis Res Ther 12:R82. 2010
    ..The present study examined the effect of collagen fragments on anabolic and catabolic activities by chondrocyte/agarose constructs subjected to dynamic compression...
  8. ncbi Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs
    T T Chowdhury
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London, UK
    Osteoarthritis Cartilage 11:688-96. 2003
    ..To examine the effect of IL-1 beta-induced *NO and PGE(2)release by stimulated superficial and deep chondrocyte/agarose constructs subjected to mechanical compression...
  9. ncbi Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression
    Tina T Chowdhury
    Medical Engineering Division, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Arch Biochem Biophys 417:105-11. 2003
    ..The uncoupled nature of the metabolic response determined in this study suggests that mechanical conditioning regimes may be fine tuned to selectively stimulate key metabolic parameters of relevance to cartilage tissue engineering...
  10. ncbi Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs
    T T Chowdhury
    School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Arthritis Res Ther 10:R35. 2008
    ....
  11. ncbi Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs
    T T Chowdhury
    IRC in Biomedical Materials and Medical Engineering Division, Department of Engineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, United Kingdom
    Biochem Biophys Res Commun 285:1168-74. 2001
    ..The inhibition of (*)NO and PGE(2) by dynamic compression is a finding of major significance that could contribute to the development of novel strategies for the treatment of cartilage-degenerative disorders...
  12. ncbi Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs
    S P Raveenthiran
    School of Engineering and Materials Science, Queen Mary, University of London, London, E1 4NS, UK
    Biomech Model Mechanobiol 8:273-83. 2009
    ..The combination of mechanical and pharmacological interventions makes this study a powerful tool to examine further the interactions of biomechanics and cell signalling in osteoarthritis...
  13. ncbi Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs
    Manoj Ramachandran
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK
    Arthritis Res Ther 13:R145. 2011
    ..The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression...
  14. ncbi Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs
    David A Lee
    School of Engineering and Materials Science, Queen Mary University of London, London, UK
    Methods Mol Biol 695:77-97. 2011
    ..Ultimately, development of methods used to analyse mechano-sensitive pathways will provide important information for the identification of appropriate pharmacological and physiotherapeutic agents for the treatment of osteoarthritis...
  15. ncbi Dynamic compression alters NFkappaB activation and IkappaB-alpha expression in IL-1beta-stimulated chondrocyte/agarose constructs
    O O Akanji
    Queen Mary University of London, UK
    Inflamm Res 59:41-52. 2010
    ..Determine the effect of IL-1beta and dynamic compression on NFkappaB activation and IkappaB-alpha gene expression in chondrocyte/agarose constructs...
  16. ncbi Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
    J J Campbell
    Medical Engineering Division, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 361:329-34. 2007
    ..Thus mechanical loading alters cortical actin dynamics, providing a potential mechanism through which chondrocytes can adapt their mechanical properties and mechanosensitivity to the local mechanical environment...
  17. ncbi Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels
    Stephanie J Bryant
    Department of Chemical Engineering, University of Colorado, Boulder, CO 80309-0424, USA
    Ann Biomed Eng 32:407-17. 2004
    ..In summary, changes in PEG hydrogel properties greatly affect how chondrocytes respond to an applied dynamic load...