Mark J Caulfield

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc Home blood pressure monitoring: new evidence for an expanded role
    Mark Caulfield
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS Med 11:e1001592. 2014
  2. pmc SLC2A9 is a high-capacity urate transporter in humans
    Mark J Caulfield
    Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    PLoS Med 5:e197. 2008
  3. ncbi request reprint Genome-wide mapping of human loci for essential hypertension
    Mark Caulfield
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine, London, UK
    Lancet 361:2118-23. 2003
  4. pmc Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
    Genome Res 17:1596-602. 2007
  5. pmc ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant
    Xiangyuan Pu
    William Harvey Research Institute, Queen Mary University of London, London, UK
    Am J Hum Genet 92:366-74. 2013
  6. pmc Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, EC1M 6BQ, UK
    Am J Hum Genet 82:139-49. 2008
  7. doi request reprint Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)
    David J Collier
    Barts and The London, Queen Mary s School of Medicine and Dentistry, UK
    J Hypertens 29:583-91. 2011
  8. pmc Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Am J Hum Genet 79:323-31. 2006
  9. doi request reprint Advances in blood pressure genomics
    Patricia B Munroe
    William Harvey Research Institute and Barts National Institute for Health Research Cardiovascular Biomedical Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ United Kingdom
    Circ Res 112:1365-79. 2013
  10. pmc Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
    Eleni Rapsomaniki
    The Farr Institute of Health Informatics Research, London, UK Epidemiology and Public Health, University College London, London, UK Electronic address
    Lancet 383:1899-911. 2014

Detail Information

Publications43

  1. pmc Home blood pressure monitoring: new evidence for an expanded role
    Mark Caulfield
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS Med 11:e1001592. 2014
    ..In a Perspective, Mark Caulfield discusses potential implications of using home blood pressure monitoring for diagnosis and treatment of hypertension. Please see later in the article for the Editors' Summary. ..
  2. pmc SLC2A9 is a high-capacity urate transporter in humans
    Mark J Caulfield
    Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    PLoS Med 5:e197. 2008
    ..We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man...
  3. ncbi request reprint Genome-wide mapping of human loci for essential hypertension
    Mark Caulfield
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine, London, UK
    Lancet 361:2118-23. 2003
    ..We describe the results of a genome scan for hypertension in a large white European population...
  4. pmc Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
    Genome Res 17:1596-602. 2007
    ....
  5. pmc ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant
    Xiangyuan Pu
    William Harvey Research Institute, Queen Mary University of London, London, UK
    Am J Hum Genet 92:366-74. 2013
    ....
  6. pmc Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, EC1M 6BQ, UK
    Am J Hum Genet 82:139-49. 2008
    ..This finding provides a potential biological mechanism for the recent association of this same allele of the same SNP with increased risk of coronary disease...
  7. doi request reprint Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)
    David J Collier
    Barts and The London, Queen Mary s School of Medicine and Dentistry, UK
    J Hypertens 29:583-91. 2011
    ....
  8. pmc Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Am J Hum Genet 79:323-31. 2006
    ..This is the first identity-by-descent regression analysis of hypertension to our knowledge, and it demonstrates the value of this approach for the incorporation of additional phenotypic information in genetic studies of complex traits...
  9. doi request reprint Advances in blood pressure genomics
    Patricia B Munroe
    William Harvey Research Institute and Barts National Institute for Health Research Cardiovascular Biomedical Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ United Kingdom
    Circ Res 112:1365-79. 2013
    ....
  10. pmc Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
    Eleni Rapsomaniki
    The Farr Institute of Health Informatics Research, London, UK Epidemiology and Public Health, University College London, London, UK Electronic address
    Lancet 383:1899-911. 2014
    ..In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease...
  11. doi request reprint Global sequence properties for superfamily prediction: a machine learning approach
    Richard J B Dobson
    The William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    J Integr Bioinform 6:109. 2009
    ..These approaches can be used to complement profile methods for detecting distant relationships where function is difficult to infer...
  12. ncbi request reprint Selection of candidate genes in hypertension
    Charles A Mein
    The Genome Centre and Clinical Pharmacology, The William Harvey Research Institute, Barts and The London, Charterhouse Square, London, UK
    Methods Mol Med 108:107-29. 2005
    ..We review the current state of play in these fields related to hypertension and show, with a particular example, how these data may help target genetic studies in the future...
  13. pmc Blood pressure loci identified with a gene-centric array
    Toby Johnson
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Am J Hum Genet 89:688-700. 2011
    ....
  14. doi request reprint Influence of matrix metalloproteinase-12 on fibrinogen level
    Anna Motterle
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Atherosclerosis 220:351-4. 2012
    ..3 (95% CI 1.9-20.8), p=0.003] and myocardial infarction [hazard ratio 5.6 (95% CI 1.7-18.3), p=0.005]. In summary, our study in mouse and humans provides in vivo evidence of an effect of MMP12 on fibrinogen level...
  15. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
    ..0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease...
  16. ncbi request reprint Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?
    Sarah Wilson
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 M 6BQ, UK
    J Cardiovasc Risk 10:137-41. 2003
    ..It is important to quantify the impact of this advice if risk assessments are to be sufficiently accurate to guide treatment decisions...
  17. ncbi request reprint Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study
    Patricia B Munroe
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute Barts and the London School of Medicine, Charterhouse Square, London, United Kingdom
    Hypertension 48:105-11. 2006
    ..07). We found increased evidence for linkage and borderline-significant evidence for association for a hypertension susceptibility locus on chromosome 5q13 that is worthy of detailed fine mapping and assessment of candidate genes...
  18. pmc Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
    Richard J Dobson
    Clinical Pharmacology, The William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    BMC Bioinformatics 7:217. 2006
    ..We show that nsSNP function prediction can be significantly improved by 100% undersampling of the majority class. The learnt rules were then applied to make predictions of function on all nsSNPs within Ensembl...
  19. pmc Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells
    Anna Motterle
    Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK
    Hum Mol Genet 21:4021-9. 2012
    ....
  20. doi request reprint Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm
    David J Collier
    Barts and The London, Queen Mary s School of Medicine and Dentistry, UK
    J Hypertens 29:592-9. 2011
    ..The Lipid-Lowering Arm of the Anglo-Scandinavian Cardiac Outcomes Trial allowed an evaluation of the efficacy and safety of atorvastatin among older (≥ 65 years) and younger (<65 years) patients with hypertension...
  21. doi request reprint Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential
    Suborno M Ghosh
    William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London, London, United Kingdom
    Hypertension 61:1091-102. 2013
    ....
  22. ncbi request reprint Genetics of essential hypertension
    Charles A Mein
    Clinical Pharmacology and The Genome Centre, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Hum Mol Genet 13:R169-75. 2004
    ..We also report some of the initial findings from pharmacogenetic studies...
  23. ncbi request reprint Recent advances in the identification of genes for human hypertension
    Ana C B Marcano
    Clinical Pharmacology and The Genome Centre, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Expert Rev Cardiovasc Ther 3:733-41. 2005
    ....
  24. doi request reprint Ethnic differences in blood pressure response to first and second-line antihypertensive therapies in patients randomized in the ASCOT Trial
    Ajay K Gupta
    ICCH, Imperial College London, London, UK
    Am J Hypertens 23:1023-30. 2010
    ..Some studies suggest that blood pressure (BP)-lowering effects of commonly used antihypertensive drugs differ among ethnic groups. However, differences in the response to second-line therapy have not been studied extensively...
  25. ncbi request reprint Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomis
    Peter S Sever
    Imperial College, London, UK
    Lancet 361:1149-58. 2003
    ..No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemic...
  26. ncbi request reprint Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomis
    Peter S Sever
    Imperial College, London, UK
    Drugs 64:43-60. 2004
    ..No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemic...
  27. ncbi request reprint Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study
    Stephen J Newhouse
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, London, UK
    Hum Mol Genet 14:1805-14. 2005
    ....
  28. ncbi request reprint Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)
    Neil R Poulter
    Imperial College London, London, UK
    Lancet 366:907-13. 2005
    ..86 and 0.77, respectively). Our aim was to assess to what extent these differences were due to significant differences in blood pressures and in other variables noted after randomisation...
  29. doi request reprint Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences and Genetics, University of Leicester, UK
    Hypertension 51:1658-64. 2008
    ..Notably, variants in KCNJ1, which causes Bartter syndrome type 2, were strongly associated, potentially providing a novel target for intervention...
  30. ncbi request reprint Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial--lipid-lowering arm (ASCOT-LLA)
    Peter S Sever
    International Centre for Circulatory Health, NHLI, Faculty of Medicine, Imperial College London, St Mary s Campus, 59 N Wharf Road, London W2 1PG, U K
    Diabetes Care 28:1151-7. 2005
    ..This study aims to establish the benefits of lowering cholesterol in diabetic patients with well-controlled hypertension and average/below-average cholesterol concentrations, but without established coronary disease...
  31. ncbi request reprint Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
    ..Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril...
  32. ncbi request reprint Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study
    Sandosh Padmanabhan
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
    Hypertension 47:603-8. 2006
    ..We have demonstrated for the first time identification of a significant locus by partitioning different pathways of hypertension using drug response...
  33. ncbi request reprint Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension
    Jordana Tzenova Bell
    Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 15:1365-74. 2006
    ..This approach has discovered novel loci for hypertension and offers a unique potential to use existing data to uncover novel regions involved in complex human diseases...
  34. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  35. ncbi request reprint Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial
    Peter Sever
    Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, 59 North Wharf Road, London W2 1PG, UK
    Eur Heart J 27:2982-8. 2006
    ....
  36. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  37. pmc Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension
    Ana Carolina Braga Marçano
    J Med Genet 44:603-5. 2007
    ..In particular, a haplotype of three genetic polymorphisms (rs2276047, rs9886 and an insertion/deletion polymorphism in intron 1) was found to be strongly associated with increased susceptibility to hypertension...
  38. doi request reprint The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes
    Jan Ostergren
    Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    J Hypertens 26:2103-11. 2008
    ....
  39. doi request reprint The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure
    Peter S Sever
    International Centre for Circulatory Health, Imperial College London, 59 North Wharf Road, London W2 1PG, UK
    Eur Heart J 29:499-508. 2008
    ..To determine the cardiovascular benefits in those originally assigned atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-2.2 years after closure of the lipid-lowering arm of the trial (ASCOT-LLA)...
  40. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  41. ncbi request reprint Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency
    Marianne Barr
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, UK
    Hypertension 49:113-9. 2007
    ..This study strongly suggests that the impaired 11beta-hydroxylase efficiency associated previously with the CYP11B2 -344 and intron conversion variants is because of linkage with these newly identified polymorphisms in CYP11B1...
  42. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  43. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...