Paul W Caton

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK
    Diabetologia 56:1068-77. 2013
  2. ncbi Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase
    Paul W Caton
    William Harvey Research Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
    Life Sci 84:738-44. 2009
  3. ncbi Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism
    Paul W Caton
    Department of Translational Medicine and Therapeutics, Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK
    J Endocrinol 208:273-83. 2011
  4. ncbi Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK
    Diabetologia 54:3083-92. 2011
  5. ncbi Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    Paul W Caton
    Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London, UK
    J Endocrinol 205:97-106. 2010
  6. ncbi PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
    Paul W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Biochem J 437:521-30. 2011
  7. ncbi PPAR control: it's SIRTainly as easy as PGC
    Mary C Sugden
    Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    J Endocrinol 204:93-104. 2010
  8. ncbi Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function
    Mark J Holness
    Queen Mary University of London, Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Bart s and The London, London, United Kingdom
    Nutrition 26:491-501. 2010
  9. ncbi Regulation of vascular endothelial function by procyanidin-rich foods and beverages
    Paul W Caton
    Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
    J Agric Food Chem 58:4008-13. 2010

Detail Information

Publications9

  1. ncbi Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK
    Diabetologia 56:1068-77. 2013
    ..As chronic inflammation and mitochondrial dysfunction are key factors mediating pancreatic beta cell impairment in type 2 diabetes, we investigated the role of SIRT3 in the maintenance of beta cell function and mass in type 2 diabetes...
  2. ncbi Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase
    Paul W Caton
    William Harvey Research Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
    Life Sci 84:738-44. 2009
    ..Previous studies of gluconeogenesis in endotoxemia have focused solely on PCK1. We investigated the relative roles of the two isoforms in hepatic and renal gluconeogenesis in a rat model of endotoxic shock, and in cultured hepatocytes...
  3. ncbi Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism
    Paul W Caton
    Department of Translational Medicine and Therapeutics, Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK
    J Endocrinol 208:273-83. 2011
    ..These results highlight the need for a greater understanding of the role of SIRT1 in metabolic regulation and indicate the potential for adverse effects of SIRT1 activators if used therapeutically...
  4. ncbi Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK
    Diabetologia 54:3083-92. 2011
    ..We hypothesised that altered NAMPT activity might contribute to the suppression of islet function associated with inflammation, and aimed to determine whether NMN could improve cytokine-mediated islet dysfunction...
  5. ncbi Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    Paul W Caton
    Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London, UK
    J Endocrinol 205:97-106. 2010
    ..In conclusion, induction of GCN5 and SIRT1 potentially represents a critical mechanism of action of metformin. In addition, these data identify induction of hepatic GCN5 as a potential therapeutic strategy for treatment of T2DM...
  6. ncbi PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
    Paul W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Biochem J 437:521-30. 2011
    ..In summary, we therefore propose that a LXR-PPARα signalling axis acts as a metabolostatic regulatory mechanism to optimize substrate selection and disposition in skeletal muscle according to metabolic requirement...
  7. ncbi PPAR control: it's SIRTainly as easy as PGC
    Mary C Sugden
    Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    J Endocrinol 204:93-104. 2010
    ..Finally, we comment on the potential of pharmaceutical manipulation of these targets as well as the possible problems associated with this strategy...
  8. ncbi Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function
    Mark J Holness
    Queen Mary University of London, Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Bart s and The London, London, United Kingdom
    Nutrition 26:491-501. 2010
    ..Emphasis is placed on the potential importance of the protein deacetylase sirtuin-1 as a central co-ordinator...
  9. ncbi Regulation of vascular endothelial function by procyanidin-rich foods and beverages
    Paul W Caton
    Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
    J Agric Food Chem 58:4008-13. 2010
    ..Future investigations of procyanidin-rich products should assess the role KLF2 induction plays in the beneficial vascular effects of high flavonoid consumption...