Paul W Caton

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. doi request reprint Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Diabetologia 56:1068-77. 2013
  2. doi request reprint Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase
    Paul W Caton
    William Harvey Research Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
    Life Sci 84:738-44. 2009
  3. doi request reprint Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism
    Paul W Caton
    Department of Translational Medicine and Therapeutics, Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK
    J Endocrinol 208:273-83. 2011
  4. doi request reprint Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK
    Diabetologia 54:3083-92. 2011
  5. doi request reprint Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    Paul W Caton
    Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London, UK
    J Endocrinol 205:97-106. 2010
  6. doi request reprint PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
    Paul W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Biochem J 437:521-30. 2011
  7. doi request reprint Regulation of vascular endothelial function by procyanidin-rich foods and beverages
    Paul W Caton
    Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
    J Agric Food Chem 58:4008-13. 2010
  8. doi request reprint PPAR control: it's SIRTainly as easy as PGC
    Mary C Sugden
    Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    J Endocrinol 204:93-104. 2010
  9. doi request reprint Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function
    Mark J Holness
    Queen Mary University of London, Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Bart s and The London, London, United Kingdom
    Nutrition 26:491-501. 2010

Detail Information

Publications9

  1. doi request reprint Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Diabetologia 56:1068-77. 2013
    ..As chronic inflammation and mitochondrial dysfunction are key factors mediating pancreatic beta cell impairment in type 2 diabetes, we investigated the role of SIRT3 in the maintenance of beta cell function and mass in type 2 diabetes...
  2. doi request reprint Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase
    Paul W Caton
    William Harvey Research Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom
    Life Sci 84:738-44. 2009
    ..Previous studies of gluconeogenesis in endotoxemia have focused solely on PCK1. We investigated the relative roles of the two isoforms in hepatic and renal gluconeogenesis in a rat model of endotoxic shock, and in cultured hepatocytes...
  3. doi request reprint Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism
    Paul W Caton
    Department of Translational Medicine and Therapeutics, Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK
    J Endocrinol 208:273-83. 2011
    ..These results highlight the need for a greater understanding of the role of SIRT1 in metabolic regulation and indicate the potential for adverse effects of SIRT1 activators if used therapeutically...
  4. doi request reprint Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
    P W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK
    Diabetologia 54:3083-92. 2011
    ..We hypothesised that altered NAMPT activity might contribute to the suppression of islet function associated with inflammation, and aimed to determine whether NMN could improve cytokine-mediated islet dysfunction...
  5. doi request reprint Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    Paul W Caton
    Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London, UK
    J Endocrinol 205:97-106. 2010
    ..In conclusion, induction of GCN5 and SIRT1 potentially represents a critical mechanism of action of metformin. In addition, these data identify induction of hepatic GCN5 as a potential therapeutic strategy for treatment of T2DM...
  6. doi request reprint PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
    Paul W Caton
    Centre for Diabetes, Blizard Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Biochem J 437:521-30. 2011
    ..In summary, we therefore propose that a LXR-PPARα signalling axis acts as a metabolostatic regulatory mechanism to optimize substrate selection and disposition in skeletal muscle according to metabolic requirement...
  7. doi request reprint Regulation of vascular endothelial function by procyanidin-rich foods and beverages
    Paul W Caton
    Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
    J Agric Food Chem 58:4008-13. 2010
    ..Future investigations of procyanidin-rich products should assess the role KLF2 induction plays in the beneficial vascular effects of high flavonoid consumption...
  8. doi request reprint PPAR control: it's SIRTainly as easy as PGC
    Mary C Sugden
    Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    J Endocrinol 204:93-104. 2010
    ..Finally, we comment on the potential of pharmaceutical manipulation of these targets as well as the possible problems associated with this strategy...
  9. doi request reprint Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function
    Mark J Holness
    Queen Mary University of London, Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Bart s and The London, London, United Kingdom
    Nutrition 26:491-501. 2010
    ..Emphasis is placed on the potential importance of the protein deacetylase sirtuin-1 as a central co-ordinator...