Research Topics
| Deborah AshbySummaryAffiliation: Queen Mary Country: UK Publications
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Detail Information
Publications
Bayesian statistics in medicine: a 25 year reviewDeborah Ashby
Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, Charterhouse Square, London EC1M 6BQ, UK
Stat Med 25:3589-631. 2006....
TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052]Pamela L Cross
Centre for Health Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
BMC Musculoskelet Disord 6:55. 2005..Patient preferences may influence the comparative effectiveness of drugs delivered via different routes...- Managing Injuries of the Neck Trial (MINT): design of a randomised controlled trial of treatments for whiplash associated disordersSarah E Lamb
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
BMC Musculoskelet Disord 8:7. 2007..use of The Whiplash Book versus usual advice when patients first attend the emergency department; 2. referral to physiotherapy versus reinforcement of advice for patients with continuing symptoms at three weeks... - Where's the utility in Bayesian data-monitoring of clinical trials?Deborah Ashby
Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, UK
Clin Trials 2:197-205; discussion 205-8. 2005..A natural statistical framework for evidence-based medicine is a Bayesian approach to decision-making that incorporates an integrated summary of the available evidence and associated uncertainty with assessment of utilities... 
Establishing causality in the assessment of safety of medicines for childrenDeborah Ashby
Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Acta Paediatr 97:1611-6. 2008..Data on safety of medicines in children typically arises from various sources, rendering assessment of causality challenging...- Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference studyMartin Underwood
Centre for Health Sciences, Barts and The London, Queen Mary, University of London, London E1 2AT
BMJ 336:138-42. 2008..To determine whether older patients with chronic knee pain should be advised to use topical or oral non-steroidal anti-inflammatory drugs (NSAIDs)... - A systematic review of pain drawing literature: should pain drawings be used for psychologic screening?Dawn Carnes
Institute of Health Sciences Education, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
Clin J Pain 22:449-57. 2006..We systematically reviewed the literature that directly compared pain drawing scoring systems with measures of psychologic state... - Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis methodSandra M Eldridge
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
Int J Epidemiol 35:1292-300. 2006..This can affect trial power, but standard sample size formulae for these trials ignore this. Previous studies addressing this issue have mostly focused on continuous outcomes or methods that are sometimes difficult to use in practice... - Lessons for cluster randomized trials in the twenty-first century: a systematic review of trials in primary careSandra M Eldridge
Centre for General Practice and Primary Care, Institute of Community Health Sciences, Bar and the London, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
Clin Trials 1:80-90. 2004..There is little recent research on the methodologic quality of cluster randomized trials and none focuses on primary health care where these trials are increasingly common... - Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivityKamaldeep S Bhui
Centre for Psychiatry, Wolson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
BMC Med 9:26. 2011..This paper reports the prevalence of chronic fatigue (CF) and CFS in an ethnically diverse population sample and tests whether prevalence varies by social adversity, social support, physical inactivity, anxiety and depression... - Lack of effect of influenza immunisation on anticoagulant control in patients on long-term warfarinPeter MacCallum
Department of Haematology, Barts and The London NHS Trust, London, UK
Pharmacoepidemiol Drug Saf 16:786-9. 2007..We therefore prospectively evaluated the effect of influenza vaccination on International Normalised Ratio (INR) control in patients on long-term warfarin... - Internal and external validity of cluster randomised trials: systematic review of recent trialsSandra Eldridge
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, London E1 2AT
BMJ 336:876-80. 2008..To assess aspects of the internal validity of recently published cluster randomised trials and explore the reporting of information useful in assessing the external validity of these trials... - A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and copingSokratis Dinos
Centre for Psychiatry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Int J Epidemiol 38:1554-70. 2009..If there are convincing differences in prevalence and risk factors across all or some ethnic groups, investigating the causes of these can help unravel the pathophysiology of CFS... - Thrombosis prevention trial: compliance with warfarin treatment and investigation of a retained effectAlicja R Rudnicka
Department of Environmental and Preventive Medicine, Medical Research Council Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, England
Arch Intern Med 163:1454-60. 2003..This article examines compliance (duration of treatment) with warfarin treatment and whether warfarin has a retained effect... - Smooth muscle cholinergic denervation hypersensitivity in diverticular diseaseMark Golder
Academic Department of Surgery, Barts and the London School of Medicine and Dentistry, Whitechapel, London, UK
Lancet 361:1945-51. 2003..We aimed to investigate the role of smooth muscle and neural cholinergic activity in the pathogenesis of this disease... - Financial incentives to improve adherence to anti-psychotic maintenance medication in non-adherent patients - a cluster randomised controlled trial (FIAT)Stefan Priebe
Unit for Social and Community Psychiatry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Newham Centre for Mental Health, London, UK
BMC Psychiatry 9:61. 2009.... - Informed patient consent to participation in cluster randomized trials: an empirical exploration of trials in primary careSandra M Eldridge
Centre for General Practice and Primary Care, Institute of Community Health Sciences, Queen Mary, University of London, UK
Clin Trials 2:91-8. 2005..A more public debate may clarify the general acceptability of not obtaining consent in certain situations... - Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysisAlicja R Rudnicka
Division of Community Health Sciences, St George s, University of London, UK
Invest Ophthalmol Vis Sci 47:4254-61. 2006..To quantify the variation in primary open-angle glaucoma (OAG) prevalence with age, gender, race, year of publication, and survey methodology... - Oral protein energy supplements for children with cystic fibrosis: CALICO multicentre randomised controlled trialVanessa J Poustie
University of Liverpool Division of Child Health, Royal Liverpool Children's Hospital, Liverpool L12 2AP
BMJ 332:632-6. 2006..Oral protein energy supplements should not be regarded as an essential part of the management of this group of children. TRIAL REGISTRATION: ISRCTN: 95744468... - High prevalence but low impact of data extraction and reporting errors were found in Cochrane systematic reviewsAshley P Jones
Alder Hey Children's Hospital, The University of Liverpool, Institute of Child Health, Eaton Road, Liverpool, L12 2AP, England
J Clin Epidemiol 58:741-2. 2005..CONCLUSIONS: Important errors were identified in a high proportion of reviews. A variety of problems relating to the reporting of results within a review were identified, but these did not lead to substantial changes in any conclusion... - Attenuated Salmonella typhimurium SL3261 as a vaccine vector for recombinant antigen in rabbitsDeborah Ashby
Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada
J Immunol Methods 299:153-64. 2005..ducreyi infection, and is suitable for pre-clinical evaluation of Salmonella vector-based H. ducreyi vaccine antigen candidates... - Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control studyCarlos Martinez
General Practice Research Database Division, Medicines and Healthcare products Regulatory Agency, London SW8 5NQ
BMJ 330:389. 2005..We found some weak evidence of an increased risk of non-fatal self harm for current SSRI use among those aged 18 or younger. However, preferential prescribing of SSRIs to patients at higher risk of suicidal behaviour cannot be ruled out... - Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety reviewDavid Gunnell
Department of Social Medicine, University of Bristol, Bristol BS8 2PR
BMJ 330:385. 2005..To investigate whether selective serotonin reuptake inhibitor (SSRI) antidepressants are associated with an increased risk of suicide related outcomes in adults... - Systematic reviews and lifelong diseasesHeather E Elphick
University of Liverpool Institute of Child Health, Alder Hey Children's Hospital, Liverpool L12 2AP
BMJ 325:381-4. 2002 - Diet and colorectal cancer: an investigation of the lectin/galactose hypothesisRichard C Evans
Department of Medicine, University of Liverpool, England
Gastroenterology 122:1784-92. 2002..This provides further evidence that the association between diet and colon cancer is mediated via specific food components and may explain the discrepant results of studies addressing the protective effects of fiber...