Scott A Akker

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc Clinical Use of Cinacalcet in MEN1 Hyperparathyroidism
    V J Moyes
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Int J Endocrinol 2010:906163. 2010
  2. ncbi request reprint Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexon
    Scott A Akker
    Department of Endocrinology, 5th Floor, King George V Block, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, United Kingdom
    Mol Endocrinol 21:2529-40. 2007
  3. doi request reprint Long-term remission and recurrence rates in Cushing's disease: predictive factors in a single-centre study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, Barts and The London NHS Trust, Barts and the London School of Medicine, London, UK
    Eur J Endocrinol 168:639-48. 2013
  4. pmc Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene
    Umasuthan Srirangalingam
    Department of Endocrinology, William Harvey Research Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    BMC Mol Biol 14:5. 2013
  5. doi request reprint Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours
    Umasuthan Srirangalingam
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Endocr Relat Cancer 16:515-25. 2009
  6. ncbi request reprint Diagnosing unilateral primary aldosteronism - comparison of a clinical prediction score, computed tomography and adrenal venous sampling
    W C Candy Sze
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 81:25-30. 2014
  7. doi request reprint A prospective evaluation of postural stimulation testing, computed tomography and adrenal vein sampling in the differential diagnosis of primary aldosteronism
    Jeshen H G Lau
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 76:182-8. 2012
  8. doi request reprint Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 72:305-11. 2010
  9. doi request reprint The prevalence and characteristic features of cyclicity and variability in Cushing's disease
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Eur J Endocrinol 160:1011-8. 2009
  10. doi request reprint Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers
    Umasuthan Srirangalingam
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, UK
    Clin Endocrinol (Oxf) 69:587-96. 2008

Collaborators

Detail Information

Publications15

  1. pmc Clinical Use of Cinacalcet in MEN1 Hyperparathyroidism
    V J Moyes
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Int J Endocrinol 2010:906163. 2010
    ..Cinacalcet was well tolerated by six patients; one experienced nausea and one experienced diarrhoea. Conclusion. Cinacalcet is an effective and well-tolerated medical treatment for the management of complex primary hyperparathyroidism...
  2. ncbi request reprint Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexon
    Scott A Akker
    Department of Endocrinology, 5th Floor, King George V Block, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, United Kingdom
    Mol Endocrinol 21:2529-40. 2007
    ..Immunoprecipitation experiments with three other pseudoexons suggested that pre-spliceosomal binding of U1 snRNP is a potential general mechanism of suppression of pseudoexons...
  3. doi request reprint Long-term remission and recurrence rates in Cushing's disease: predictive factors in a single-centre study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, Barts and The London NHS Trust, Barts and the London School of Medicine, London, UK
    Eur J Endocrinol 168:639-48. 2013
    ..To investigate the early and late outcomes of patients with Cushing's disease (CD) submitted to a neurosurgical procedure as first-line treatment...
  4. pmc Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene
    Umasuthan Srirangalingam
    Department of Endocrinology, William Harvey Research Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    BMC Mol Biol 14:5. 2013
    ..Due to its length, exon 26 contains multiple pseudo splice sites which are not spliced, but which conform to the degenerate splice site consensus...
  5. doi request reprint Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours
    Umasuthan Srirangalingam
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Endocr Relat Cancer 16:515-25. 2009
    ..VHL-related tumours tend to be adrenal phaeochromocytomas, frequently bilateral and associated with a milder phenotype...
  6. ncbi request reprint Diagnosing unilateral primary aldosteronism - comparison of a clinical prediction score, computed tomography and adrenal venous sampling
    W C Candy Sze
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 81:25-30. 2014
    ..It has been suggested that a recently developed and published clinical prediction score (CPS) may correctly identify some patients as having unilateral disease, without recourse to adrenal venous sampling...
  7. doi request reprint A prospective evaluation of postural stimulation testing, computed tomography and adrenal vein sampling in the differential diagnosis of primary aldosteronism
    Jeshen H G Lau
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 76:182-8. 2012
    ..Various series have reported the utility of postural stimulation testing (PST), cross-sectional imaging and adrenal vein sampling (AVS) in the assessment of PA, but most of these studies were retrospective...
  8. doi request reprint Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 72:305-11. 2010
    ..Mitotane treatment in adrenocortical carcinoma (ACC) results in unreliable measurement of serum total cortisol (TC) levels because of an elevation in corticosteroid-binding globulin (CBG)...
  9. doi request reprint The prevalence and characteristic features of cyclicity and variability in Cushing's disease
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Eur J Endocrinol 160:1011-8. 2009
    ..The aim of the present study was to investigate the prevalence of cyclicity and variability in patients with Cushing's disease, and to identify putative distinctive features...
  10. doi request reprint Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers
    Umasuthan Srirangalingam
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, UK
    Clin Endocrinol (Oxf) 69:587-96. 2008
    ..The aim of this study was to describe the clinical manifestations of subjects with SDH-B gene mutations...
  11. doi request reprint Are serotonin metabolite levels related to bone mineral density in patients with neuroendocrine tumours?
    Piya Sen Gupta
    Department of Endocrinology, Barts and the London School of Medicine, QMUL, London, UK
    Clin Endocrinol (Oxf) 80:246-52. 2014
    ..Evaluation of the relationship between 5-HIAA and BMD in patients with NETs may provide insights into the relationship between serotonin and BMD...
  12. doi request reprint Diagnosis and localisation of insulinoma: the value of modern magnetic resonance imaging in conjunction with calcium stimulation catheterisation
    Maralyn R Druce
    Department of Endocrinology, Barts and the London Medical School, St Bartholomew s Hospital, London, UK
    Eur J Endocrinol 162:971-8. 2010
    ..Preoperative localisation of insulinoma improves cure rate and reduces complications, but may be challenging...
  13. ncbi request reprint Putting some spine into alternative splicing
    Bernard Khoo
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Trends Biotechnol 21:328-30. 2003
    ..Two recent papers show that the defect in splicing of exon 7 of SMN2 is specifically corrected by small synthetic effectors. These new and specific approaches have potential in the treatment of diseases caused by defective splicing...
  14. ncbi request reprint Clinical experience in the screening and management of a large kindred with familial isolated pituitary adenoma due to an aryl hydrocarbon receptor interacting protein (AIP) mutation
    Fred Williams
    Regional Center for Endocrinology and Diabetes F W, S H, A B A, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, United Kingdom Department of Medical Genetics L B, P J M, Belfast Health and Social Care Trust, Belfast BT9 7AB, Northern Ireland, United Kingdom Department of Endocrinology H S C, H L S, S A A, M K, Barts and London School of Medicine, Queen Mary University of London, London EC1A 6BQ, United Kingdom North East Thames Regional Genetics Service A V K, Great Ormond Street Hospital, London WC1N 3JH, United Kingdom Department of Endocrinology S M O, St James University Hospital, Leeds LS9 7TF, United Kingdom Department of Radiology J E, St Bartholomew Hospital, London EC1A 7BE, United Kingdom and Department of Endocrinology N A, Royal Belfast Hospital for Sick Children, Belfast, BT12 6BA, United Kingdom
    J Clin Endocrinol Metab 99:1122-31. 2014
    ..We describe our experience with a large family with R304* AIP mutation and discuss some of the diagnostic dilemmas and management issues...
  15. ncbi request reprint Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors
    Michel Procopiou
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A7BE, UK
    Eur J Endocrinol 161:131-40. 2009
    ..To define the test characteristics of an enzyme immunoassay (EIA) for plasma-free metanephrines (metanephrine and normetanephrine) in the diagnosis of pheochromocytoma and paraganglioma...