Research Topics
Genomes and GenesSpecies | Scott A AkkerSummaryAffiliation: Queen Mary Country: UK Publications
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Publications
Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexonScott A Akker
Department of Endocrinology, 5th Floor, King George V Block, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, United Kingdom
Mol Endocrinol 21:2529-40. 2007..Immunoprecipitation experiments with three other pseudoexons suggested that pre-spliceosomal binding of U1 snRNP is a potential general mechanism of suppression of pseudoexons...
Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumoursUmasuthan Srirangalingam
Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
Endocr Relat Cancer 16:515-25. 2009..VHL-related tumours tend to be adrenal phaeochromocytomas, frequently bilateral and associated with a milder phenotype...- A prospective evaluation of postural stimulation testing, computed tomography and adrenal vein sampling in the differential diagnosis of primary aldosteronismJeshen H G Lau
Department of Endocrinology, St Bartholomew s Hospital, London, UK
Clin Endocrinol (Oxf) 76:182-8. 2012..Various series have reported the utility of postural stimulation testing (PST), cross-sectional imaging and adrenal vein sampling (AVS) in the assessment of PA, but most of these studies were retrospective... - The prevalence and characteristic features of cyclicity and variability in Cushing's diseaseKrystallenia I Alexandraki
Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
Eur J Endocrinol 160:1011-8. 2009..The aim of the present study was to investigate the prevalence of cyclicity and variability in patients with Cushing's disease, and to identify putative distinctive features... - Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot studyKrystallenia I Alexandraki
Department of Endocrinology, St Bartholomew s Hospital, London, UK
Clin Endocrinol (Oxf) 72:305-11. 2010..Mitotane treatment in adrenocortical carcinoma (ACC) results in unreliable measurement of serum total cortisol (TC) levels because of an elevation in corticosteroid-binding globulin (CBG)... - Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriersUmasuthan Srirangalingam
Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, UK
Clin Endocrinol (Oxf) 69:587-96. 2008..The aim of this study was to describe the clinical manifestations of subjects with SDH-B gene mutations... - Diagnosis and localisation of insulinoma: the value of modern magnetic resonance imaging in conjunction with calcium stimulation catheterisationMaralyn R Druce
Department of Endocrinology, Barts and the London Medical School, St Bartholomew s Hospital, London, UK
Eur J Endocrinol 162:971-8. 2010..Preoperative localisation of insulinoma improves cure rate and reduces complications, but may be challenging... - Putting some spine into alternative splicingBernard Khoo
Department of Endocrinology, St Bartholomew's Hospital, London EC1A 7BE, UK
Trends Biotechnol 21:328-30. 2003..Two recent papers show that the defect in splicing of exon 7 of SMN2 is specifically corrected by small synthetic effectors. These new and specific approaches have potential in the treatment of diseases caused by defective splicing... - Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumorsMichel Procopiou
Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A7BE, UK
Eur J Endocrinol 161:131-40. 2009..To define the test characteristics of an enzyme immunoassay (EIA) for plasma-free metanephrines (metanephrine and normetanephrine) in the diagnosis of pheochromocytoma and paraganglioma...