R N Price

Summary

Country: UK

Publications

  1. pmc Plasmodium vivax trophozoites insensitive to chloroquine
    Wesley W Sharrock
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Malar J 7:94. 2008
  2. pmc World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria
    Christopher V Plowe
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 6:121. 2007
  3. pmc The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
    Sue J Lee
    Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 7:149. 2008
  4. pmc Comparison of three molecular methods for the detection and speciation of Plasmodium vivax and Plasmodium falciparum
    Prapaporn Boonma
    Department of Parasitology, Faculty of Public Health, Mahidol University, Bangkok, Thailand
    Malar J 6:124. 2007
  5. pmc A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria
    Stephane Picot
    Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, Lyon, France
    Malar J 8:89. 2009
  6. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
  7. ncbi request reprint Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    Ric N Price
    Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Clin Infect Dis 42:1570-7. 2006
  8. ncbi request reprint Drug resistant falciparum malaria: clinical consequences and strategies for prevention
    R N Price
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
    Drug Resist Updat 4:187-96. 2001
  9. ncbi request reprint Factors contributing to anemia after uncomplicated falciparum malaria
    R N Price
    Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
    Am J Trop Med Hyg 65:614-22. 2001
  10. pmc Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malaria
    R N Price
    Information Health Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, NT 0811, Australia
    Antimicrob Agents Chemother 51:4090-7. 2007

Collaborators

Detail Information

Publications44

  1. pmc Plasmodium vivax trophozoites insensitive to chloroquine
    Wesley W Sharrock
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Malar J 7:94. 2008
    ..vivax clinical isolates suggest that only ring stages (early trophozoites) are sensitive to chloroquine. In this study, the stage specific action of chloroquine was investigated in synchronous cryopreserved isolates of P. vivax...
  2. pmc World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria
    Christopher V Plowe
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 6:121. 2007
    ....
  3. pmc The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
    Sue J Lee
    Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 7:149. 2008
    ..Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other...
  4. pmc Comparison of three molecular methods for the detection and speciation of Plasmodium vivax and Plasmodium falciparum
    Prapaporn Boonma
    Department of Parasitology, Faculty of Public Health, Mahidol University, Bangkok, Thailand
    Malar J 6:124. 2007
    ..PCR assays offer an alternative to microscopy which has been shown to have superior sensitivity and specificity. Unfortunately few comparative studies have been done on the various molecular based speciation methods...
  5. pmc A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria
    Stephane Picot
    Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, Lyon, France
    Malar J 8:89. 2009
    ..The purpose of this systematic review was to determine the risk of treatment failure associated with specific polymorphisms in the parasite genome or gene copy number...
  6. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
    ..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed...
  7. ncbi request reprint Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    Ric N Price
    Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Clin Infect Dis 42:1570-7. 2006
    ..Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)...
  8. ncbi request reprint Drug resistant falciparum malaria: clinical consequences and strategies for prevention
    R N Price
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
    Drug Resist Updat 4:187-96. 2001
    ..These short term measures will need to be accompanied by a longer term strategy to encourage antimalarial drug research and development...
  9. ncbi request reprint Factors contributing to anemia after uncomplicated falciparum malaria
    R N Price
    Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
    Am J Trop Med Hyg 65:614-22. 2001
    ..Children aged < 5 years of age were more likely than older children or adults to become anemic. Coinfection with P. vivax attenuates the anemia of falciparum malaria, presumably by modifying the severity of the infection...
  10. pmc Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malaria
    R N Price
    Information Health Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, NT 0811, Australia
    Antimicrob Agents Chemother 51:4090-7. 2007
    ..Lower plasma piperaquine concentrations and higher failure rates in children suggest that dose revision may be warranted in this age group...
  11. pmc Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison
    A Ratcliff
    International Health Programme, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Lancet 369:757-65. 2007
    ..Our aim was to compare the safety and efficacy of dihydroartemisinin-piperaquine with that of artemether-lumefantrine in patients with uncomplicated malaria caused by multidrug-resistant P falciparum and P vivax...
  12. ncbi request reprint Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria
    R N Price
    Shoklo Malaria Research Unit, Tak Province, Thailand
    Trans R Soc Trop Med Hyg 91:574-7. 1997
    ..This regimen is safe, well tolerated, and highly effective in the treatment of multi-drug resistant falciparum malaria...
  13. ncbi request reprint Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria
    R N Price
    Shoklo Malaria Research Unit, Tak Province, Thailand
    Trans R Soc Trop Med Hyg 89:523-7. 1995
    ..6-5.4]). Mefloquine should no longer be used alone for the treatment of multidrug resistant falciparum malaria in this area. Three-day combination regimens with artesunate or artemether are well tolerated and more effective...
  14. pmc In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax
    R N Price
    Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Antimicrob Agents Chemother 54:5146-50. 2010
    ..vivax and P. falciparum highlights the suitability of the drug as a novel partner for artemisinin-based combination therapy in regions where the two species are coendemic...
  15. doi request reprint Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax
    R Suwanarusk
    International Health Division, Menzies School of Health Research, Darwin, Australia
    J Infect Dis 198:1558-64. 2008
    ..Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia...
  16. ncbi request reprint A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malaria
    M van Vugt
    Shoklo Malaria Research Unit, Mae Sot, Tak Province, Thailand
    Am J Trop Med Hyg 62:65-9. 2000
    ..This study failed to detect any evidence of significant neurotoxicity in patients treated previously with oral artemether or artesunate for acute malaria...
  17. pmc Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia
    A Ratcliff
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
    Trans R Soc Trop Med Hyg 101:351-9. 2007
    ..falciparum and P. vivax exists both to first- and second-line therapies. Preliminary data indicate that amodiaquine retains superior efficacy compared with CQ for CQ-resistant P. vivax...
  18. pmc Determinants of in vitro drug susceptibility testing of Plasmodium vivax
    B Russell
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Antimicrob Agents Chemother 52:1040-5. 2008
    ..vivax and suggest that susceptibility to chloroquine may be associated with variable growth rates. These findings have important implications for the phenotypic and downstream genetic characterization of P. vivax...
  19. ncbi request reprint Artemisinin drugs: novel antimalarial agents
    R N Price
    Centre for Tropical Diseases, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Expert Opin Investig Drugs 9:1815-27. 2000
    ..Artemisinin, artesunate and artemether are well-tolerated in both adults and children, with no evidence to date of serious clinical toxicity...
  20. pmc Artemisinin combination therapy for vivax malaria
    Nicholas M Douglas
    Menzies School of Health Research, Darwin, NT, Australia
    Lancet Infect Dis 10:405-16. 2010
    ..Analyses of the cost-effectiveness of ACTs for both Plasmodium species are needed to assess the role of these drugs in the control and elimination of vivax malaria...
  21. pmc The effect of varying analytical methods on estimates of anti-malarial clinical efficacy
    Wendy J Verret
    Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    Malar J 8:77. 2009
    ..The aim of this study was to quantify the magnitude of the differences between efficacy estimates derived from these approaches and identify the factors underlying these differences...
  22. pmc Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms
    Rossarin Suwanarusk
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    PLoS ONE 2:e1089. 2007
    ..vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined...
  23. pmc Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
    Verena Ilona Carrara
    Shoklo Malaria Research Unit, Tak, Thailand
    PLoS ONE 4:e4551. 2009
    ....
  24. pmc Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Malar J 8:122. 2009
    ..It is not known whether natural exposure to Plasmodium falciparum stimulates HGXPRT T cell reactivity in humans...
  25. doi request reprint Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responses
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Infect Dis 198:134-42. 2008
    ..In cross-sectional and longitudinal studies, we measured MSP5 antibody responses in Papuans with acute Plasmodium falciparum malaria, Plasmodium vivax malaria, and mixed P. falciparum and P. vivax malaria and in those with past exposure...
  26. doi request reprint New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance
    Ric N Price
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Curr Opin Infect Dis 22:430-5. 2009
    ..vivax infection. We review the evidence for severe disease and the spread of drug-resistant P. vivax and speculate how these maybe related...
  27. doi request reprint Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua, Indonesia
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, and Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia
    J Infect Dis 202:109-12. 2010
    ..P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum...
  28. ncbi request reprint Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria
    Oliver T Mytton
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 77:447-50. 2007
    ..At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram...
  29. pmc Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in papua, Indonesia
    Graeme P Maguire
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 192:1966-74. 2005
    ..In patients with severe malaria, acute respiratory distress syndrome usually develops after the start of drug treatment and is a major cause of death. Its pathogenesis is not well understood...
  30. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    ..Clinical trials in SM of adjunctive agents to improve endothelial NO bioavailability, including l-arginine, are warranted...
  31. pmc Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin NT 0810, Australia
    Proc Natl Acad Sci U S A 105:17097-102. 2008
    ..Agents that improve endothelial NO, reduce WPB exocytosis, and/or antagonize Ang-2 may have therapeutic roles in SM...
  32. pmc Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Pathog 6:e1000868. 2010
    ..72) in those with SM. ADMA is increased in SM and associated with decreased vascular and pulmonary NO bioavailability. Inhibition of NOS by ADMA may contribute to increased mortality in severe malaria...
  33. pmc Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Royal Darwin Hospital, Darwin, NT 0811, Australia
    J Infect Dis 200:1522-9. 2009
    ..We examined the relationship of plasma hemoglobin and myoglobin to endothelial dysfunction and disease severity in malaria...
  34. pmc Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation
    Nicholas M Anstey
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT 0811, Australia
    J Infect Dis 195:589-96. 2007
    ..The mechanisms underlying lung injury in vivax malaria are not well understood. Inflammatory responses to Plasmodium falciparum and P. vivax, to our knowledge, have not previously been compared at an organ level...
  35. pmc Improving case definitions for severe malaria
    Nicholas M Anstey
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Med 4:e267. 2007
  36. pmc Vivax malaria: neglected and not benign
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Casuarina, Darwin, Northern Territory 0811, Australia
    Am J Trop Med Hyg 77:79-87. 2007
    ..Without these, vivax malaria will continue to be neglected by ministries of health, policy makers, researchers, and funding bodies...
  37. pmc Safety profile of L-arginine infusion in moderately severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS ONE 3:e2347. 2008
    ..We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in adults with moderately severe malaria...
  38. pmc Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 198:602-8. 2008
    ..L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria...
  39. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia...
  40. ncbi request reprint Improving the availability of artesunate for treatment of severe malaria
    Nicholas M Anstey
    Med J Aust 184:3-4. 2006
  41. ncbi request reprint Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand
    Anne Catrin Uhlemann
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, London, United Kingdom
    J Infect Dis 195:134-41. 2007
    ..We assessed how administration of different antimalarial drugs altered pfmdr1 polymorphism in parasites from patients who experienced treatment failure...
  42. doi request reprint Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trends Parasitol 24:159-63. 2008
    ..Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials...
  43. ncbi request reprint Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
    ..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
  44. pmc Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic
    Jeanne Rini Poespoprodjo
    District Health Authority, School of Health Research National Institute of Health Research and Development Malaria Research Program, Indonesia
    Clin Infect Dis 46:1374-81. 2008
    ..Plasmodium falciparum infection exerts a considerable burden on pregnant women, but less is known about the adverse consequences of Plasmodium vivax infection...