E D Williamson

Summary

Affiliation: Porton Down
Country: UK

Publications

  1. ncbi request reprint A single dose sub-unit vaccine protects against pneumonic plague
    E D Williamson
    DERA Chemical and Biological Defence Sector, Porton Down, Wiltshire SP4 0JQ, Salisbury, UK
    Vaccine 19:566-71. 2000
  2. pmc Human immune response to a plague vaccine comprising recombinant F1 and V antigens
    E D Williamson
    Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Infect Immun 73:3598-608. 2005
  3. ncbi request reprint Immunisation against plague by transcutaneous and intradermal application of subunit antigens
    J E Eyles
    Biomedical Sciences, Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 22:4365-73. 2004
  4. pmc Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization
    J Hill
    Microbiology, CBD Porton Down, Salisbury, Wiltshire, United Kingdom
    Infect Immun 65:4476-82. 1997
  5. ncbi request reprint Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague
    E D Williamson
    Dstl Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 25:1142-8. 2007
  6. ncbi request reprint Protective efficacy of a fully recombinant plague vaccine in the guinea pig
    S M Jones
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 21:3912-8. 2003
  7. pmc Immunogenicity of recombinant protective antigen and efficacy against aerosol challenge with anthrax
    E D Williamson
    Defence Science and Technology Laboratory Porton Down, Salisbury, Wilts SP4 0JQ, United Kingdom
    Infect Immun 73:5978-87. 2005
  8. ncbi request reprint A biocompatible microdevice for core body temperature monitoring in the early diagnosis of infectious disease
    E D Williamson
    Dstl Porton Down, Salisbury, Wilts, UK, SP4 0JQ
    Biomed Microdevices 9:51-60. 2007
  9. ncbi request reprint Mouse model characterisation for anthrax vaccine development: comparison of one inbred and one outbred mouse strain
    H C Flick-Smith
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    Microb Pathog 38:33-40. 2005
  10. ncbi request reprint Immunogenicity of the rF1+rV vaccine for plague with identification of potential immune correlates
    E D Williamson
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wilts UK SP4 0JQ, UK
    Microb Pathog 42:11-21. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint A single dose sub-unit vaccine protects against pneumonic plague
    E D Williamson
    DERA Chemical and Biological Defence Sector, Porton Down, Wiltshire SP4 0JQ, Salisbury, UK
    Vaccine 19:566-71. 2000
    ..The enhanced protective efficacy of this sub-unit vaccine administered as a single dose compared with an existing vaccine has been demonstrated in an outbred animal model of pneumonic plague...
  2. pmc Human immune response to a plague vaccine comprising recombinant F1 and V antigens
    E D Williamson
    Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Infect Immun 73:3598-608. 2005
    ..Potential serological immune correlates of protection have been investigated, but no trends specific to vaccination could be detected in cellular markers...
  3. ncbi request reprint Immunisation against plague by transcutaneous and intradermal application of subunit antigens
    J E Eyles
    Biomedical Sciences, Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 22:4365-73. 2004
    ..These data suggest that transcutaneous immunisation may be a simple and non-invasive method for immunising individuals against plague...
  4. pmc Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization
    J Hill
    Microbiology, CBD Porton Down, Salisbury, Wiltshire, United Kingdom
    Infect Immun 65:4476-82. 1997
    ....
  5. ncbi request reprint Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague
    E D Williamson
    Dstl Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 25:1142-8. 2007
    ....
  6. ncbi request reprint Protective efficacy of a fully recombinant plague vaccine in the guinea pig
    S M Jones
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 21:3912-8. 2003
    ..Cross-protection of the mouse with guinea pig IgG suggests that the recognition of neutralising epitopes in the F1 and V proteins is conserved between these two species...
  7. pmc Immunogenicity of recombinant protective antigen and efficacy against aerosol challenge with anthrax
    E D Williamson
    Defence Science and Technology Laboratory Porton Down, Salisbury, Wilts SP4 0JQ, United Kingdom
    Infect Immun 73:5978-87. 2005
    ..anthracis. These data provide some preliminary evidence for the existence of immune correlates of protection against anthrax infection in rhesus macaques immunized with rPA...
  8. ncbi request reprint A biocompatible microdevice for core body temperature monitoring in the early diagnosis of infectious disease
    E D Williamson
    Dstl Porton Down, Salisbury, Wilts, UK, SP4 0JQ
    Biomed Microdevices 9:51-60. 2007
    ....
  9. ncbi request reprint Mouse model characterisation for anthrax vaccine development: comparison of one inbred and one outbred mouse strain
    H C Flick-Smith
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    Microb Pathog 38:33-40. 2005
    ..An assessment of protection in the TO mouse against aerosol challenge with the fully virulent strain of B. anthracis, Ames, was also made...
  10. ncbi request reprint Immunogenicity of the rF1+rV vaccine for plague with identification of potential immune correlates
    E D Williamson
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wilts UK SP4 0JQ, UK
    Microb Pathog 42:11-21. 2007
    ..Serum samples from representative macaques within this time period also inhibited the Yersinia-mediated cytotoxicity of J774 macrophages in a qualitative in vitro assay of type three secretion...
  11. ncbi request reprint Immunological aspects of polymer microsphere vaccine delivery systems
    J E Eyles
    Biomedical Sciences, Dstl, Porton Downs, Salisbury, UK
    J Drug Target 11:509-14. 2003
    ..These data support the tenet that microencapsulation serves to modify the uptake, trafficking and processing of antigens...
  12. ncbi request reprint Vaccine development for potential bioterrorism agents
    R W Titball
    Defence Science and Technology Laboratory, Porton Down, Salisbury, UK
    Curr Drug Targets Infect Disord 3:255-62. 2003
    ..The prospects for the development of a new generation of bioterrorism vaccines which exploit these technologies are reviewed in this manuscript...
  13. doi request reprint Plague
    E D Williamson
    Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 27:D56-60. 2009
    ..This paper reviews the progress towards an improved vaccine for plague and assesses the likely impact of a prophylactic vaccine for bubonic and pneumonic plague...
  14. ncbi request reprint Protection against plague following immunisation with microencapsulated V antigen is reduced by co-encapsulation with IFN-gamma or IL-4, but not IL-6
    K F Griffin
    Dstl Biomedical Sciences, Porton Down, Salisbury, SP4 0JQ, Wiltshire, UK
    Vaccine 20:3650-7. 2002
    ..pestis strain GB; however protective efficacy was impaired by co-encapsulating either IFN-gamma or IL-4 with rV...
  15. ncbi request reprint Co-immunisation with a plasmid DNA cocktail primes mice against anthrax and plague
    E D Williamson
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 OJQ, UK
    Vaccine 20:2933-41. 2002
    ..pestis compared with priming only with plasmid DNA encoding the V antigen and boosting with rV. This enhancement may be due to the effect of CpG motifs known to be present in the plasmid DNA construct encoding PA...
  16. ncbi request reprint Stimulation of spleen cells in vitro by nanospheric particles containing antigen
    J E Eyles
    Dstl, Porton Down, SP4 0JQ, Salisbury, UK
    J Control Release 86:25-32. 2003
    ..This mechanism is likely to be distinct from non-specific effects caused by components of the delivery vehicle itself...
  17. pmc The fraction 1 and V protein antigens of Yersinia pestis activate dendritic cells to induce primary T cell responses
    R Kingston
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
    Clin Exp Immunol 149:561-9. 2007
    ..This study suggests an important role for DC, or factors secreted by them, in the induction of protective immunity to plague by the rF1 and rV antigens...
  18. ncbi request reprint An aroA mutant of Yersinia pestis is attenuated in guinea-pigs, but virulent in mice
    P C Oyston
    Chemical and Biological Defence Establishment, Salisbury, Wiltshire, UK
    Microbiology 142:1847-53. 1996
    ..Unusually for an aro-defective mutant, the Y. pestis aroA mutant was virulent in mice, with a median dose which induced morbidity of death similar to that of the wild-type, although time to death was significantly prolonged...
  19. ncbi request reprint Tissue distribution of radioactivity following intranasal administration of radioactive microspheres
    J E Eyles
    Pharmaceutical Sciences, Life and Health Sciences, Aston University, Birmingham, UK
    J Pharm Pharmacol 53:601-7. 2001
    ..This effect may contribute to the effectiveness of pulmonary delivered antigen-loaded microparticles as humoral immunogens...
  20. ncbi request reprint Passive transfer of protection against Bacillus anthracis infection in a murine model
    R J Beedham
    Pathobiology, CBD, DERA Porton Down, Salisbury, SP4 0JQ, Wiltshire, UK
    Vaccine 19:4409-16. 2001
    ..The results demonstrated that an antibody response maybe important in protection against B. anthracis infection, under the conditions tested. The results provide further data for the development of an improved anthrax vaccine...
  21. ncbi request reprint Distribution of productive antigen-processing activity for MHC class II presentation in macrophages
    A von Delwig
    Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    Scand J Immunol 62:243-50. 2005
    ..The data suggest that endosomal compartments expressing Rab5 guanosine triphosphatase can productively process protein antigens for presentation by mature MHC class II molecules...
  22. ncbi request reprint Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration
    J E Eyles
    DERA (Chemical and Biological Defence Sector, Porton Down, Wiltshire SP4 OJQ, Salisbury, UK
    Vaccine 19:4732-42. 2001
    ....
  23. ncbi request reprint Molecular variation between the alpha-toxins from the type strain (NCTC 8237) and clinical isolates of Clostridium perfringens associated with disease in man and animals
    A Ginter
    Division Immunologie Animale, Centre d Economie Rurale, Marloie, Belgium
    Microbiology 142:191-8. 1996
    ..The changes in amino acid sequence did not affect the ability of a C-terminal domain vaccine, derived from the alpha-toxin of strain NCTC 8237, to induce protection against the alpha-toxin from a bovine enteric strain of C. perfringens...
  24. pmc Macromolecular organization of the Yersinia pestis capsular F1 antigen: insights from time-of-flight mass spectrometry
    M A Tito
    Oxford Centre for Molecular Sciences, New Chemistry Laboratory, Oxford, OX1 3QT, United Kingdom
    Protein Sci 10:2408-13. 2001
    ..More generally, the data show that the symmetry and packing of macromolecular complexes can be determined solely from mass spectrometry, without any prior knowledge of higher order structure..
  25. pmc Probing molecular interactions in intact antibody: antigen complexes, an electrospray time-of-flight mass spectrometry approach
    M A Tito
    Oxford Centre for Molecular Sciences, New Chemistry Laboratory, Oxford OX1 3QT, United Kingdom
    Biophys J 81:3503-9. 2001
    ..More generally this work demonstrates a rapid means of assessing antigen subunit interactions as well as the stoichiometry and specificity of binding in antibody-antigen complexes...
  26. ncbi request reprint Vaccines against dangerous pathogens
    E D Williamson
    Dstl, Chemical and Biological Sciences, Porton Down, Salisbury, UK
    Br Med Bull 62:163-73. 2002
    ..Emphasis is also placed on the derivation of surrogate markers of efficacy and a demonstration that these correlate with protection in the animal model...