Richard J Thomas

Summary

Affiliation: Porton Down
Country: UK

Publications

  1. pmc Particle size and pathogenicity in the respiratory tract
    Richard James Thomas
    Defence Science and Technology Laboratories Dstl Salisbury, Wiltshire, UK
    Virulence 4:847-58. 2013
  2. pmc Particle-size dependent effects in the Balb/c murine model of inhalational melioidosis
    Richard J Thomas
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Salisbury Wiltshire, UK
    Front Cell Infect Microbiol 2:101. 2012
  3. doi request reprint Influence of particle size on the pathology and efficacy of vaccination in a murine model of inhalational anthrax
    Richard Thomas
    Defence, Science and Technology Laboratory Dstl, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 59:1415-27. 2010
  4. pmc Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols
    Richard J Thomas
    Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP40JQ, United Kingdom
    Infect Immun 77:1315-23. 2009
  5. pmc Characterization and deposition of respirable large- and small-particle bioaerosols
    Richard J Thomas
    Defence Science and Technology Laboratory, Salisbury, Wiltshire, United Kingdom
    Appl Environ Microbiol 74:6437-43. 2008
  6. pmc Receptor mimicry as novel therapeutic treatment for biothreat agents
    Richard J Thomas
    Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire UK
    Bioeng Bugs 1:17-30. 2010
  7. ncbi request reprint Structural modification of a base disaccharide alters antiadhesion properties towards Yersinia pestis
    Richard J Thomas
    Defence, Science and Technology Laboratories Dstl, Wiltshire, UK
    FEMS Immunol Med Microbiol 49:410-4. 2007
  8. ncbi request reprint Attachment of Yersinia pestis to human respiratory cell lines is inhibited by certain oligosaccharides
    Richard Thomas
    Defence, Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 55:309-15. 2006
  9. ncbi request reprint Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogens
    Richard Thomas
    Defence Science and Technology Laboratories Dstl, Biomedical Sciences, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 53:833-40. 2004
  10. pmc The cell membrane as a major site of damage during aerosolization of Escherichia coli
    Richard J Thomas
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Appl Environ Microbiol 77:920-5. 2011

Collaborators

Detail Information

Publications15

  1. pmc Particle size and pathogenicity in the respiratory tract
    Richard James Thomas
    Defence Science and Technology Laboratories Dstl Salisbury, Wiltshire, UK
    Virulence 4:847-58. 2013
    ..The olfactory, gastrointestinal, and ophthalmic systems are also infected in a pathogen-dependent manner. The relevant literature is reviewed with respect to particle size and infection of the URT in animal models and humans. ..
  2. pmc Particle-size dependent effects in the Balb/c murine model of inhalational melioidosis
    Richard J Thomas
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Salisbury Wiltshire, UK
    Front Cell Infect Microbiol 2:101. 2012
    ..However, both treatment regimes exhibited significant relapse when therapy was discontinued with massive enlargement and abscessation of the lungs, spleen, and cervical lymph nodes observed...
  3. doi request reprint Influence of particle size on the pathology and efficacy of vaccination in a murine model of inhalational anthrax
    Richard Thomas
    Defence, Science and Technology Laboratory Dstl, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 59:1415-27. 2010
    ..anthracis infections arising from the inhalation of 1 and 12 μm particle aerosols, providing 73-80% survival under a suboptimum immunization schedule...
  4. pmc Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols
    Richard J Thomas
    Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP40JQ, United Kingdom
    Infect Immun 77:1315-23. 2009
    ..Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols...
  5. pmc Characterization and deposition of respirable large- and small-particle bioaerosols
    Richard J Thomas
    Defence Science and Technology Laboratory, Salisbury, Wiltshire, United Kingdom
    Appl Environ Microbiol 74:6437-43. 2008
    ..The aerosols generated by the Collison nebulizer and the FFAG differ with respect to mass distribution, distribution of the entrapped particulates, bacterial survival, and deposition within the murine respiratory tract...
  6. pmc Receptor mimicry as novel therapeutic treatment for biothreat agents
    Richard J Thomas
    Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire UK
    Bioeng Bugs 1:17-30. 2010
    ..A cocktail of multivalent oligosaccharides based on the minimal binding structures of identified adhesins would offer the best candidates for anti-adhesion therapy...
  7. ncbi request reprint Structural modification of a base disaccharide alters antiadhesion properties towards Yersinia pestis
    Richard J Thomas
    Defence, Science and Technology Laboratories Dstl, Wiltshire, UK
    FEMS Immunol Med Microbiol 49:410-4. 2007
    ..The data indicate that targeted modification of receptor ligands could offer a novel therapeutic preventing Y. pestis attachment to host cells...
  8. ncbi request reprint Attachment of Yersinia pestis to human respiratory cell lines is inhibited by certain oligosaccharides
    Richard Thomas
    Defence, Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 55:309-15. 2006
    ..Disaccharides such as GalNAcbeta1-3Gal and GalNAcbeta1-4Gal were also good inhibitors, particularly for the RPMI-2650 cell line. This demonstrates the potential of oligosaccharides as potential anti-adhesion therapeutics...
  9. ncbi request reprint Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogens
    Richard Thomas
    Defence Science and Technology Laboratories Dstl, Biomedical Sciences, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 53:833-40. 2004
    ..Burkholderia pseudomallei attachment was particularly susceptible to oligosaccharide inhibition. Combinations of such compounds may serve as a novel generic therapeutics for respiratory tract infections...
  10. pmc The cell membrane as a major site of damage during aerosolization of Escherichia coli
    Richard J Thomas
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Appl Environ Microbiol 77:920-5. 2011
    ..The results indicate that the physiology of an aerosolized bacterium is linked to the method of aerosol generation and may affect the interpretation of a range of aerobiological phenomenon...
  11. ncbi request reprint Oligosaccharide receptor mimics inhibit Legionella pneumophila attachment to human respiratory epithelial cells
    Richard J Thomas
    Defence, Science and Technology Laboratories, Biomedical Sciences, CBS Porton Down, Salisbury, Wiltshire
    Microb Pathog 36:83-92. 2004
    ..The identified compounds have the potential to be used as novel treatments for Legionnaire's disease...
  12. pmc A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo
    Angela E Essex-Lopresti
    Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Infect Immun 73:1260-4. 2005
    ..A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence...
  13. ncbi request reprint 2-phenylimidazopyridines, a new series of Golgi compounds with potent antiviral activity
    Homayon Banie
    Avanir Pharmaceuticals, 101 Enterprise, Aliso Viejo, CA 92656, USA
    J Med Chem 50:5984-93. 2007
    ..These agents may provide an alternative antiviral approach, particularly for treating resistant strains...
  14. ncbi request reprint Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergy
    Mark L Richards
    Avanir Pharmaceuticals, 11388 Sorrento Valley Road, San Diego, CA 92121, USA
    Eur J Med Chem 41:950-69. 2006
    ..The broad profile of these compounds thus underscores their potential for treating the multifarious pathology of asthma...
  15. ncbi request reprint Synthesis and NMR studies of (13)C-labeled vitamin D metabolites
    William H Okamura
    Department of Chemistry, University of California, Riverside, California 92521, USA
    J Org Chem 67:1637-50. 2002
    ....