Helen Mumford

Summary

Affiliation: Porton Down
Country: UK

Publications

  1. doi request reprint Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning
    Helen Mumford
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Chem Biol Interact 203:160-6. 2013
  2. ncbi request reprint A novel approach to assessing percutaneous VX poisoning in the conscious guinea-pig
    Helen Mumford
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
    J Appl Toxicol 28:694-702. 2008
  3. doi request reprint Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig
    Helen Mumford
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Chem Biol Interact 187:304-8. 2010
  4. doi request reprint Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs
    Helen Mumford
    Department of Biomedical Sciences, Dstl, Porton Down, Salisbury, UK
    Clin Toxicol (Phila) 49:287-97. 2011
  5. pmc Post-exposure therapy with recombinant human BuChE following percutaneous VX challenge in guinea-pigs
    Helen Mumford
    Physiology, Pharmacology and Behaviour Team, Biomedical Sciences Department, Building 4, Dstl Porton Down, Salisbury SP40JQ, UK
    Toxicol Lett 206:29-34. 2011
  6. ncbi request reprint Development of next generation medical countermeasures to nerve agent poisoning
    Janet Wetherell
    Biomedical Sciences Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Toxicology 233:120-7. 2007
  7. ncbi request reprint A novel approach for medical countermeasures to nerve agent poisoning in the guinea-pig
    Janet Wetherell
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Neurotoxicology 27:485-91. 2006

Detail Information

Publications7

  1. doi request reprint Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning
    Helen Mumford
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Chem Biol Interact 203:160-6. 2013
    ....
  2. ncbi request reprint A novel approach to assessing percutaneous VX poisoning in the conscious guinea-pig
    Helen Mumford
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
    J Appl Toxicol 28:694-702. 2008
    ..Future studies will use this model to assess the benefit of administering medical countermeasures in response to a defined decrease in heart rate...
  3. doi request reprint Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig
    Helen Mumford
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Chem Biol Interact 187:304-8. 2010
    ..Post-exposure therapy is a promising additional indication for the concept of use of this material, and one that has particular relevance in a civilian exposure scenario...
  4. doi request reprint Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs
    Helen Mumford
    Department of Biomedical Sciences, Dstl, Porton Down, Salisbury, UK
    Clin Toxicol (Phila) 49:287-97. 2011
    ..The opportunity for post-exposure treatment may have particular relevance in civilian settings, and this is a promising indication for the use of huBuChE...
  5. pmc Post-exposure therapy with recombinant human BuChE following percutaneous VX challenge in guinea-pigs
    Helen Mumford
    Physiology, Pharmacology and Behaviour Team, Biomedical Sciences Department, Building 4, Dstl Porton Down, Salisbury SP40JQ, UK
    Toxicol Lett 206:29-34. 2011
    ..g. seizure, bradycardia and hypothermia) observed in control animals. The opportunity for post-exposure treatment may have utility in both civilian and military scenarios, and this is a promising indication for the use of a bioscavenger...
  6. ncbi request reprint Development of next generation medical countermeasures to nerve agent poisoning
    Janet Wetherell
    Biomedical Sciences Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Toxicology 233:120-7. 2007
    ..These studies will now be extended to include other agents and will be taken forward to studies in non-human primates where the incidence of intussusception will be closely monitored...
  7. ncbi request reprint A novel approach for medical countermeasures to nerve agent poisoning in the guinea-pig
    Janet Wetherell
    Biomedical Sciences Department, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Neurotoxicology 27:485-91. 2006
    ....