Stephen L Michell

Summary

Affiliation: Porton Down
Country: UK

Publications

  1. ncbi The MPB83 antigen from Mycobacterium bovis contains O-linked mannose and (1-->3)-mannobiose moieties
    Stephen L Michell
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    J Biol Chem 278:16423-32. 2003
  2. ncbi The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens
    Rebecca M Thomas
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom
    Infect Immun 75:371-8. 2007
  3. ncbi A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112
    Timothy S Milne
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 56:1268-76. 2007
  4. ncbi Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis
    Anna Lena Forslund
    Department of Medical Countermeasures, Division of NBC Defence, Swedish Defence Research Agency, Umea
    Mol Microbiol 59:1818-30. 2006
  5. ncbi An intracellularly inducible gene involved in virulence and polyphosphate production in Francisella
    Mark I Richards
    Microbiology, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 57:1183-92. 2008

Collaborators

Detail Information

Publications5

  1. ncbi The MPB83 antigen from Mycobacterium bovis contains O-linked mannose and (1-->3)-mannobiose moieties
    Stephen L Michell
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    J Biol Chem 278:16423-32. 2003
    ..Given such a possibility characterization of mycobacterial glycoproteins is a step toward understanding their functional role and elucidating the mechanisms of mycobacterial glycosylation...
  2. ncbi The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens
    Rebecca M Thomas
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom
    Infect Immun 75:371-8. 2007
    ..The O antigen of F. tularensis subsp. tularensis appeared to be important for intracellular survival whereas the O antigen of F. novicida appeared to be critical for serum resistance and less important for intracellular survival...
  3. ncbi A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112
    Timothy S Milne
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 56:1268-76. 2007
    ..Furthermore, the deltaFTT0025 mutant was attenuated in a BALB/c mouse model of infection relative to wild-type F. tularensis subsp. novicida U112...
  4. ncbi Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis
    Anna Lena Forslund
    Department of Medical Countermeasures, Division of NBC Defence, Swedish Defence Research Agency, Umea
    Mol Microbiol 59:1818-30. 2006
    ..Our findings indicate that this putative pilin is critical for Francisella infections that occur via peripheral routes...
  5. ncbi An intracellularly inducible gene involved in virulence and polyphosphate production in Francisella
    Mark I Richards
    Microbiology, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 57:1183-92. 2008
    ..The mutants exhibited defects for intracellular growth in macrophages and were attenuated in mice, indicating a key role for the putative polyphosphate kinase in the virulence of Francisella...