Stephen L Michell
Affiliation: Porton Down
- The MPB83 antigen from Mycobacterium bovis contains O-linked mannose and (1-->3)-mannobiose moietiesStephen L Michell
TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
J Biol Chem 278:16423-32. 2003..Given such a possibility characterization of mycobacterial glycoproteins is a step toward understanding their functional role and elucidating the mechanisms of mycobacterial glycosylation...
- The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigensRebecca M Thomas
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom
Infect Immun 75:371-8. 2007..The O antigen of F. tularensis subsp. tularensis appeared to be important for intracellular survival whereas the O antigen of F. novicida appeared to be critical for serum resistance and less important for intracellular survival...
- A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112Timothy S Milne
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 56:1268-76. 2007..Furthermore, the deltaFTT0025 mutant was attenuated in a BALB/c mouse model of infection relative to wild-type F. tularensis subsp. novicida U112...
- Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensisAnna Lena Forslund
Department of Medical Countermeasures, Division of NBC Defence, Swedish Defence Research Agency, Umea
Mol Microbiol 59:1818-30. 2006..Our findings indicate that this putative pilin is critical for Francisella infections that occur via peripheral routes...
- An intracellularly inducible gene involved in virulence and polyphosphate production in FrancisellaMark I Richards
Microbiology, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
J Med Microbiol 57:1183-92. 2008..The mutants exhibited defects for intracellular growth in macrophages and were attenuated in mice, indicating a key role for the putative polyphosphate kinase in the virulence of Francisella...