Research Topics
| Jim HillSummaryAffiliation: Porton Down Country: UK Publications
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Detail Information
Publications
Administration of antibody to the lung protects mice against pneumonic plagueJim Hill
Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
Infect Immun 74:3068-70. 2006..These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague...- Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestisJim Hill
Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
Infect Immun 71:2234-8. 2003..Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague... 
N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infectionJim Hill
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Vaccine 27:7073-9. 2009..3 protects by binding to LcrV(Ype) and interfering with protein-protein interactions necessary for type three secretion...- A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivoAngela E Essex-Lopresti
Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
Infect Immun 73:1260-4. 2005..A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence... 
Identification of outer membrane proteins of Yersinia pestis through biotinylationSophie J Smither
Dstl, Porton Down, Room 201 Bldg 7a, Salisbury, Wilts, SP4 OJQ, UK
J Microbiol Methods 68:26-31. 2007..Tagged proteins were visualised through streptavidin probing of Western blots. Seven biotinylated proteins of Y. pestis were identified including two porins and the putative virulence factor catalase peroxidase...- Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunityJim E Eyles
Biomedical Sciences Department, Dstl, Porton Down, Wiltshire SP4 0JQ, UK
Vaccine 25:7301-6. 2007..pestis: intradermal injection might therefore be considered as a potential minimally invasive method of plague vaccine administration. These data have implications for the design of therapeutic strategies against plague infection... - Small protective fragments of the Yersinia pestis V antigenClaire Vernazza
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
Vaccine 27:2775-80. 2009..pestis in mice was determined. The smallest protective fragment of V antigen identified comprised amino acids 135-262. Finally the ability of this fragment to confer protection when given in the context of a DNA vaccine was confirmed... - Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosisMark P Stevens
Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, UK
Microbiology 150:2669-76. 2004..Mice inoculated with the B. pseudomallei bipD mutant were partially protected against subsequent challenge with wild-type B. pseudomallei. However, immunization of mice with purified BipD protein was not protective... - The weak interaction of LcrV and TLR2 does not contribute to the virulence of Yersinia pestisDagmar Reithmeier-Rost
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Lehrstuhl Bakteriologie, Pettenkoferstrasse 9a, 80336 Munchen, Germany
Microbes Infect 9:997-1002. 2007..The low TLR2-activity of Y. pestis LcrV and associated cytokine expression might explain why - in contrast to Y. enterocolitica O:8 infection - TLR2-deficient mice are not more resistant than wild-type mice in a bubonic plague model... - Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domainsDaniel G Lawton
Department of Biological Sciences, Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College of Science, Technology and Medicine, London SW7 2AY, United Kingdom
J Biol Chem 277:38714-22. 2002.... - A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulenceAndreas Sing
Lehrstuhl Bakteriologie, Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Pettenkoferstrasse 9a, 80336 Munich, Germany
Proc Natl Acad Sci U S A 102:16049-54. 2005..LcrV is a defined bacterial virulence factor shown to target the TLR system for evasion of the host's immune response...