Helen S Garmory

Summary

Affiliation: Porton Down
Country: UK

Publications

  1. ncbi The effect of recombinant plasmids on in vivo colonisation of Salmonella enterica serovar Typhimurium strains is not reflected by in vitro cellular invasion assays
    Helen S Garmory
    Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 20:3239-43. 2002
  2. ncbi Salmonella vaccines for use in humans: present and future perspectives
    Helen S Garmory
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    FEMS Microbiol Rev 26:339-53. 2002
  3. ncbi DNA vaccines for biodefence
    Helen S Garmory
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK
    Adv Drug Deliv Rev 57:1343-61. 2005
  4. ncbi Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella
    Helen S Garmory
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Porton Down, SP4 0JQ, Salisbury, UK
    Microb Pathog 34:115-9. 2003
  5. ncbi Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague
    Helen S Garmory
    Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 21:3051-7. 2003
  6. ncbi ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies
    Helen S Garmory
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 72:6757-63. 2004
  7. ncbi The use of live attenuated bacteria as a delivery system for heterologous antigens
    Helen S Garmory
    Department of Biomedical Sciences, Salisbury, UK
    J Drug Target 11:471-9. 2003
  8. ncbi Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the Yersinia pestis V antigen
    Helen S Garmory
    Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 22:947-57. 2004
  9. ncbi A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice
    Margaret Morton
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 22:2524-32. 2004
  10. ncbi Antibiotic-free plasmid stabilization by operator-repressor titration for vaccine delivery by using live Salmonella enterica Serovar typhimurium
    Helen S Garmory
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, United Kingdom
    Infect Immun 73:2005-11. 2005

Collaborators

Detail Information

Publications17

  1. ncbi The effect of recombinant plasmids on in vivo colonisation of Salmonella enterica serovar Typhimurium strains is not reflected by in vitro cellular invasion assays
    Helen S Garmory
    Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 20:3239-43. 2002
    ....
  2. ncbi Salmonella vaccines for use in humans: present and future perspectives
    Helen S Garmory
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    FEMS Microbiol Rev 26:339-53. 2002
    ..In many cases, the problems associated with expression of antigens in Salmonella have been successfully addressed and the future of Salmonella vaccine development is very promising...
  3. ncbi DNA vaccines for biodefence
    Helen S Garmory
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK
    Adv Drug Deliv Rev 57:1343-61. 2005
    ..These advantages make DNA vaccination a promising approach for the development of vaccines for biodefence. In this review, the potential of DNA vaccines for biodefence is discussed...
  4. ncbi Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella
    Helen S Garmory
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Porton Down, SP4 0JQ, Salisbury, UK
    Microb Pathog 34:115-9. 2003
    ..These results suggest that the mechanism needs to be further elucidated in order to rationally improve the system...
  5. ncbi Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague
    Helen S Garmory
    Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 21:3051-7. 2003
    ....
  6. ncbi ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies
    Helen S Garmory
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 72:6757-63. 2004
  7. ncbi The use of live attenuated bacteria as a delivery system for heterologous antigens
    Helen S Garmory
    Department of Biomedical Sciences, Salisbury, UK
    J Drug Target 11:471-9. 2003
    ..In this review, these strategies and their use in the development of a delivery system for the Yersinia pestis V antigen are described...
  8. ncbi Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the Yersinia pestis V antigen
    Helen S Garmory
    Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 22:947-57. 2004
    ..In addition, the protection achieved could be increased by using a 'prime and boost' strategy, administering the DNA vaccine followed by recombinant V antigen. These results show promise for a DNA vaccine against plague...
  9. ncbi A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice
    Margaret Morton
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 22:2524-32. 2004
    ..Thus, the results demonstrate that attenuated strains of S. enterica serovar Typhi which express Y. pestis F1 antigen may be developed to provide an oral vaccine against plague suitable for use in humans...
  10. ncbi Antibiotic-free plasmid stabilization by operator-repressor titration for vaccine delivery by using live Salmonella enterica Serovar typhimurium
    Helen S Garmory
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, United Kingdom
    Infect Immun 73:2005-11. 2005
    ..This technology can easily be used to convert any suitable attenuated strain to an antibiotic-free ORT strain for recombinant protein vaccine delivery in humans...
  11. ncbi Efficacy of DNA vaccines expressing the type F botulinum toxin Hc fragment using different promoters
    Amit P Jathoul
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 22:3942-6. 2004
    ..The results from this study indicate that the selection of promoter used in DNA vaccination studies may be of importance in designing optimised vaccines...
  12. ncbi Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge
    Helen S Garmory
    Defence Science and Technology Laboratory, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 71:3831-6. 2003
    ..These mice were protected against intraperitoneal challenge with 100 or 1,000 50% lethal doses of B. anthracis strain STI. This work contributes to the development of a Salmonella-based orally delivered anthrax vaccine...
  13. ncbi An association between ATP binding cassette systems, genome sizes and lifestyles of bacteria
    David N Harland
    Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK
    Res Microbiol 156:434-42. 2005
    ..Furthermore, the distribution of the ABC systems into families indicates that the process of reductive evolution is responsible for retaining particular types of ABC systems as bacteria adapt to particular niches...
  14. ncbi Vaccination against type F botulinum toxin using attenuated Salmonella enterica var Typhimurium strains expressing the BoNT/F H(C) fragment
    Susan Foynes
    Department of Biological Sciences, Centre for Molecular Microbiology, Imperial College for Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, UK
    Vaccine 21:1052-9. 2003
    ..These results demonstrate the feasibility of an orally delivered vaccine against botulinum toxin type F...
  15. ncbi Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: evidence for transcriptional regulation of the beta2-toxin-encoding gene
    Ben Harrison
    Department of Microbiology, Oregon State University, 220 Nash Hall, Corvallis, OR 97331, USA
    Appl Environ Microbiol 71:8362-70. 2005
    ..Collectively, our present results suggest that CPB2 merits further study as an accessory toxin in C. perfringens-associated SD...
  16. ncbi Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets
    Michael Waters
    Department of Microbiology, Oregon State University, Corvallis, Oregon 9731, USA
    J Clin Microbiol 41:3584-91. 2003
    ..Collectively, our present results support a significant association between CPB2-positive C. perfringens isolates and diarrhea in piglets...
  17. ncbi Regulated expression of the beta2-toxin gene (cpb2) in Clostridium perfringens type a isolates from horses with gastrointestinal diseases
    Michael Waters
    Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
    J Clin Microbiol 43:4002-9. 2005
    ..perfringens cell and that decreased transcription and/or message instability may be involved, at least in part, in the low CPB2 production noted for horse GI disease isolates in comparison to that noted for pig GI disease isolate CWC245...