Stephen J Elvin

Summary

Affiliation: Porton Down
Country: UK

Publications

  1. ncbi request reprint Role for mucosal immune responses and cell-mediated immune functions in protection from airborne challenge with Venezuelan equine encephalitis virus
    Stephen J Elvin
    Defence Science and Technology Laboratories, Chemical and Biological Sciences, Porton Down, Salisbury, Wiltshire, United Kingdom
    J Med Virol 67:384-93. 2002
  2. ncbi request reprint Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague
    Stephen J Elvin
    Defence Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
    Microb Pathog 37:177-84. 2004
  3. ncbi request reprint Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine
    Stephen J Elvin
    Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 24:4433-9. 2006
  4. pmc Protection against heterologous Burkholderia pseudomallei strains by dendritic cell immunization
    Stephen J Elvin
    Biomedical Sciences, Dstl Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 74:1706-11. 2006
  5. pmc Administration of antibody to the lung protects mice against pneumonic plague
    Jim Hill
    Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
    Infect Immun 74:3068-70. 2006
  6. ncbi request reprint Immunological responses after immunisation of mice with microparticles containing antigen and single stranded RNA (polyuridylic acid)
    Angie Westwood
    Building 7A, Dstl, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 24:1736-43. 2006
  7. pmc Humoral and cell-mediated adaptive immune responses are required for protection against Burkholderia pseudomallei challenge and bacterial clearance postinfection
    Gareth D Healey
    Host Pathogen Analysis, Bldg 7A, Rm 201, Dstl, Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 73:5945-51. 2005
  8. ncbi request reprint Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection
    Stephen J Elvin
    Defence Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
    Nature 430:417. 2004
  9. pmc Antibiotic-free plasmid stabilization by operator-repressor titration for vaccine delivery by using live Salmonella enterica Serovar typhimurium
    Helen S Garmory
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, United Kingdom
    Infect Immun 73:2005-11. 2005
  10. pmc The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection
    Mikio Tanabe
    Division of Cell and Molecular Biology, Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 74:3687-91. 2006

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Role for mucosal immune responses and cell-mediated immune functions in protection from airborne challenge with Venezuelan equine encephalitis virus
    Stephen J Elvin
    Defence Science and Technology Laboratories, Chemical and Biological Sciences, Porton Down, Salisbury, Wiltshire, United Kingdom
    J Med Virol 67:384-93. 2002
    ..This implies that cell-mediated immune functions are required for protection against airborne challenge with virulent VEEV...
  2. ncbi request reprint Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague
    Stephen J Elvin
    Defence Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
    Microb Pathog 37:177-84. 2004
    ..It appears therefore that type 1 immune mechanisms, activated following Stat 4 phosphorylation, are essential in protection against plague...
  3. ncbi request reprint Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine
    Stephen J Elvin
    Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 24:4433-9. 2006
    ..Microencapsulation of these vaccine antigens has the added advantage that controlled release of the antigens occurs in vivo, so that protective immunity can be induced after only a single immunising dose...
  4. pmc Protection against heterologous Burkholderia pseudomallei strains by dendritic cell immunization
    Stephen J Elvin
    Biomedical Sciences, Dstl Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 74:1706-11. 2006
    ..These results show that a vaccine strategy that actively targets dendritic cells can evoke protective immune responses...
  5. pmc Administration of antibody to the lung protects mice against pneumonic plague
    Jim Hill
    Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
    Infect Immun 74:3068-70. 2006
    ..These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague...
  6. ncbi request reprint Immunological responses after immunisation of mice with microparticles containing antigen and single stranded RNA (polyuridylic acid)
    Angie Westwood
    Building 7A, Dstl, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 24:1736-43. 2006
    ..05). These data demonstrate, for the first time, that appropriately formulated ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses...
  7. pmc Humoral and cell-mediated adaptive immune responses are required for protection against Burkholderia pseudomallei challenge and bacterial clearance postinfection
    Gareth D Healey
    Host Pathogen Analysis, Bldg 7A, Rm 201, Dstl, Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 73:5945-51. 2005
    ..These results indicate the importance of both cell-mediated and humoral immune mechanisms in protection against intracellular pathogens...
  8. ncbi request reprint Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection
    Stephen J Elvin
    Defence Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
    Nature 430:417. 2004
    ..pestis by Ccr5-deficient macrophages in vitro. Our results indicate that the role of Ccr5 in Y. pestis infection may therefore be more complex than previously thought...
  9. pmc Antibiotic-free plasmid stabilization by operator-repressor titration for vaccine delivery by using live Salmonella enterica Serovar typhimurium
    Helen S Garmory
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, United Kingdom
    Infect Immun 73:2005-11. 2005
    ..This technology can easily be used to convert any suitable attenuated strain to an antibiotic-free ORT strain for recombinant protein vaccine delivery in humans...
  10. pmc The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection
    Mikio Tanabe
    Division of Cell and Molecular Biology, Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 74:3687-91. 2006
    ..When the immunized mice were challenged with Y. pestis, the OppA-immunized mice showed an increased time to death compared to other groups, and protection appeared to correlate with the level of immunoglobulin G antibody to OppA...
  11. ncbi request reprint The weak interaction of LcrV and TLR2 does not contribute to the virulence of Yersinia pestis
    Dagmar Reithmeier-Rost
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Lehrstuhl Bakteriologie, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    Microbes Infect 9:997-1002. 2007
    ..The low TLR2-activity of Y. pestis LcrV and associated cytokine expression might explain why - in contrast to Y. enterocolitica O:8 infection - TLR2-deficient mice are not more resistant than wild-type mice in a bubonic plague model...