Porton Down

Summary

Organization: Porton Down
Country: UK

Top Publications

  1. doi Predicting conserved essential genes in bacteria: in silico identification of putative drug targets
    Melanie Duffield
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Mol Biosyst 6:2482-9. 2010
  2. pmc Influence of environmental stress on distributions of times to first division in Escherichia coli populations, as determined by digital-image analysis of individual cells
    Gordon W Niven
    School of Food Biosciences, The University of Reading, P O Box 226, Whiteknights, Reading RG6 6AP, United Kingdom
    Appl Environ Microbiol 74:3757-63. 2008
  3. ncbi The use of doxycycline as a protectant against sulphur mustard in HaCaT cells
    Christopher D Lindsay
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Appl Toxicol 28:665-73. 2008
  4. ncbi Polysaccharides and virulence of Burkholderia pseudomallei
    M Sarkar-Tyson
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 56:1005-10. 2007
  5. ncbi Francisella tularensis genomics and proteomics
    Richard W Titball
    Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK
    Ann N Y Acad Sci 1105:98-121. 2007
  6. ncbi Structural modification of a base disaccharide alters antiadhesion properties towards Yersinia pestis
    Richard J Thomas
    Defence, Science and Technology Laboratories Dstl, Wiltshire, UK
    FEMS Immunol Med Microbiol 49:410-4. 2007
  7. ncbi Inhibition of multiple strains of Venezuelan equine encephalitis virus by a pool of four short interfering RNAs
    Lyn O'Brien
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Antiviral Res 75:20-9. 2007
  8. ncbi Development of methods to measure humoral immune responses against selected antigens in the common marmoset (Callithrix jacchus) and the effect of pyridostigmine bromide administration
    Gareth D Griffiths
    Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, UK
    Int Immunopharmacol 6:1755-64. 2006
  9. ncbi Development of next generation medical countermeasures to nerve agent poisoning
    Janet Wetherell
    Biomedical Sciences Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Toxicology 233:120-7. 2007
  10. ncbi Analysis of the sulphur mustard metabolites thiodiglycol and thiodiglycol sulphoxide in urine using isotope-dilution gas chromatography-ion trap tandem mass spectrometry
    James Riches
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 845:114-20. 2007

Detail Information

Publications62

  1. doi Predicting conserved essential genes in bacteria: in silico identification of putative drug targets
    Melanie Duffield
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Mol Biosyst 6:2482-9. 2010
    ..Identification of essential proteins common in diverse bacterial genera can then be used to facilitate the selection of effective targets for novel broad-spectrum antibiotics...
  2. pmc Influence of environmental stress on distributions of times to first division in Escherichia coli populations, as determined by digital-image analysis of individual cells
    Gordon W Niven
    School of Food Biosciences, The University of Reading, P O Box 226, Whiteknights, Reading RG6 6AP, United Kingdom
    Appl Environ Microbiol 74:3757-63. 2008
    ..Relative division times were greater for heat-stressed cells than for those growing under osmotic stress...
  3. ncbi The use of doxycycline as a protectant against sulphur mustard in HaCaT cells
    Christopher D Lindsay
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Appl Toxicol 28:665-73. 2008
    ..The specific value of protease inhibitors in this capacity remains to be determined...
  4. ncbi Polysaccharides and virulence of Burkholderia pseudomallei
    M Sarkar-Tyson
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 56:1005-10. 2007
    ..However, immunization with killed polysaccharide mutant strains conferred different degrees of protection, demonstrating the immunological importance of the polysaccharide clusters on the surface of B. pseudomallei...
  5. ncbi Francisella tularensis genomics and proteomics
    Richard W Titball
    Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK
    Ann N Y Acad Sci 1105:98-121. 2007
    ..These proteins might be exploited as components of vaccines or diagnostic systems...
  6. ncbi Structural modification of a base disaccharide alters antiadhesion properties towards Yersinia pestis
    Richard J Thomas
    Defence, Science and Technology Laboratories Dstl, Wiltshire, UK
    FEMS Immunol Med Microbiol 49:410-4. 2007
    ..The data indicate that targeted modification of receptor ligands could offer a novel therapeutic preventing Y. pestis attachment to host cells...
  7. ncbi Inhibition of multiple strains of Venezuelan equine encephalitis virus by a pool of four short interfering RNAs
    Lyn O'Brien
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Antiviral Res 75:20-9. 2007
    ....
  8. ncbi Development of methods to measure humoral immune responses against selected antigens in the common marmoset (Callithrix jacchus) and the effect of pyridostigmine bromide administration
    Gareth D Griffiths
    Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, UK
    Int Immunopharmacol 6:1755-64. 2006
    ..The killed whole cell plague vaccine induced a response which was at the limit of detection of the assay. Coadministered PB had no discernable effect on immunological responses in this study...
  9. ncbi Development of next generation medical countermeasures to nerve agent poisoning
    Janet Wetherell
    Biomedical Sciences Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Toxicology 233:120-7. 2007
    ..These studies will now be extended to include other agents and will be taken forward to studies in non-human primates where the incidence of intussusception will be closely monitored...
  10. ncbi Analysis of the sulphur mustard metabolites thiodiglycol and thiodiglycol sulphoxide in urine using isotope-dilution gas chromatography-ion trap tandem mass spectrometry
    James Riches
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 845:114-20. 2007
    ..Levels of thiodiglycol were 1 and 3 ng/ml, which increased to 78 and 104 ng/ml after treatment of the urine with titanium trichloride...
  11. pmc Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei
    Caroline A Rowland
    Biomedical Sciences, Dstl, Porton Down, Salisbury, SP4 0JQ, United Kingdom
    Infect Immun 74:5333-40. 2006
    ..Our data show that B. mallei is susceptible to cell-mediated immune responses which promote expression of type 1 cytokines. This suggests that development of effective vaccines against glanders should target the production of IFN-gamma...
  12. ncbi Identification of outer membrane proteins of Yersinia pestis through biotinylation
    Sophie J Smither
    Dstl, Porton Down, Room 201 Bldg 7a, Salisbury, Wilts, SP4 OJQ, UK
    J Microbiol Methods 68:26-31. 2007
    ..Tagged proteins were visualised through streptavidin probing of Western blots. Seven biotinylated proteins of Y. pestis were identified including two porins and the putative virulence factor catalase peroxidase...
  13. ncbi Multiple vaccine and pyridostigmine interactions: effects on EEG and sleep in the common marmoset
    K E Williams
    Dstl Biomedical Sciences Department, Porton Down, Salisbury, SP4 0JQ, UK
    Pharmacol Biochem Behav 84:282-93. 2006
    ..Where statistical differences were detected between treatments, the magnitudes of the difference were relatively minor and therefore not regarded as having long term biological significance...
  14. ncbi Multiple vaccine and pyridostigmine interactions: effects on cognition, muscle function and health outcomes in marmosets
    D Stevens
    Dstl Biomedical Sciences, Porton Down, Salisbury, SP4 0JQ, UK
    Pharmacol Biochem Behav 84:207-18. 2006
    ..These changes were transient in nature and their magnitude were minor and, in consequence, was not regarded as having long-term biological significance...
  15. doi A review of biosensors and biologically-inspired systems for explosives detection
    Richard G Smith
    Bldg S18, DSTL Fort Halstead, Sevenoaks, Kent, UK
    Analyst 133:571-84. 2008
    ....
  16. pmc Experimental respiratory anthrax infection in the common marmoset (Callithrix jacchus)
    Mark S Lever
    Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire, UK
    Int J Exp Pathol 89:171-9. 2008
    ..13 x 10(3) spores in the cynomolgus macaque. This suggests that the common marmoset is an appropriate alternative NHP and will be used for the evaluation of medical countermeasures against respiratory anthrax infection...
  17. doi The skin reservoir of sulphur mustard
    I J Hattersley
    Dstl Biomedical Sciences Department, Biomedical Systems, Dstl Porton Down, Salisbury, Wiltshire, UK
    Toxicol In Vitro 22:1539-46. 2008
    ..The extractable reservoir was at least 20 times the amount required per cm(2) estimated to cause a response in all of the human population, as defined by studies carried out in human volunteers during the 1940s...
  18. pmc Liposomal delivery of p-ialB and p-omp25 DNA vaccines improves immunogenicity but fails to provide full protection against B. melitensis challenge
    Nicola J Commander
    Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Genet Vaccines Ther 8:5. 2010
    ..The present study was undertaken to further understand the immune response generated by the protective vaccination regimens and to evaluate cationic liposome adsorption as a delivery method to improve vaccine utility...
  19. pmc Bioavailability and efficacy of levofloxacin against Francisella tularensis in the common marmoset (Callithrix jacchus)
    Michelle Nelson
    Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Antimicrob Agents Chemother 54:3922-6. 2010
    ..The marmoset appears to be an appropriate animal model for the evaluation of postexposure therapies...
  20. pmc Characterization of lethal inhalational infection with Francisella tularensis in the common marmoset (Callithrix jacchus)
    Michelle Nelson
    Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 59:1107-13. 2010
    ....
  21. doi History and perspectives of bioanalytical methods for chemical warfare agent detection
    Robin M Black
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1207-15. 2010
    ..The concern for terrorist use of CW agents has stimulated the development of higher throughput analytical methods in support of homeland security...
  22. pmc Development of a novel monoclonal antibody with reactivity to a wide range of Venezuelan equine encephalitis virus strains
    Lyn M O'Brien
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
    Virol J 6:206. 2009
    ..However, to be truly effective, the antibody should recognise multiple strains of VEEV and broadly reactive monoclonal antibodies are rarely and only coincidentally isolated using classical hybridoma technology...
  23. doi Francisella virulence: significant advances, ongoing challenges and unmet needs
    Petra C F Oyston
    Biomedical Sciences, Dstl Porton Down, Salisbury, UK
    Expert Rev Vaccines 8:1575-85. 2009
    ..Better animal models to more accurately represent human responses to infection are also required...
  24. pmc Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell
    Riccardo D'Elia
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    BMC Genomics 10:492. 2009
    ..The S isolate survives to chronicity within the C57BL/6 host whereas E and J are expelled prior to reaching fecundity. How the S isolate survives so successfully in its host is unclear...
  25. doi Francisella tularensis vaccines
    Petra C F Oyston
    Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
    Vaccine 27:D48-51. 2009
    ..Alternative approaches to produce subunit vaccines and defined attenuated strains are also in progress. However, the limitations of animal models may make licensing a candidate vaccine challenging...
  26. doi Inflammatory gene expression in response to sub-lethal ricin exposure in Balb/c mice
    Jonathan David
    Immunotoxicology Group, Biology, Biomedical Sciences, Defence Science and Technology Laboratory, Salisbury, Wiltshire, SP4 0JQ, UK
    Toxicology 264:119-30. 2009
    ..This work was conducted as part of a wider programme of work to compare a number of militarily relevant lung damaging agents, with a view to establishing a rational basis for the identification of more generic medical countermeasures...
  27. pmc Improved efficacy of a gene optimised adenovirus-based vaccine for venezuelan equine encephalitis virus
    Amanda J Williams
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK
    Virol J 6:118. 2009
    ..We have applied this to an adenovirus (ad)-based vaccine encoding structural proteins (E3-E2-6K) of Venezuelan equine encephalitis virus (VEEV)...
  28. pmc Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols
    Richard J Thomas
    Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP40JQ, United Kingdom
    Infect Immun 77:1315-23. 2009
    ..Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols...
  29. pmc Characterization and deposition of respirable large- and small-particle bioaerosols
    Richard J Thomas
    Defence Science and Technology Laboratory, Salisbury, Wiltshire, United Kingdom
    Appl Environ Microbiol 74:6437-43. 2008
    ..The aerosols generated by the Collison nebulizer and the FFAG differ with respect to mass distribution, distribution of the entrapped particulates, bacterial survival, and deposition within the murine respiratory tract...
  30. ncbi A proactive approach to the coagulopathy of trauma: the rationale and guidelines for treatment
    E Kirkman
    Defence Science and Technology Laboratory, Porron Down, Salisbury 5P4 0JQ, UK
    J R Army Med Corps 153:302-6. 2007
  31. ncbi Closed cup vapor systems in percutaneous exposure studies: what is the dose?
    Christopher H Dalton
    Dstl Biomedical Sciences, CBD Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom
    J Anal Toxicol 30:165-70. 2006
    ..15 cm2 and 740 +/- 224 mg/m3 for a surface area of 2.54 cm2). The assumption that SVC gives an acceptable measure of the Ct was shown to be valid by comparison with sulfur mustard recovered from the skin...
  32. ncbi The pathogen Pseudomonas aeruginosa negatively affects the attraction response of the nematode Caenorhabditis elegans to bacteria
    Thomas R Laws
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 OJQ, UK
    Microb Pathog 40:293-7. 2006
    ..P. aeruginosa strain PA14 cells that had been killed by UV light, or which had been exposed to chloramphenicol, did not mediate this effect. We therefore propose that C. elegans reacts to a factor produced by P. aeruginosa strain PA14...
  33. ncbi A guinea pig hippocampal slice model of organophosphate-induced seizure activity
    Patrick K Harrison
    Biomedical Sciences, Dstl, Bldg 04, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Pharmacol Exp Ther 310:678-86. 2004
    ....
  34. ncbi Identification of proteins in the exosporium of Bacillus anthracis
    Caroline Redmond
    Defence Science Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Microbiology 150:355-63. 2004
    ..CotY, ExsY and CotB are homologues of Bacillus subtilis outer spore coat proteins, but ExsF and ExsK are specific to B. anthracis and other members of the Bacillus cereus group...
  35. ncbi Oligosaccharide receptor mimics inhibit Legionella pneumophila attachment to human respiratory epithelial cells
    Richard J Thomas
    Defence, Science and Technology Laboratories, Biomedical Sciences, CBS Porton Down, Salisbury, Wiltshire
    Microb Pathog 36:83-92. 2004
    ..The identified compounds have the potential to be used as novel treatments for Legionnaire's disease...
  36. ncbi Vaccine development for potential bioterrorism agents
    R W Titball
    Defence Science and Technology Laboratory, Porton Down, Salisbury, UK
    Curr Drug Targets Infect Disord 3:255-62. 2003
    ..The prospects for the development of a new generation of bioterrorism vaccines which exploit these technologies are reviewed in this manuscript...
  37. ncbi Derivatisation reactions in the chromatographic analysis of chemical warfare agents and their degradation products
    Robin M Black
    J Chromatogr A 1000:253-81. 2003
    ..This review focuses on derivatisation reactions used in the chromatographic analysis of chemical warfare agents, their degradation products and metabolites...
  38. ncbi A new model for laser-induced thermal damage in the retina
    S J Till
    Defence Science and Technology Laboratory, Room PE206, Dstl St Andrews Road, Malvern, Worcestershire WR14 3PS, UK
    Bull Math Biol 65:731-46. 2003
    ..The work will also help minimize the need for further animal experimentation to set laser eye safety standards...
  39. ncbi Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice
    Patrick K Harrison
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Wiltshire, Salisbury SP4 0JQ, UK
    Eur J Pharmacol 471:97-104. 2003
    ..These data suggest that partial adenosine A(1) receptor agonists, which have fewer cardiovascular effects, should be further evaluated in vivo as potential treatments for organophosphate poisoning...
  40. ncbi Expression of heterologous O-antigen in Yersinia pestis KIM does not affect virulence by the intravenous route
    P C F Oyston
    Microbiology, Dstl, CBS Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 52:289-94. 2003
    ..Assays showed no alteration in the ability of Y. pestis to resist lysis by cationic antimicrobial peptides, serum or polymyxin...
  41. ncbi Antibody and interleukin-12 treatment in murine models of encephalitogenic flavivirus (St. Louis encephalitis, tick-borne encephalitis) and alphavirus (Venezuelan equine encephalitis) infection
    R J Phillpotts
    Dstl Porton Down, Wiltshire SP4 OJQ, England
    J Interferon Cytokine Res 23:47-50. 2003
    ..These data confirm the need to fully understand the pathogenesis of viral infection before cytokine intervention may be employed as a broad-spectrum antiviral therapy...
  42. ncbi Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella
    Helen S Garmory
    Department of Biomedical Sciences, Dstl Chemical and Biological Sciences, Porton Down, SP4 0JQ, Salisbury, UK
    Microb Pathog 34:115-9. 2003
    ..These results suggest that the mechanism needs to be further elucidated in order to rationally improve the system...
  43. ncbi Yersinia: an update
    Petra C F Oyston
    Dstl Porton Down, Salisbury, Wiltshire, UK SP4 0JQ
    Trends Microbiol 10:550-1. 2002
    ..The 8th International Symposium on Yersinia was held in Turku, Finland, 4-8 September 2002...
  44. ncbi Evaluation of barrier creams against sulphur mustard. I. In vitro studies using human skin
    Robert P Chilcott
    Dstl Biomedical Sciences, Porton Down, Salisbury, UK
    Skin Pharmacol Appl Skin Physiol 15:225-35. 2002
    ..These data indicate that (1) perceived conditions of use, (2) compatibility with existing protective equipment and (3) the rate and extent of SM skin absorption must all be taken into account when evaluating barrier creams in vitro...
  45. ncbi Role for mucosal immune responses and cell-mediated immune functions in protection from airborne challenge with Venezuelan equine encephalitis virus
    Stephen J Elvin
    Defence Science and Technology Laboratories, Chemical and Biological Sciences, Porton Down, Salisbury, Wiltshire, United Kingdom
    J Med Virol 67:384-93. 2002
    ..This implies that cell-mediated immune functions are required for protection against airborne challenge with virulent VEEV...
  46. ncbi Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the Yersinia pestis V antigen
    Helen S Garmory
    Dstl Chemical and Biological Sciences, Porton Down, Salisbury SP4 0JQ, UK
    Vaccine 22:947-57. 2004
    ..In addition, the protection achieved could be increased by using a 'prime and boost' strategy, administering the DNA vaccine followed by recombinant V antigen. These results show promise for a DNA vaccine against plague...
  47. ncbi Yersinia pestis (plague) vaccines
    Richard W Titball
    Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
    Expert Opin Biol Ther 4:965-73. 2004
    ..Of these, an injected subunit vaccine is likely to offer the best near-term solution to the provision of a vaccine that protects against both bubonic and pneumonic plague...
  48. ncbi The use of live attenuated bacteria as a delivery system for heterologous antigens
    Helen S Garmory
    Department of Biomedical Sciences, Salisbury, UK
    J Drug Target 11:471-9. 2003
    ..In this review, these strategies and their use in the development of a delivery system for the Yersinia pestis V antigen are described...
  49. pmc Administration of antibody to the lung protects mice against pneumonic plague
    Jim Hill
    Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
    Infect Immun 74:3068-70. 2006
    ..These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague...
  50. ncbi A non-invasive method for studying an index of pupil diameter and visual performance in the rhesus monkey
    Sarah J Fairhall
    Dstl Biomedical Sciences, Porton Down, Salisbury, UK
    J Med Primatol 35:67-77. 2006
    ....
  51. ncbi Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine
    Stephen J Elvin
    Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 24:4433-9. 2006
    ..Microencapsulation of these vaccine antigens has the added advantage that controlled release of the antigens occurs in vivo, so that protective immunity can be induced after only a single immunising dose...
  52. ncbi Attachment of Yersinia pestis to human respiratory cell lines is inhibited by certain oligosaccharides
    Richard Thomas
    Defence, Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 55:309-15. 2006
    ..Disaccharides such as GalNAcbeta1-3Gal and GalNAcbeta1-4Gal were also good inhibitors, particularly for the RPMI-2650 cell line. This demonstrates the potential of oligosaccharides as potential anti-adhesion therapeutics...
  53. ncbi A dam mutant of Yersinia pestis is attenuated and induces protection against plague
    Victoria L Robinson
    Defence Science and Technology Laboratory, Biomedical Sciences, Salisbury, Wilts, UK
    FEMS Microbiol Lett 252:251-6. 2005
    ..These results confirm the key role of Dam in the regulation of virulence, and its potential role as a target for the generation of attenuated strains of pathogenic bacteria...
  54. ncbi Gas gangrene: an open and closed case
    Richard W Titball
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    Microbiology 151:2821-8. 2005
  55. pmc Immunogenicity of recombinant protective antigen and efficacy against aerosol challenge with anthrax
    E D Williamson
    Defence Science and Technology Laboratory Porton Down, Salisbury, Wilts SP4 0JQ, United Kingdom
    Infect Immun 73:5978-87. 2005
    ..anthracis. These data provide some preliminary evidence for the existence of immune correlates of protection against anthrax infection in rhesus macaques immunized with rPA...
  56. pmc Human immune response to a plague vaccine comprising recombinant F1 and V antigens
    E D Williamson
    Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
    Infect Immun 73:3598-608. 2005
    ..Potential serological immune correlates of protection have been investigated, but no trends specific to vaccination could be detected in cellular markers...
  57. ncbi A simple method for assessing muscle function in common marmosets
    D J Stevens
    Biomedical Sciences Department, Dstl Porton Down, Salisbury SP4 0JQ, UK
    Lab Anim 39:162-8. 2005
    ..Over a 4-5 month period, 38 of 42 animals were successfully trained to displace weights of up to 920 g (mean 612+/-20 g). Performance, following initial training, was stable and independent of gender or body weight...
  58. ncbi An association between ATP binding cassette systems, genome sizes and lifestyles of bacteria
    David N Harland
    Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK
    Res Microbiol 156:434-42. 2005
    ..Furthermore, the distribution of the ABC systems into families indicates that the process of reductive evolution is responsible for retaining particular types of ABC systems as bacteria adapt to particular niches...
  59. ncbi VP22 enhances antibody responses from DNA vaccines but not by intercellular spread
    Stuart D Perkins
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 OJQ, UK
    Vaccine 23:1931-40. 2005
    ..These data suggest that amplification of the immune response may occur via mechanisms other than VP22-mediated intercellular spread of antigen...
  60. ncbi Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine
    Kate Griffin
    Defence Science and Technology Laboratories, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    FEMS Immunol Med Microbiol 43:425-30. 2005
    ..This finding might have implications when considering the co-administration of other vaccine combinations...
  61. ncbi Optimisation of solvent desorption conditions for chemical warfare agent and simulant compounds from Porapak Q using experimental design. I. Methyl salicylate and di(propylene glycol) monomethyl ether
    Bob Muir
    Defence Science and Technology Laboratory, Building 383b, Porton Down, Salisbury SP4 OJQ, England, UK
    J Chromatogr A 1038:183-7. 2004
    ..Atmospheric detection limits for both simulants were estimated to be 0.2 mg m(-3) allowing the trace analysis of these compounds by gas chromatography with flame ionisation detection (GC-FID)...
  62. ncbi A liquid-based method for the assessment of bacterial pathogenicity using the nematode Caenorhabditis elegans
    Martin P Smith
    Dstl, Chemical and Biological Sciences, Porton Down, Salisbury SP4 OJQ, UK
    FEMS Microbiol Lett 210:181-5. 2002
    ..Using this assay,P. aeruginosa PA01 inhibited the feeding of C. elegans mutant phm-2. Such liquid-based feeding assays are ideally suited to the high-throughput screening of mutants of bacterial pathogens...