Hannah J Welters

Summary

Affiliation: Peninsula Medical School
Country: UK

Publications

  1. doi request reprint The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway
    Hannah J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, UK
    J Endocrinol 197:543-52. 2008
  2. pmc Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells
    Eleftheria Diakogiannaki
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, John Bull Building, Plymouth, Devon, UK
    J Endocrinol 194:283-91. 2007
  3. doi request reprint Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids
    Eleftheria Diakogiannaki
    Peninsula Medical School, Institute of Biomedical and Clinical Science, John Bull Building, Plymouth PL6 8BU, UK
    J Endocrinol 197:553-63. 2008
  4. doi request reprint The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells
    Noel G Morgan
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK
    Biochem Soc Trans 36:905-8. 2008
  5. doi request reprint Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways
    Anna Kaminski
    Institute of Biomedical and Clinical Science, John Bull Building, Peninsula Medical School, Plymouth, Devon PL6 8BU, UK
    Biosci Rep 30:169-75. 2010
  6. ncbi request reprint Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells
    Hannah J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, Research Way, Plymouth, Devon PL6 8BU, UK
    J Endocrinol 190:171-81. 2006
  7. ncbi request reprint Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate
    Hannah J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Devon, Research Way, Plymouth, PL6 8BU, UK
    Apoptosis 11:1231-8. 2006

Collaborators

Detail Information

Publications7

  1. doi request reprint The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway
    Hannah J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, UK
    J Endocrinol 197:543-52. 2008
    ..We conclude that PTP-BL plays an important role in the regulation of cell cycle progression in pancreatic beta-cells, and that it interacts functionally with components of the Wnt signalling pathway...
  2. pmc Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells
    Eleftheria Diakogiannaki
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, John Bull Building, Plymouth, Devon, UK
    J Endocrinol 194:283-91. 2007
    ..The results suggest that monounsaturated fatty acids can promote cell viability and mitogenesis by a mechanism that does not require their metabolism and is independent of alterations in TAG formation...
  3. doi request reprint Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids
    Eleftheria Diakogiannaki
    Peninsula Medical School, Institute of Biomedical and Clinical Science, John Bull Building, Plymouth PL6 8BU, UK
    J Endocrinol 197:553-63. 2008
    ..This effect is antagonised by monounsaturates that may exert their anti-apoptotic actions by regulating the activity of one or more kinase enzymes involved in mediating the phosphorylation of eIF2 alpha...
  4. doi request reprint The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells
    Noel G Morgan
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK
    Biochem Soc Trans 36:905-8. 2008
    ..The present review explores the differential effects of these various fatty acids on beta-cell viability and considers the possible mechanisms involved in cytoprotection by mono-unsaturates...
  5. doi request reprint Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways
    Anna Kaminski
    Institute of Biomedical and Clinical Science, John Bull Building, Peninsula Medical School, Plymouth, Devon PL6 8BU, UK
    Biosci Rep 30:169-75. 2010
    ..These findings may have implications for future therapeutic strategies for the management of diabetes...
  6. ncbi request reprint Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells
    Hannah J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, Research Way, Plymouth, Devon PL6 8BU, UK
    J Endocrinol 190:171-81. 2006
    ....
  7. ncbi request reprint Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate
    Hannah J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Devon, Research Way, Plymouth, PL6 8BU, UK
    Apoptosis 11:1231-8. 2006
    ....