M N Weedon

Summary

Affiliation: Peninsula Medical School
Country: UK

Publications

  1. pmc Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Am J Hum Genet 80:1150-61. 2007
  2. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
  3. pmc Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans
    Giriraj R Chandak
    Genome Research Group, Centre for Cellular and Molecular Biology, Hyderabad, India
    BMC Med Genet 7:76. 2006
  4. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
  5. doi request reprint Reaching new heights: insights into the genetics of human stature
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, Magdalen Road, Exeter, EX1 2LU, UK
    Trends Genet 24:595-603. 2008
  6. ncbi request reprint The importance of TCF7L2
    M N Weedon
    Peninsula Medical School, Exeter, UK
    Diabet Med 24:1062-6. 2007
  7. ncbi request reprint Insights on pathogenesis of type 2 diabetes from MODY genetics
    Michael N Weedon
    Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, Peninsula Medical School, St Lukes Campus, Magdalen Road, Exeter EX1 2LU, UK
    Curr Diab Rep 7:131-8. 2007
  8. pmc Type 2 diabetes risk alleles are associated with reduced size at birth
    Rachel M Freathy
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 58:1428-33. 2009
  9. pmc Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
    Michael N Weedon
    Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
    PLoS Med 3:e374. 2006
  10. pmc Circulating beta-carotene levels and type 2 diabetes-cause or effect?
    J R B Perry
    Peninsula Medical School, Exeter, UK
    Diabetologia 52:2117-21. 2009

Detail Information

Publications57

  1. pmc Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Am J Hum Genet 80:1150-61. 2007
    ..In conclusion, we have identified the first type 2 diabetes-susceptibility allele to be reproducibly associated with birth weight. Common gene variants can substantially influence normal birth-weight variation...
  2. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  3. pmc Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans
    Giriraj R Chandak
    Genome Research Group, Centre for Cellular and Molecular Biology, Hyderabad, India
    BMC Med Genet 7:76. 2006
    ..There are few studies of these variants in South Asians. We investigated whether the two APOA5 variants also show similar association with various lipid parameters in Indian population as in the UK white subjects...
  4. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
    ..We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population...
  5. doi request reprint Reaching new heights: insights into the genetics of human stature
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, Magdalen Road, Exeter, EX1 2LU, UK
    Trends Genet 24:595-603. 2008
    ..We also discuss the strong probability of finding several hundred more such loci in the near future...
  6. ncbi request reprint The importance of TCF7L2
    M N Weedon
    Peninsula Medical School, Exeter, UK
    Diabet Med 24:1062-6. 2007
    ..This short review focuses on the TCF7L2 finding and discusses its significance for Type 2 diabetes genetic studies and for clinical practice...
  7. ncbi request reprint Insights on pathogenesis of type 2 diabetes from MODY genetics
    Michael N Weedon
    Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, Peninsula Medical School, St Lukes Campus, Magdalen Road, Exeter EX1 2LU, UK
    Curr Diab Rep 7:131-8. 2007
    ..We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes...
  8. pmc Type 2 diabetes risk alleles are associated with reduced size at birth
    Rachel M Freathy
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 58:1428-33. 2009
    ..We tested whether common genetic variants that predispose to type 2 diabetes also reduce birth weight...
  9. pmc Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
    Michael N Weedon
    Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
    PLoS Med 3:e374. 2006
    ..The value of analyzing multiple alleles simultaneously is not well studied. This is often because, for any given disease, very few common risk alleles have been confirmed...
  10. pmc Circulating beta-carotene levels and type 2 diabetes-cause or effect?
    J R B Perry
    Peninsula Medical School, Exeter, UK
    Diabetologia 52:2117-21. 2009
    ..In this study we used a Mendelian randomisation approach to provide evidence for or against the causal role of the antioxidant vitamin beta-carotene in type 2 diabetes...
  11. pmc Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes
    S Rafiq
    Peninsula Medical School, University of Exeter, Magdalen Road, Exeter, EX1 2LU, UK
    Diabetologia 51:2205-13. 2008
    ..We tested the hypothesis that common gene variants known to alter circulating levels of inflammatory proteins, or known to alter autoimmune-related disease risk, influence type 2 diabetes risk...
  12. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  13. ncbi request reprint A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population
    Michael N Weedon
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 54:2487-91. 2005
    ..31 [1.08-1.59], P = 0.007). Further studies are required to investigate this association, demonstrating the difficulty of defining the role of rare (<5%) alleles in type 2 diabetes risk...
  14. ncbi request reprint The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies
    N M G De Silva
    Peninsula Medical School, Exeter, UK
    Diabet Med 24:1067-72. 2007
    ..We aimed to compare the impact of TCF7L2 in UK community-based Type 2 diabetic subjects with that in subjects ascertained for genetic studies...
  15. ncbi request reprint Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom
    JOP 7:295-302. 2006
    ..The single nucleotide polymorphisms C-2578A (rs699947), G-1154A (rs1570360) and G-634C (rs2010963) in the 5'-region of VEGF are associated with altered serum concentrations of the protein...
  16. ncbi request reprint Variants in the aromatase gene and on the Y-chromosome are not associated with adult height or insulin resistance in a UK population
    Michael N Weedon
    Centre for Molecular Genetics, Peninsula Medical School, Exeter and Regional Endocrine Laboratory, University Hospital Birmingham NHS Trust, UK
    Clin Endocrinol (Oxf) 59:175-9. 2003
    ....
  17. ncbi request reprint Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    Anna L Gloyn
    Centre for Molecular Genetics, Peninsula Medical School, Exeter, UK
    Diabetes 52:568-72. 2003
    ..000002); but the ABCC8 variants were not associated. Our results confirm that E23K increases risk of type 2 diabetes and show that large-scale association studies are important for the identification of diabetes susceptibility alleles...
  18. ncbi request reprint No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians
    Michael N Weedon
    Molecular Genetics, Peninsula Medical School, Barrack Road, Exeter, EX2 5DW, UK
    Diabetes 55:3175-9. 2006
    ..25 [1.10-1.43], P = 0.0007), although there was some evidence of publication bias. In conclusion, we find no evidence that previously associated variants of ENPP1 are associated with type 2 diabetes or obesity in the U.K. population...
  19. ncbi request reprint What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice?
    H Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    J Intern Med 263:16-27. 2008
    ..In this review, we present some recent, exciting findings from studies that have used the GWA approach, and discuss the clinical application of identifying disease susceptibility genes and variants...
  20. pmc Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
    Hana Lango Allen
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, U K
    Diabetes 59:266-71. 2010
    ..We investigated the hypothesis that common polygenic variants that predispose to type 2 diabetes might account for the difference in age at diagnosis...
  21. pmc The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    BMC Med Genet 7:51. 2006
    ..We performed a large case-control and family-based study to test the hypothesis that KL-VS is associated with type 2 diabetes in a UK Caucasian population...
  22. pmc Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
    Diabetes 57:1419-26. 2008
    ..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...
  23. pmc Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study
    Anna Murray
    Penninsula Medical School, University of Exeter, Exeter, UK
    Hum Mol Genet 20:186-92. 2011
    ..The discriminative power is still limited, but as more variants are discovered they may be useful for predicting reproductive lifespan...
  24. pmc An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people
    Timothy M Frayling
    Peninsula Medical School, Exeter, United Kingdom
    J Gerontol A Biol Sci Med Sci 62:73-8. 2007
    ..The role of common variation in the IL-18 gene on serum concentrations and functioning in old age is unknown...
  25. pmc Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance
    N Maneka G De Silva
    Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Diabetes 60:1008-18. 2011
    ..We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally influence the risk of type 2 diabetes and raise normal fasting glucose levels and hepatic insulin resistance...
  26. pmc A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    J Negat Results Biomed 5:18. 2006
    ..We genotyped 1396 subjects (fathers, mothers and children) from a consecutive birth study for the CSH1.01 marker and analysed genotypes for association with 1-year weight in boys and fasting insulin in fathers...
  27. pmc Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes
    E L Edghill
    Institute of Biomedical and Clinical Science Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter, UK
    Diabet Med 28:681-4. 2011
    ..In contrast, the role of low frequency genetic variants (minor allele frequency 0.1-5%) in Type 2 diabetes is not known. The aim of this study was to assess the role of low frequency PDX1 (also called IPF1) variants in Type 2 diabetes...
  28. pmc Hundreds of variants clustered in genomic loci and biological pathways affect human height
    Hana Lango Allen
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK
    Nature 467:832-8. 2010
    ....
  29. ncbi request reprint Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population
    Michael N Weedon
    Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Barrack Road, Exeter, UK
    Diabetes 53:3002-6. 2004
    ..1-linked cases. In conclusion, we have replicated the association of the HNF4alpha P2 promoter haplotype with type 2 diabetes in a U.K. Caucasian population where there is no evidence of linkage to 20q...
  30. pmc A common variant of HMGA2 is associated with adult and childhood height in the general population
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 39:1245-50. 2007
    ..There are few examples of common genetic variants reproducibly associated with human quantitativetraits; these results represent, to our knowledge, the first consistently replicated association with adult and childhood height...
  31. ncbi request reprint Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene
    Michael N Weedon
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter EX2 5AX, U K
    Diabetes 54:576-81. 2005
    ..This study establishes that common genetic variation, in addition to rare mutations and environmental factors, can affect both FPG and birth weight...
  32. pmc Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach
    John R B Perry
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Diabetes 58:1463-7. 2009
    ..In a complementary approach to these single-marker studies, we attempted to identify biological pathways associated with type 2 diabetes. This approach could allow us to identify additional risk loci...
  33. pmc A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy
    Rachel M Freathy
    Genetics of Complex Traits, Peninsula Medical School, Institute of Biomedical and Clinical Science, Magdalen Road, Exeter EX1 2LU, UK
    Hum Mol Genet 18:2922-7. 2009
    ..Our data support the role of genetic factors in influencing smoking cessation during pregnancy...
  34. pmc Improved genetic testing for monogenic diabetes using targeted next-generation sequencing
    S Ellard
    Institute for Biomedical and Clinical Science, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK
    Diabetologia 56:1958-63. 2013
    ..Next-generation sequencing enables the simultaneous analysis of multiple genes in a single test. Our aim was to develop a targeted next-generation sequencing assay to detect mutations in all known MODY and neonatal diabetes genes...
  35. pmc Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
    John R B Perry
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, UK
    Hum Mol Genet 19:535-44. 2010
    ..Our results, together with those from another recent genetic study, strengthen evidence that SHBG and sex hormones are involved in the aetiology of type 2 diabetes...
  36. pmc A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses
    Michael N Weedon
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, EX1 2LU, UK
    Am J Hum Genet 79:991-1001. 2006
    ..In conclusion, a comprehensive analysis of common variation of the glucokinase gene shows that this is the first gene to be reproducibly associated with fasting glucose and fetal growth...
  37. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...
  38. pmc A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects
    S Rafiq
    Peninsula Medical School, Institute of Biomedical and Clinical Science, Exeter, UK
    Genes Immun 8:552-9. 2007
    ..A common variant of the IL-6r gene results in major changes in IL-6r and IL-6 serum levels, but with no apparent effect on gp130 levels or on inflammatory status in the general population...
  39. pmc A genome-wide association study identifies protein quantitative trait loci (pQTLs)
    David Melzer
    Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
    PLoS Genet 4:e1000072. 2008
    ..These include the presence of strong genetic effects in cis locations. The identification of protein quantitative trait loci (pQTLs) may be a powerful complementary method of improving our understanding of disease pathways...
  40. ncbi request reprint Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels
    S Rafiq
    Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, UK
    Genes Immun 8:344-51. 2007
    ..03), alpha-2 macroglobulin (P=0.008) and adiponectin (P=0.007) serum levels. In conclusion, common variation across the IL-1RN gene is strongly associated with IL-1RA levels...
  41. pmc Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
    John R B Perry
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Nat Genet 41:648-50. 2009
    ..The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation...
  42. ncbi request reprint Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk
    Christopher J Groves
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
    Diabetes 55:2640-4. 2006
    ..4 x 10(-14) combining case-control and family-based analyses for rs4506565) exceeds genome-wide significance criteria and clearly establishes TCF7L2 as a type 2 diabetes susceptibility gene of substantial importance...
  43. ncbi request reprint Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
    Wendy Winckler
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Diabetes 56:685-93. 2007
    ..We conclude that although rare variants in these six genes explain most cases of MODY, common variants in these same genes contribute very modestly, if at all, to the common form of type 2 diabetes...
  44. ncbi request reprint Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses
    Takafumi Tsuchiya
    Departments of Medicine and Human Genetics, The University of Chicago, 5841 S Maryland Ave, MC1027, Chicago, IL 60637, USA
    Mol Genet Metab 89:174-84. 2006
    ..68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans...
  45. ncbi request reprint Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach
    Anna L Gloyn
    Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK
    Diabetes 55:2272-6. 2006
    ..Using a study sufficiently powered to detect odds ratios of <1.2, we conclude that common variation in the TNDM region does not play an important role in the genetic susceptibility to type 2 diabetes...
  46. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  47. pmc Common variants in WFS1 confer risk of type 2 diabetes
    Manjinder S Sandhu
    UK Medical Research Council MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Nat Genet 39:951-3. 2007
    ..Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes...
  48. ncbi request reprint Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects
    Simon M S Mitchell
    Centre for Molecular Genetics, Peninsula Medical School, Barrack Road, Exeter EX2 5AX, U K
    Diabetes 52:1276-9. 2003
    ..Our study suggests that genetic variation in SHP is unlikely to be common in the predisposition to diabetes, obesity, or increased birth weight in U.K. Caucasians...
  49. ncbi request reprint Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels
    Thomas M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, UK
    Eur J Hum Genet 15:679-84. 2007
    ..08). In conclusion, these data (involving >4600 subjects) provide no evidence that common variants of the KCNJ11 E23K polymorphism have a major influence on PCOS susceptibility, though modest effect sizes (OR<1.25) cannot be excluded...
  50. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  51. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  52. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  53. pmc Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility
    Michael N Weedon
    Am J Hum Genet 73:1208-12. 2003
  54. ncbi request reprint Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    Laura Pascoe
    Diabetes Research Group, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 56:3101-4. 2007
    ..Our objective was to explore the relationships between the diabetes-associated alleles and measures of beta-cell function and whole-body insulin sensitivity...
  55. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  56. pmc A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 93:3075-81. 2008
    ..We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones...
  57. ncbi request reprint Tall stories: the fundamental difficulties of genetic association studies
    Michael N Weedon
    Clin Endocrinol (Oxf) 60:145-6. 2004