David Melzer

Summary

Affiliation: Peninsula Medical School
Country: UK

Publications

  1. pmc An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people
    Timothy M Frayling
    Peninsula Medical School, Exeter, United Kingdom
    J Gerontol A Biol Sci Med Sci 62:73-8. 2007
  2. ncbi Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence
    Iain Lang
    Epidemiology and Public Health Group, Peninsula Medical School, RD and E Wonford Site, Exeter, UK
    Age Ageing 36:256-61. 2007
  3. ncbi Genetic variation and human aging: progress and prospects
    David Melzer
    Peninsula Medical School, University of Exeter, Exeter, UK
    J Gerontol A Biol Sci Med Sci 62:301-7. 2007
  4. doi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
  5. pmc Urinary bisphenol a concentration and angiography-defined coronary artery stenosis
    David Melzer
    Epidemiology and Public Health Group, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
    PLoS ONE 7:e43378. 2012
  6. pmc Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people
    Anna Murray
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
    Eur Heart J 30:1711-9. 2009
  7. pmc Daily bisphenol A excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study
    Tamara Galloway
    School of Biosciences, University of Exeter, Exeter, United Kingdom
    Environ Health Perspect 118:1603-8. 2010
  8. pmc Genomics and successful aging: grounds for renewed optimism?
    L C Pilling
    Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    J Gerontol A Biol Sci Med Sci 67:511-9. 2012
  9. doi Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women
    David Melzer
    Epidemiology and Public Health Group, Peninsula College of Medicine and Dentistry, Barrack Road, Exeter, United Kingdom
    Circulation 125:1482-90. 2012
  10. ncbi What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts
    Iain Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, UK
    J Am Geriatr Soc 55:49-57. 2007

Detail Information

Publications81

  1. pmc An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people
    Timothy M Frayling
    Peninsula Medical School, Exeter, United Kingdom
    J Gerontol A Biol Sci Med Sci 62:73-8. 2007
    ..The role of common variation in the IL-18 gene on serum concentrations and functioning in old age is unknown...
  2. ncbi Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence
    Iain Lang
    Epidemiology and Public Health Group, Peninsula Medical School, RD and E Wonford Site, Exeter, UK
    Age Ageing 36:256-61. 2007
    ....
  3. ncbi Genetic variation and human aging: progress and prospects
    David Melzer
    Peninsula Medical School, University of Exeter, Exeter, UK
    J Gerontol A Biol Sci Med Sci 62:301-7. 2007
    ..Although much of the existing evidence is fragmentary, recent exciting findings and robust methods are taking the field rapidly forward...
  4. doi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
    ..Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans...
  5. pmc Urinary bisphenol a concentration and angiography-defined coronary artery stenosis
    David Melzer
    Epidemiology and Public Health Group, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
    PLoS ONE 7:e43378. 2012
    ..Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses...
  6. pmc Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people
    Anna Murray
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
    Eur Heart J 30:1711-9. 2009
    ..We aimed to estimate combined effects of proven SNPs on LDL, HDL, and triglyceride concentrations and MI history in a representative older population...
  7. pmc Daily bisphenol A excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study
    Tamara Galloway
    School of Biosciences, University of Exeter, Exeter, United Kingdom
    Environ Health Perspect 118:1603-8. 2010
    ..Bisphenol A (BPA) is a high production volume chemical widely used in packaging for food and beverages. Numerous studies have demonstrated that BPA can alter endocrine function in animals, yet human studies remain limited...
  8. pmc Genomics and successful aging: grounds for renewed optimism?
    L C Pilling
    Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    J Gerontol A Biol Sci Med Sci 67:511-9. 2012
    ..Genome-wide association studies have identified many risk associated single-nucleotide polymorphisms for these conditions, but much heritability remains unaccounted for. Nevertheless, a great deal is being learned...
  9. doi Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women
    David Melzer
    Epidemiology and Public Health Group, Peninsula College of Medicine and Dentistry, Barrack Road, Exeter, United Kingdom
    Circulation 125:1482-90. 2012
    ..Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional risk factors...
  10. ncbi What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts
    Iain Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, UK
    J Am Geriatr Soc 55:49-57. 2007
    ..To estimate disability plus mortality risks in older people according to level of alcohol intake...
  11. ncbi Mobility disability in the middle-aged: cross-sectional associations in the English Longitudinal Study of Ageing
    David Melzer
    Department of Epidemiology and Public Health, Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
    Age Ageing 34:594-602. 2005
    ..Whether mobility disability has different causes in the middle-aged has received limited attention...
  12. pmc The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, UK
    J Gerontol A Biol Sci Med Sci 60:1319-23. 2005
    ....
  13. doi Genetic polymorphisms and human aging: association studies deliver
    David Melzer
    Genetics of Ageing Group, Epidemiology and Public Health, Peninsula College of Medicine and Dentistry, Exeter, United Kingdom
    Rejuvenation Res 11:523-6. 2008
    ..Many other GWA findings are in novel pathways, providing new potential targets for interventions to slow aging...
  14. pmc Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06
    David Melzer
    Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
    PLoS ONE 5:e8673. 2010
    ..We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years...
  15. pmc Genetic tests for common diseases: new insights, old concerns
    David Melzer
    Peninsula Medical School, University of Exeter, Exeter EX1 2LU
    BMJ 336:590-3. 2008
  16. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
    ..We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population...
  17. pmc A common variant of the p16(INK4a) genetic region is associated with physical function in older people
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
    Mech Ageing Dev 128:370-7. 2007
    ..The mechanism involved may be via greater cellular restorative activity and reduced stem cell senescence...
  18. pmc Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
    Diabetes 57:1419-26. 2008
    ..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...
  19. pmc Neighbourhood deprivation and incident mobility disability in older adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter EX2 5DW, UK
    Age Ageing 37:403-10. 2008
    ..to assess whether incident mobility disability and neighbourhood deprivation in older people are associated independent of the effects of individual socio-economic status, health behaviours and health status...
  20. doi Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010
    Jessica Tyrrell
    European Centre for Environment and Human Health, University of Exeter Medical School, University of Exeter, United Kingdom
    Environ Int 59:328-35. 2013
    ....
  21. pmc Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults
    Lorna W Harries
    Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
    Rejuvenation Res 15:395-404. 2012
    ....
  22. ncbi Changes in splicing factor expression are associated with advancing age in man
    Alice C Holly
    Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK
    Mech Ageing Dev 134:356-66. 2013
    ..These findings suggest for the first time that ATM, a core element in the DNA damage response, is a key regulator of the splicing machinery in man. ..
  23. pmc Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults
    David Melzer
    Epidemiology and Public Health, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
    Environ Health Perspect 119:1788-93. 2011
    ....
  24. pmc Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey
    Elizabeth A Gardener
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Forvie Site, Cambridge, UK
    J Gen Intern Med 21:1091-6. 2006
    ..Lower limb mobility disabilities are well understood in older people, but the causes in middle age have attracted little attention...
  25. doi Towards a gene expression biomarker set for human biological age
    Alice C Holly
    Institute of Biomedical and Clinical Science, Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
    Aging Cell 12:324-6. 2013
    ..64, 0.74, 0.74; P = 2.4 × 10(-2) , 3.5 × 10(-4) , 1.8 × 10(-2) , 1.5 × 10(-2) , respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age...
  26. pmc Framingham Stroke Risk Profile and poor cognitive function: a population-based study
    David J Llewellyn
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 8:12. 2008
    ..The objective of this study was to examine the relationship between 10-year risk for incident stroke and cognitive function in a large population-based sample...
  27. pmc Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction"
    Ambarish Dutta
    Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
    J Am Geriatr Soc 59:963-71. 2011
    ..To identify predictors of extraordinary survival...
  28. pmc The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies
    Neil E Rice
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, UK
    Int J Epidemiol 38:1374-9. 2009
    ..We aimed to examine associations between the PON1 Q192R polymorphism and self-reported poor health and depression in two independent population-based studies...
  29. pmc Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people
    Christie Cluett
    Peninsula Medical School, RD and E Wonford Site, Exeter, UK
    Neurobiol Aging 31:1563-8. 2010
    ..The mechanisms underlying the associations with cognitive impairment and LOAD require further elucidation, but both genes are interesting candidates for involvement in age-related cognitive impairment...
  30. doi Obesity, physical function, and mortality in older adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Am Geriatr Soc 56:1474-8. 2008
    ..To estimate the effects of excess body weight on objective and subjective physical function and mortality risks in noninstitutionalized older adults...
  31. pmc Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999-2004
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Toxicol Environ Health A 72:402-9. 2009
    ..00 to 1.49). Low-level cobalt exposure, assessed through urinary concentrations of this essential heavy metal, may be a risk factor for age-related physical impairments. Independent replication is needed to confirm this association...
  32. doi Baby boomers nearing retirement: the healthiest generation?
    Neil E Rice
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    Rejuvenation Res 13:105-14. 2010
    ..The baby-boom generation is entering retirement. Having experienced unprecedented prosperity and improved medical technology, they should be the healthiest generation ever...
  33. pmc Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association
    Andrew R Wood
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK
    Hum Mol Genet 20:4082-92. 2011
    ....
  34. ncbi The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction
    Ambarish Dutta
    Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, UK
    Circ Cardiovasc Genet 4:542-8. 2011
    ..We estimated 9p21 associations with CAD and all-cause mortality in a CAD diagnosis-free older population. We also estimated classification gains on adding the variant to the Framingham Risk Score (FRS) for CAD...
  35. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  36. ncbi Uric acid measurement improves prediction of cardiovascular mortality in later life
    Ambarish Dutta
    Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, UK
    J Am Geriatr Soc 61:319-26. 2013
    ....
  37. ncbi Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations
    Lorna W Harries
    Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 5DW, UK
    Mech Ageing Dev 133:556-62. 2012
    ..Work is needed to establish whether these changes are predictive of human longevity and whether further mTOR inhibition would be beneficial in older people...
  38. pmc Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
    Lorna W Harries
    Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Aging Cell 10:868-78. 2011
    ..05]. This is supported by our observation of age-associated disruption to the balance of alternatively expressed isoforms for selected genes, suggesting that modification of mRNA processing may be a feature of human aging...
  39. doi Common health predictors of early retirement: findings from the English Longitudinal Study of Ageing
    Neil E Rice
    Peninsula Medical School, University of Exeter, Exeter EX2 5DW, UK
    Age Ageing 40:54-61. 2011
    ..Summary health measures predict early retirement, but more specific symptoms and conditions need to be identified to guide efforts to delay retirement...
  40. ncbi Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Am Geriatr Soc 55:1836-41. 2007
    ..To assess the association between physical activity and subsequent physical functioning in middle-aged adults across a range of body mass index (BMI) categories...
  41. ncbi Vitamin D and risk of cognitive decline in elderly persons
    David J Llewellyn
    Public Health and Epidemiology Group, Peninsula Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, England
    Arch Intern Med 170:1135-41. 2010
    ..To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia...
  42. ncbi Smoking cessation and transition into retirement: analyses from the English Longitudinal Study of Ageing
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, UK
    Age Ageing 36:638-43. 2007
    ..Transitions such as retirement may represent points at which changes in health behaviour occur...
  43. pmc Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation
    Andrew R Wood
    Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
    PLoS ONE 8:e64343. 2013
    ..007) and alpha1-antitrypsin that predisposes to emphysema (P = 2.5×10(-12)). Our data provide important proof of principle that 1000 Genomes imputation will detect novel, low frequency-large effect associations...
  44. ncbi Longer lived parents: protective associations with cancer incidence and overall mortality
    Ambarish Dutta
    MBBCh, Medical School, Barrack Road, Exeter, EX2 5DW, UK
    J Gerontol A Biol Sci Med Sci 68:1409-18. 2013
    ..Children of centenarians have lower cardiovascular disease prevalence and live longer. We aimed to estimate associations between the full range of parental attained ages and health status in a middle-aged U.S. representative sample...
  45. ncbi Variation in thresholds for reporting mobility disability between national population subgroups and studies
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 2SR, UK
    J Gerontol A Biol Sci Med Sci 59:1295-303. 2004
    ..We also aimed to compare reported and tested performance across two national population studies...
  46. pmc The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people
    Christie Cluett
    Peninsula Medical School, Exeter, United Kingdom
    Circ Cardiovasc Genet 2:347-53. 2009
    ..09 for PAD (P=0.075). We aimed at estimating the association of this variant with an Ankle-Brachial Index (ABI) and PAD in 3 older populations...
  47. ncbi The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Age Ageing 32:619-25. 2003
    ..Evidence of the MOBLI 's responsiveness over time has been presented. Evidence of the predictive validity of the index is needed...
  48. ncbi Performance tests and disability: developing an objective index of mobility-related limitation in older populations
    Tzuo Yun Lan
    Department of Public Health and Primary Care, University of Cambridge, United Kingdom
    J Gerontol A Biol Sci Med Sci 57:M294-301. 2002
    ..This study aimed to identify an index of mobility-related limitations composed of physiological measures that are most closely associated with reported mobility disability in elders...
  49. pmc Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey
    David Melzer
    Epidemiology and Public Health Group, eninsula Medical School, Exeter, United Kingdom
    Environ Health Perspect 118:686-92. 2010
    ..Their persistence in the environment plus toxicity in animal models has raised concern over low-level chronic exposure effects on human health...
  50. doi Personality profile of the children of long-lived parents
    Evangelia E Antoniou
    Department of Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, UK
    J Gerontol B Psychol Sci Soc Sci 68:730-8. 2013
    ..We used a 5-factor personality model to investigate the relationship between parental longevity and offspring personality...
  51. doi Vitamin D and cognitive function
    Maya Soni
    Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Scand J Clin Lab Invest Suppl 243:79-82. 2012
    ..Large, well designed randomized controlled trials are now needed to determine whether vitamin D supplementation is effective at preventing or treating Alzheimer's disease and dementia...
  52. pmc CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength
    Lorna W Harries
    Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Aging Cell 11:262-8. 2012
    ..This association may be consistent with mouse model evidence of CEBPB-triggered muscle repair: if this mechanism is confirmed, it may provide a target for intervention to protect and enhance aging muscle...
  53. pmc Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Am Geriatr Soc 56:191-8. 2008
    ..To assess the relationship between cognitive function, socioeconomic status, and neighborhood deprivation (lack of local resources of all types, financial and otherwise)...
  54. doi Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing
    Kara N Stevens
    Peninsula Medical School, Epidemiology and Public Health Group, UK
    Age Ageing 37:300-5. 2008
    ..to identify socio-economic, behavioural and disease status risks for impaired balance or self-reported dizziness in older people from a large population-based study...
  55. doi Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans
    Alice C Holly
    Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK
    Mech Ageing Dev 135:50-6. 2014
    ..SF3B1 encodes a critical component of the U2 snRNP; altered expression of this gene may therefore contribute to the loss of regulated mRNA splicing that occurs with age. ..
  56. pmc A genome-wide association study identifies protein quantitative trait loci (pQTLs)
    David Melzer
    Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
    PLoS Genet 4:e1000072. 2008
    ..These include the presence of strong genetic effects in cis locations. The identification of protein quantitative trait loci (pQTLs) may be a powerful complementary method of improving our understanding of disease pathways...
  57. ncbi Decline in Common Mental Disorder prevalence in men during the sixth decade of life. Evidence from the National Psychiatric Morbidity Survey
    David Melzer
    Epidemiology for Policy Group, Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Soc Psychiatry Psychiatr Epidemiol 39:33-8. 2004
    ..Adverse occupational conditions and involuntary exit from work are linked to high rates of common mental disorders, but voluntary retirement is associated with improved mental health...
  58. pmc The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    BMC Med Genet 7:51. 2006
    ..We performed a large case-control and family-based study to test the hypothesis that KL-VS is associated with type 2 diabetes in a UK Caucasian population...
  59. ncbi Neighborhood deprivation, individual socioeconomic status, and frailty in older adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, England
    J Am Geriatr Soc 57:1776-80. 2009
    ..To assess how individual socioeconomic status and neighborhood deprivation affect frailty...
  60. ncbi Socio-demographic correlates of mobility disability in older Brazilians: results of the first national survey
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Age Ageing 33:253-9. 2004
    ..Brazil is characterised by gross socio-economic inequalities, but there have been no previous national data on disability prevalence...
  61. pmc Vitamin D and cognitive impairment in the elderly U.S. population
    David J Llewellyn
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Road, Exeter, EX2 5DW, UK
    J Gerontol A Biol Sci Med Sci 66:59-65. 2011
    ..Our objective was to investigate the association between vitamin D deficiency and cognitive impairment in the elderly U.S. population...
  62. ncbi The mental health of early retirees-- national interview survey in Britain
    Julian W Buxton
    Epidemiology for Policy Group, Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Soc Psychiatry Psychiatr Epidemiol 40:99-105. 2005
    ..There is intense political interest in retaining older workers in the workforce, to fund lengthening retirements. While health is important in early exit from work, the health of early retirees has been little studied...
  63. doi Human genetic variations: Beacons on the pathways to successful ageing
    Christie Cluett
    Peninsula Medical School, Exeter, Devon, United Kingdom
    Mech Ageing Dev 130:553-63. 2009
    ..They also confirm the central role of cell cycle and re-growth as a key pathway underlying the human variation in successful ageing...
  64. ncbi Low prevalence of depression and anxiety is linked to statutory retirement ages rather than personal work exit: a national survey
    Elena Villamil
    Epidemiology for Policy Group, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Psychol Med 36:999-1009. 2006
    ..The aim of this study was to establish whether work status, age or other known risk factors account for the reduced prevalence of depressive episode and anxiety disorder around retirement ages for men and for women...
  65. ncbi Responsiveness of the index of mobility limitation: comparison with gait speed alone in the longitudinal aging study amsterdam
    Tzuo Yun Lan
    Department of Public Health and Primary Care, University of Cambridge, UK
    J Gerontol A Biol Sci Med Sci 58:721-7. 2003
    ..In this article, we examine whether the index is responsive to changes in self-reported mobility disability...
  66. ncbi Social position and the common mental disorders with disability: estimates from the National Psychiatric Survey of Great Britain
    David Melzer
    Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Soc Psychiatry Psychiatr Epidemiol 38:238-43. 2003
    ..This project aimed to estimate effect sizes and independence of social position markers as risk factors for common mental disorders. Disorders with disability were examined to identify groups with high clinical and policy priority...
  67. ncbi Pharmacogenetics: policy needs for personal prescribing
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 2SR, UK
    J Health Serv Res Policy 10:40-4. 2005
    ....
  68. pmc A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses
    Michael N Weedon
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, EX1 2LU, UK
    Am J Hum Genet 79:991-1001. 2006
    ..In conclusion, a comprehensive analysis of common variation of the glucokinase gene shows that this is the first gene to be reproducibly associated with fasting glucose and fetal growth...
  69. ncbi Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life
    David Melzer
    Demography and Biometry Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    Aging Clin Exp Res 15:60-6. 2003
    ..in people aged 65 and over who died in the US in 1993, and to measure mobility outcomes during their last year of life...
  70. pmc Self reported receipt of care consistent with 32 quality indicators: national population survey of adults aged 50 or more in England
    Nicholas Steel
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 337:a957. 2008
    ..To assess the receipt of effective healthcare interventions in England by adults aged 50 or more with serious health conditions...
  71. ncbi [Disability among elderly women in Brazil]
    Maria Isabel Parahyba
    Universidade Aberta da Terceira Idade, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
    Rev Saude Publica 39:383-90. 2005
    ..To estimate disability rates and explore associations, identifying the most significant socioeconomic markers associated with the prevalence of mobility disability among elderly women...
  72. ncbi Retirement and mental health: analysis of the Australian national survey of mental health and well-being
    Peter Butterworth
    Centre for Mental Health Research, The Australian National University, Canberra, ACT Australia
    Soc Sci Med 62:1179-91. 2006
    ..Given current policy changes in many countries to curtail early retirement, these findings highlight the need to consider mental health, and its influencing factors, when encouraging continued employment amongst older adults...
  73. ncbi Mental health and the timing of men's retirement
    Sarah C Gill
    Centre for Mental Health Research, Bldg 63, Eggleston Rd, The Australian National University, Canberra, ACT, Australia, 0200
    Soc Psychiatry Psychiatr Epidemiol 41:515-22. 2006
    ..The aim of this analysis was to investigate this pattern of results in a national sample of Australian men, and the mediating role of socio-demographic factors...
  74. ncbi Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS)
    Carol Jagger
    Leicester Nuffield Research Unit, Department of Health Sciences, University of Leicester, Leicester, UK
    Int J Epidemiol 36:358-65. 2007
    ....
  75. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
    ..The specific associations with ALP levels may point to genes for bone or intestinal diseases...
  76. ncbi Social inequalities and the common mental disorders: a systematic review of the evidence
    Tom Fryers
    Department of Psychiatry, University of Leicester, Leicester, UK
    Soc Psychiatry Psychiatr Epidemiol 38:229-37. 2003
    ..This study reviews the published evidence on the links between conventional markers of social position and the common mental disorders in developed countries...
  77. ncbi Racial disparities in receipt of hip and knee joint replacements are not explained by need: the Health and Retirement Study 1998-2004
    Nicholas Steel
    School of Medicine, Health Policy and Practice, University of East Anglia, Earlham Road, Norwich, Norfolk, NR4 7TJ, United Kingdom
    J Gerontol A Biol Sci Med Sci 63:629-34. 2008
    ..Hip and knee joint replacement rates vary by demographic group. This article describes the epidemiology of need for joint replacement, and of subsequent receipt of a joint replacement by those in need...
  78. ncbi Closing the gaps--enhancing the regulation of genetic tests using responsive regulation
    Stuart Hogarth
    Institute for Science and Society at the University of Nottingham, UK
    Food Drug Law J 62:831-48. 2007
  79. pmc A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 93:3075-81. 2008
    ..We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones...
  80. ncbi Trends in service use and treatment for mental disorders in adults throughout Great Britain
    Traolach S Brugha
    Brandon Mental Health Unit, Department of Health Sciences, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Psychiatry 185:378-84. 2004
    ..Trends in health treatments and outcomes in the general population may be used to monitor achievement of health targets...
  81. ncbi Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity
    Traolach Brugha
    University of Leicester, Department of Health Sciences, Brandon Mental Health Unit, Leicester General Hospital, Gwendolen Rd, Leicester LE5 4PW, UK
    Am J Psychiatry 162:774-80. 2005
    ..The authors compared two samples of subjects 16-64 years of age: those from the general population of residents in Great Britain and prisoners in England and Wales...