David Melzer

..The role of common variation in the IL-18 gene on serum concentrations and functioning in old age is unknown...

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..Although much of the existing evidence is fragmentary, recent exciting findings and robust methods are taking the field rapidly forward...

..Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans...

..Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses...

..Genome-wide association studies have identified many risk associated single-nucleotide polymorphisms for these conditions, but much heritability remains unaccounted for. Nevertheless, a great deal is being learned...

..Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional risk factors...

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..We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population...

..Many other GWA findings are in novel pathways, providing new potential targets for interventions to slow aging...

..To estimate disability plus mortality risks in older people according to level of alcohol intake...

..Whether mobility disability has different causes in the middle-aged has received limited attention...

..The mechanism involved may be via greater cellular restorative activity and reduced stem cell senescence...

..We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years...

..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...

..to assess whether incident mobility disability and neighbourhood deprivation in older people are associated independent of the effects of individual socio-economic status, health behaviours and health status...

..More clinical attention paid to disabling symptoms may lead to disability reductions in later life...

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..The objective of this study was to examine the relationship between 10-year risk for incident stroke and cognitive function in a large population-based sample...

..We aimed to examine associations between the PON1 Q192R polymorphism and self-reported poor health and depression in two independent population-based studies...

..00 to 1.49). Low-level cobalt exposure, assessed through urinary concentrations of this essential heavy metal, may be a risk factor for age-related physical impairments. Independent replication is needed to confirm this association...

..To identify predictors of extraordinary survival...

..The baby-boom generation is entering retirement. Having experienced unprecedented prosperity and improved medical technology, they should be the healthiest generation ever...

..To estimate the effects of excess body weight on objective and subjective physical function and mortality risks in noninstitutionalized older adults...

..The mechanisms underlying the associations with cognitive impairment and LOAD require further elucidation, but both genes are interesting candidates for involvement in age-related cognitive impairment...

..We estimated 9p21 associations with CAD and all-cause mortality in a CAD diagnosis-free older population. We also estimated classification gains on adding the variant to the Framingham Risk Score (FRS) for CAD...

..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...

..We aimed to estimate combined effects of proven SNPs on LDL, HDL, and triglyceride concentrations and MI history in a representative older population...

..64, 0.74, 0.74; P = 2.4 × 10(-2) , 3.5 × 10(-4) , 1.8 × 10(-2) , 1.5 × 10(-2) , respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age...

..Work is needed to establish whether these changes are predictive of human longevity and whether further mTOR inhibition would be beneficial in older people...

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..05]. This is supported by our observation of age-associated disruption to the balance of alternatively expressed isoforms for selected genes, suggesting that modification of mRNA processing may be a feature of human aging...

..Bisphenol A (BPA) is a high production volume chemical widely used in packaging for food and beverages. Numerous studies have demonstrated that BPA can alter endocrine function in animals, yet human studies remain limited...

..To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia...

..We also aimed to compare reported and tested performance across two national population studies...

..Summary health measures predict early retirement, but more specific symptoms and conditions need to be identified to guide efforts to delay retirement...

..To assess the association between physical activity and subsequent physical functioning in middle-aged adults across a range of body mass index (BMI) categories...

..Transitions such as retirement may represent points at which changes in health behaviour occur...

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..Evidence of the MOBLI 's responsiveness over time has been presented. Evidence of the predictive validity of the index is needed...

..09 for PAD (P=0.075). We aimed at estimating the association of this variant with an Ankle-Brachial Index (ABI) and PAD in 3 older populations...

..CONCLUSIONS: Subsets of measures associated with reported mobility disability could provide objective indices of mobility-related limitation for comparing populations or long-term population health monitoring...

..These include the presence of strong genetic effects in cis locations. The identification of protein quantitative trait loci (pQTLs) may be a powerful complementary method of improving our understanding of disease pathways...

..Large, well designed randomized controlled trials are now needed to determine whether vitamin D supplementation is effective at preventing or treating Alzheimer's disease and dementia...

..This association may be consistent with mouse model evidence of CEBPB-triggered muscle repair: if this mechanism is confirmed, it may provide a target for intervention to protect and enhance aging muscle...

..to identify socio-economic, behavioural and disease status risks for impaired balance or self-reported dizziness in older people from a large population-based study...

..To assess the relationship between cognitive function, socioeconomic status, and neighborhood deprivation (lack of local resources of all types, financial and otherwise)...

..Their persistence in the environment plus toxicity in animal models has raised concern over low-level chronic exposure effects on human health...

..We performed a large case-control and family-based study to test the hypothesis that KL-VS is associated with type 2 diabetes in a UK Caucasian population...

..Our objective was to investigate the association between vitamin D deficiency and cognitive impairment in the elderly U.S. population...

..Brazil is characterised by gross socio-economic inequalities, but there have been no previous national data on disability prevalence...

..To assess how individual socioeconomic status and neighborhood deprivation affect frailty...

..Understanding the mechanisms of this excess of mental disorders in early retiree men may be a prerequisite to increasing the numbers seeking or staying in work up to age 65...

..This property is strongly supportive of its validity for epidemiological comparison of older populations across countries or over longer periods of time...

..Adverse occupational conditions and involuntary exit from work are linked to high rates of common mental disorders, but voluntary retirement is associated with improved mental health...

..No studied risk factor reduced the associations between age group and disorders. This population scale recovery may provide a model for understanding non-genetic factors...

..They also confirm the central role of cell cycle and re-growth as a key pathway underlying the human variation in successful ageing...

..This project aimed to estimate effect sizes and independence of social position markers as risk factors for common mental disorders. Disorders with disability were examined to identify groups with high clinical and policy priority...

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..In conclusion, a comprehensive analysis of common variation of the glucokinase gene shows that this is the first gene to be reproducibly associated with fasting glucose and fetal growth...

..To assess the receipt of effective healthcare interventions in England by adults aged 50 or more with serious health conditions...

..Given current policy changes in many countries to curtail early retirement, these findings highlight the need to consider mental health, and its influencing factors, when encouraging continued employment amongst older adults...

..To estimate disability rates and explore associations, identifying the most significant socioeconomic markers associated with the prevalence of mobility disability among elderly women...

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..in people aged 65 and over who died in the US in 1993, and to measure mobility outcomes during their last year of life...

..The aim of this analysis was to investigate this pattern of results in a national sample of Australian men, and the mediating role of socio-demographic factors...

..The specific associations with ALP levels may point to genes for bone or intestinal diseases...

..Trends in health treatments and outcomes in the general population may be used to monitor achievement of health targets...

..We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones...

..Hip and knee joint replacement rates vary by demographic group. This article describes the epidemiology of need for joint replacement, and of subsequent receipt of a joint replacement by those in need...

..Longitudinal research is needed to better understand these prevalence differences...

..More precise indicators of education, employment and material circumstances are better markers of increased rates than occupational social class...