Research Topics
Species | R PettipherSummaryAffiliation: Oxagen Ltd Country: UK Publications
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Detail Information
Publications
The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responsesR Pettipher
Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, UK
Br J Pharmacol 153:S191-9. 2008..The role played by CRTH2 in promoting the production of Th2 cytokines and IgE make antagonism of this receptor a particularly attractive approach to the treatment of chronic allergic disease...
The application of genetics to the discovery of better medicinesRoy Pettipher
Oxagen Ltd, Abingdon, OX1 4RY, UK
Pharmacogenomics 3:257-63. 2002..Rather, it is essential to combine genetic studies with carefully conducted preclinical and clinical experiments to extract the true value of high-throughput genetics-based research...
Antagonists of the prostaglandin D2 receptor CRTH2Roy Pettipher
Pharmacology, Oxagen Ltd, Abingdon, Oxon, UK
Drug News Perspect 21:317-22. 2008..The central role played by CRTH2 in mediating these effects suggests that antagonism of this receptor is an attractive approach to the treatment of chronic allergic disease...- Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseasesRoy Pettipher
Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK
Nat Rev Drug Discov 6:313-25. 2007..We also discuss recent progress in the discovery and development of selective antagonists of these receptors... - Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophilsRoy Pettipher
Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, OX14 4RY, United Kingdom
J Pharmacol Exp Ther 340:473-82. 2012..o.). These data indicate that OC000459 is a potent, selective, and orally active DP₂ antagonist that retains activity in human whole blood and inhibits mast cell-dependent activation of both human Th2 lymphocytes and eosinophils... - Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studiesRoy Pettipher
Department of Drug and Target Discovery, Oxagen Ltd, 91 Milton Park, Abingdon, Oxon OX14 4RY, UK
Curr Opin Pharmacol 5:412-7. 2005.... - A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytesShân L Vinall
Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom
Immunology 121:577-84. 2007.... - A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatantsShân L Gyles
Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom
Immunology 119:362-8. 2006..These data suggest that PGD2, or closely related metabolites of arachidonic acid, produced from mast cells may play a central role in the activation of CRTH2+ CD4+ Th2 lymphocytes through a CRTH2-dependent mechanism... - Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cellsL Xue
Oxagen Ltd, Abingdon, Oxon, UK
Clin Exp Immunol 156:126-33. 2009.... - Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2)Luzheng Xue
Oxagen Limited, 91 Milton Park, Abingdon, Oxon OX14 4RY, United Kingdom
Biochem Pharmacol 73:843-53. 2007..These data suggest that PI3K and Ca2+/calcineurin/NFAT signalling pathways are critically involved in pro-inflammatory responses of Th2 cells to PGD2... - Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2Richard E Armer
Oxagen Ltd, 91 Milton Park, Abingdon, Oxfordshire, OX14 4RY, UK
J Med Chem 48:6174-7. 2005..The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis... - Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytesLucien Gazi
Drug Discovery Department, Oxagen Limited, 91 Milton Park, Abingdon, Oxon OX14 4RY, UK
Prostaglandins Other Lipid Mediat 75:153-67. 2005..These data also confirm the selective effect of other PGD2 metabolites on CRTH2 and illustrate how the metabolism of PGD2 may influence the pattern of leukocyte infiltration at sites of allergic inflammation... - Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathwayLuzheng Xue
Oxagen Ltd, Abingdon, United Kingdom
J Immunol 182:7580-6. 2009..These data suggest that in addition to promoting the recruitment and activation of Th2 cells, PGD(2) may also impede the resolution of allergic inflammation through inhibiting apoptosis of Th2 cells... - Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cellsLuzheng Xue
Oxagen Limited, Abingdon, Oxon, United Kingdom
J Immunol 175:6531-6. 2005....