R Pettipher

Summary

Affiliation: Oxagen Ltd
Country: UK

Publications

  1. pmc The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses
    R Pettipher
    Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, UK
    Br J Pharmacol 153:S191-9. 2008
  2. ncbi request reprint The application of genetics to the discovery of better medicines
    Roy Pettipher
    Oxagen Ltd, Abingdon, OX1 4RY, UK
    Pharmacogenomics 3:257-63. 2002
  3. doi request reprint Antagonists of the prostaglandin D2 receptor CRTH2
    Roy Pettipher
    Pharmacology, Oxagen Ltd, Abingdon, Oxon, UK
    Drug News Perspect 21:317-22. 2008
  4. ncbi request reprint Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
    Roy Pettipher
    Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK
    Nat Rev Drug Discov 6:313-25. 2007
  5. doi request reprint Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils
    Roy Pettipher
    Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, OX14 4RY, United Kingdom
    J Pharmacol Exp Ther 340:473-82. 2012
  6. ncbi request reprint Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies
    Roy Pettipher
    Department of Drug and Target Discovery, Oxagen Ltd, 91 Milton Park, Abingdon, Oxon OX14 4RY, UK
    Curr Opin Pharmacol 5:412-7. 2005
  7. pmc A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes
    Shân L Vinall
    Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom
    Immunology 121:577-84. 2007
  8. pmc A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants
    Shân L Gyles
    Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom
    Immunology 119:362-8. 2006
  9. pmc Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells
    L Xue
    Oxagen Ltd, Abingdon, Oxon, UK
    Clin Exp Immunol 156:126-33. 2009
  10. ncbi request reprint Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2)
    Luzheng Xue
    Oxagen Limited, 91 Milton Park, Abingdon, Oxon OX14 4RY, United Kingdom
    Biochem Pharmacol 73:843-53. 2007

Collaborators

Detail Information

Publications14

  1. pmc The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses
    R Pettipher
    Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, UK
    Br J Pharmacol 153:S191-9. 2008
    ..The role played by CRTH2 in promoting the production of Th2 cytokines and IgE make antagonism of this receptor a particularly attractive approach to the treatment of chronic allergic disease...
  2. ncbi request reprint The application of genetics to the discovery of better medicines
    Roy Pettipher
    Oxagen Ltd, Abingdon, OX1 4RY, UK
    Pharmacogenomics 3:257-63. 2002
    ..Rather, it is essential to combine genetic studies with carefully conducted preclinical and clinical experiments to extract the true value of high-throughput genetics-based research...
  3. doi request reprint Antagonists of the prostaglandin D2 receptor CRTH2
    Roy Pettipher
    Pharmacology, Oxagen Ltd, Abingdon, Oxon, UK
    Drug News Perspect 21:317-22. 2008
    ..The central role played by CRTH2 in mediating these effects suggests that antagonism of this receptor is an attractive approach to the treatment of chronic allergic disease...
  4. ncbi request reprint Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
    Roy Pettipher
    Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK
    Nat Rev Drug Discov 6:313-25. 2007
    ..We also discuss recent progress in the discovery and development of selective antagonists of these receptors...
  5. doi request reprint Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils
    Roy Pettipher
    Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, OX14 4RY, United Kingdom
    J Pharmacol Exp Ther 340:473-82. 2012
    ..o.). These data indicate that OC000459 is a potent, selective, and orally active DP₂ antagonist that retains activity in human whole blood and inhibits mast cell-dependent activation of both human Th2 lymphocytes and eosinophils...
  6. ncbi request reprint Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies
    Roy Pettipher
    Department of Drug and Target Discovery, Oxagen Ltd, 91 Milton Park, Abingdon, Oxon OX14 4RY, UK
    Curr Opin Pharmacol 5:412-7. 2005
    ....
  7. pmc A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes
    Shân L Vinall
    Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom
    Immunology 121:577-84. 2007
    ....
  8. pmc A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants
    Shân L Gyles
    Department of Drug Discovery, Oxagen Ltd, Abingdon, Oxon, United Kingdom
    Immunology 119:362-8. 2006
    ..These data suggest that PGD2, or closely related metabolites of arachidonic acid, produced from mast cells may play a central role in the activation of CRTH2+ CD4+ Th2 lymphocytes through a CRTH2-dependent mechanism...
  9. pmc Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells
    L Xue
    Oxagen Ltd, Abingdon, Oxon, UK
    Clin Exp Immunol 156:126-33. 2009
    ....
  10. ncbi request reprint Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2)
    Luzheng Xue
    Oxagen Limited, 91 Milton Park, Abingdon, Oxon OX14 4RY, United Kingdom
    Biochem Pharmacol 73:843-53. 2007
    ..These data suggest that PI3K and Ca2+/calcineurin/NFAT signalling pathways are critically involved in pro-inflammatory responses of Th2 cells to PGD2...
  11. ncbi request reprint Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2
    Richard E Armer
    Oxagen Ltd, 91 Milton Park, Abingdon, Oxfordshire, OX14 4RY, UK
    J Med Chem 48:6174-7. 2005
    ..The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis...
  12. ncbi request reprint Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes
    Lucien Gazi
    Drug Discovery Department, Oxagen Limited, 91 Milton Park, Abingdon, Oxon OX14 4RY, UK
    Prostaglandins Other Lipid Mediat 75:153-67. 2005
    ..These data also confirm the selective effect of other PGD2 metabolites on CRTH2 and illustrate how the metabolism of PGD2 may influence the pattern of leukocyte infiltration at sites of allergic inflammation...
  13. doi request reprint Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway
    Luzheng Xue
    Oxagen Ltd, Abingdon, United Kingdom
    J Immunol 182:7580-6. 2009
    ..These data suggest that in addition to promoting the recruitment and activation of Th2 cells, PGD(2) may also impede the resolution of allergic inflammation through inhibiting apoptosis of Th2 cells...
  14. ncbi request reprint Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells
    Luzheng Xue
    Oxagen Limited, Abingdon, Oxon, United Kingdom
    J Immunol 175:6531-6. 2005
    ....