Olakunle James Onaolapo


Country: UK


  1. Onaolapo A, Ayeni O, Ogundeji M, Ajao A, Onaolapo O, Owolabi A. Subchronic ketamine alters behaviour, metabolic indices and brain morphology in adolescent rats: involvement of oxidative stress, glutamate toxicity and caspase-3-mediated apoptosis. J Chem Neuroanat. 2018;: pubmed publisher
    ..In conclusion, subchronic administration of ketamine to adolescent rats was associated with dose-related memory loss, oxidative stress and possibly caspase-3 mediated neurodegenerative changes. ..
  2. Onaolapo A, Onaolapo O. Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin's roles in prophylaxis and management. World J Diabetes. 2018;9:99-114 pubmed publisher
    ..Also, the possibility of using melatonin and its analogs for the "prophylaxis" or management of diabetes mellitus is also considered. ..
  3. Onaolapo A, Onaolapo O. Food additives, food and the concept of 'food addiction': Is stimulation of the brain reward circuit by food sufficient to trigger addiction?. Pathophysiology. 2018;25:263-276 pubmed publisher
  4. Onaolapo A, Onaolapo O. Caffeine's influence on object recognition and working-memory in prepubertal mice and its modulation by gender. Pathophysiology. 2015;22:223-30 pubmed publisher
    ..The findings suggest that acute caffeine injection improves non-spatial memory retention in female mice but not in males; spatial working-memory is however improved in males but not in females. ..
  5. Onaolapo A, Onaolapo O, Nwoha P. Alterations in behaviour, cerebral cortical morphology and cerebral oxidative stress markers following aspartame ingestion. J Chem Neuroanat. 2016;78:42-56 pubmed publisher
    ..These data therefore supports the need for caution in the indiscriminate use of aspartame as a non-nutritive sweetener. ..
  6. Onaolapo A, Adebayo A, Onaolapo O. Oral phenytoin protects against experimental cyclophosphamide-chemotherapy induced hair loss. Pathophysiology. 2018;25:31-39 pubmed publisher
    ..This study showed that oral phenytoin can suppress hair loss due to CYP therapy in rats; however, further studies are needed to evaluate its potential application in chemotherapy-induced alopecia. ..
  7. Onaolapo O, Adekola M, Azeez T, Salami K, Onaolapo A. l-Methionine and silymarin: A comparison of prophylactic protective capabilities in acetaminophen-induced injuries of the liver, kidney and cerebral cortex. Biomed Pharmacother. 2017;85:323-333 pubmed publisher
    ..This study highlights an obstacle to seeking the 'ideal' protective agent against acetaminophen overdose. ..
  8. Onaolapo A, Abdusalam S, Onaolapo O. Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers. Pathophysiology. 2017;24:51-62 pubmed publisher
    ..The study shows that co-administration of silymarin with aspartame was associated with significant attenuation of central effects, when compared to administration of aspartame alone. ..
  9. Onaolapo O, Paul T, Onaolapo A. Comparative effects of sertraline, haloperidol or olanzapine treatments on ketamine-induced changes in mouse behaviours. Metab Brain Dis. 2017;32:1475-1489 pubmed publisher
    ..In conclusion, this study shows that sertraline's ability to counteract ketamine-induced behavioural changes in mice is comparable to known antipsychotics. ..

More Information


  1. Onaolapo O, Ademakinwa O, Olalekan T, Onaolapo A. Ketamine-induced behavioural and brain oxidative changes in mice: an assessment of possible beneficial effects of zinc as mono- or adjunct therapy. Psychopharmacology (Berl). 2017;234:2707-2725 pubmed publisher
    ..Zinc may have the potential of a possible therapeutic agent and/or adjunct in the reversal of schizophrenia-like changes in behaviour and brain oxidative status. ..
  2. Onaolapo A, Adebayo A, Onaolapo O. Exogenous daytime melatonin modulates response of adolescent mice in a repeated unpredictable stress paradigm. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:149-161 pubmed publisher
    ..Administration of melatonin in repeatedly stressed adolescent mice was associated with improved central excitation, enhancement of working memory, anxiolysis and reduced systemic response to stress. ..
  3. Onaolapo A, Onaolapo O, Nwoha P. Aspartame and the hippocampus: Revealing a bi-directional, dose/time-dependent behavioural and morphological shift in mice. Neurobiol Learn Mem. 2017;139:76-88 pubmed publisher
    ..Oral aspartame significantly altered behaviour, anti-oxidant status and morphology of the hippocampus in mice; also, it may probably trigger hippocampal adult neurogenesis. ..
  4. Onaolapo A, Aina O, Onaolapo O. Melatonin attenuates behavioural deficits and reduces brain oxidative stress in a rodent model of schizophrenia. Biomed Pharmacother. 2017;92:373-383 pubmed publisher
    ..Administration of melatonin was associated with variable degrees of reversal of these effects. In conclusion, melatonin may have the potential of a possible therapeutic agent and/or adjunct in the management of schizophrenia. ..