David J Nutt

Summary

Country: UK

Publications

  1. ncbi Relationship of neurotransmitters to the symptoms of major depressive disorder
    David J Nutt
    Psychopharmacology Unit, University of Bristol, United Kingdom
    J Clin Psychiatry 69:4-7. 2008
  2. doi Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C]diprenorphine PET study
    Tim M Williams
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, UK
    Eur Neuropsychopharmacol 19:740-8. 2009
  3. ncbi Depleting serotonin enhances both cardiovascular and psychological stress reactivity in recovered patients with anxiety disorders
    Simon J C Davies
    Psychopharmacology Unit, University of Bristol, Whitson Street, Bristol BS1 8NY, United Kingdom
    J Clin Psychopharmacol 26:414-8. 2006
  4. doi A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions
    Anne Lingford-Hughes
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    J Psychopharmacol 26:273-81. 2012
  5. ncbi A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers
    Louise M Paterson
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
    Psychopharmacology (Berl) 191:943-50. 2007
  6. ncbi Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study
    Tim M Williams
    Psychopharmacology Unit, University of Bristol, and Bristol Specialist Drug Service, Blackberry Hill Hospital, UK
    Br J Psychiatry 191:63-9. 2007
  7. ncbi In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I2 binding in relation to MAO: evidence for two distinct I2 binding sites
    Louise M Paterson
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK
    Neuropharmacology 52:395-404. 2007
  8. ncbi Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist
    David J Nutt
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK
    Neuropharmacology 53:810-20. 2007
  9. doi Redistribution of slow wave activity of sleep during pharmacological treatment of depression with paroxetine but not with nefazodone
    Spilios V Argyropoulos
    Psychopharmacology Unit, University of Bristol, Bristol, BS1 3NY, UK
    J Sleep Res 18:342-8. 2009
  10. ncbi The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans
    Sue J Wilson
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 19:609-13. 2005

Detail Information

Publications68

  1. ncbi Relationship of neurotransmitters to the symptoms of major depressive disorder
    David J Nutt
    Psychopharmacology Unit, University of Bristol, United Kingdom
    J Clin Psychiatry 69:4-7. 2008
    ....
  2. doi Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C]diprenorphine PET study
    Tim M Williams
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, UK
    Eur Neuropsychopharmacol 19:740-8. 2009
    ..This confirms previous work showing increased opioid receptor availability in early abstinence from substances of abuse and correlation with craving suggesting that the opioid system plays a fundamental role in this phase of addiction...
  3. ncbi Depleting serotonin enhances both cardiovascular and psychological stress reactivity in recovered patients with anxiety disorders
    Simon J C Davies
    Psychopharmacology Unit, University of Bristol, Whitson Street, Bristol BS1 8NY, United Kingdom
    J Clin Psychopharmacol 26:414-8. 2006
    ....
  4. doi A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions
    Anne Lingford-Hughes
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    J Psychopharmacol 26:273-81. 2012
    ..We speculate that the reduced limbic [(11)C]Ro15 4513 binding seen here results from the effects of alcohol, though we cannot currently distinguish whether they are compensatory in nature or evidence of brain toxicity...
  5. ncbi A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers
    Louise M Paterson
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
    Psychopharmacology (Berl) 191:943-50. 2007
    ..Insomnia is a common and disabling complaint for which there is a need for improved treatments. Successful drug discovery relies on the use of appropriate animal models to assess likely outcome in the clinic...
  6. ncbi Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study
    Tim M Williams
    Psychopharmacology Unit, University of Bristol, and Bristol Specialist Drug Service, Blackberry Hill Hospital, UK
    Br J Psychiatry 191:63-9. 2007
    ..Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood...
  7. ncbi In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I2 binding in relation to MAO: evidence for two distinct I2 binding sites
    Louise M Paterson
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK
    Neuropharmacology 52:395-404. 2007
    ..These data indicate that the high affinity site which is occupied by [(3)H]2BFI and irreversibly binds BU99006, is not the same as that which causes inhibition of MAO, and may point to the existence of another I(2) binding site...
  8. ncbi Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist
    David J Nutt
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK
    Neuropharmacology 53:810-20. 2007
    ....
  9. doi Redistribution of slow wave activity of sleep during pharmacological treatment of depression with paroxetine but not with nefazodone
    Spilios V Argyropoulos
    Psychopharmacology Unit, University of Bristol, Bristol, BS1 3NY, UK
    J Sleep Res 18:342-8. 2009
    ..Higher mDSR did not predict therapeutic response. 5-HT(2A) blockade by nefazodone does not increase SWA above normal levels...
  10. ncbi The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans
    Sue J Wilson
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 19:609-13. 2005
    ..Wakefulness in sleep was significantly greatest after morning eptapirone. REM sleep effects were greatest after evening eptapirone, suggesting a greater effect on central serotonin receptors than that of buspirone...
  11. doi Brain dopamine response in human opioid addiction
    Mark R C Daglish
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, UK
    Br J Psychiatry 193:65-72. 2008
    ..Drugs of dependence cause dopamine release in the rat striatum. Human neuroimaging studies have shown an increase in dopamine in the equivalent region in response to stimulants and other drugs...
  12. pmc Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images
    James F M Myers
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Cereb Blood Flow Metab 32:731-44. 2012
    ..The proposed method for [(11)C]Ro15-4513 analysis may allow more accurate selective binding assays and estimation of drug occupancy for other nonselective ligands...
  13. ncbi A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers
    Jayne E Bailey
    Psychopharmacology Unit, Department of Respiratory Medicine, University of Bristol, United Bristol Healthcare Trust, UK
    J Psychopharmacol 21:42-9. 2007
    ..In these studies we have shown that this CO2 model of anxiety is sensitive to lorazepam and to a lesser extent paroxetine. This gives support to its utility as an experimental model of general anxiety disorder in healthy volunteers...
  14. doi Effects of 7.5% CO2 challenge in generalized anxiety disorder
    Kate Seddon
    University of Bristol, Psychopharmacology Unit, Bristol, UK
    J Psychopharmacol 25:43-51. 2011
    ..In conclusion, 20 min of 7.5% CO(2) gas inhalation increases anxiety responses in patients with generalized anxiety disorder, and this is reliable over time...
  15. doi Is the association of hypertension and panic disorder explained by clustering of autonomic panic symptoms in hypertensive patients?
    Simon J C Davies
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Affect Disord 111:344-50. 2008
    ....
  16. ncbi Estimation of endogenous noradrenaline release in rat brain in vivo using [3H]RX 821002
    Robin J Tyacke
    Psychopharmacology Unit, University of Bristol, Bristol, BS1 3NY, UK
    Synapse 55:126-32. 2005
    ....
  17. doi Antidepressant-induced jitteriness/anxiety syndrome: systematic review
    Lindsey I Sinclair
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Bristol BS1 3NY, UK
    Br J Psychiatry 194:483-90. 2009
    ..However, we believe that it is inconsistently defined and that robust evidence to support the phenomenon is lacking...
  18. doi Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls
    Robin L Carhart-Harris
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    Psychopharmacology (Berl) 206:187-96. 2009
    ..This study sought to test the association between 3,4-methylenedioxymethamphetamine use, serotonergic function and sleep...
  19. doi The effects of 7.5% carbon dioxide inhalation on task performance in healthy volunteers
    Alison Diaper
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 26:487-96. 2012
    ..Therefore, inhalation of 7.5% CO(2) produces effects on task performance which are consistent with anxiety...
  20. ncbi Imaging alcohol cue exposure in alcohol dependence using a PET 15O-H2O paradigm: results from a pilot study
    Anne R Lingford-Hughes
    Psychopharmacology Unit, University of Bristol, UK
    Addict Biol 11:107-15. 2006
    ..Comparisons with the finding in opiate dependence suggest a shared region, the anterior cingulate/left medial prefrontal cortex is involved in the cue response in dependent subjects but not controls...
  21. ncbi Tryptophan depletion reverses the therapeutic effect of selective serotonin reuptake inhibitors in social anxiety disorder
    Spilios V Argyropoulos
    Psychopharmacology Unit, University of Bristol, Bristol, United Kingdom
    Biol Psychiatry 56:503-9. 2004
    ..The present study tested the hypothesis that temporary reduction in central 5-HT transmission, through acute tryptophan depletion, could reverse the therapeutic effect of the SSRIs in social anxiety disorder (SAD) patients...
  22. doi Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects
    Amy Green
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 27:265-75. 2013
    ..Changes in taste perception may underlie altered consumption of refined sugars in opiate users...
  23. pmc Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, University of Bristol, Bristol BS8 2BN, United Kingdom
    Proc Natl Acad Sci U S A 109:2138-43. 2012
    ..These results strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition...
  24. ncbi The role of dopamine and norepinephrine in depression and antidepressant treatment
    David J Nutt
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol, UK
    J Clin Psychiatry 67:3-8. 2006
    ..This research has identified novel potential targets, with the goal of developing new antidepressant drugs with better efficacy and faster onset of action than current "gold-standard" treatments...
  25. ncbi Understanding the neurobiology of comorbidity in anxiety disorders
    David J Nutt
    Psychopharmacology Unit, University of Bristol, Bristol, United Kingdom
    CNS Spectr 11:13-20. 2006
    ..Sufficient and significant differences between these disorders support the view that they are independent entities. Shared abnormalities in the 5HT1A receptor function, for example, may help explain some of the comorbidity...
  26. doi GABA-A receptors and the response to CO(2) inhalation - a translational trans-species model of anxiety?
    Jayne E Bailey
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Pharmacol Biochem Behav 90:51-7. 2008
    ..This paper reviews some of the evidence and attempts to relate and compare these findings across species from the human to the Drosophila...
  27. pmc Identification of an imidazoline binding protein: creatine kinase and an imidazoline-2 binding site
    Atsuko Kimura
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    Brain Res 1279:21-8. 2009
    ..The importance of B-CK in regulating neuronal activity and neurotransmitter release may well explain the various actions of I(2) ligands in brain and the alterations in densities of I(2) binding sites in psychiatric disorders...
  28. doi Evaluation of an operant successive negative contrast task as a method to study affective state in rodents
    Emma N Mitchell
    School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom
    Behav Brain Res 234:155-60. 2012
    ..Rather than inducing a negative affective state in rats, the barren housing conditions resulted in a relatively more positive affective state in the chamber when compared to animals living in a highly enriched environment...
  29. doi Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic
    Alison Diaper
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 27:135-45. 2013
    ..This may be due to a lack of sensitivity of the CO(2) challenges in healthy volunteers to these drug types...
  30. doi Elucidation of neurobiology of anxiety disorders in children through pharmacological challenge tests and cortisol measurements: a systematic review
    Berta Garcia de Miguel
    University of Bristol, Psychopharmacology Unit, Bristol, UK
    J Psychopharmacol 26:431-42. 2012
    ..Further research is required to fully understand the biology and progression of childhood anxiety disorders...
  31. doi Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study
    Alastair G Reid
    Psychopharmacology Unit, University of Bristol, UK alastair reid bristol ac uk
    J Psychopharmacol 22:7-10. 2008
    ..We suggest that level of nondependent alcohol use could influence reduced thalamic grey matter volume in opioid-dependent subjects...
  32. doi The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO(2) -induced anxiety
    Alison Diaper
    Psychopharmacology Unit, University of Bristol, Academic Unit of Psychiatry, Bristol, UK
    Hum Psychopharmacol 27:540-8. 2012
    ..Results may be indicative of dose-dependent effects of lorazepam in a CO(2) model of anxiety. Copyright © 2012 John Wiley & Sons, Ltd...
  33. ncbi Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: clinical and preclinical studies
    Jan K Melichar
    Psychopharmacology Unit, University of Bristol, Whitson St, Bristol, BS1 3NY, UK
    J Pharmacol Exp Ther 312:309-15. 2005
    ..This has implications for understanding the actions of methadone in comparison with other opioid drugs such as partial agonists and antagonists...
  34. ncbi Consensus statement on the benefit to the community of ESEMeD (European Study of the Epidemiology of Mental Disorders) survey data on depression and anxiety
    David J Nutt
    University of Bristol, Bristol, United Kingdom
    J Clin Psychiatry 68:42-8. 2007
    ..In addition, how this large and unique dataset may be utilized for maximum benefit to patients is outlined...
  35. ncbi Human taste thresholds are modulated by serotonin and noradrenaline
    Tom P Heath
    Department of Physiology, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:12664-71. 2006
    ..In addition, we show that the general anxiety level is directly related to taste perception, suggesting that altered taste and appetite seen in affective disorders may reflect an actual change in the gustatory system...
  36. ncbi Acute tryptophan depletion. Part I: rationale and methodology
    Sean D Hood
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, England, UK
    Aust N Z J Psychiatry 39:558-64. 2005
    ..This review, the first of two articles, describes the rationale behind this technique and provides detail on how it is applied in research settings...
  37. ncbi Consensus statement and research needs: the role of dopamine and norepinephrine in depression and antidepressant treatment
    David J Nutt
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol, UK
    J Clin Psychiatry 67:46-9. 2006
    ..In addition, the faculty discussed the importance of patient psychoeducation and self-management as well as the ways in which disease models of depression affect treatment...
  38. ncbi Death and dependence: current controversies over the selective serotonin reuptake inhibitors
    David J Nutt
    University of Bristol, Psychopharmacology Unit, School of Medical Sciences, University Walk, Bristol, UK
    J Psychopharmacol 17:355-64. 2003
    ..There is no evidence they are addictive in the formal sense of leading to a drug dependence syndrome. Some suggestions on the way these issues can be more precisely defined and studied in future are given...
  39. ncbi Overview of diagnosis and drug treatments of anxiety disorders
    David J Nutt
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    CNS Spectr 10:49-56. 2005
    ....
  40. ncbi Harmane and harmalan are bioactive components of classical clonidine-displacing substance
    Christine A Parker
    Psychopharmacology Unit, University of Bristol, UK
    Biochemistry 43:16385-92. 2004
    ..We therefore propose that the beta-carbolines harmane and harmalan represent active components of classical CDS. The identification of these compounds will allow us to establish clear physiological roles for CDS...
  41. ncbi Structural and functional brain changes in posttraumatic stress disorder
    David J Nutt
    Psychopharmacology Unit, University of Bristol, Bristol, United Kingdom
    J Clin Psychiatry 65:11-7. 2004
    ..The findings of structural and functional neuroimaging studies of PTSD are reviewed as they relate to our current understanding of the pathophysiology of this disorder...
  42. ncbi Correlation of subjective and objective sleep measurements at different stages of the treatment of depression
    Spilios V Argyropoulos
    Psychopharmacology Unit, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Psychiatry Res 120:179-90. 2003
    ..The partial discrepancy between subjective and objective measures suggests that a cognitive element is combined with the biological element to produce the sleep problems reported by depressed patients...
  43. ncbi Tolerability and safety aspects of mirtazapine
    David J Nutt
    University of Bristol, Psychopharmacology Unit, Bristol, UK
    Hum Psychopharmacol 17:S37-41. 2002
    ..In conclusion, mirtazapine has a good tolerability and safety profile that demonstrates several benefits over other antidepressants...
  44. ncbi NICE: The National Institute of Clinical Excellence -- or Eccentricity? Reflections on the Z-drugs as hypnotics
    David J Nutt
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 19:125-7. 2005
  45. doi Cyproterone to treat aggressivity in dementia: a clinical case and systematic review
    Blanca M Bolea-Alamanac
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 25:141-5. 2011
    ..Despite there being evidence to support our observations of a useful role for cyproterone in aggressivity in dementia, further studies are needed to establish the efficacy and safety of this therapeutic option...
  46. ncbi Behavioral and cardiovascular effects of 7.5% CO2 in human volunteers
    Jayne E Bailey
    Psychopharmacology Unit, University of Bristol, The Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Bristol, United Kingdom
    Depress Anxiety 21:18-25. 2005
    ....
  47. ncbi Comparison of alterations in c-fos and Egr-1 (zif268) expression throughout the rat brain following acute administration of different classes of antidepressant compounds
    David A Slattery
    Psychopharmacology Unit, Dorothy Hodgkin Building, Whitson Street, University of Bristol, Bristol, UK
    Neuropsychopharmacology 30:1278-87. 2005
    ....
  48. doi GABAergic control of novelty stress-responsive epigenetic and gene expression mechanisms in the rat dentate gyrus
    Andreas Papadopoulos
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    Eur Neuropsychopharmacol 21:316-24. 2011
    ..Furthermore, GABA appears to exert its controller activity through modulation of NMDA receptor function. These findings may be of significance for the elucidation of anxiety disorders especially PTSD...
  49. ncbi Informed consent--a new approach to drug regulation?
    David J Nutt
    University of Bristol, Psychopharmacology Unit, Dorothy Hodgkin Building, Bristol UK
    J Psychopharmacol 20:3-4. 2006
  50. ncbi Functional connectivity analysis of the neural circuits of opiate craving: "more" rather than "different"?
    Mark R C Daglish
    Psychopharmacology Unit, University of Bristol, UK
    Neuroimage 20:1964-70. 2003
    ..This argues that neural circuits of dependence and craving are not specific "craving" or "addiction" brain regions but are "normal" circuits activated to a greater degree...
  51. ncbi Brain imaging studies in human addicts
    Mark R C Daglish
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    Eur Neuropsychopharmacol 13:453-8. 2003
    ..g., time asleep. Finally, 11C-Ro15-4513 offers new opportunities for imaging the GABA-BDZ system...
  52. ncbi The neuropharmacology of serotonin and noradrenaline in depression
    David J Nutt
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, UK
    Int Clin Psychopharmacol 17:S1-12. 2002
    ..Taken together, the data collected over the last 40 years have allowed the emergence of a unified monoamine hypothesis of antidepressant drug action...
  53. ncbi Pharmacological characterisation of novel alpha 2-adrenoceptor antagonists as potential brain imaging agents
    Emma S J Robinson
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 46:847-55. 2004
    ..Further studies using radiolabelled forms of these ligands and a more extensive characterisation of their binding profiles are necessary but these initial evaluations demonstrate their potential...
  54. ncbi Is there cognitive impairment in clinically 'healthy' abstinent alcohol dependence?
    Simon J C Davies
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
    Alcohol Alcohol 40:498-503. 2005
    ....
  55. ncbi Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients recovered on paroxetine
    Caroline Bell
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, UK
    J Psychopharmacol 16:5-14. 2002
    ..This implies that in panic disorder increased 5-HT availability is important in maintaining the response to SSRIs...
  56. ncbi Acute tryptophan depletion. Part II: clinical effects and implications
    Caroline J Bell
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
    Aust N Z J Psychiatry 39:565-74. 2005
    ..This article details the clinical studies to date and discusses the implications of this research methodology...
  57. ncbi Generalized anxiety disorder: comorbidity, comparative biology and treatment
    David J Nutt
    School of Medical Sciences, University of Bristol, UK
    Int J Neuropsychopharmacol 5:315-25. 2002
    ..Finally, current pharmacological and non-pharmacological treatment options for GAD are reviewed, with particular attention being paid to published clinical-trial data...
  58. ncbi Mechanism of action of antidepressants
    Francesc Artigas
    Spanish Research Council, Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, Barcelona, Spain
    Psychopharmacol Bull 36:123-32. 2002
    ..It is hoped that the development of drugs with multiple sites of action will translate into improved clinical efficacy in the treatment of depression...
  59. ncbi Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology
    David S Baldwin
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK
    J Psychopharmacol 19:567-96. 2005
    ..The guidelines cover the diagnosis of anxiety disorders and key steps in clinical management, including acute treatment, relapse prevention and approaches for patients who do not respond to first-line treatments...
  60. ncbi Resolution of sleepiness and fatigue in major depressive disorder: A comparison of bupropion and the selective serotonin reuptake inhibitors
    George I Papakostas
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 60:1350-5. 2006
    ....
  61. ncbi MDMA, politics and medical research: have we thrown the baby out with the bathwater?
    Ben Sessa
    J Psychopharmacol 21:787-91. 2007
  62. ncbi The unhappy saga of 'happy pills'
    David J Nutt
    J Psychopharmacol 17:251. 2003
  63. ncbi Dopamine and social anxiety disorder
    Hayley M Robinson
    Rev Bras Psiquiatr 28:263-4. 2006
  64. ncbi The effect of 1-(4,5-dihydro-1H-imidazol-2-yl) isoquinoline on monoamine release and turnover in the rat frontal cortex
    Haya Abu Ghazaleh
    Psychopharmacology Unit, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Neurosci Lett 422:109-13. 2007
    ..In addition, BU98008 did not appear to affect serotonergic neurotransmission in the frontal cortex. In conclusion, the present study demonstrates that BU98008 shares some functional similarities with known selective I(2)-BS ligands...
  65. doi Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:3-23. 2008
    ..It is the major problem facing efforts to identify the possible 'suicidal effects' of antidepressants...
  66. pmc Treatment of anxiety and depressive disorders in patients with cardiovascular disease
    Simon J C Davies
    Psychopharmacology Unit, Dorothy Hodgkin Building, Bristol BS1 3NY
    BMJ 328:939-43. 2004
  67. ncbi Which antidepressants have demonstrated superior efficacy? A review of the evidence
    Stuart A Montgomery
    Imperial College School of Medicine, University of London, UK
    Int Clin Psychopharmacol 22:323-9. 2007
    ..This review of published data found evidence that only a very few antidepressants are shown to be more effective than others...
  68. ncbi Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test
    David P Finn
    Psychopharmacology Unit, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Psychopharmacology (Berl) 167:195-202. 2003
    ..Selective I(2) receptor ligands modulate central monoamine levels and activate the hypothalamo-pituitary-adrenal (HPA) axis and may have potential as antidepressants...