P W Ewan
Affiliation: Nuffield Orthopaedic Centre
- Long-term prospective observational study of patients with peanut and nut allergy after participation in a management planP W Ewan
Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, Cambridge, UK
Lancet 357:111-5. 2001..We devised and assessed a management programme providing advice on nut avoidance and emergency medication...
- Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 childrenA T Clark
Department of Allergy, Addenbrookes Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
Allergy 62:913-6. 2007..Cashew nut allergy is becoming common, but the risk of severe reactions in comparison with peanut allergy is unknown...
- Successful oral tolerance induction in severe peanut allergyA T Clark
Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Box 40, Addenbrooke s Hospital, Hills Roads, Cambridge CB2 2QQ, UK
Allergy 64:1218-20. 2009..Peanut allergy is common, potentially severe and rarely resolves causing impaired quality of life. No disease-modifying treatment exists and there is therefore a need to develop a therapeutic intervention...
- Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapyS M McHugh
Molecular Immunopathology Unit, Medical Research Centre, Cambridge, UK
Clin Exp Allergy 25:828-38. 1995..The mechanism of immunotherapy is unclear. Allergic disease is known to involve enhanced TH-2 cytokine responses to allergen...
- Patterns of immunoglobulin G responses to egg and peanut allergens are distinct: ovalbumin-specific immunoglobulin responses are ubiquitous, but peanut-specific immunoglobulin responses are up-regulated in peanut allergyS S Tay
Department of Medicine, Cambridge University, Cambridge, UK
Clin Exp Allergy 37:1512-8. 2007..The clinical significance of food-specific IgG subclasses in food allergy and tolerance remains unclear. Specific IgG titres are often reported in non-standardized units, which do not allow comparisons between studies or allergens...
- T cell proliferation and cytokine responses to ovalbumin and ovomucoid detected in children with and without egg allergyS S Tay
Department of Medicine, Addenbrookes Hospital, Cambridge University, Cambridge, UK
Clin Exp Allergy 37:1519-27. 2007..The specific T cell responses in egg allergy and resolution have not been fully elucidated...
- Efficacy of a management plan based on severity assessment in longitudinal and case-controlled studies of 747 children with nut allergy: proposal for good practiceP W Ewan
Department of Allergy, Addenbrookes NHS Trust, University of Cambridge Clinical School, Cambridge, UK
Clin Exp Allergy 35:751-6. 2005..Our criteria for selective prescription of EpiPen in the context of this management plan were appropriate. This is the first study to provide evidence on which to inform practice...
- BSACI guidelines for the investigation of suspected anaphylaxis during general anaesthesiaP W Ewan
Allergy Clinic, Cambridge University NHS Foundation Trust, Cambridge, UK
Clin Exp Allergy 40:15-31. 2010..We suggest this focus since there is a distinct lack of validated data for testing, thus requiring experience in interpreting tests and because of the serious consequences of diagnostic error...
- New insight into immunological mechanisms of venom immunotherapyP W Ewan
Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, University of Cambridge Clinical School, Cambridge, UK
Curr Opin Allergy Clin Immunol 1:367-74. 2001..Immunostimulatory DNA sequences have an adjuvant effect and induce T helper type 1 cytokines, independent of antigen. They may be co-administered with allergen and used to redirect allergen-specific T helper type 2 responses...
- British Society for Allergy and Clinical Immunology guidelines for the management of egg allergyA T Clark
Allergy Department, Cambridge University NHS Foundation Trust, Cambridge, UK
Clin Exp Allergy 40:1116-29. 2010..The document encompasses epidemiology, risk factors, diagnosis, treatment, prognosis and co-morbid associations...
- Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cellsT L Rowland
Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, England, UK
Immunopharmacology 40:11-20. 1998..Due to their markedly different effects on cytokine production, and the fact that both drugs act at the level of transcription, we believe they influence separate pathways involved in cytokine gene regulation...
- Paracetamol hypersensitivity: clinical features, mechanism and role of specific IgEK Rutkowski
Allergy Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Int Arch Allergy Immunol 159:60-4. 2012..We identified the clinical features of 32 patients with suspected paracetamol allergy, investigated the underlying mechanism and examined co-existing non-steroidal anti-inflammatory drug (NSAID) tolerance...
- IgE mediated food allergy: when is food challenge needed?P W Ewan
Allergy Dept, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, and University of Cambridge Clinical School, Cambridge, UK
Arch Dis Child 90:555-6. 2005
- Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or toleranceA T Clark
Department of Allergy and Clinical Immunology, Addenbrooke's Hospital, University of Cambridge Clinical School, Cambridge, UK
Clin Exp Allergy 33:1041-5. 2003..Understanding this is essential for accurate diagnosis. Patients with SPT > or = 8 mm and CAP > or = 15 kU/L were rarely tolerant so these levels are almost always (in > or = 95%) diagnostic...
- Anaphylaxis to patent blue V: a case series and proposed diagnostic protocolR A Haque
Department of Allergy, Addenbrooke s Hospital, Cambridge, UK
Allergy 65:396-400. 2010..On the basis of our experience of patent blue V allergy, we propose a diagnostic protocol that can be safely and reliably utilised in centres equipped for allergy testing...
- BSACI guidelines for the management of drug allergyR Mirakian
Cambridge University, NHS Foundation Trust, Allergy Clinic, Cambridge, UK
Clin Exp Allergy 39:43-61. 2009..After the diagnosis of drug allergy has been established, communication of results and patient education are vital components of overall patient management...
- Facial thermography is a sensitive and specific method for assessing food challenge outcomeA T Clark
Department of Allergy, Cambridge University Hospitals NHS Trust, Addenbrookes Hospital, Cambridge, UK
Allergy 62:744-9. 2007..Oral challenge is widely used for diagnosing food allergy but variable interpretation of subjective symptoms may cause error. Facial thermography was evaluated as a novel, objective and sensitive indicator of challenge outcome...
- Food allergy in childhoodA T Clark
Addenbrooke's Hospital, Cambridge, UK
Arch Dis Child 88:79-81. 2003
- Interleukin-10 levels increase in cutaneous biopsies of patients undergoing wasp venom immunotherapyS M Nasser
Departments of Allergy and Clinical Immunology, University of Cambridge Clinical School, Cambridge, UK
Eur J Immunol 31:3704-13. 2001..These results suggest that induction of IL-10 may be important in VIT and occur independently of the switch to a Th1 phenotype. IL-10 generation may down-regulate IL-4 expression and eosinophil recruitment...