P W Ewan

Summary

Affiliation: Nuffield Orthopaedic Centre
Country: UK

Publications

  1. ncbi Long-term prospective observational study of patients with peanut and nut allergy after participation in a management plan
    P W Ewan
    Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, Cambridge, UK
    Lancet 357:111-5. 2001
  2. ncbi Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 children
    A T Clark
    Department of Allergy, Addenbrookes Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Allergy 62:913-6. 2007
  3. ncbi Successful oral tolerance induction in severe peanut allergy
    A T Clark
    Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Box 40, Addenbrooke s Hospital, Hills Roads, Cambridge CB2 2QQ, UK
    Allergy 64:1218-20. 2009
  4. ncbi Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy
    S M McHugh
    Molecular Immunopathology Unit, Medical Research Centre, Cambridge, UK
    Clin Exp Allergy 25:828-38. 1995
  5. ncbi Patterns of immunoglobulin G responses to egg and peanut allergens are distinct: ovalbumin-specific immunoglobulin responses are ubiquitous, but peanut-specific immunoglobulin responses are up-regulated in peanut allergy
    S S Tay
    Department of Medicine, Cambridge University, Cambridge, UK
    Clin Exp Allergy 37:1512-8. 2007
  6. ncbi T cell proliferation and cytokine responses to ovalbumin and ovomucoid detected in children with and without egg allergy
    S S Tay
    Department of Medicine, Addenbrookes Hospital, Cambridge University, Cambridge, UK
    Clin Exp Allergy 37:1519-27. 2007
  7. ncbi Efficacy of a management plan based on severity assessment in longitudinal and case-controlled studies of 747 children with nut allergy: proposal for good practice
    P W Ewan
    Department of Allergy, Addenbrookes NHS Trust, University of Cambridge Clinical School, Cambridge, UK
    Clin Exp Allergy 35:751-6. 2005
  8. ncbi BSACI guidelines for the investigation of suspected anaphylaxis during general anaesthesia
    P W Ewan
    Allergy Clinic, Cambridge University NHS Foundation Trust, Cambridge, UK
    Clin Exp Allergy 40:15-31. 2010
  9. ncbi New insight into immunological mechanisms of venom immunotherapy
    P W Ewan
    Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, University of Cambridge Clinical School, Cambridge, UK
    Curr Opin Allergy Clin Immunol 1:367-74. 2001
  10. ncbi British Society for Allergy and Clinical Immunology guidelines for the management of egg allergy
    A T Clark
    Allergy Department, Cambridge University NHS Foundation Trust, Cambridge, UK
    Clin Exp Allergy 40:1116-29. 2010

Collaborators

Detail Information

Publications19

  1. ncbi Long-term prospective observational study of patients with peanut and nut allergy after participation in a management plan
    P W Ewan
    Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, Cambridge, UK
    Lancet 357:111-5. 2001
    ..We devised and assessed a management programme providing advice on nut avoidance and emergency medication...
  2. ncbi Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 children
    A T Clark
    Department of Allergy, Addenbrookes Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Allergy 62:913-6. 2007
    ..Cashew nut allergy is becoming common, but the risk of severe reactions in comparison with peanut allergy is unknown...
  3. ncbi Successful oral tolerance induction in severe peanut allergy
    A T Clark
    Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Box 40, Addenbrooke s Hospital, Hills Roads, Cambridge CB2 2QQ, UK
    Allergy 64:1218-20. 2009
    ..Peanut allergy is common, potentially severe and rarely resolves causing impaired quality of life. No disease-modifying treatment exists and there is therefore a need to develop a therapeutic intervention...
  4. ncbi Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy
    S M McHugh
    Molecular Immunopathology Unit, Medical Research Centre, Cambridge, UK
    Clin Exp Allergy 25:828-38. 1995
    ..The mechanism of immunotherapy is unclear. Allergic disease is known to involve enhanced TH-2 cytokine responses to allergen...
  5. ncbi Patterns of immunoglobulin G responses to egg and peanut allergens are distinct: ovalbumin-specific immunoglobulin responses are ubiquitous, but peanut-specific immunoglobulin responses are up-regulated in peanut allergy
    S S Tay
    Department of Medicine, Cambridge University, Cambridge, UK
    Clin Exp Allergy 37:1512-8. 2007
    ..The clinical significance of food-specific IgG subclasses in food allergy and tolerance remains unclear. Specific IgG titres are often reported in non-standardized units, which do not allow comparisons between studies or allergens...
  6. ncbi T cell proliferation and cytokine responses to ovalbumin and ovomucoid detected in children with and without egg allergy
    S S Tay
    Department of Medicine, Addenbrookes Hospital, Cambridge University, Cambridge, UK
    Clin Exp Allergy 37:1519-27. 2007
    ..The specific T cell responses in egg allergy and resolution have not been fully elucidated...
  7. ncbi Efficacy of a management plan based on severity assessment in longitudinal and case-controlled studies of 747 children with nut allergy: proposal for good practice
    P W Ewan
    Department of Allergy, Addenbrookes NHS Trust, University of Cambridge Clinical School, Cambridge, UK
    Clin Exp Allergy 35:751-6. 2005
    ..Our criteria for selective prescription of EpiPen in the context of this management plan were appropriate. This is the first study to provide evidence on which to inform practice...
  8. ncbi BSACI guidelines for the investigation of suspected anaphylaxis during general anaesthesia
    P W Ewan
    Allergy Clinic, Cambridge University NHS Foundation Trust, Cambridge, UK
    Clin Exp Allergy 40:15-31. 2010
    ..We suggest this focus since there is a distinct lack of validated data for testing, thus requiring experience in interpreting tests and because of the serious consequences of diagnostic error...
  9. ncbi New insight into immunological mechanisms of venom immunotherapy
    P W Ewan
    Department of Allergy and Clinical Immunology, Addenbrooke s Hospital, University of Cambridge Clinical School, Cambridge, UK
    Curr Opin Allergy Clin Immunol 1:367-74. 2001
    ..Immunostimulatory DNA sequences have an adjuvant effect and induce T helper type 1 cytokines, independent of antigen. They may be co-administered with allergen and used to redirect allergen-specific T helper type 2 responses...
  10. ncbi British Society for Allergy and Clinical Immunology guidelines for the management of egg allergy
    A T Clark
    Allergy Department, Cambridge University NHS Foundation Trust, Cambridge, UK
    Clin Exp Allergy 40:1116-29. 2010
    ..The document encompasses epidemiology, risk factors, diagnosis, treatment, prognosis and co-morbid associations...
  11. ncbi Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells
    T L Rowland
    Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, England, UK
    Immunopharmacology 40:11-20. 1998
    ..Due to their markedly different effects on cytokine production, and the fact that both drugs act at the level of transcription, we believe they influence separate pathways involved in cytokine gene regulation...
  12. ncbi Paracetamol hypersensitivity: clinical features, mechanism and role of specific IgE
    K Rutkowski
    Allergy Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Int Arch Allergy Immunol 159:60-4. 2012
    ..We identified the clinical features of 32 patients with suspected paracetamol allergy, investigated the underlying mechanism and examined co-existing non-steroidal anti-inflammatory drug (NSAID) tolerance...
  13. ncbi IgE mediated food allergy: when is food challenge needed?
    P W Ewan
    Allergy Dept, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, and University of Cambridge Clinical School, Cambridge, UK
    Arch Dis Child 90:555-6. 2005
  14. ncbi Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance
    A T Clark
    Department of Allergy and Clinical Immunology, Addenbrooke's Hospital, University of Cambridge Clinical School, Cambridge, UK
    Clin Exp Allergy 33:1041-5. 2003
    ..Understanding this is essential for accurate diagnosis. Patients with SPT > or = 8 mm and CAP > or = 15 kU/L were rarely tolerant so these levels are almost always (in > or = 95%) diagnostic...
  15. ncbi Anaphylaxis to patent blue V: a case series and proposed diagnostic protocol
    R A Haque
    Department of Allergy, Addenbrooke s Hospital, Cambridge, UK
    Allergy 65:396-400. 2010
    ..On the basis of our experience of patent blue V allergy, we propose a diagnostic protocol that can be safely and reliably utilised in centres equipped for allergy testing...
  16. ncbi BSACI guidelines for the management of drug allergy
    R Mirakian
    Cambridge University, NHS Foundation Trust, Allergy Clinic, Cambridge, UK
    Clin Exp Allergy 39:43-61. 2009
    ..After the diagnosis of drug allergy has been established, communication of results and patient education are vital components of overall patient management...
  17. ncbi Facial thermography is a sensitive and specific method for assessing food challenge outcome
    A T Clark
    Department of Allergy, Cambridge University Hospitals NHS Trust, Addenbrookes Hospital, Cambridge, UK
    Allergy 62:744-9. 2007
    ..Oral challenge is widely used for diagnosing food allergy but variable interpretation of subjective symptoms may cause error. Facial thermography was evaluated as a novel, objective and sensitive indicator of challenge outcome...
  18. ncbi Food allergy in childhood
    A T Clark
    Addenbrooke's Hospital, Cambridge, UK
    Arch Dis Child 88:79-81. 2003
  19. ncbi Interleukin-10 levels increase in cutaneous biopsies of patients undergoing wasp venom immunotherapy
    S M Nasser
    Departments of Allergy and Clinical Immunology, University of Cambridge Clinical School, Cambridge, UK
    Eur J Immunol 31:3704-13. 2001
    ..These results suggest that induction of IL-10 may be important in VIT and occur independently of the switch to a Th1 phenotype. IL-10 generation may down-regulate IL-4 expression and eosinophil recruitment...