Research Topics

Stephen J Forsythe

Summary

Affiliation: Nottingham Trent University
Country: UK

Publications

  1. Jackson E, Masood N, Ibrahim K, Urvoy N, Hariri S, Forsythe S. Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis. Int J Syst Evol Microbiol. 2015;65:1335-41 pubmed publisher
    ..nov. is proposed. The type strain is 1383(T) ( = NCTC 14934(T) = CECT 8567(T) = LMG 28204(T)). An emended description of Siccibacter turicensis is also provided. ..
  2. Jackson E, Flores J, Fernández Escartín E, Forsythe S. Reevaluation of a Suspected Cronobacter sakazakii Outbreak in Mexico. J Food Prot. 2015;78:1191-6 pubmed publisher
    ..from PIF to infants. These are possibly the first reported cases of Enterobacter spp. infection of infants from bacterial-contaminated PIF. ..
  3. Alzahrani H, Winter J, Boocock D, De Girolamo L, Forsythe S. Characterization of outer membrane vesicles from a neonatal meningitic strain of Cronobacter sakazakii. FEMS Microbiol Lett. 2015;362:fnv085 pubmed publisher
    ..Collectively, these data indicate that C. sakazakii OMV could play a role in pathogenesis by delivering bacterial toxins into host epithelial cells, driving proliferative and proinflammatory responses. ..
  4. Alsonosi A, Hariri S, Kajsík M, Oriešková M, Hanulík V, Röderová M, et al. The speciation and genotyping of Cronobacter isolates from hospitalised patients. Eur J Clin Microbiol Infect Dis. 2015;34:1979-88 pubmed publisher
    ..This study shows the value of applying MLST to bacterial population studies with strains from two patient cohorts, combined with PFGE for further discrimination of strains. ..
  5. Almajed F, Forsythe S. Cronobacter sakazakii clinical isolates overcome host barriers and evade the immune response. Microb Pathog. 2016;90:55-63 pubmed publisher
    ..Additionally, it was shown that C. sakazakii clinical strains have the capacity to translocate through the Caco-2 and HBMEC cell lines paracellularly. ..
  6. Jackson E, Ogrodzki P, Pascoe B, Sheppard S, Forsythe S. Draft Genome Sequence of an Enterobacter Species Associated with Illnesses and Powdered Infant Formula. Genome Announc. 2016;4: pubmed publisher
    ..Enterobacter spp. are currently permitted in PIF, but the transmission of this strain indicates that the microbiological criteria for PIF may need revision. ..
  7. Jackson E, Forsythe S. Comparative study of Cronobacter identification according to phenotyping methods. BMC Microbiol. 2016;16:146 pubmed publisher
    ..Instead, a previously published PCR-based method targeting ompA is suggested as an alternative for identification of Cronobacter species based on in silico analysis. ..
  8. Forsythe S, Dickins B, Jolley K. Cronobacter, the emergent bacterial pathogen Enterobacter sakazakii comes of age; MLST and whole genome sequence analysis. BMC Genomics. 2014;15:1121 pubmed publisher
    ..Whole genome sequencing has additionally shown a range of potential virulence and environmental fitness traits which may account for the association of C. sakazakii CC4 pathogenicity, and propensity for neonatal CNS. ..
  9. Masood N, Moore K, Farbos A, Paszkiewicz K, Dickins B, McNally A, et al. Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit. BMC Genomics. 2015;16:750 pubmed publisher
    ..It also indicated that C. sakazakii isolates from different genotype clusters have the ability to co-infect neonates. ..

More Information

Publications12

  1. Ogrodzki P, Forsythe S. Capsular profiling of the Cronobacter genus and the association of specific Cronobacter sakazakii and C. malonaticus capsule types with neonatal meningitis and necrotizing enterocolitis. BMC Genomics. 2015;16:758 pubmed publisher
  2. Alkeskas A, Ogrodzki P, Saad M, Masood N, Rhoma N, Moore K, et al. The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes. BMC Infect Dis. 2015;15:449 pubmed publisher
  3. Brandão M, Umeda N, Jackson E, Forsythe S, de Filippis I. Isolation, molecular and phenotypic characterization, and antibiotic susceptibility of Cronobacter spp. from Brazilian retail foods. Food Microbiol. 2017;63:129-138 pubmed publisher
    ..This study revealed the presence of Cronobacter spp. in foods commercialized in Brazil and the isolates showed a high diversity after MLST analysis and included two strains of the C. sakazakii ST4 neonatal meningitic pathovar. ..