G P Aithal

Summary

Affiliation: Nottingham University Hospitals
Country: UK

Publications

  1. doi request reprint Case definition and phenotype standardization in drug-induced liver injury
    G P Aithal
    Nottingham Digestive Diseases Centre, National Institute for Health Research Biomedical Research Unit, Nottingham University Hospital National Health Service Trust, Nottingham, UK
    Clin Pharmacol Ther 89:806-15. 2011
  2. pmc Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971-2001
    J West
    Division of Epidemiology and Public Health, University of Nottingham Medical School, Queen s Medical Centre University Hospital, Nottingham NG7 2UH, UK
    Br J Cancer 94:1751-8. 2006
  3. pmc The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study
    Fumi Varyani
    Department of Gastroenterology, Queens Medical Centre, Nottingham University Hospital NHS Trust, Derby Road, Nottingham, NG7 2UH, United Kingdom
    BMC Health Serv Res 13:161. 2013
  4. doi request reprint Hepatotoxicity related to antirheumatic drugs
    Guruprasad P Aithal
    Nottingham Digestive Diseases Centre, National Institute of Health Research Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Queen s Medical Centre, Derby Road, Nottingham, UK
    Nat Rev Rheumatol 7:139-50. 2011
  5. ncbi request reprint EUS-guided tissue sampling: comparison of "dual sampling" (Trucut biopsy plus FNA) with "sequential sampling" (Trucut biopsy and then FNA as required)
    G P Aithal
    Wolfson Digestive Diseases Centre, Queen s Medical Centre University Hospital, Nottingham, United Kingdom
    Endoscopy 39:725-30. 2007
  6. ncbi request reprint Mind the gap
    Guruprasad P Aithal
    Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Queen s Medical Centre, Nottingham, UK
    Altern Lab Anim 38:1-4. 2010
  7. ncbi request reprint Nonsteroidal anti-inflammatory drug-induced hepatotoxicity
    Guruprasad P Aithal
    Queen s Medical Centre, University Hospital, D Floor, South Block, Nottingham, NG7 2UH, UK
    Clin Liver Dis 11:563-75, vi-vii. 2007
  8. doi request reprint Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    Guruprasad P Aithal
    University Hospitals NHS Trust, Nottingham, United Kingdom
    Gastroenterology 135:1176-84. 2008
  9. doi request reprint High-resolution endoscopy and endoscopic ultrasound for evaluation of early neoplasia in Barrett's esophagus
    T Thomas
    Nottingham Digestive Diseases Centre and Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus, Nottingham NG7 2UH, UK
    Surg Endosc 24:1110-6. 2010
  10. doi request reprint Abnormal liver tests in people aged 75 and above: prevalence and association with mortality
    K M Fleming
    Division of Epidemiology and Public Health, University of Nottingham, Nottingham City Hospital, Nottingham, UK
    Aliment Pharmacol Ther 34:324-34. 2011

Collaborators

Detail Information

Publications38

  1. doi request reprint Case definition and phenotype standardization in drug-induced liver injury
    G P Aithal
    Nottingham Digestive Diseases Centre, National Institute for Health Research Biomedical Research Unit, Nottingham University Hospital National Health Service Trust, Nottingham, UK
    Clin Pharmacol Ther 89:806-15. 2011
    ..Consensus was also reached on approaches to characterizing DILI in the setting of chronic liver diseases, including autoimmune hepatitis (AIH)...
  2. pmc Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971-2001
    J West
    Division of Epidemiology and Public Health, University of Nottingham Medical School, Queen s Medical Centre University Hospital, Nottingham NG7 2UH, UK
    Br J Cancer 94:1751-8. 2006
    ..There has been a halving in the incidence of gallbladder cancer and a reduction of a third in extrahepatic bile duct cancer...
  3. pmc The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study
    Fumi Varyani
    Department of Gastroenterology, Queens Medical Centre, Nottingham University Hospital NHS Trust, Derby Road, Nottingham, NG7 2UH, United Kingdom
    BMC Health Serv Res 13:161. 2013
    ..The aim of this study therefore was to assess the proportion of consultant hepatologist diagnoses of Autoimmune Hepatitis which were accurately recorded in General Practice computerised records...
  4. doi request reprint Hepatotoxicity related to antirheumatic drugs
    Guruprasad P Aithal
    Nottingham Digestive Diseases Centre, National Institute of Health Research Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Queen s Medical Centre, Derby Road, Nottingham, UK
    Nat Rev Rheumatol 7:139-50. 2011
    ..Detailed understanding of genetic and environmental factors underlying an individual's susceptibility would enable risk reduction and potentially primary prevention of hepatotoxicity...
  5. ncbi request reprint EUS-guided tissue sampling: comparison of "dual sampling" (Trucut biopsy plus FNA) with "sequential sampling" (Trucut biopsy and then FNA as required)
    G P Aithal
    Wolfson Digestive Diseases Centre, Queen s Medical Centre University Hospital, Nottingham, United Kingdom
    Endoscopy 39:725-30. 2007
    ..The aim of this study was to develop a strategy of combining these two EUS-guided sampling techniques in order to maximize the diagnostic accuracy and minimize duplication...
  6. ncbi request reprint Mind the gap
    Guruprasad P Aithal
    Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Queen s Medical Centre, Nottingham, UK
    Altern Lab Anim 38:1-4. 2010
    ..The way in which these knowledge gaps are being bridged by studies involving the use of human tissues and primary cells are described...
  7. ncbi request reprint Nonsteroidal anti-inflammatory drug-induced hepatotoxicity
    Guruprasad P Aithal
    Queen s Medical Centre, University Hospital, D Floor, South Block, Nottingham, NG7 2UH, UK
    Clin Liver Dis 11:563-75, vi-vii. 2007
    ....
  8. doi request reprint Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    Guruprasad P Aithal
    University Hospitals NHS Trust, Nottingham, United Kingdom
    Gastroenterology 135:1176-84. 2008
    ..Insulin sensitizing, anti-inflammatory, and antifibrotic properties of thiazolidinediones support their use in treating NASH. We have evaluated pioglitazone in the treatment of nondiabetic patients with NASH...
  9. doi request reprint High-resolution endoscopy and endoscopic ultrasound for evaluation of early neoplasia in Barrett's esophagus
    T Thomas
    Nottingham Digestive Diseases Centre and Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus, Nottingham NG7 2UH, UK
    Surg Endosc 24:1110-6. 2010
    ..This study aimed to determine whether the lesion morphology of the EBN shown on high-resolution endoscopy predicts EUS and histologic tumor stage...
  10. doi request reprint Abnormal liver tests in people aged 75 and above: prevalence and association with mortality
    K M Fleming
    Division of Epidemiology and Public Health, University of Nottingham, Nottingham City Hospital, Nottingham, UK
    Aliment Pharmacol Ther 34:324-34. 2011
    ..Despite their common use the occurrence and consequences of abnormal liver tests remain unclear...
  11. doi request reprint Regional anthropometric measures associated with the severity of liver injury in patients with non-alcoholic fatty liver disease
    V Subramanian
    National Institute for Health Research Biomedical Research Unit in Gastrointestinal and Liver Disease, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK
    Aliment Pharmacol Ther 37:455-63. 2013
    ..Not all NAFLD patients are obese and many obese patients do not have NAFLD. Impaired peripheral fat storage may increase the delivery of lipids to the liver and facilitate NAFLD progression...
  12. doi request reprint Endoscopic-ultrasound-guided mural trucut biopsy in the investigation of unexplained thickening of esophagogastric wall
    T Thomas
    Nottingham Digestive Diseases Centre Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Queens Medical Centre, United Kingdom
    Endoscopy 41:335-9. 2009
    ..We aimed to evaluate the efficacy and safety of EUS-guided mural trucut biopsies (TCB) in detecting underlying malignancy in patients with thickened esophagogastric wall and negative mucosal biopsies...
  13. ncbi request reprint Effectiveness of a nurse-led alcohol liaison service in a secondary care medical unit
    S D Ryder
    Department of Gastroenterology, Queens Medical Centre Campus, Nottingham University Hospitals NHS Trust
    Clin Med 10:435-40. 2010
    ..It is believed that this model of care is an effective means of intervening in people with alcohol-related problems...
  14. pmc The antecedents of biliary cancer: a primary care case-control study in the United Kingdom
    M J Grainge
    Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    Br J Cancer 100:178-80. 2009
    ..Increased risks were observed for cigarette smoking, diabetes, gallstone disease and obesity...
  15. doi request reprint Development and evaluation of a nurse-led transient elastography service for the staging of hepatic fibrosis in patients with suspected chronic liver disease
    R B McCorry
    Department of Hepatology, National Institute of Health Research Biomedical Research Unit, Nottingham University Hospital NHS Trust, Nottingham NG7 2UH, UK
    QJM 105:749-54. 2012
    ..The studies performed to date have used physician operators. With the potential use of TE for screening of community-based populations for liver disease, we aimed to evaluate the performance of nurse operators...
  16. ncbi request reprint Elevated serum alanine transaminase in patients with type 1 or type 2 diabetes mellitus
    J West
    Division of Epidemiology and Public Health, University of Nottingham Medical School, Nottingham, UK
    QJM 99:871-6. 2006
    ..The risk of chronic liver disease is higher in diabetics, and serum alanine transaminase (ALT) is a sensitive predictor of mortality from liver disease...
  17. ncbi request reprint Autoimmune cholestatic liver disease in people with coeliac disease: a population-based study of their association
    A Lawson
    Wolfson Digestive Disease Foundation, University Hospital, Queen s Medical Centre, Nottingham, UK
    Aliment Pharmacol Ther 21:401-5. 2005
    ..Population data supporting an association between the autoimmune cholestatic liver diseases, primary biliary cirrhosis and primary sclerosing cholangitis and coeliac disease, is limited and at times contradictory...
  18. ncbi request reprint Monitoring methotrexate-induced hepatic fibrosis in patients with psoriasis: are serial liver biopsies justified?
    G P Aithal
    Queen s Medical Centre University Hospital, Nottingham, UK
    Aliment Pharmacol Ther 19:391-9. 2004
    ..Reports that up to 26% of subjects with psoriasis develop cirrhosis have led to a recommendation of serial liver biopsies after each cumulative dose of 1500 mg of methotrexate...
  19. ncbi request reprint Brunner's gland hyperplasia at the ampulla of Vater
    S E J Janes
    Department of Surgery, Queens Medical Centre, Nottingham, United Kingdom
    J Postgrad Med 52:38-40. 2006
    ..In addition, we present the previously unreported endoscopic ultrasound findings. The subsequent literature review focuses on the pathophysiology, clinical presentation, diagnosis and management of BGH...
  20. ncbi request reprint Monitoring liver function during methotrexate therapy for psoriasis: are routine biopsies really necessary?
    James A Thomas
    Queen s Medical Centre, University Hospital, Nottingham, UK
    Am J Clin Dermatol 6:357-63. 2005
    ..Advances in the non-invasive assessment of liver fibrogenesis may eventually further reduce the need for biopsy...
  21. ncbi request reprint The pathological response to neoadjuvant chemotherapy with FOLFOX-4 for colorectal liver metastases: a comparative study
    Mark M Aloysius
    Division of Gastrointestinal Surgery, Wolfson Digestive Diseases Centre, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Virchows Arch 451:943-8. 2007
    ..001). The response to FOLFOX-4 was associated with tumour necrosis, fibrosis and inflammation. More than two thirds of patients undergoing hepatectomy after FOLFOX-4 had steatosis despite being non-obese...
  22. doi request reprint Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: a general population-based study
    Kate M Fleming
    Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
    J Hepatol 49:732-8. 2008
    ..To determine the incidence and prevalence of cirrhosis in the United Kingdom...
  23. ncbi request reprint Concurrent mucinous cystadenoma of the liver and bile duct: a rare cause of jaundice
    Quentin M Nunes
    Section of Surgery, Department of Hepatology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Gastrointest Endosc 63:870-2. 2006
  24. ncbi request reprint When is a herb a drug?
    Guruprasad P Aithal
    Queens Medical Centre, University Hospital, Nottingham, UK
    Eur J Gastroenterol Hepatol 17:391-3. 2005
    ..Herbal medicines should be regulated more systematically and monitoring for adverse reaction should improve...
  25. ncbi request reprint EUS-guided pancreatic cyst brushing: a comparative study in a tertiary referral centre
    Titus Thomas
    Biomedical Research Unit, Nottingham Digestive Diseases Centre and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
    JOP 11:163-9. 2010
    ..Fluid analysis obtained by EUS guided FNA is used to aid in diagnosis and management of cystic lesions in the pancreas. Complementing fluid aspiration with brushing of cyst wall may increase the cellular yield...
  26. ncbi request reprint Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers
    Indra Neil Guha
    Liver Group, University of Southampton, Southampton, UK
    Hepatology 47:455-60. 2008
    ..The addition of established simple markers augments the diagnostic performance across different stages of fibrosis, which will potentially allow superior stratification of patients with NAFLD for emerging therapeutic strategies...
  27. ncbi request reprint Accuracy of EUS for detection of intraductal papillary mucinous tumor of the pancreas
    Guruprasad P Aithal
    Digestive Disease Center and Department of Biostatistics, Medical University of South Carolina, Charleston, USA
    Gastrointest Endosc 56:701-7. 2002
    ..This study assessed the accuracy of EUS for detection of IPMT and identified features that discriminate IPMT from chronic pancreatitis...
  28. ncbi request reprint Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
    Guruprasad P Aithal
    School of Clinical Medical Sciences Hepatology, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Hepatology 39:1430-40. 2004
    ..In conclusion, the observed polymorphisms, resulting in low IL-10 and high IL-4 gene transcription, could favor a T helper (Th)-2 mediated antibody response to neoantigenic stimulation associated with disease susceptibility...
  29. ncbi request reprint Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma
    Rachel E Bullock
    J Hepatol 41:685-6. 2004
  30. ncbi request reprint Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity
    Guruprasad P Aithal
    Expert Opin Drug Saf 3:519-23. 2004
    ..Understanding the mechanisms of idiosyncratic hepatotoxicity may increase our ability to identify susceptible individuals and hence, prevent serious adverse reactions...
  31. ncbi request reprint EUS-guided Trucut mural biopsies in the investigation of unexplained thickening of the esophagogastric wall
    Guruprasad P Aithal
    Division of Gastroenterology and Pathology, Queen s Medical Centre University Hospital, Nottingham, United Kingdom
    Gastrointest Endosc 62:624-9. 2005
    ..We examined whether it is feasible to obtain diagnostic tissue core from the gut wall by using EUS-guided Trucut biopsy technique in this group of patients...
  32. ncbi request reprint Squamous cell carcinoma of the pancreas: report of a case and review of the literature
    George K Anagnostopoulos
    Wolfson Digestive Diseases Centre, Queen s Medical Centre, University Hospital, Nottingham, United Kingdom
    JOP 7:47-50. 2006
    ..Although, squamous metaplasia of the ductal columnar cells can be observed during periods of inflammation, squamous cell pancreatic carcinoma is an extremely rare tumour...
  33. ncbi request reprint Fracture risk in people with primary biliary cirrhosis: a population-based cohort study
    Masoud Solaymani-Dodaran
    Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
    Gastroenterology 131:1752-7. 2006
    ..We have performed a cohort study using the General Practice Research Database to quantify the excess fracture risk in people with PBC...
  34. ncbi request reprint Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes
    Ann K Daly
    School of Clinical and Laboratory Sciences, University of Newcastle Medical School, Framlington Place, Newcastle upon Tyne, UK
    Gastroenterology 132:272-81. 2007
    ....
  35. ncbi request reprint Dangerous liaisons: drug, host and the environment
    Guruprasad P Aithal
    J Hepatol 46:995-8. 2007
  36. ncbi request reprint Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study
    Hannah Jackson
    University of Nottingham Medical School, Division of Epidemiology and Public Health, Medical School, Queen s Medical Centre, Nottingham, United Kingdom
    Hepatology 46:1131-7. 2007
    ..The increased risk of primary liver cancer in ursodeoxycholic acid-treated patients was 3-fold (HR, 3.17; 95% CI, 0.64-15.62), in contrast to an 8-fold increase in those not treated (HR, 7.77; 95% CI, 1.30-46.65)...
  37. ncbi request reprint Helical CT versus EUS with fine needle aspiration for celiac nodal assessment in patients with esophageal cancer
    Joseph Romagnuolo
    Division of Gastroenterology, University of Calgary, Alberta, Canada
    Gastrointest Endosc 55:648-54. 2002
    ..Helical CT has theoretical advantages over "slice" CT in this regard, but its performance has not yet been prospectively studied...