D Middleton

Summary

Affiliation: Northern Ireland
Country: UK

Publications

  1. ncbi KIR genes
    Derek Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, UK
    Transpl Immunol 14:135-42. 2005
  2. ncbi Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 66:836-41. 2005
  3. ncbi HLA Typing from Serology to Sequencing Era
    Derek Middelton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Iran J Allergy Asthma Immunol 4:53-66. 2005
  4. ncbi 14th International HLA and Immunogenetics Workshop: report on KIR receptors and their applications
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 69:85-7. 2007
  5. ncbi Studies on the expression of the deleted KIR2DS4*003 gene product and distribution of KIR2DS4 deleted and nondeleted versions in different populations
    Derek Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, Northern Ireland
    Hum Immunol 68:128-34. 2007
  6. ncbi HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, UK
    Tissue Antigens 63:555-61. 2004
  7. ncbi New allele frequency database: http://www.allelefrequencies.net
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast, Northern Ireland
    Tissue Antigens 61:403-7. 2003
  8. ncbi Natural killer cells and their receptors
    Derek Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, UK
    Transpl Immunol 10:147-64. 2002
  9. ncbi No association in frequency of KIR receptors in patients with rheumatoid arthritis from Northern Ireland
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 69:577-82. 2007
  10. ncbi KIR allele and gene polymorphism group (KAG)
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, BT9 7TS Northern Ireland
    Mol Immunol 42:455-7. 2005

Collaborators

Detail Information

Publications79

  1. ncbi KIR genes
    Derek Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, UK
    Transpl Immunol 14:135-42. 2005
    ..This review updates the on-going investigations into KIR genes and their alleles with the main emphasis on what has taken place in this laboratory over the last 3 years...
  2. ncbi Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 66:836-41. 2005
    ..An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group...
  3. ncbi HLA Typing from Serology to Sequencing Era
    Derek Middelton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Iran J Allergy Asthma Immunol 4:53-66. 2005
    ..The last two decades have seen a massive growth in the application of DNA technology in Histocompatibility and Immunogenetics. This review summarises the history and application of DNA methods in this area...
  4. ncbi 14th International HLA and Immunogenetics Workshop: report on KIR receptors and their applications
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 69:85-7. 2007
    ..To introduce this work, we provide an introduction to KIR receptors and an outline of previous applications of KIR receptor typing prior to the Workshop...
  5. ncbi Studies on the expression of the deleted KIR2DS4*003 gene product and distribution of KIR2DS4 deleted and nondeleted versions in different populations
    Derek Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, Northern Ireland
    Hum Immunol 68:128-34. 2007
    ..A trend was observed towards decreased frequencies of KIR2DS4 deleted variant occurrence in populations having KIR2DS4 as the only activating KIR gene...
  6. ncbi HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, UK
    Tissue Antigens 63:555-61. 2004
    ..In addition, knowing which alleles do/do not occur in this population will aid in the distinction of ambiguities which result from the use of many of the typing kits available...
  7. ncbi New allele frequency database: http://www.allelefrequencies.net
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast, Northern Ireland
    Tissue Antigens 61:403-7. 2003
    ..Data for HLA alleles has been added but this will be extended to include frequency data of polymorphisms in other immunogenetic regions, e.g. cytokines, KIR receptors, MIC...
  8. ncbi Natural killer cells and their receptors
    Derek Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, UK
    Transpl Immunol 10:147-64. 2002
    ..The roles that NK cells and their receptors have with various facets of transplantation, disease, pregnancy and control of virus infection in humans are described...
  9. ncbi No association in frequency of KIR receptors in patients with rheumatoid arthritis from Northern Ireland
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 69:577-82. 2007
    ..Furthermore, no differences were found when the patients were sub-divided according to gender or shared epitope and when the presence of the human leucocyte antigen ligand was taken into account...
  10. ncbi KIR allele and gene polymorphism group (KAG)
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, BT9 7TS Northern Ireland
    Mol Immunol 42:455-7. 2005
    ..Discussion took place on nomenclature issues of the KIR genes and their alleles, and a website has been developed to collect frequencies of KIR genes and alleles in various diverse populations...
  11. ncbi KIR haplotype content at the allele level in 77 Northern Irish families
    D Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, BT9 7TS, Northern Ireland, UK
    Immunogenetics 59:145-58. 2007
    ..1%, 9.7% and 12.6% for KIR2DL4, KIR3DL2 and KIR3DL1 genes, respectively, but 62.6% and 53% for KIR2DL3 and KIR2DS4 genes, respectively, despite the fact that no one allele dominated the frequency in any of these genes...
  12. ncbi Investigation of KIR gene frequencies in type 1 diabetes mellitus
    Derek Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, and University of Ulster, Coleraine, Northern Ireland
    Hum Immunol 67:986-90. 2006
    ..The KIR gene 2DS5 was significantly decreased in patients versus controls, but this was no longer significant after correction for the number of comparisons made...
  13. ncbi Analysis of KIR gene frequencies in HLA class I characterised bladder, colorectal and laryngeal tumours
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, Northern Ireland, UK
    Tissue Antigens 69:220-6. 2007
    ..Finally, in the group of colorectal carcinomas, there was an overall significant difference in the frequencies of C group heterozygosity and homozygosity with HLA alterations on the tumour...
  14. ncbi No association of KIR genes with Behcet's disease
    D Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, UK
    Tissue Antigens 70:435-8. 2007
    ..Thus, no association was identified between presence or absence of any of the 14 KIR genes studied and BD. In addition, we did not find any associations of KIR with various manifestations of the disease nor with gender or age of onset...
  15. ncbi Identification of three novel alleles of HLA-DRB1 and HLA-A in the Brazilian population
    H Abdeen
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, UK
    Tissue Antigens 69:607-10. 2007
    ..These three novel alleles may have originated from other HLA alleles by gene conversion. However, it is also possible that HLA-A*2471 has evolved from one of the alleles of the HLA-A*2402 group through a point mutation...
  16. ncbi Characterisation of a novel HLA-A pseudogene, HLA-BEL, with significant sequence identity with a gorilla MHC class I gene
    F Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast
    Tissue Antigens 54:360-9. 1999
    ..Its unique gene structure gives a possible insight into the evolutionary pathway that created HLA class I genes...
  17. doi Investigation of killer cell immunoglobulin-like receptor gene diversity, KIR2DL1 and KIR2DS1
    A Meenagh
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, UK
    Tissue Antigens 72:383-91. 2008
    ..Results also indicated an inherited KIR2DL1/2DS1 splice variant present in a haplotype with several core loci absent, in two families...
  18. ncbi Analysis of the distribution of HLA-B alleles in populations from five continents
    F Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 62:645-50. 2001
    ..HLA-B allele frequencies and HLA-A/B two locus haplotype frequencies were compiled for each population...
  19. ncbi Analysis of the distribution of HLA-A alleles in populations from five continents
    D Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland, UK
    Hum Immunol 61:1048-52. 2000
    ..It would appear by their presence in all populations studied, either rural or indigenous, that certain alleles are very important in pathogen peptide presentation...
  20. ncbi Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2
    A Meenagh
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, UK
    Tissue Antigens 64:226-34. 2004
    ..A high level of KIR3DL2 allelic polymorphism has been identified...
  21. doi Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5
    A Gonzalez
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, UK
    Tissue Antigens 72:11-20. 2008
    ..This information complements published reports by our laboratory for allele-level typing of other KIR members, totaling 12 of the 17 known genes. These methods are allowing us to characterize KIR haplotypes in our population...
  22. ncbi A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey
    L D Maxwell
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 60:254-8. 2002
    ..Parallels with a recent study in the rhesus monkey highlighting access to the same open reading frame as the deletion variant, also predicting a soluble KIR molecule, are drawn...
  23. ncbi Association of functional heme oxygenase-1 gene promoter polymorphism with renal transplantation outcomes
    A E Courtney
    Nephrology Research Group, Queen s University of Belfast, and Regional Nephrology Unit, Belfast City Hospital, Belfast BT9 7AB, UK
    Am J Transplant 7:908-13. 2007
    ..There is no evidence of a protective effect for the S-allele of the HO-1 gene promoter polymorphism on graft or recipient survival in clinical renal transplantation...
  24. ncbi Characterization of HLA-B*3921 and confirmation of HLA-B*4415, two variant HLA-B alleles identified in the Omani population
    F Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast
    Tissue Antigens 56:376-9. 2000
    ..In addition we confirm the existence of HLA-B*4415, an allele closely related to HLA-B*4501 differing only at the Bw4/Bw6 epitope...
  25. doi No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis
    J McCappin
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, UK
    Tissue Antigens 75:68-73. 2010
    ..We found no association in frequencies of the alleles of these genes in AS. In addition, no differences were found when the patients and controls were differentiated by gender...
  26. ncbi Aberrant splicing of intron 1 creates a novel null HLA-B*1501 allele
    M D Curran
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, UK
    Tissue Antigens 53:244-52. 1999
    ..Our data predicts that the HLA-B*1501 null allele would express a small truncated protein containing the signal sequence fused to an ORF within intron 1 and terminating (out of frame) just within exon 2...
  27. ncbi Characterisation of a new HLA-B allele, HLA-B*0720, identified in the Cuban population
    F Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 57:80-2. 2001
    ..To date, 286 HLA-B alleles have been identified and characterised. We describe a new HLA-B*07 allele present in a Cuban Caucasoid individual, which has been officially named HLA-B*0720...
  28. ncbi Investigation of killer cell immunoglobulin-like receptor gene diversity: IV. KIR3DL1/S1
    Iris A Halfpenny
    Northern Ireland Regional Histocomatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 65:602-12. 2004
    ..Use of the PCR-SSOP system has confirmed the presence of multiple copies of KIR3DL1/S1 alleles in a number of individuals...
  29. ncbi Study of age-association with cytokine gene polymorphisms in an aged Irish population
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, Belfast City Hospital, Belfast BT9 7TS, UK
    Mech Ageing Dev 124:199-206. 2003
    ..These findings would suggest that polymorphism of cytokine genes may not play as crucial a role in healthy ageing as previously believed...
  30. ncbi HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, BT9 7TS, Northern Ireland, Belfast, UK
    Mech Ageing Dev 124:563-7. 2003
    ..However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide...
  31. ncbi Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires
    K A Crum
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast
    Tissue Antigens 56:313-26. 2000
    ..The segregation analysis concluded that at least 3 distinct gene loci encode 2DL1-4 and at least 4 gene loci encode the non-inhibitory KIR2DS1-2DS5. In the case of 3DL1-2 and 3DS1, our data suggests 3 gene loci, one for each subfamily...
  32. ncbi Modification of an HLA-B PCR-SSOP typing system leading to improved allele determination
    D Middleton
    Northern Ireland Tissue Typing Laboratory, City Hospital, Belfast, Northern Ireland, United Kingdom
    Tissue Antigens 45:232-6. 1995
    ..When the method was applied to the typing of 66 consecutive cadaveric donors there were three donors whose type differed from the serological type...
  33. ncbi Investigation of killer cell immunoglobulin-like receptor gene diversity III. KIR2DL3
    L Keaney
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 64:188-94. 2004
    ..In addition, cell line DNA and Centre d'Etude du Humaine (CEPH) families, both from the 13th International Histocompatibility Workshop have been investigated, establishing control data for this gene...
  34. ncbi Investigation of killer cell immunoglobulin-like receptor gene diversity: II. KIR2DS4
    Lynn D Maxwell
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 65:613-21. 2004
    ..Haplotype segregation, with respect to KIR2DS4 alleles, has been examined by using the local family data. Within all sample groups investigated, four KIR2DS4 alleles were identified, two of which are novel to this investigation...
  35. ncbi Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America
    Ashley Meenagh
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 63:1055-61. 2002
    ..Five populations were investigated, Northern Ireland, South African Zulu, Omani, Singapore Chinese and Mexican Mestizos...
  36. ncbi PCR-sequence-specific oligonucleotide probe typing for HLA-A, -B, and -DR
    Derek Middleton
    Belfast City Hospital, Belfast, United Kingdom
    Methods Mol Biol 210:67-112. 2003
  37. ncbi A HLA-Cw*03 allele, Cw*0322Q with limited or no expression
    D Middleton
    Northern Ireland Histocompatiblity and Immunogenetics Laboratory, Blood Transfusion Building, Belfast City Hospital, Belfast, BT9 7TS, Northern Ireland
    Tissue Antigens 67:343-5. 2006
  38. ncbi Identification of a new HLA-B*55 allele, HLA-B*5503
    F Williams
    Northern Ireland Tissue Typing Laboratory, City Hospital, Belfast, United Kingdom
    Tissue Antigens 48:598-9. 1996
  39. ncbi A novel HLA-B allele, HLA-B*1803
    M D Curran
    Northern Ireland Tissue Typing Laboratory, City Hospital, Belfast, Northern Ireland, United Kingdom
    Tissue Antigens 48:708-10. 1996
  40. ncbi Killer immunoglobulin receptor gene and allele frequencies in Caucasoid, Oriental and Black populations from different continents
    D Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 71:105-13. 2008
    ..allelefrequencies.net). In total, 5134 individuals were analysed and the populations grouped, with some exceptions, according to a geographical gradient...
  41. ncbi Mitochondrial DNA polymorphism: its role in longevity of the Irish population
    O A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Blood Transfusing Building, Belfast NI BT9 7TS, UK
    Exp Gerontol 36:1161-78. 2001
    ..164...
  42. ncbi Investigation of KIR diversity in immunosenescence and longevity within the Irish population
    Lynn D Maxwell
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, Northern Ireland, UK
    Exp Gerontol 39:1223-32. 2004
    ..In view of the lack of studies to date, investigating the role of the KIR gene system in healthy ageing, further analysis of KIR diversity is required to fully elucidate it's role in respect to age-related disease and longevity...
  43. ncbi Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population
    Alison P Watt
    Respiratory Research Group, The Queen s University of Belfast, United Kingdom
    J Cyst Fibros 6:363-5. 2007
    ..This study observed no differences in the frequency of cytokine promoter polymorphisms associated with variant levels of expression in patients with CF and a non-CF population of Northern Ireland...
  44. ncbi The role of human leukocyte antigen genes in the formation of abdominal aortic aneurysms
    Stephen A Badger
    Vascular and Endovascular Surgery Centre, Belfast City Hospital, Belfast, United Kingdom
    J Vasc Surg 45:475-80. 2007
    ..This study was conducted to determine if a difference exists in human leukocyte antigen (HLA) allele distribution between patients with AAA and population controls, and between patients with small and large AAA...
  45. ncbi Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 64:729-32. 2003
    ..It is our assumption that an unequal crossover event has occurred between differing KIR haplotypes resulting in the duplication of the 2DL4, 3DS1/3DL1 genes on the newly formed haplotype(s)...
  46. ncbi Investigation of killer cell immunoglobulinlike receptor gene diversity: I. KIR2DL4
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 65:31-8. 2004
    ..Additionally, the KIR2DL4 allele status of cell line DNA and CEPH families, from the 13th International Histocompatibility Workshop and local families, have also been investigated...
  47. ncbi Molecular diversity of the HLA-C gene identified in a caucasian population
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Northern, Belfast, Ireland
    Hum Immunol 63:602-13. 2002
    ..HLA-Cw allele frequencies occurring within the Northern Ireland population have been compiled, along with estimations of HLA-B/Cw haplotype frequencies...
  48. ncbi Identification of medically important pathogenic fungi by reference strand-mediated conformational analysis (RSCA)
    Brian P McIlhatton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    J Med Microbiol 51:468-78. 2002
    ..This technique displays enormous potential as an alternative to DNA sequence determination and has the potential to become an automated technique that can be implemented in the routine setting...
  49. ncbi Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants
    Irene M Rea
    Department of Geriatric Medicine, Queens University of Belfast, Whitla Medical Building, 97, Lisburn Road, Belfast, UK
    Mech Ageing Dev 124:555-61. 2003
    ....
  50. ncbi High resolution HLA-DRB1 identification of a Caucasian population
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 65:66-77. 2004
    ..Evidence for selection was seen on haplotypes HLA-A*010101-B*0801-DRB1*030101 and HLA-A*290201-B*440301-DRB1*070101 based on their patterns of linkage disequilibrium...
  51. ncbi Characterisation of a new HLA-B allele, HLA-B*0724
    D Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland, UK
    Tissue Antigens 57:471-3. 2001
  52. ncbi A new HLA-B51 allele, B*5107 in RCE55 detected and characterized by PCR-SSOP, cloning and nucleotide sequence determination
    M D Curran
    Northern Ireland Tissue Typing Laboratory, City Hospital, Belfast
    Tissue Antigens 48:228-30. 1996
  53. ncbi The IL12B 3' untranslated region DNA polymorphism is not associated with early-onset type 1 diabetes
    R M McCormack
    Department of Medical Genetics, Queen s University Belfast, Belfast, Northern Ireland
    Genes Immun 3:433-5. 2002
    ..8% vs 80.8%; P=0.98) or family-based (49.7% transmissions; P=0.94) studies. Our results do not support earlier reports of an association between allele 1 in the 3'UTR of the IL12B gene and type 1 diabetes...
  54. ncbi Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population
    H Abdeen
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, UK
    Tissue Antigens 69:273-6. 2007
    ..It appears that HLA-B*3569 arose from the analogous HLA-B*3510 through a point mutation. However, HLA-B*4450 may have arisen from HLA-B*440301 and -B*4425 by gene conversion...
  55. ncbi Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Northern Ireland, Belfast, UK
    Exp Gerontol 38:561-5. 2003
    ....
  56. doi Killer cell immunoglobulin-like receptor allele discrimination by high-resolution melting
    Asensio Gonzalez
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, United Kingdom
    Hum Immunol 70:858-63. 2009
    ..The ongoing refinement of KIR haplotype distribution in our control population will help in disease association studies involving the KIR genes...
  57. ncbi Genetic, morphometric and immunohistochemical markers of latent coeliac disease
    S D Johnston
    Department of Medicine, Queen s University, Belfast, Northern Ireland, UK
    Eur J Gastroenterol Hepatol 11:1283-8. 1999
    ....
  58. doi Differential RNA expression of KIR alleles
    Colum McErlean
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland, UK
    Immunogenetics 62:431-40. 2010
    ..Thus, variation of KIR expression on cell surfaces more likely involves post-transcriptional mechanisms...
  59. ncbi mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast BT9 7TS, Northern Ireland, UK
    Exp Gerontol 38:397-405. 2003
    ..These findings lead one to postulate that the mt4216C variant, in linkage with the mtDNA TJ cluster, may influence mitochondrial dysfunction, resulting in an increased risk of PD...
  60. ncbi A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, Belfast City Hospital, Belfast BT9 7TS, UK
    Neuroreport 13:1621-5. 2002
    ..These results would suggest that polymorphism of the alpha-synuclein gene may not play as significant a role in the pathogenesis of idiopathic PD as previously hypothesised...
  61. ncbi Are threesomes worth considering?
    Derek Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory City Hospital, Belfast, Northern Ireland
    Transplantation 77:801-2. 2004
  62. ncbi Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy
    Aisling E Courtney
    Nephrology Research Group, Queen s University Belfast, Belfast, UK
    Nephrol Dial Transplant 23:608-11. 2008
    ..We report the first assessment of the role of this HO-1 gene promoter polymorphism in chronic kidney disease due to autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IgAN)...
  63. ncbi Mitochondrial DNA damage in lymphocytes: a role in immunosenescence?
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, Northern Ireland BT9 7TS, UK
    Exp Gerontol 37:329-40. 2002
    ..A similar explanation may also apply to the in vitro model of T cell ageing if the vast majority of the cells are replicating rather than entering senescence...
  64. ncbi The repercussions of implementing flow cytometry as a single HLA antibody screening technique in prospective renal transplant recipients
    Bernadette Magee
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast BT9 7TS, UK
    Transpl Int 19:105-9. 2006
    ....
  65. ncbi Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish
    Owen A Ross
    Department of Geriatric Medicine, Belfast, Ireland
    Hum Immunol 65:340-6. 2004
    ....
  66. ncbi The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated
    Natalia Gómez-Lozano
    Servicio de Inmunologia, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Eur J Immunol 35:16-24. 2005
    ..The putative KIR3DP1*004 product, like those of the related genes LAIR-2 and LILRA3/ILT6/LIR4, is predicted to be secreted to the extracellular medium rather than anchored to the cell membrane...
  67. ncbi HLA genes in Madeira Island (Portugal) inferred from sequence-based typing: footprints from different origins
    Hélder Spínola
    Human Genetics Laboratory, University of Madeira, Campus of Penteada, 9000 399 Funchal, Portugal
    Mol Immunol 43:1726-8. 2006
    ..Despite this African genetic input, haplotype and allele frequencies were predominantly from European origin, mostly common to mainland Portugal...
  68. ncbi HLA class I polymorphism in the Cuban population
    Annia Ferrer
    Center of Genetic Engineering and Biotechnology, Havana, Cuba
    Hum Immunol 68:918-27. 2007
    ..Our results provide useful information for the further studies of the Cuban population evolution and disease association in terms of HLA class I genes...
  69. ncbi Analysis of KIR ligand incompatibility in human renal transplantation
    T Hien Tran
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:1121-3. 2005
    ..No effect of KIR ligand matching on graft survival was observed in cadaver kidney transplants. Our results indicate that KIR ligand matching cannot be recommended as a strategy for improving renal allograft survival...
  70. ncbi HLA polymorphisms in Cabo Verde and Guiné-Bissau inferred from sequence-based typing
    Hélder Spínola
    Human Genetics Laboratory, University of Madeira, Campus of Penteada, Funchal, Portugal
    Hum Immunol 66:1082-92. 2005
    ..Dendrograms and principal coordinates analysis show that Guineans are more similar to North Africans than other HLA-studied sub-Saharans, probably from ancient and recent genetic contacts with other peoples, namely East Africans...
  71. ncbi Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, United Kingdom
    Hum Immunol 64:648-54. 2003
  72. ncbi Functional polymorphism of the KIR3DL1/S1 receptor on human NK cells
    Geraldine M O'Connor
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 178:235-41. 2007
    ..In contrast to the inhibitory KIR3DL1 allotypes, KIR3DS1 did not recognize HLA-Bw4 on EBV-transformed cell lines...
  73. ncbi Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    Immunogenetics 55:220-6. 2003
  74. ncbi Human NK cell education by inhibitory receptors for MHC class I
    Nicolas Anfossi
    Innate Pharma, 13009 Marseille, France
    Immunity 25:331-42. 2006
    ..These results show the involvement of KIR-MHC class I interactions in the calibration of NK cell effector capacities, suggesting its role in the subsequent "missing self" recognition...
  75. ncbi A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell lines
    Mark A Cook
    Cancer Research, UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    Hum Immunol 64:567-71. 2003
    ..Further improvements in typing may be required if population and clinical studies are to produce accurate results...
  76. doi Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations
    Raja Rajalingam
    UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Immunogenetics 60:207-17. 2008
    ..Whether or not natural selection has acted to enrich group-B KIR haplotypes in these migratory descendants is an issue that requires objective testing...
  77. ncbi The outcome of pediatric cadaveric renal transplantation in the UK and Eire
    Rachel J Johnson
    Department of Pediatric Nephrology, Royal Manchester Children s Hospital, Pendlebury, Manchester M27 4HA, UK
    Pediatr Transplant 6:367-77. 2002
    ..The poor outcome associated with very young donors should discourage pediatric units from transplanting kidneys from such young donors. The reasons for late losses in older recipients need investigation...
  78. doi Temporal, quantitative, and functional characteristics of single-KIR-positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation
    Luca Vago
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS H San Raffaele, Via Olgettina 60, 20132, Milano, Italy
    Blood 112:3488-99. 2008
    ....
  79. ncbi Current and emerging technology for HLA typing
    Derek Middleton
    N Ireland Histocompatibility and Immunogenetics Laboratory, Belfast, N Ireland
    Int J Hematol 76:150-1. 2002
    ..New methods or variations of existing methods are continually being developed. However the cost of equipment makes it difficult for a laboratory to decide on which methods to use...